Abstract: The present invention is a method for encapsulating active protein in a polymeric nanocarrier. The instant method employs homogenization at subzero temperatures so that enzyme activity is retained. Enzymes which can be encapsulated by the present method include, for example, antioxidant enzymes and xenobiotic detoxifying enzymes. Encapsulation of an enzyme protects it from protease degradation and increases therapeutic half-life. Advantageously, polymeric nanoparticles of the invention are permeable to enzyme substrates and therefore enzymes encapsulated by the instant method can exert their effect without release from the nanocarrier. Methods for decomposing a reactive oxygen species, protecting against vascular oxidative stress, and detoxifying a xenobiotic are also provided.

Abstract: A method of selectively preparing a chiral 2S-amino alcohol useful in preparation of an amide sulfonated or acylated with alkyl, substituted aryl or substituted heteroaryl is described. The method involves reacting a di-tert-butyl diazene-1,2-dicarboxylate with a (4S)-4-benzyl-3-[(S)-trifluoromethyl-alkyl substituted alkanoyl]-1,3-oxazolidin-2-one to afford a di-tert-butyl 1-(1S,2S)-([(4S)-4-benzyl-2-oxo-1,3-oxazolidine-3-yl]-carbonyl}-trifluoromethyl-alkyl substituted alkyl)hydrazine-1,2-dicarboxylate. This dicarboxylate is then reduced to yield di-tert-butyl 1-(1S,2S)-[trifluoromethyl-alkyl substituted alkyl]hydrazine-1-(hydroxymethyl)-1,2-dicarboxylate. The resulting product is deblocked with an acid to yield the acid addition salt of (2S,3S)-trifluoro-hydrazino-methyl alkan-1-ol. The acid addition salt of (2S,3S)-trifluor-2-hydrazino-methyl alkan-1-ol is hydrogenated in the presence of a suitable metal catalyst to yield the amino alcohol (2S,3S)-2-amino-trifluoro-methyl alkan-1-ol HCl.

Abstract: This invention provides progesterone receptor modulators having the structure: wherein R1 to R7, X, and Q are as defined in the specification; or a pharmaceutically acceptable salt thereof.

Abstract: A method and apparatus for depositing material on a substrate is provided in which material (4) is deposited on a substrate (8) by arranging the material in a container (2), and contacting the surface of the material (4) with a beam of electrons so as to evaporate the material and transfer it to the substrate. A shield (7) opaque to electrons is arranged to cover a portion of the surface contacted by the beam of electrons. Relative movement occurs between the container (2) on one hand and the shield (7) and the beam of electrons on the other hand such that the portion of the surface previously contacted by the beam of electrons is no longer covered by the shield and is exposed to the substrate (8).

Abstract: Methods for preparing oxindole and thio-oxindole compounds are provided, which compounds are useful as precursors to useful pharmaceutical compounds. Specifically provided are methods for preparing 5-pyrrole-3,3-oxindole compounds and 5-(7-fluoro-3,3-dimethyl-2-oxo-2,3-dihydro-1H-indol-5-yl)-1-methyl-1H-pyrrole-2-carbonitrile. Also provided are methods for preparing iminobenzo[b]thiophene and benzo[b]thiophenone compounds.

Abstract: Pharmaceutical compositions relating to vasoactive intestinal polypeptides and methods for the treatment of metabolic disorders, including diabetes, insulin resistance, metabolic acidosis and obesity are presented. Methods of using the vasoactive intestinal polypeptide compositions are also disclosed.

Abstract: In a method of creating an electroluminescent device, a plurality of organic electroluminescent pixels (10) are created on a transparent substrate (7), active electronic circuitry (14) is created on a second separate substrate (15), and the two substrates are assembled together with the active electronic circuitry (14) facing the transparent substrate (7) in such a manner as to form discrete electrical connections (17) between the active electronic circuitry and the organic light emitting diode pixels (10). An insulating matrix material (18) can then be used to fill the space between the substrates (7, 15).

Abstract: A ceiling panel installation bracket has first and second flanges, and is alternatively attachable to an overhead joist or to a vertical surface of a top plate spanning a set of wall studs. The bracket has a hinged flange to which an elongated, oblique, floor-engaging, panel support can be secured. Two assemblies, each consisting of a bracket and an elongated panel support are used in laterally space relationship to guide a ceiling panel into place. Retractable stops provided on the oblique supports are used to support a ceiling panel temporarily.

Abstract: Methods for preparing cyclic carbamates and thiocarbamates containing cyanopyrrole moieties and of the formula are provided. Z are the same or different and are H, optionally substituted C1 to C6 alkyl, or CORA; RA is H, optionally substituted C1 to C6 alkyl, optionally substituted C1 to C6 alkoxy, or optionally substituted C1 to C6 aminoalkyl; Q are the same or different and are H, OH, NH2, CN, halogen, optionally substituted C1 to C6 alkyl, optionally substituted C2 to C6 alkenyl, optionally substituted C1 to C6 alkynyl, optionally substituted C1 to C6 alkoxy, optionally substituted C1 to C6 aminoalkyl, or CORB; and RB is H, optionally substituted C1 to C6 alkyl, optionally substituted C1 to C6 alkoxy, or optionally substituted C1 to C6 aminoalkyl.

Abstract: A child-resistant and senior-friendly unit dose package has a hollow container body and a tray with a plurality of items secured thereto for being dispensed from the container body. The container body has an end with an elongate opening defined by a rim, and the tray can be slid to a retracted position in which the tray is located within the container body and a dispensing position in which the tray extends at least partially through the opening of the container body. The package includes a separate cap removably securable to the container body to seal the opening and prevent access to the tray. Multiple simultaneous manipulations are required to remove the cap from the container body thereby providing a child-resistant connection.

Abstract: A grease filter has upper and lower baffle assemblies that define tortuous paths for exhaust air flowing therethrough. The baffles in the upper assembly include a perforated metal strips and bent free edges to maximize grease extraction from the exhaust air. A hinge connects the upper and lower baffle assemblies and permits the assemblies to pivot from a closed position to an open position. In the open position, access is provided to all surfaces of the assemblies so that they can be efficiently cleaned.

Abstract: A high purity Ru powder wherein the content of the respective alkali metal elements such as Na and K is 10 wtppm or less, and the content of Al is in the range of 1 to 50 wtppm. Further provided is a manufacturing method of such high purity Ru powder wherein Ru raw material having a purity of 3N (99.9%) or less is used as an anode and electrolytic refining is performed in a solution. Further still, provided is a high purity Ru powder for manufacturing a sputtering target which is capable of reducing harmful substances as much as possible, generates few particles during deposition, has a uniform film thickness distribution, has a purity of 4N (99.99%) or higher, and is suitable in forming a capacitor electrode material of a semiconductor memory; a sputtering target obtained by sintering such high purity Ru powder; a thin film obtained by sputtering this target; and a manufacturing method of the foregoing high purity Ru powder.

Abstract: Methods for minimizing the formation of thioamide compounds using decoy agents during reactions, such as thionations of carbonyl compounds containing nitrile groups, and the products thereby are provided.

Abstract: A grease filter has upper and lower baffle assemblies that define tortuous paths for exhaust air flowing therethrough. A hinge connects the upper and lower baffle assemblies and permits the assemblies to pivot from a closed position to an open position. In the open position, access is provided to all surfaces of the assemblies so that they can be efficiently cleaned. A locking mechanism secures the baffle assemblies in the closed position and is located on a peripheral side of the assemblies opposite the hinge. A kitchen ventilation system and method of cleaning a grease filter are also provided.

Abstract: In a personal headlamp, a housing, containing both an illumination source and a power source, is mounted in cantilever fashion on a bracket that comprises a back part and a collar fastened to, and extending forward from, the back part. A resilient pawl, which extends from the back part through a slot in the collar, is engageable with any selected one of a series of circumferentially spaced notches formed on a ring-like protrusion on the housing that fits rotatably into the collar.

Abstract: Methods of using compounds which are progesterone receptor agonists for contraception and the treatment of progesterone-related maladies alone or in combination with an estrogen receptor agonist or progesterone receptor antagonist are provided. These compounds have the structure: wherein R1, R2, R3, R4, R5, and Q1 are defined herein.

Abstract: A method of generating synthetic metabolites of tanaproget derivatives thereof is provided. These compounds and methods of using these derivatives for detecting tanaproget metabolites in samples are provided.

Abstract: Pharmaceutical compositions relating to vasoactive intestinal polypeptides and methods for the treatment of metabolic disorders, including diabetes, insulin resistance, metabolic acidosis and obesity are presented. Methods of using the vasoactive intestinal polypeptide compositions are also disclosed.

Abstract: A single isolated antibody or antibody fragment thereof binds to multiple variant sequences within an epitope of HIV-1 Tat protein displayed in multiple strains and subtypes of HIV-1. This “pan-epitope” antibody is useful in therapeutic and prophylactic compositions and treatments of HIV-1 infection, regardless of strain. This pan-epitope antibody is useful in assays for the detection of levels of HIV-1 based on a measurement of the amount of Tat protein in a biological sample.