Patents Represented by Attorney, Agent or Law Firm Howson and Howson
  • Connector for sports goal frame
    Patent number: 7300059
    Abstract: An assembly including a tubular connector and at least one framing member having a hollow open end and a longitudinally-extending recessed channel. The recessed channel is formed by at least a pair of opposed inwardly-directed walls having inner peripheral surfaces that taper toward one another in a substantially V-shaped configuration. The connector is slidably received within the hollow end of the framing member and has a longitudinally-extending inset track for cooperatively receiving and engaging the tapered inner peripheral surfaces of the channel walls of the framing member. The inset track has outer peripheral surfaces formed by outwardly tapered walls, whereby when the inset track and recessed channel are urged together by a fastener, a slip-resistant joint is formed therebetween. Sports goal assemblies and methods of assembly are also disclosed.
    Type: Grant
    Filed: December 28, 2005
    Date of Patent: November 27, 2007
    Assignee: Kwik Goal Ltd.
    Inventor: Anthony Caruso
  • Cyanopyrrole-phenyl amide progesterone receptor modulators and uses thereof
    Patent number: 7297713
    Abstract: Progesterone receptor modulators of formula I, or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R4, R5, R6, and R7 are as defined herein. These compounds are useful for contraception and hormone replacement therapy. Also provided are products containing these compounds.
    Type: Grant
    Filed: July 27, 2006
    Date of Patent: November 20, 2007
    Assignee: Wyeth
    Inventors: Casey Cameron McComas, Andrew Fensome, Edward George Melenski
  • Electronic tone generation system and batons therefor
    Patent number: 7294777
    Abstract: An electronic tone generation system including a plurality of separate, portable, handheld transmitters, or batons, that are provided as “instruments” to one or more players. Each baton can be activated to send a signal, preferably a wireless signal, to a single receiver which produces an output signal fed to a tone generator, preferably a MIDI tone generator, which produces audible sounds via an amplifier and speakers. For example, the batons can correspond to different musical notes as played by a selected musical instrument and the batons can be played in concert to produce a musical or other audible presentation. Alternatively, selected batons can be designated to play in one voice, while others batons are set to play other voices.
    Type: Grant
    Filed: January 6, 2005
    Date of Patent: November 13, 2007
    Assignee: Schulmerich Carillons, Inc.
    Inventors: Mark R. Hofmeister, Gregory L. Schwartz
  • Portable light
    Patent number: 7293898
    Abstract: A portable personal headlamp utilizes an array of light-emitting diodes on the front face of a circuit board. Arc-shaped projections on the front face of a finned heat sink are in heat-conducting relationship with printed conductors on the rear face of the circuit board, which partially surround one lead of each light-emitting diode.
    Type: Grant
    Filed: July 29, 2005
    Date of Patent: November 13, 2007
    Assignee: Princeton Tectonics, Inc.
    Inventors: Yos Kumthampinij, Kenneth Zorovich, Walter Andrew
  • Hybrid anion exchanger for selective removal of contaminating ligands from fluids and method of manufacture thereof
    Patent number: 7291578
    Abstract: Polymeric anion exchangers are used as host materials in which hydrated Fe(III) Oxides (HFO) are irreversibly dispersed within the exchanger beads. Since the anion exchangers have positively charged quaternary ammonium functional groups, anionic ligands such as arsenates, chromates, oxalates, phosphates, phthalates can permeate in and out of the gel phase and are not subjected to the Donnan exclusion effect. Consequently, anion exchanger-supported HFO micro particles exhibit significantly greater capacity to remove arsenic and other ligands in comparison with cation exchanger supports. Loading of HFO particles is carried out by preliminary loading of the anion exchange resin with an oxidizing anion such as MnO4? or OCl?, followed by passage of a Ferrous Sulfate solution through the resin.
    Type: Grant
    Filed: August 24, 2004
    Date of Patent: November 6, 2007
    Inventors: Arup K. SenGupta, Luis H. Cumbal
  • Cyanopyrrole-sulfonamide progesterone receptor modulators and uses thereof
    Patent number: 7291643
    Abstract: Progesterone receptor modulators of formula I, or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R4, R5, R6 and R7 are as defined herein, are useful for contraception and hormone replacement therapy are described. Also provided are products containing these compounds.
    Type: Grant
    Filed: July 27, 2006
    Date of Patent: November 6, 2007
    Assignee: Wyeth
    Inventors: Casey Cameron McComas, Andrew Fensome, Edward George Melenski
  • Methods of generating chimeric adenoviruses and uses for such chimeric adenoviruses
    Patent number: 7291498
    Abstract: A method for providing an adenovirus from a serotype which does not grow efficiently in a desired cell line with the ability to grow in that cell line is described. The method involves replacing the left and right termini of the adenovirus with the corresponding termini from an adenovirus which grow efficiently in the desired cell line. At a minimum, the left terminus spans the 5? inverted terminal repeat, the left terminus spans the E4 region and the 3? inverted terminal repeat. The resulting chimeric adenovirus contains the internal regions spanning the genes encoding the penton, hexon and fiber from the serotype which does not grow efficiently in the desired cell. Also provided are vectors constructed from novel simian adenovirus sequences and proteins, host cells containing same, and uses thereof.
    Type: Grant
    Filed: June 20, 2003
    Date of Patent: November 6, 2007
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Soumitra Roy, James M. Wilson
  • Recovery of CCI-779 from mother liquors
    Patent number: 7288647
    Abstract: The invention provides a process for recovering CCI-779 from mother liquors.
    Type: Grant
    Filed: February 22, 2006
    Date of Patent: October 30, 2007
    Assignee: Wyeth
    Inventors: Chia-Cheng Shaw, Warren Chew, Bogdan Kazimierz Wilk, Genevieve Fortier
  • Method for die casting an aluminum base frame used in a transmission device
    Patent number: 7287572
    Abstract: A cast aluminum base frame of a movable guide for a timing chain in an internal combustion engine is produced by a die in which the parting lines are located so that the shoe-engaging surface of the base frame and the pivot shaft-receiving hole are each formed by a continuous surface of the die, without oppositely pitched drafts.
    Type: Grant
    Filed: March 8, 2006
    Date of Patent: October 30, 2007
    Assignee: Tsubakimoto Chain Co.
    Inventors: Osamu Yoshida, Kozo Inoue
  • Fastener with tightening structure
    Patent number: 7284939
    Abstract: A tightening structure for locking, comprises a nut, a bolt, and a washer with a hole through which an axis of the bolt passes. To enable the structure to lock more firmly, a recessed part symmetrical with respect to an axis, and having a generally trapezoidal shape in cross section, is formed in the nut, and a projection, symmetrical with respect to an axis, and having a generally trapezoidal cross section is formed on the washer. The hole in the washer is eccentric to the projection of the washer.
    Type: Grant
    Filed: February 16, 2006
    Date of Patent: October 23, 2007
    Inventor: Teruo Nakagami
  • Mutant forms of cholera holotoxin as an adjuvant
    Patent number: 7285281
    Abstract: Mutant cholera holotoxins comprising a cholera toxin subunit A having single amino acid substitutions in the amino acid positions 16 or 72 or a double amino acid substitution in the amino acid positions 16 and 68 or 68 and 72 have reduced toxicity compared to the wild-type cholera holotoxin. The mutant cholera holotoxins are useful as adjuvants in immunogenic compositions to enhance the immune response in a vertebrate host to a selected antigen from a pathogenic bacterium, virus, fungus, or parasite, a cancer cell, a tumor cell, an allergen, or a self-molecule.
    Type: Grant
    Filed: June 5, 2002
    Date of Patent: October 23, 2007
    Assignees: Wyeth Holdings Corporation, The Regents of the University of Colorado, A Body Corporate
    Inventors: Bruce A. Green, Randall K. Holmes, Michael G. Jobling, Duzhang Zhu
  • Methods for increasing the production of ethanol from microbial fermentation
    Patent number: 7285402
    Abstract: A stable continuous method for producing ethanol from the anaerobic bacterial fermentation of a gaseous substrate containing at least one reducing gas involves culturing a fermentation bioreactor anaerobic, acetogenic bacteria in a liquid nutrient medium; supplying the gaseous substrate to the bioreactor; and manipulating the bacteria in the bioreactor by reducing the redox potential, or increasing the NAD(P)H TO NAD(P) ratio, in the fermentation broth after the bacteria achieves a steady state and stable cell concentration in the bioreactor. The free acetic acid concentration in the bioreactor is maintained at less than 5 g/L free acid. This method allows ethanol to be produced in the fermentation broth in the bioreactor at a productivity greater than 10 g/L per day. Both ethanol and acetate are produced in a ratio of ethanol to acetate ranging from 1:1 to 20:1.
    Type: Grant
    Filed: July 23, 2001
    Date of Patent: October 23, 2007
    Assignee: Emmaus Foundation, Inc.
    Inventors: James L. Gaddy, Dinesh K. Arora, Ching-Whan Ko, John Randall Phillips, Rahul Basu, Carl V. Wikstrom, Edgar C. Clausen
  • Adeno-associated virus (AAV) serotype 8 sequences, vectors containing same, and uses therefor
    Patent number: 7282199
    Abstract: Sequences of a serotype 8 adeno-associated virus and vectors and host cells containing these sequences are provided. Also described are methods of using such host cells and vectors in production of rAAV particles. rAAV8-mediated delivery of therapeutic and immunogenic genes, including Factor VIII, is also provided.
    Type: Grant
    Filed: April 25, 2003
    Date of Patent: October 16, 2007
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Guangping Gao, James M. Wilson, Mauricio R. Alvira
  • Rapamycin polymorphs and uses thereof
    Patent number: 7282505
    Abstract: The present invention provides rapamycin polymorph Form II. This invention also provides processes for preparing rapamycin polymorph Form II and pharmaceutical compositions including rapamycin polymorph Form II.
    Type: Grant
    Filed: August 18, 2005
    Date of Patent: October 16, 2007
    Assignee: Wyeth
    Inventors: Tianmin Zhu, Mahdi B. Fawzi
  • Sputtering target containing zinc sulfide as major component, optical recording medium on which phase change optical disk protective film containing zinc sulfide as major component is formed by using the target, and method for manufacturing the sputtering target
    Patent number: 7279211
    Abstract: Provided is a sputtering target and an optical recording medium having formed thereon a phase change optical disc protective film having zinc sulfide as its principal component employing such a target, as well as the manufacturing method thereof, characterized in that the sputtering target has zinc sulfide as its principal component, and is capable of adjusting the refractive index of a film containing conductive oxide in the range of 2.0 to 2.6. This sputtering target, and an optical recording medium having formed thereon a phase change optical disc protective film having zinc sulfide as its principal component employing such a target, is capable of reducing particles (dust emission) and nodules that arise during sputtering, has minimal variation in quality and is capable of improving mass productiveness, and in which the crystal grain is fine and has a high density of 90% or more.
    Type: Grant
    Filed: December 11, 2002
    Date of Patent: October 9, 2007
    Assignee: Nippon Mining & Metals Co., Ltd.
    Inventors: Masataka Yahagi, Hideo Takami
  • Rapamycin analogues and uses thereof in the treatment of neurological disorders
    Patent number: 7276498
    Abstract: The present invention provides compounds of the following structure, wherein R1, R2, R4, R4?, R6, R7, and R15 are defined above: These compounds are useful in treating neurological disorders or complications due to stroke or head injury; benign or malignant neoplastic disease, carcinomas and adenocarcinomas; proliferative disorders; and inflammatory disorders. The compounds are therefore useful as neuroprotective and neuroregenerative, anti-proliferative, and anti-inflammatory agents.
    Type: Grant
    Filed: December 15, 2005
    Date of Patent: October 2, 2007
    Assignee: Wyeth
    Inventors: Edmund Idris Graziani, Kevin Pong, Jerauld Skotnicki
  • Rapamycin derivatives and the uses thereof in the treatment of neurological disorders
    Patent number: 7273874
    Abstract: The present invention provides compounds of the following structure, wherein R1-R9, R15, and n are defined herein. These compounds are useful in treating neurological disorders or complications due to stroke or head injury, and as neuroprotective and neuroregenerative agents.
    Type: Grant
    Filed: December 15, 2005
    Date of Patent: September 25, 2007
    Assignee: Wyeth
    Inventors: Edmund Idris Graziani, Kevin Pong, Jerauld Skotnicki
  • Amorphous rapamycin 42-ester with 3-hydroxy-2-(hydroxymethyl)-2-methylpropionic acid and its pharmaceutical compositions
    Patent number: 7271177
    Abstract: The present invention provides an amorphous form of rapamycin 42-ester with 3-hydroxy-2-(hydroxymethyl)-2-methylpropionic acid. This invention also provides processes for preparing the amorphous form and pharmaceutical compositions including the amorphous form.
    Type: Grant
    Filed: August 31, 2004
    Date of Patent: September 18, 2007
    Assignee: Wyeth
    Inventors: Eric J. Benjamin, Muhammad Ashraf, Ashwinkumar Jain
  • Regiospecific synthesis of rapamycin 42-ester derivatives
    Patent number: 7268144
    Abstract: A method for the regiospecific synthesis of rapamycin 42-ester derivatives is described. The method involves lipase-catalyzed acetylation of 42-hydroxy of rapamycin with an acyl donor such as a vinyl ester, an isopropenyl ester or an anhydride in a suitable organic solvent.
    Type: Grant
    Filed: April 12, 2005
    Date of Patent: September 11, 2007
    Assignee: Wyeth
    Inventors: Jianxin Gu, Ping Cai, Mark E. Ruppen
  • Cyclothiocarbamate derivatives as progesterone receptor modulators and methods of treating skin disorders
    Patent number: 7268149
    Abstract: The present invention provides methods of treating skin disorders includes delivering to a mammal a composition containing a compound of formula I, or tautomers thereof, in a regimen, wherein formula I is: and wherein R1-R5 and Q1 are defined as described herein. Specifically, methods for treating acne, hirsutism, and conditioning the skin are described. Also provided are novel PR modulators of formula II.
    Type: Grant
    Filed: June 23, 2003
    Date of Patent: September 11, 2007
    Assignee: Wyeth
    Inventors: Andrew Fensome, Diane Deborah Harrison, Richard Craig Winneker, Puwen Zhang, Jeffrey Curtis Kern, Eugene Anthony Terefenko