Abstract: The present invention relates to processes for the preparation of compounds useful as inhibitors of p38 kinase. The processes of the present invention are amenable for large scale preparation and produce stable phenyl-6-(1-(phenyl)ureido)nicotinamides in high purity and yields.

Abstract: A phase-change memory device includes a first insulator having a hole therethrough, a first electrode that conforms at least partially to the hole, a phase-change material in electrical communication with the first electrode, and a second electrode in electrical communication with the phase-change material. When current is passed from the first electrode to the second electrode through the phase-change material, at least one of the first and second electrodes remains unreactive with the phase change material.

Abstract: The present invention relates to compounds which inhibit IMPDH. This invention also relates to pharmaceutical compositions comprising these compounds. The compounds and pharmaceutical compositions of this invention are particularly well suited for inhibiting IMPDH enzyme activity and consequently, may be advantageously used as therapeutic agents for IMPDH-mediated processes. This invention also relates to methods for inhibiting the activity of IMPDH using the compounds of this invention and related compounds.

Abstract: Compounds represented by formula I: or pharmaceutically acceptable salts and solvates thereof, wherein R1, X, Y, and Z are as defined herein, are useful for treating flaviviridae viral infections.

Abstract: A system for providing at least a partially mounted tire and wheel assembly is disclosed. The system includes the steps of using a prime mover to bring a tire and wheel together and using the primer mover to work on at least one of the tire or the wheel to mount the tire and the wheel together, wherein the work performed by the prime mover is the only positive work introduced into the tire/wheel system.

Abstract: The present invention relates to modulators of muscarinic receptors of formula (I). The present invention also provides impositions comprising such modulators, and methods therewith for treating muscarinic receptor mediated diseases.

Abstract: The invention relates to a device and a method for producing tailored blanks. The device comprises a workpiece carrier for the sheets (15a, 15b) that are to be joined into tailored blanks in the butt joint by welding. The invention further comprises a plurality of laser welding heads (14a, 14b), which are arranged one behind the other over the workpiece carrier and along the butt joint to be welded and can be moved with an advancing device (11a, 11b), wherein the heads can be aligned with the joint using positioning means, wherein at least two combined laser cutting and welding heads (14a, 14b) are carried by at least two independent arms (13a, 13b), each associated with independent units (11a, 11b) of the advancing device, and wherein the positioning means can adjust the distances of the units (11a, 11b) in the direction of the butt joint and also the distances of the cutting and welding heads (14a, 14b) in the transversal direction to the butt joint.

Abstract: An external-cavity laser module includes a package defining an enclosure, the package including a base having a surface internal to the enclosure, a thermoelectric cooler within the enclosure, the thermoelectric cooler including an upper carrier plate and a lower carrier plate, the lower carrier plate being placed on the internal surface of the base and the thermoelectric cooler (TEC) being configured to stabilize the temperature of the upper carrier plate at a substantially constant temperature. The laser module further includes a laser assembly housed within the enclosure, including a gain medium for emitting an optical beam into the external cavity and an end mirror. Variations of the environmental temperature with respect to the thermally stabilized temperature cause mechanical deformations of the TEC upper carrier plate that is in thermal coupling with the laser assembly. The mechanical deformations in turn induce variations in the optical path length of the laser cavity.

Abstract: The present invention relates to therapeutic combinations comprising a protease inhibitor and a polymerase inhibitor for the treatment of HCV. The present invention also relates to therapeutic combinations comprising VX-950 and a polymerase inhibitor. Also within the scope of the invention are methods using the therapeutic combinations of the present invention for treating HCV infection or alleviating one or more symptoms thereof in a patient. The present invention also provides kits comprising the combinations of the present invention.

Abstract: The present invention relates to spiroindoline modulators of muscarinic receptors. The present invention also provides compositions comprising such spiroindoline modulators, and methods therewith for treating muscarinic receptor mediated diseases.

Abstract: The present invention relates to peptidomimetic compounds useful as protease inhibitors, particularly as serine protease inhibitors and more particularly as hepatitis C NS3 protease inhibitors; intermediates thereto; their preparation including novel steroselective processes to intermediates. The invention is also directed to pharmaceutical compositions and to methods for using the compounds for inhibiting HCV protease or treating a patient suffering from an HCV infection or physiological condition related to the infection. Also provided are pharmaceutical combinations comprising, in addition to one or more HCV serine protease inhibitors, one or more interferons exhibiting anti-HCV activity and/or one or more compounds having anti HCV activity and a pharmaceutically acceptable carrier, and methods for treating or preventing a HCV infection in a patient using the compositions. The present invention is also directed to a kit or pharmaceutical pack for treating or preventing HCV infection in a patient.

Abstract: A fastener is disclosed. The fastener includes a housing, wherein the housing forms a housing cavity, wherein the housing cavity includes at least one recess; a cage at least partially disposed in said housing cavity, wherein an outer surface of the cage is spaced apart from an inner surface of the housing that forms the housing cavity, wherein the cage defines a cage cavity, and a plurality of passages aligned with said at least one recess; a plurality of retaining members at least partially retained within said plurality of passages; and a plunger at least partially disposed in said cage cavity, wherein said plunger is at least partially movable within said cage cavity between a first position to cause said one or more retaining members to be displaced radially outwardly thereby mechanically coupling said housing to said cage, and a second position to allow said one or more retaining members to be displaced radially inwardly thereby allowing said housing to be uncoupled from said cage.

Abstract: In one aspect, the invention provides compounds of Formula I or pharmaceutically acceptable salts thereof. In another aspect, the invention provides methods for treatment of diseases or disorders mediated by a protein kinase, comprising administering a therapeutically effective amount of a compound of this invention.

Abstract: This invention relates to processes and intermediates for the preparation of salts of deuterated, enantiomericallv enriched alpha-amino beta-hydroxy acids of Formula 1 wherein the variables R1,R?1 and R?2 are defined herein, and wherein the process may comprise the steps of forming a salt of a compound of Formula 1, and crystallizing said salt to give a compound of greater than 55% enantiomeric excess.

Abstract: The present invention relates to compounds useful as inhibitors of protein kinase. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. The invention also provides processes for preparing compounds of the inventions.

Abstract: The invention is directed to Compounds of Formula I and pharmaceutically acceptable salts or solvates thereof, as well as methods of making and using the compounds.

Abstract: A method of fabricating a turning mirror for an optical device includes the steps of depositing on a substrate, which defines a plane in which an optical signal propagates in a propagating direction, a photoresist layer sensitive to electrons and to UV radiation. The material in which the photoresist layer is formed, has a contrast not larger than 3. A first portion of the photoresist layer is exposed to an electron beam, wherein the electron dose of the electron beam exposure is varied within the first portion according to a selected pattern, and wherein the electron does to which a given region in the photoresist is exposed, depends on the resulting photoresist height in the given region after development. A second portion of the photoresist layer is exposed to UV radiation; the first and the second portions are overlapped at least in a third portion.

Abstract: The invention relates to ion channel modulators of formula Ia, pharmaceutical compositions thereof, and to methods of treating diseases using such compounds where activation or hyperactivity of calcium and/or sodium ion channels is implicated in the disease state.

Abstract: A document scanner is disclosed. The document scanner includes a document bed having a surface to position a document. The document bed includes a slot in which a presentment apparatus is positioned. The presentment apparatus includes a first rigid layers a second compressible layer, and a third lower friction layer. A method of use of the document scanner is disclosed as well.