Abstract: A single isolated antibody or antibody fragment thereof binds to multiple variant sequences within an epitope of HIV-1 Tat protein displayed in multiple strains and subtypes of HIV-1. This “pan-epitope” antibody is useful in therapeutic and prophylactic compositions and treatments of HIV-1 infection, regardless of strain. This pan-epitope antibody is useful in assays for the detection of levels of HIV-1 based on a measurement of the amount of Tat protein in a biological sample.

Abstract: The present invention provides purified crystalline CCI-779 and processes for preparing the same.

Abstract: A method of treating gastroesophageal reflux disease (GERD), ulcers of the stomach or duodenum, or Zollinger-Ellison Syndrome in a human, by administering pantoprazole sodium multiparticulates is described. The pantoprazole multiparticulates have a spheroid core of pantoprazole or an enantiomer thereof, or a salt thereof, a surfactant, and a disintegrant; a sub coat which is comprised of hydroxypropyl methylcellulose (hypromellose) and water, an enteric coat on the subcoat, and a final seal coat over the enteric coat, which is composed of hydroxypropyl methylcellulose (hypromellose) and water.

Abstract: Pantoprazole sodium multiparticulates are described which avoid sticking to nasogastric and gastronomy tubes. The pantoprazole multiparticulates have a spheroid core of pantoprazole or an enantiomer thereof, or a salt thereof, a surfactant, and a disintegrant; a sub coat which is comprised of hydroxypropyl methylcellulose(hypromellose) and water, an enteric coat on the sub-coat, and a final seal coat over the enteric coat, which is composed of hydroxypropyl methylcellulose(hypromellose) and water.

Abstract: A compound of Formula (I), or pharmaceutically acceptable salts and/or hydrates or prodrugs thereof, wherein Formula (I) has the structure: is provided, wherein R1-R7 are defined herein. These compounds are useful in medicaments for treating a disease selected from the group consisting of Alzheimer's Disease, amyloid angiopathy, cerebral amyloid angiopathy, systemic amyloidosis, hereditary cerebral hemorrhage with amyloidosis of the Dutch type, inclusion body myositis, mild cognitive impairment (MCI) and Down's syndrome, in a subject.

Abstract: Link plates of a silent chain are produced by first shaving the inner surfaces of the connecting pin holes, the sprocket tooth-engaging surfaces, and the backs of the link plates, and then forming dimples on those surfaces by shot-peening.

Abstract: Compounds of Formula (I), are provided where T is CHO, COR8, or C(OH)R1R2; R1 and R2 are hydrogen, optionally substituted lower alkyl, CF3, optionally substituted alkenyl, or optionally substituted alkynyl; R3 is hydrogen or optionally substituted lower alkyl; R4 is (CF3)nalkyl, (CF3)n(substituted alkyl), (CF3)nalkylphenyl, (CF3)nalkyl(substituted phenyl), or (F)ncycloalkyl; n=1-3; R5 is hydrogen, halogen, CF3, diene fused to Y when Y?C, or substituted diene fused to Y when Y?C; W, Y and Z are C, CR6 or N where at least one of W, Y or Z are C; R6 is hydrogen, halogen, or optionally substituted lower alkyl; X is O, S, SO2, or NR7; R7 is hydrogen, optionally substituted lower alkyl, optionally substituted benzyl, or optionally substituted phenyl; and R8 is lower alkyl, CF3, or optionally substituted phenyl. Methods of preparing and using these compounds for inhibiting beta amyloid production and for treatment of Alzheimer's Disease and Down's syndrome are also described.

Abstract: Pantoprazole sodium multiparticulates are described which avoid sticking to nasogastric and gastronomy tubes. The pantoprazole multiparticulates have a spheroid core of pantoprazole or an enantiomer thereof, or a salt thereof, a surfactant, and a distintegrant; a sub coat which is comprised of hydroxypropyl methylcellulose (hypromellose) and water, an enteric coat on the sub-coat, and a final seal coat over the enteric coat, which is composed of hydroxypropyl methylcellulose (hypromellose) and water.

Abstract: A method for controlling an electronic line-scan camera having at least two lines with light-sensitive pixels by means of external trigger signals. A predetermined number of lines of the sensor are exposed due to a first external trigger signal and the image information of the first exposed line and that of the subsequent line or lines are each output successively.

Abstract: Biosolids and fly ash are mixed together in stated proportions, spread on soil, and tilled to provide a soil amendment that ameliorates off-gassing of noxious odors.

Abstract: A tensioner for maintaining tension in a timing chain or belt comprises a pivotally mounted lever body biased in a direction to increase tension in the chain or belt, and having a built-in, one-way clutch permitting the lever to pivot the tension-increasing direction but blocking pivoting movement in the opposite direction.

Abstract: In a plastic hydraulic tensioner having an oil reservoir formed as a recess in a portion of a synthetic resin tensioner body adapted to engage a tensioner mounting surface on an engine block, metal bushings are insert-molded in the synthetic resin tensioner body for receiving mounting bolts by which the tensioner is secured to an engine block. The outer circumferential surface of each bushing is provided with at least one flat portion or at least one concave groove, and a protruding portion of the bushing is formed adjacent the end of the flat or groove remote from the engine block-contacting end of the bushing.

Abstract: 41-methoxy-labeled rapamycin 42-ester with 3-hydroxy-2-(hydroxymethyl)-2-methylpropionic acid (CCI-779) compounds are provided, along with methods for the synthesis and use thereof.

Abstract: A guide for a traveling transmission medium such as a timing chain comprises a resin shoe for sliding contact with the transmission medium, supported on a base frame having an two flanges and a web in an I-shaped cross-section. The base frame is produced from aluminum by die casting, using a three-part mold. Two parts of the mold cooperate to form a part of the mold cavity that forms one of the flanges and the web of the base frame, and a third part of the mold cooperates with the first two parts to form a part of the cavity in which the other flange of the base frame is formed without a draft.

Abstract: In a sprocket for a chain transmission, teeth are disposed around the circumference of the sprocket at intervals. Arc-shaped tooth gap bottoms are formed between adjacent teeth, and each tooth gap bottom is continuous with the facing tooth surfaces of its adjacent teeth. Each tooth is formed so that its thickness is greater than the thickness of an ISO tooth form and gradually becomes thinner from the pitch line toward the tooth head. At engagement of the chain with the sprocket, a roller first comes into contact with a back tooth surface so that polygonal movement is suppressed.

Abstract: The invention provides for the use of an mTOR inhibitor in the treatment or inhibition of fibroids.

Abstract: A mortar and debris collection device for use within a cavity wall to prevent the blockage of weep holes at the base of the wall. The cavity wall assembly includes a masonry wall, an adjacent inner wall, a wall cavity therebetween, and a free-standing elongate strip of openwork material located within the cavity forming a debris collection surface a spaced distance above a base surface of the cavity. Preferably, the openwork material is inserted and positioned within the cavity after the inner wall and only a base portion of the outer masonry wall is constructed. Thereafter, the upper portion of the outer masonry wall is constructed and any mortar or debris falling into the cavity is caught and supported on the debris collection surface.

Abstract: In a sliding contact chain guide of the kind used in the timing transmission of an internal combustion engine, a synthetic resin guide shoe is attached to a pivoting support arm by protrusions formed as unitary parts of the shoe, which engage notches formed in the support arm. L-shaped protrusions formed on one side edge of the shoe engage both the back face and one side edge of the arm, and strip shaped protrusions on the opposite side edge of the shoe engage the opposite side edge of the arm. An L-shaped protrusion is formed adjacent one end of the shoe on the edge having the strip-shaped protrusions.

Abstract: The present invention relates to a hafnium silicide target for forming a gate oxide film composed of HfSi1.02-2.00. Obtained is a hafnium silicide target superior in workability and embrittlement resistance, and suitable for forming a HfSiO film and HfSiON film that may be used as a high dielectric gate insulation film in substitute for a SiO2 film, and to the manufacturing method thereof.