Abstract: The invention relates to purification of (2S,3S)-3-[[(1S)-1-isobutoxymethyl-3-methylbutyl]carbamoyl]oxirane-2-carboxylic acid [hereinafter, referred to as the carboxylic acid] using the salt of the carboxylic acid with an organic amine selected from the group consisting of piperazine, adamantane amines and others. The invention also relates to providing crystalline sodium salt of the carboxylic acid. The sodium salt is usable as a material for preparing medicaments and improved in storage stability, and has the following characteristics: DSC: exothermic peak observed at a temperature in the range of 170 to 175° C. with weight decrease; and characteristic absorption bands of infrared absorption spectrum (KBr tablet): 3255, 2950, 2860, 1670, 1630, 1550, 1460, 1435, 1395, 1365, 1310, 1260, 1110, 890 cm?1.

Abstract: An apparatus for assembling a tire and a wheel is disclosed. The apparatus includes a single-cell workstation including a device that retains a wheel, and a plurality of sub-stations. The device moves the wheel to each of the plurality of sub-stations, without releasing the wheel, to assemble a tire-wheel assembly. A method is also disclosed.

Abstract: An inflator device is disclosed. The inflator device includes a seal assembly that maintains, while sealing from ambient pressure, an open air passageway between a tire bead and wheel bead seat during an inflation procedure. A seal for the inflator device is also disclosed. The seal includes a ring-shape having a flexible inner periphery that is adapted to maintain, while sealing from ambient pressure, an open air passageway between a tire bead and wheel bead seat during an inflation procedure.

Abstract: The present invention relates to compounds useful as inhibitors of protein kinases, particularly of JAK family kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.

Abstract: Solid forms of N-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide are described herein, including crystalline forms thereof.

Abstract: Compounds represented by formula I: or pharmaceutically acceptable salts and solvates thereof, wherein R1, X, Y, Y1, and Z are as defined herein, are useful for treating flaviviridae viral infections.

Abstract: Decorative paper for decorative coating materials comprising a base paper and an ink receiving layer dyed in such a way that the decorative paper has after impregnation with impregnating resins and pressing as laminate the same coloring as the coloring of a laminate of a decorative paper that does not comprise an ink receiving layer.

Abstract: A support post for a safety fence assembly. The post includes an outer tube having a floor engaging end for engagement with a floor, an inner tube adapted for sliding telescoping engagement with the outer tube, and a ceiling engaging end for engagement with a ceiling coupled to the inner tube. The post also includes a locking lever assembly with a collar element positioned on the inner tube, and a lever pivotable about a pivot pin for moving the collar element to a tilted configuration in which the collar element is tilted relative to the inner tube for engagement of the collar element with the inner tube. The lever is movable between a release position, in which the collar element is slidably movable longitudinally along the inner tube, and a lock position, in which the collar element is tilted relative to the inner tube and engaged therewith.

Abstract: An optical modulator has an optical splitter for splitting an input light beam into a first and second light beam; a first and a second wave-guide arm connected to the optical splitter for receiving and transmitting therethrough the first and second light beam, respectively, the waveguide arms each including a core region having group IV semiconductor material or a combination of group IV semiconductor materials; an optical combiner connected to the first and second waveguide arm for receiving the first and second light beam and combining them into an output light beam; a first and a second electrode structure associated with the first and second waveguide arm, respectively; and a driving circuit for supplying voltage to the first and second electrode structure. The driving circuit is adapted to supply a first modulation voltage super-imposed to a first bias voltage to the first electrode structure and a second modulation voltage superimposed to a second bias voltage to the second electrode structure.

Abstract: A photodetector structure includes a silicon-based waveguide in which optical signals to be detected travel in a given direction and are confined therein and a germanium layer disposed in contact with a portion of the silicon-based waveguide so that an evanescent tail of the propagating optical signal in the waveguide is coupled into the germanium layer. In addition, the germanium layer includes a mesa having a length along the signal propagating direction and a width in a direction substantially perpendicular to the propagating direction, in which the width of said mesa is smaller than its length. The photodetector also comprises a first and a second metal contacts, the first metallic contact being located on the germanium layer, the said second metallic contact being located on the silicon-based waveguide, the first and second contacts being used to collect electrons generated by light absorption to obtain an output electric signal.

Abstract: An apparatus for capturing images from checks and other financial and payment-related documents includes a base unit including an input slot for receiving a document to be processed. A transport stage located within the base unit receives the document from the input slot. The transport stage includes a document track, a processing device located along the document track, and a one-way gate located along the document track after the processing device. The document track includes a second, return path extending from a location at the one-way gate to a location before the processing device. A bi-directional drive mechanism receives the document as the document passes through the one-way gate in the forward direction. The bi-directional drive mechanism then reverses direction to drive the document in the reverse direction.

Abstract: A hand-operated document processor includes a base for receiving a document containing magnetic ink character data to be read and recognized, and a manually operated moving magnetic ink character recognition (MICR) subsystem. The subsystem includes a MICR read head. Movement of the subsystem causes the MICR read head to pass over the magnetic ink character data on the document. The base further includes a series of embedded markers that may be magnetic or optical. A speed sensing sensor is positioned such that the speed sensing sensor passes over the series of markers as the MICR read head passes over the magnetic ink character data on the document. MICR reading and recognition logic receives the signal from the MICR read head and the signal from the speed sensing sensor to provide position feedback information to the logic for use during character data recognition.

Abstract: A purified polypeptide includes an ApoA1 mimetic or fragment thereof that are resistant to oxidation.

Abstract: A method of determining whether a tumor will be non-responsive to sunitinib therapy including detecting whether IL-8 or MMP12 expression levels in the tumor are elevated as compared to a control, that is, a tumor having elevated IL-8 or MMP12 levels will be non-responsive to sunitinib. Also, a method for inhibiting the proliferation or causing the death of a sunitinib-resistant tumor cell by contacting the cell with an agent that inhibits IL-8 or MMP12 activity and with sunitinib, whereby proliferation of the tumor cell is inhibited or the tumor cell dies. Further, the invention includes compositions and kits that include an IL-8 inhibitor or an MMP12 inhibitor and sunitinib, and related methods of treatment.

Abstract: A vehicle panel (10) includes a core layer (12) and a layer of metalized film (14) bonded to the core layer (12). In one embodiment, the core layer (12) is made of a material with heat absorption or insulation properties. The layer of metalized film (14) is made of a material having heat reflective properties that can be bonded to the core layer (12). Alternatively, a compatible bonding agent can be applied to the core layer, the metalized film, or both. To form the vehicle panel (10), the layer metalized film (14) is positioned on one half of a mold tool and the core layer (12) is positioned on the other half of the mold tool. Heat is applied to the core layer (12) and the mold tool is closed such that the heat from the core layer (12) causes the metalized film (14) to be in a formable state and bonds to the core layer (12).

Abstract: A filter element is removably positionable within a filter housing defining a filter chamber for said filter element. The filter housing comprises a standpipe extending within the filter chamber. The filter element includes a tubular filter media circumscribing the standpipe, a first end cap supporting the filter media at one end thereof, a second end cap longitudinally spaced from the first end cap and supporting the filter media at the opposite end thereof, and a center tube extending between the first and second end caps. The center tube has at least one inlet opening therethrough, a bypass opening at a first end thereof adjacent to the first end cap and a standpipe opening at a second end thereof adjacent to the second end cap and through which the standpipe is adapted to be inserted longitudinally into the center tube.

Abstract: The present invention relates to substituted 5,6-dihydroimidazo[1,5-f]pteridines of formula I: which are useful as inhibitors of protein kinase. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. The invention also provides processes for preparing compounds of the invention.