Patents Represented by Attorney Hueschen and Sage

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  • Benzothiazine and benzothiadiazine derivatives method for preparing same and pharmaceutical compositions containing same
    Patent number: 7253161
    Abstract: Compounds of formula (I): wherein: R1 represents aryl or heteroaryl, R2 represents hydrogen, halogen or hydroxy, A represents CR4R5 or NR4, R3 represents hydrogen, alkyl or cycloalkyl, R4 represents hydrogen or alkyl, or A represents nitrogen and, together with adjacent —CHR3—, forms the ring wherein m represents 1, 2 or 3, R5 represents hydrogen or halogen, their isomers and also their addition salts. Medicaments.
    Type: Grant
    Filed: December 20, 2002
    Date of Patent: August 7, 2007
    Assignee: Les Laboratoires Servier
    Inventors: Alex Cordi, Patrice Desos, Pierre Lestage
  • Process for the synthesis and crystalline form of agomelatine
    Patent number: 7250531
    Abstract: A process for the industrial synthesis and a new crystalline form of the compound of formula (I): Medicinal products containing the same which are useful in treating disorders of the melatoninergic system.
    Type: Grant
    Filed: February 7, 2005
    Date of Patent: July 31, 2007
    Assignee: Les Laboratoires Servier
    Inventors: Jean-Claude Souvie, Isaac Gonzalez Blanco, Gilles Thominot, Geneviève Chapuis, Stéphane Horvath, Gérard Damien
  • Benzothiazine and benzothiadiazine compounds
    Patent number: 7250411
    Abstract: Compounds of formula (I): wherein: R1 represents hydroxy or RCO—O—, R2 represents hydrogen, halogen, hydroxy or R?CO—O, R, R?, which may be identical or different, represent linear or branched (C1-C6)alkyl optionally substituted by aryl, linear or branched (C2-C6)alkenyl optionally substituted by aryl, linear or branched (C1-C6)perhaloalkyl, (C3-C7)cycloalkyl, adamantyl, aryl or heteroaryl, R3 represents hydrogen, linear or branched (C1-C6)alkyl or (C3-C7)cycloalkyl, A represents CR4R5 or NR4, R4 represents hydrogen or linear or branched (C1-C6)alkyl, their isomers and also their addition salts with a pharmaceutically acceptable acid or base. Medicaments.
    Type: Grant
    Filed: December 20, 2002
    Date of Patent: July 31, 2007
    Assignee: Les Laboratoires Servier
    Inventors: Alex Cordi, Patrice Desos, Pierre Lestage
  • Azabicyclic, azatricyclic and azaspirocyclic derivatives of aminocyclohexane NMDA, 5HT, and neuronal nicotinic receptor antagonists
    Patent number: 7238703
    Abstract: Azabicyclic, azatricyclic and azaspirocyclic derivatives of aminocyclohexanes which are systemically-active as NMDA, 5HT3, and nicotinic receptor antagonists, pharmaceutical compositions comprising the same, method of preparation thereof, and method of treating CNS disorders which involve disturbances of glutamatergic, serotoninergic, and nicotinic transmission, treating immunomodulatory disorders, and antimalaria, antitrypanosomal, anti-Borne virus, anti-HSV and anti-Hepatitis C virus activity.
    Type: Grant
    Filed: August 11, 2005
    Date of Patent: July 3, 2007
    Assignee: Merz Pharma GmbH & Co. KGAA
    Inventors: Christopher G. R. Parsons, Markus Henrich, Wojciech Danysz, Ivars Kalvinsh, Valerjans Kauss, Aigars Jirgensons, Markus Gold, Maksims Vanejevs
  • Process for the industrial synthesis of the methyl diester of 5-amino-3-carboxymethyl-4-cyano-2-thiophenecarboxylic acid, and application to the synthesis of bivalent salts of ranelic acid and their hydrates
    Patent number: 7238815
    Abstract: Process for the industrial synthesis of the compound of formula (I): Application to the synthesis of bivalent salts of ranelic acid and more especially strontium ranelate and its hydrates.
    Type: Grant
    Filed: February 21, 2006
    Date of Patent: July 3, 2007
    Assignee: Les Laboratoires Servier
    Inventors: Lucile Vaysse-Ludot, Jean-Pierre Lecouve, Pascal Langlois
  • Polycyclic azaindole compounds
    Patent number: 7235550
    Abstract: The invention relates to compounds of formula (I): wherein: G1 represents an alkylene chain as defined in the description, A represents R2 and R3 represent hydrogen, alkyl, alkoxy or hydroxy or together form oxo, R4 and R5 represent hydrogen, R1 is as defined in the description, and medicinal products containing the same which are useful in treating or preventing melatoninergic disorders.
    Type: Grant
    Filed: October 9, 2002
    Date of Patent: June 26, 2007
    Assignee: Les Laboratoires Servier
    Inventors: Gérald Guillaumet, Marie-Claude Viaud, Hervé Van de Poel, Philippe Delagrange, Caroline Bennejean, Pierre Renard
  • Meldonium salts, method of their preparation and pharmaceutical composition on their basis
    Patent number: 7223797
    Abstract: New salts of Meldonium, the method of their preparation, and pharmaceutical formulation on their basis have been described. The general formula of these salts is X?(CH3)3N+NHCH2CH2COOH where X? is an acid anion selected from the group of pharmaceutically acceptable acids. Practically non-hygroscopic and/or increased thermal stability and/or lasting action Meldonium hydrogen salts of fumaric acid, phosphoric acid, oxalic acid, maleic acid, and pamoic acid as well as Meldonium orotate and galactarate are especially suitable. Novel pharmaceutical formulations containing non-hygroscopic and/or increased thermal stability and/or and/or lasting action 3-(2,2,2-trimethylhydrazinium) propionate salts for oral parenteral, rectal, and transdermal introduction are concurrently described.
    Type: Grant
    Filed: July 15, 2004
    Date of Patent: May 29, 2007
    Assignee: Joint Stock Company “Grindeks”
    Inventors: Ivars Kalvinsh, Anatolijs Birmans
  • Process for the synthesis of perindopril and its pharmaceutically acceptable salts
    Patent number: 7223872
    Abstract: A process for the synthesis of perindopril of formula (I): and its pharmaceutically acceptable salts.
    Type: Grant
    Filed: August 27, 2004
    Date of Patent: May 29, 2007
    Assignee: Les Laboratoires Servier
    Inventors: Thierry Dubuffet, Jean-Pierre Lecouve
  • Method for the synthesis of perindopril and the pharmaceutically acceptable salts thereof
    Patent number: 7220776
    Abstract: Process for the synthesis of perindopril of formula (I): and its pharmaceutically acceptable salts.
    Type: Grant
    Filed: June 28, 2004
    Date of Patent: May 22, 2007
    Assignee: LES Laboratoires Servier
    Inventors: Thierry Dubuffet, Jean-Pierre Lecouve
  • Peptide fragment of respiratory syncytial virus protein G, immunogenic agent, pharmaceutical composition containing it and preparation method
    Patent number: 7220545
    Abstract: A polypeptide useful as an immunogen element and characterised in that it is carried on the peptide sequence between amino acid residues 130–230 of the G protein sequence of the human respiratory syncytial virus of sub-groups A and B, or of the bovine respiratory syncytial virus, or on a sequence at least 80% homologous thereto. An immunogenic agent or pharmaceutical composition containing said polypeptide, and a method for preparing same, are also disclosed.
    Type: Grant
    Filed: September 5, 2003
    Date of Patent: May 22, 2007
    Assignee: Pierre Fabre Medicament
    Inventors: Hans Binz, Thien Ngoc N′Guyen, Thierry Baussant, Michel Trudel
  • Isoquinoline compounds
    Patent number: 7214689
    Abstract: The invention relatests compound of formula (I): wherein: n is 1, 2 or 3, A represents a group X represents N or NR1, R2 represents an alkoxy, cycloalkyloxy or cycloalkylalkyloxy group. and medicinal products containing the same which are useful in treading or in preventing melatoninergic disorder.
    Type: Grant
    Filed: April 8, 2004
    Date of Patent: May 8, 2007
    Assignee: Les Laboratoires Servier
    Inventors: Sophie Poissonnier-Durieux, Valérie Wallez, Anne Gasnereau, Said Yous, Daniel Lesieur, Philippe Delagrange, Pierre Renard, Caroline Bennejean, Jean Albert Boutin, Valérie Audinot
  • Process for the industrial synthesis of strontium ranelate and its hydrates
    Patent number: 7214805
    Abstract: The process for the industrial The synthesis of strontium ranelate of formula (I): and its hydrates.
    Type: Grant
    Filed: September 24, 2003
    Date of Patent: May 8, 2007
    Assignee: Les Laboratoires Servier
    Inventors: Lucile Vaysse-Ludot, Jean-Pierre Lecouve, Pascal Langlois
  • Process for synthesis of perindopril and pharmaceutically acceptable salts thereof
    Patent number: 7208607
    Abstract: Process for the synthesis of perindopril of formula (I): and pharmaceutically acceptable salts thereof.
    Type: Grant
    Filed: November 18, 2004
    Date of Patent: April 24, 2007
    Assignee: Les Laboratoires Servier
    Inventors: Thierry DuBuffet, Pascal Langlois
  • Substituted [1,4] benzodioxino[2,3-e] isoindole derivatives, method for preparing and pharmaceutical compositions containing same
    Patent number: 7202255
    Abstract: Compounds of formula (I): wherein: A is as defined in the description, Y represents a group selected from an oxygen atom and a methylene group, R2 represents a hydrogen atom and in that case: R3 represents a group selected from a hydrogen atom and the groups linear or branched (C1–C6)alkyl, aryl, aryl-(C1–C6)alkyl (in which the alkyl moiety is linear or branched) and SO2CF3, or R2 and R3 form a bond, R1 represents a group selected from a hydrogen atom and the groups linear or branched (C1–C6)alkyl, aryl and aryl-(C1–C6)alkyl (in which the alkyl moiety is linear or branched) or a linear or branched (C1–C6)alkylene chain, Z1 and Z2 each represent a hydrogen atom or Z1 and Z2, together with the carbon atoms carrying them, form a phenyl group. Medicaments.
    Type: Grant
    Filed: October 17, 2003
    Date of Patent: April 10, 2007
    Assignee: Les Laboratoires Servier
    Inventors: Gerard Coudert, Nathalie Ayerbe, Franck Lepifre, Sylvain Routier, Daniel-Henri Caignard, Pierre Renard, John Hickman, Alain Pierre, Stephane Leonce
  • Method for the synthesis of s-indoline-2-carboxylic acid and application thereof in the synthesis of perindopril
    Patent number: 7196204
    Abstract: Process for the synthesis of (2S)-indoline-2-carboxylic acid of formula (I): Application in the synthesis of perindopril and its pharmaceutically acceptable salts.
    Type: Grant
    Filed: April 7, 2004
    Date of Patent: March 27, 2007
    Assignee: Les Laboratoires Servier
    Inventors: Jean-Claude Souvie, Jean-Pierre Lecouve
  • Modified vaccinia ankara virus variant
    Patent number: 7189536
    Abstract: The present invention provides an attenuated virus, which is derived from Modified Vaccinia Ankara virus and characterized by the loss of its capability to reproductively replicate in human cell lines. It further describes recombinant viruses derived from this virus and the use of the virus, or its recombinants, as a medicament or vaccine. A method is provided for inducing an immune response in individuals who may be immune-compromised, receiving antiviral therapy, or have a pre-existing immunity to the vaccine virus. In addition, a method is provided for the administration of a therapeutically effective amount of the virus, or its recombinants, in a vaccinia virus prime/vaccinia virus boost innoculation regimen.
    Type: Grant
    Filed: May 16, 2003
    Date of Patent: March 13, 2007
    Assignee: Bavarian Nordic A/S
    Inventors: Paul Chaplin, Paul Howley, Christine Meisinger
  • Substituted cyclic compounds, preparation method and pharmaceutical compositions containing them
    Patent number: 7183318
    Abstract: The invention concerns compounds of formula (1): R-A-R? wherein: A is as defined in the description; R represent a group (V), (VI), (VII), or (VIII), where E, Q, R1, R2, R3, v and R4 are as defined in the description; R? represents a —(CH2)t—R5 group wherein t and R5 are as defined in the description, and medicaments containing the same
    Type: Grant
    Filed: June 16, 2003
    Date of Patent: February 27, 2007
    Assignee: Les Laboratoires Servier
    Inventors: Daniel Lesieur, Frederique Klupsch, Gerald Guillaumet, Marie-Claude Viaud, Michel Langlois, Caroline Bennejean, Pierre Renard, Philippe Delagrange
  • Metod for the synthesis of perindopril and the pharmaceutically acceptable salts thereof
    Patent number: 7183308
    Abstract: A process for the synthesis of perindopril of formula (I): and its pharmaceutically acceptable salts.
    Type: Grant
    Filed: August 27, 2004
    Date of Patent: February 27, 2007
    Assignee: Les Laboratoires Servier
    Inventors: Thierry Dubuffet, Jean-Pierre Lecouve
  • Pharmaceutical compositions for nasal delivery of oestradiol and norethisterone
    Patent number: 7182960
    Abstract: The present invention relates to a pharmaceutical composition for administration by the nasal route of 17-?-oestradiol and norethisterone.
    Type: Grant
    Filed: July 18, 2002
    Date of Patent: February 27, 2007
    Assignee: Les Laboratoires Servier
    Inventors: Gilles Fonknechten, Patrick Wuthrich, Yannis Tsouderos, Claire Varin
  • Method of synthesising perindopril and the pharmaceutically acceptable salts thereof
    Patent number: 7179833
    Abstract: Process for the synthesis of perindopril of formula (I): and its pharmaceutically acceptable salts.
    Type: Grant
    Filed: June 28, 2004
    Date of Patent: February 20, 2007
    Assignee: Les Laboratoires Servier
    Inventors: Thierry Dubuffet, Jean-Pierre Lecouve