Patents Represented by Attorney Harry E. Westlake, Jr.

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  • Tricyclicdicarboximides
    Patent number: 4061763
    Abstract: Tricyclicdicarboximides representatively prepared by the Diels-Alder condensation of a cyclic diene such as cycloheptatriene, cyclooctatetraene and the like with a dienophile such as substituted N-phenylmaleimide and the like are disclosed having pharmaceutical utility as minor tranquilizers and anti-convulsants. Also disclosed are processes for the preparation of such tricyclicdicarboximides; pharmaceutical compositions comprising such compounds and their salt, ester and amide derivatives, and methods of treatment comprising administering such compounds and compositions.
    Type: Grant
    Filed: August 12, 1976
    Date of Patent: December 6, 1977
    Assignee: Merck & Co., Inc.
    Inventors: Kenneth L. Shepard, William J. Paleveda, Jr.
  • Certain 16-aryloxy-11,12-seco-prostaglandins
    Patent number: 4061643
    Abstract: This invention relates to aryloxy-, alkoxy-, arylthio-, and alkylthio-11,12-seco-prostaglandins and to processes for their manufacture. These compounds have prostaglandin-like activity and are particularly useful in fertility control such as for estrus synchronization in animals and postcoital contraceptive agents in humans.
    Type: Grant
    Filed: September 9, 1976
    Date of Patent: December 6, 1977
    Assignee: Merck & Co., Inc.
    Inventors: Edward J. Cragoe, Jr., John B. Bicking
  • (+) AND (-) 1-Methyl-4-(3-cyano-5H-dibenzo(a,d)-cyclohepten-5-ylidene)piperidine containing compositions and methods for using same
    Patent number: 4060622
    Abstract: Resolution of 1-methyl-4-(3-cyano-5H-dibenzo-[a,d]-cyclohepten-5-ylidene)piperidine provides a levorotary isomer (-) having major tranquilizer pharmaceutical utility and a dextrorotary isomer (+) having anticholinergic pharmaceutical utility. Also disclosed are pharmaceutical compositions comprising either isomer substantially free of the other; pharmaceutical compositions comprising preferred ratios of the (+) and (-) isomers; and methods of treatment comprising administering such compounds and compositions.
    Type: Grant
    Filed: January 27, 1976
    Date of Patent: November 29, 1977
    Assignee: Merck & Co., Inc.
    Inventor: David C. Remy
  • 8-Halo-11,12-secoprostaglandins
    Patent number: 4059601
    Abstract: This invention relates to 11,12-secoprostaglandins and processes for their manufacture. These compounds have prostaglandin-like biological activity and are particularly useful as renal vasodilators, for the treatment of hypertension, and for the prevention of thrombus formation.
    Type: Grant
    Filed: July 8, 1976
    Date of Patent: November 22, 1977
    Assignee: Merck & Co., Inc.
    Inventors: Edward J. Cragoe, Jr., John B. Bicking
  • 8-Methyl-, phenyl-, or substituted phenyl-11,12-secoprostaglandins
    Patent number: 4059602
    Abstract: This invention relates to 11,12-secoprostaglandins and processes for their manufacture. These compounds have prostaglandin-like biological activity and are particularly useful as renal vasodilators, for the treatment of hypertension, and for the prevention of thrombus formation.
    Type: Grant
    Filed: July 8, 1976
    Date of Patent: November 22, 1977
    Assignee: Merck & Co., Inc.
    Inventors: Edward J. Cragoe, Jr., John B. Bicking
  • Certain thiazolidine compounds
    Patent number: 4059587
    Abstract: This invention relates to novel 8-aza-9-oxo-11-thia-, -11-oxothia-, and -11-dioxothia-prostanoic acid compounds, salts, and derivatives thereof and also to processes for the preparation of such compounds. These compounds have prostaglandin-like biological activity and are particularly useful as renal vasodilators, for the treatment of certain autoimmune diseases, and in preventing thrombus formation.
    Type: Grant
    Filed: May 24, 1976
    Date of Patent: November 22, 1977
    Assignee: Merck & Co., Inc.
    Inventors: Robert L. Smith, Ta-Jyh Lee, Edward J. Cragoe, Jr.
  • Substituted imidazole compounds and therapeutic compositions therewith
    Patent number: 4058614
    Abstract: Substituted imidazole compounds which are useful as anti-hypertensive agents or as xanthine oxidase inhibitors.
    Type: Grant
    Filed: February 18, 1976
    Date of Patent: November 15, 1977
    Assignee: Merck & Co., Inc.
    Inventor: John J. Baldwin
  • Amino acid esters
    Patent number: 4058530
    Abstract: Derivatives of .alpha.-methyl-3,4-dihydroxyphenylalanine which are useful in compositions as anti-hypertensive agents.
    Type: Grant
    Filed: March 18, 1976
    Date of Patent: November 15, 1977
    Assignee: Merck & Co., Inc.
    Inventor: Walfred S. Saari
  • 5-Mercaptopyridoxine esters
    Patent number: 4057637
    Abstract: Mercaptoalkylpyridines and various derivatives thereof have utility in the treatment of rheumatoid arthritis. The compounds useful in the method of treatment are generally prepared from known pyridine derivatives and, principally, from pyridoxine and related compounds.
    Type: Grant
    Filed: May 11, 1976
    Date of Patent: November 8, 1977
    Assignee: Merck & Co., Inc.
    Inventors: Tsung-Ying Shen, Howard Jones, Dennis M. Mulvey, Conrad P. Dorn
  • Acyl cyanoguanidines
    Patent number: 4057642
    Abstract: Certain novel acyl cyanoguanidines, their preparation, pharmaceutical compositions and novel methods of treating inflammation and autoimmune diseases such as rheumatoid arthritis are disclosed.
    Type: Grant
    Filed: September 30, 1975
    Date of Patent: November 8, 1977
    Assignee: Merck & Co., Inc.
    Inventors: Howard Jones, Tsung-Ying Shen
  • Pyrrolo[2,1-b][3]benzazepines
    Patent number: 4056536
    Abstract: 11H-Pyrrolo[2,1-b][3]benzazepin-11-one and derivatives thereof are generally prepared by Friedel-Crafts ring closure of a N-styrylpyrrole-2-carboxylic acid derivative. They are useful intermediates in the synthesis of skeletal muscle relaxants and tranquilizers such as 11-(3-dimethylaminopropylidene)-2-cyano-11H-pyrrolo[2,1-b][3]benzazepine.
    Type: Grant
    Filed: June 29, 1976
    Date of Patent: November 1, 1977
    Assignee: Merck & Co., Inc.
    Inventors: Joseph G. Atkinson, Patrice C. Belanger, Clarence S. Rooney, Susan F. Britcher
  • Process for making paper products of improved dry strength
    Patent number: 4056432
    Abstract: Paper products exhibiting markedly improved dry strength properties are produced by adding to the cellulose paper dispersion a chitin-based compound comprising chitosan alone or a graft copolymer of certain acrylic and/or diallylic monomers grafted onto the chitosan as a substrate.
    Type: Grant
    Filed: July 6, 1971
    Date of Patent: November 1, 1977
    Assignee: Calgon Corporation
    Inventors: Robert Clayton Slagel, Gloria DiMarco Sinkovitz
  • 10-Aza-11,12-secoprostaglandins
    Patent number: 4055597
    Abstract: This invention relates to 10-aza-11,12-secoprostaglandins and processes for their manufacture. These compounds have prostaglandin-like biological activity and are particularly useful as renal vasodilators.
    Type: Grant
    Filed: June 2, 1975
    Date of Patent: October 25, 1977
    Assignee: Merck & Co., Inc.
    Inventors: Edward J. Cragoe, Jr., John B. Bicking
  • 11,12-Seco-prostaglandins
    Patent number: 4055596
    Abstract: The invention is concerned with novel 16-aryloxy-, 16-alkoxy-, 16-arylthio- and 16-alkylthio-8-aza-9-dioxothia-11,12-seco-prostaglandins and processes for their preparation. These novel compounds are useful as pharmaceuticals since they can be used in animals for estrus synchronization and treatment of infertility due to persistence of luteal function.
    Type: Grant
    Filed: July 14, 1976
    Date of Patent: October 25, 1977
    Assignee: Merck & Co., Inc.
    Inventors: Edward J. Cragoe, Jr., James H. Jones
  • Dihydro- and tetrahydro- iminothiazines
    Patent number: 4054652
    Abstract: Dihydro- and tetrahydro-iminothiazines are inhibitors of indoleamine-N-methyl transferase in vivo.
    Type: Grant
    Filed: June 15, 1976
    Date of Patent: October 18, 1977
    Assignee: Merck & Co., Inc.
    Inventors: Clarence S. Rooney, Joshua Rokach, Edward J. Cragoe, Jr.
  • Method of using cementing composition having improved flow properties
    Patent number: 4053323
    Abstract: Methods of using aqueous hydraulic cement compositions containing polyamido-sulfonic compounds as flow-property-improving and turbulence-inducing additives are disclosed.
    Type: Grant
    Filed: March 4, 1977
    Date of Patent: October 11, 1977
    Assignee: Calgon Corporation
    Inventors: Sally Lee Adams, Michael M. Cook, Fred David Martin
  • Heterocyclic dihydroanthracen imines
    Patent number: 4052508
    Abstract: Heterocyclic dihydroanthracen imines are disclosed to be useful as minor tranquilizers, anticonvulsants, muscle relaxants and to be useful in the treatment of extrapyramidal disorders such as Parkinson's disease; also disclosed are processes for the preparation of such compounds; pharmaceutical compositions comprising such compounds; and methods of treatment comprising administering such compounds and compositions.
    Type: Grant
    Filed: April 7, 1975
    Date of Patent: October 4, 1977
    Assignee: Merck & Co., Inc.
    Inventors: Paul S. Anderson, Marcia E. Christy, Gerald S. Ponticello
  • Sinister-3,5-disubstituted oxozolidines their preparation and use
    Patent number: 4051144
    Abstract: Preparation of S-3-X-4-(3-substituted amino-2-hydroxypropoxy)-1,2,5-thiadiazole beta adrenergic blocking agents using as starting material an optically active alkalmine in the sinister configuration, or a derivative of said alkamine, which is reacted with an 3-X-4-chloro(or RO-where R is hydrogen or an alkali metal)-1,2,5-thiadiazole. Certain3-morpholino-4-chloro(or RO-)-1,2,5-thiadiazoles and certain alkamines and their preparation also are described. Preferred alkamines are S-3,5-disubstituted oxazolidines.
    Type: Grant
    Filed: December 4, 1974
    Date of Patent: September 27, 1977
    Assignee: Charles E. Frosst & Co.
    Inventors: Leonard M. Weinstock, Roger J. Tull, Dennis M. Mulvey
  • Amino acid esters
    Patent number: 4051169
    Abstract: Derivatives of .alpha.-methyl-3,4-dihydroxyphenylalanine which are useful in compositions as anti-hypertensive agents.
    Type: Grant
    Filed: March 21, 1975
    Date of Patent: September 27, 1977
    Assignee: Merck & Co., Inc.
    Inventor: Walfred S. Saari
  • 3-Dimethylsulfamoyl-5-[amino(alkyl or alkylidene)]-5H-dibenzo [a,d]cycloheptenes
    Patent number: 4048223
    Abstract: This invention relates to new derivatives of dibenzocycloheptenes and to processes for making them. More particularly, the invention includes 5H-dibenzo[a,d]-cycloheptenes and 10,11-dihydro-5H-dibenzo[a,d]cycloheptenes which are substituted at their 5-carbon atom with an aminopropyl or an aminopropylidene radical. The amino entity may be either primary or secondary and if secondary, the substituent may be either a lower alkyl or alkenyl radical having up to 6 carbon atoms, cycloalkyl having up to 8 carbon atoms or an aralkyl radical. The dibenzocycloheptene nucleus may be further substituted. The invention also includes the intermediates used for obtaining these products. Also included are derivatives such as acyl derivatives which yield the active compound under physiological conditions.
    Type: Grant
    Filed: October 6, 1976
    Date of Patent: September 13, 1977
    Assignee: Merck & Co., Inc.
    Inventor: Edward L. Engelhardt