Patents Represented by Attorney Harry E. Westlake, Jr.
  • Patent number: 4020169
    Abstract: Trifluoromethylthiocopper, formed in situ by the reaction of bis-(trifluoromethylthio)mercury with copper, reacts with aromatic bromides and iodides to give aryl trifluoromethyl sulfides.
    Type: Grant
    Filed: December 22, 1975
    Date of Patent: April 26, 1977
    Assignee: Merck & Co., Inc.
    Inventors: David C. Remy, Mark B. Freedman
  • Patent number: 4018702
    Abstract: A method of inhibiting corrosion and scale formation in an aqueous system is disclosed which comprises the step of treating the said system with 0.1 to 500 parts per million by weight of the total aqueous content of the said system, of a composition which comprises amine adducts of maleic anhydride polymers and which may additionally include zinc.
    Type: Grant
    Filed: February 12, 1976
    Date of Patent: April 19, 1977
    Assignee: Calgon Corporation
    Inventors: Bennett P. Boffardi, Michael M. Cook, Paul H. Ralston
  • Patent number: 4018802
    Abstract: This invention relates to 9-thia-, 9-oxothia, and 9-dioxothia-11,12-seco-prostaglandins and processes for their manufacture. These compounds have prostaglandin-like biological activity and are particularly useful for the treatment of skin diseases such as psoriasis, for the prevention of Thrombus formation, in stimulating the production of growth hormone in intact animals, and as regulators of the immune response.
    Type: Grant
    Filed: March 22, 1976
    Date of Patent: April 19, 1977
    Assignee: Merck & Co., Inc.
    Inventors: Edward J. Cragoe, Jr., John B. Bicking, Robert L. Smith
  • Patent number: 4018701
    Abstract: Use of phosphorous acid (H.sub.3 PO.sub.3) and zinc to inhibit the corrosion of metals by oxygen-bearing waters.
    Type: Grant
    Filed: July 31, 1975
    Date of Patent: April 19, 1977
    Assignee: Calgon Corporation
    Inventors: Paul Hotchkiss Ralston, Bennett Patsy Boffardi
  • Patent number: 4017543
    Abstract: This application discloses methods of preparing .alpha.,.alpha.-diloweralkyl substituted benzylamines by the catalytic hydrogenation of the corresponding .alpha.,.alpha.-dialkyl-4-(phenyl-ethynyl)-benzylamine. The produced .alpha.,.alpha.-diloweralkylamines are converted to the corresponding N-alkyl and N,N-dialkyl derivatives thereof. The amines and their alkylated derivatives are useful as antiarrhythmics.
    Type: Grant
    Filed: October 23, 1975
    Date of Patent: April 12, 1977
    Assignee: Merck & Co., Inc.
    Inventor: Marcia Elizabeth Christy
  • Patent number: 4015991
    Abstract: Improved cementing compositions and their use in cementing operations is disclosed, wherein copolymers of hydrolyzed acrylamide and 2-acrylamido-2-methylpropane sulfonic acid derivatives are used as fluid loss additives for aqueous hydraulic cement slurries.
    Type: Grant
    Filed: May 10, 1976
    Date of Patent: April 5, 1977
    Assignee: Calgon Corporation
    Inventors: Leonard J. Persinski, Michael M. Cook, Sally Lee Adams
  • Patent number: 4014817
    Abstract: An improved method of manufacturing activated carbon from dried, bituminous, subbituminous, and lignite coal by sizing and simultaneously drying and oxidizing, and thereafter activating the sized coal, wherein the improvement comprises acid washing the coal prior to carrying out the said manufacturing method.
    Type: Grant
    Filed: April 3, 1975
    Date of Patent: March 29, 1977
    Assignee: Calgon Corporation
    Inventors: Bruce C. Johnson, Rabindra Kumar Sinha, John Emery Urbanic
  • Patent number: 4011909
    Abstract: Methods of using aqueous hydraulic cement compositions containing polyamido-sulfonic compounds as flow-property-improving and turbulence-inducing additives are disclosed.
    Type: Grant
    Filed: January 29, 1976
    Date of Patent: March 15, 1977
    Assignee: Calgon Corporation
    Inventors: Sally Lee Adams, Fred David Martin, Michael M. Cook
  • Patent number: 4012327
    Abstract: Alcohols, particularly anhydrous alcohols, thickened with aminomethylated polyacrylamide, used as fracturing fluids for stimulating well production.
    Type: Grant
    Filed: February 12, 1975
    Date of Patent: March 15, 1977
    Assignee: Calgon Corporation
    Inventors: Jerry Emile Boothe, Fred David Martin
  • Patent number: 4011326
    Abstract: Oxazolo[4,5-b]pyridine substituted in the 2-position with a polyhydrobicycloaryl group are topical anti-inflammatory agents. They are prepared by condensing a 2-amino-3-hydroxypyridine with the appropriate carboxylic compound.
    Type: Grant
    Filed: July 29, 1975
    Date of Patent: March 8, 1977
    Assignee: Merck & Co., Inc.
    Inventor: Norman P. Jensen
  • Patent number: 4006233
    Abstract: Tricyclicdicarboximides representatively prepared by the Diels-Alder condensation of a cyclic diene such as cycloheptatriene, cyclooctatetraene and the like with a dienophile such as substituted N-phenylmaleimide and the like are disclosed having pharmaceutical utility as minor tranquilizers and anti-convulsants. Also disclosed are processes for the preparation of such tricyclicdicarboximides; pharmaceutical compositions comprising such compounds and their salt, ester and amide derivatives; and methods of treatment comprising administering such compounds and compositions.
    Type: Grant
    Filed: May 9, 1975
    Date of Patent: February 1, 1977
    Assignee: Merck & Co., Inc.
    Inventors: Kenneth L. Shepard, William J. Paleveda, Jr.
  • Patent number: 4005106
    Abstract: Racemic or optically-active prostaglandin E.sub.1 is synthesized from racemic or optically-active precursors in good yield at the various steps from 3.alpha.,6,7,7.alpha.-tetrahydro-4-methyl-2-oxo-1.beta.-indaneheptanoic acid methyl ester proceeding through 2.alpha.-(2-carboxyethyl)-3.beta.-hydroxy-5-oxo-1.beta.-cyclopentaneheptan oic acid methyl ester, .delta.-lactone, 5-cyclic ethylene acetal, 2.alpha.-(2-carboxy-2-formylethyl)-3.beta.-hydroxy-5-oxo-1.beta.-cyclopent aneheptanoic acid methyl ester, .delta.-lactone, 5-cyclic ethylene acetal, 2.alpha.-(2-carboxy-2-oxoetyl)-3.beta.-hydroxy-5-oxo-1.beta.-cyclopentaneh eptanoic acid methyl ester, .delta.-lactone, 5-cyclic ethylene acetal, and 3.beta.-hydroxy-2.alpha.-(3-oxo-1-octenyl)-5-oxo-1.beta.-cyclopentanehepta noic acid methyl ester, 5-cyclic ethylene acetal.
    Type: Grant
    Filed: May 7, 1975
    Date of Patent: January 25, 1977
    Assignee: Merck & Co., Inc.
    Inventors: Norman L. Wendler, David Taub, Harry L. Slates, Zbigniew S. Zelawski
  • Patent number: 4002589
    Abstract: Water-soluble segmented polymers of the ##STR1## A--B--A, and (A--B).sub.n types wherein the A-segments are grafted homopolymer, copolymer and/or terpolymer segments of water-soluble vinyl monomers, and the B-segments are homopolymer segments of poly(vinyl pyrrolidone) or poly(vinyl alcohol), are prepared by a process employing inverse emulsion techniques and cerium (IV) salt initiators.
    Type: Grant
    Filed: January 13, 1975
    Date of Patent: January 11, 1977
    Assignee: Calgon Corporation
    Inventors: David E. Farley, Janice Elaine Morgan
  • Patent number: 4000286
    Abstract: 3H-1,2,3-Triazolo[4,5-b]pyridines substituted in the 3-position have utility as analgesic, anti-inflammatory and anti-pyretic agents. They are prepared by diazotization of a 3-amino-2-(substitute) aminopyridine.
    Type: Grant
    Filed: October 3, 1975
    Date of Patent: December 28, 1976
    Assignee: Merck & Co., Inc.
    Inventors: Robert L. Clark, Arsenio A. Pessolano, Tsung-Ying Shen
  • Patent number: 3998849
    Abstract: Racemic or optically-active prostaglandin E.sub.1 is synthesized from racemic or optically-active precursors in good yield at the various steps from 3.alpha.,6,7,7.alpha.-tetrahydro-4-methyl-2-oxo-1.beta.-indaneheptanoic acid methyl ester proceeding through 2.alpha.-(2-carboxyethyl)-3.beta.-hydroxy-5-oxo-1.beta.-cyclopentaneheptan oic acid methyl ester, .delta.-lactone, 5-cyclic ethylene acetal, 2.alpha.-(2-carboxy-2-formylethyl)-3.beta.-hydroxy-5-oxo-1.beta.-cyclopent aneheptanoic acid methyl ester, .delta.-lactone, 5-cyclic ethylene acetal, 2.alpha.-(2-carboxy-2-oxoethyl)-3.beta.-hydroxy-5-oxo-1.beta.-cyclopentane heptanoic acid methyl ester, .delta.-lactone, 5-cyclic ethylene acetal, and 3.beta.-hydroxy-2.alpha.-(3-oxo-1-octenyl)-5-oxo-1.beta.-cyclopentanehepta noic acid methyl ester, 5-cyclic ethylene acetal.
    Type: Grant
    Filed: May 8, 1975
    Date of Patent: December 21, 1976
    Assignee: Merck & Co., Inc.
    Inventors: Norman L. Wendler, David Taub, Harry L. Slates, Zbigniew S. Zelawski
  • Patent number: 3998875
    Abstract: Invention relates to improved processes for preparing 5-fluoro-2-methyl-1-(p-methylsulfinylbenzylidene)-indenyl-3-acetic acid, to intermediates thereof, and to the preparation of said intermediates.
    Type: Grant
    Filed: October 2, 1974
    Date of Patent: December 21, 1976
    Assignee: Merck & Co., Inc.
    Inventors: Roger J. Tull, David G. Melillg
  • Patent number: 3996018
    Abstract: Crystals are grown in a column through which a supersaturated solution flows upwardly while large crystals having one dimension substantially greater than another dimension taken from the bottom of the column are fractured externally of the column and the fractured particles are returned to the upper end of the column where fines are separated from larger seed type particles.
    Type: Grant
    Filed: January 29, 1976
    Date of Patent: December 7, 1976
    Assignee: Merck & Co., Inc.
    Inventor: Michael Midler, Jr.
  • Patent number: 3994806
    Abstract: In the flocculation and removal of suspended matter from water, combinations of cationic and nonionic water-soluble polymers are found to be more effective than equivalent concentrations of cationics alone, and significantly lower concentrations of the combination are found to be equivalent in effect to higher concentrations of cationic polymers alone.
    Type: Grant
    Filed: March 8, 1972
    Date of Patent: November 30, 1976
    Assignee: Calgon Corporation
    Inventors: Emerson George Rausch, Ramon Anthony Muia
  • Patent number: 3994852
    Abstract: Improved cementing compositions and their use in well cementing operations is disclosed, wherein polyvinylpyrrolidone-polyacrylamide triblock polymers are used as fluid loss additives for aqueous hydraulic cement slurries.
    Type: Grant
    Filed: July 17, 1975
    Date of Patent: November 30, 1976
    Assignee: Calgon Corporation
    Inventors: Sally Lee Adams, Lawrence James Guilbault, Fred David Martin
  • Patent number: 3993134
    Abstract: Aqueous hydraulic cement compositions containing polymaleic anhydride as a flow-property-improving and turbulence-inducing additive and their use in cementing wells is disclosed.
    Type: Grant
    Filed: October 16, 1975
    Date of Patent: November 23, 1976
    Assignee: Calgon Corporation
    Inventors: Sally L. Adams, Michael M. Cook, Fred David Martin