Patents Represented by Attorney Hueschen and Sage

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  • Process for the synthesis of ivabradine and addition salts thereof with a pharmaceutically acceptable acid
    Patent number: 7176197
    Abstract: Process for the synthesis of ivabradine of formula (I): addition salts with a pharmaceutically acceptable acid and hydrates thereof. ? crystalline form of ivabradine hydrochloride. Medicinal products containing the a crystalline form of ivabradine hydrochloride, which are useful as bradycardics.
    Type: Grant
    Filed: February 14, 2005
    Date of Patent: February 13, 2007
    Assignee: Les Laboratoires Servier
    Inventors: Jean-Michel Lerestif, Jean-Pierre Lecouve, Jean-Claude Souvie, Daniel Brigot, Stéphane Horvath, Marie-Noëlle Auguste, Gérard Damien
  • Method for synthesising perindopril and the pharmaceutically acceptable salt thereof
    Patent number: 7166633
    Abstract: Process for the synthesis of perindopril of formula (I): and pharmaceutically acceptable salts thereof.
    Type: Grant
    Filed: February 27, 2004
    Date of Patent: January 23, 2007
    Assignee: Les Laboratories Servier
    Inventors: Thierry Dubuffet, Pascal Langlois
  • Substituted biphenyl derivatives, method for preparing same and pharmaceutical compositions containing same
    Patent number: 7161035
    Abstract: The invention relates to compounds of formula (I): wherein: B represents a hydrogen atom, a COOR group, a CONRR? group, or a (C1–C6)alkyl group substituted by a COOR, CONRR? or OR group, G1 represents a —X?—(CH2)n—X—(CH2)m—X?— chain wherein X, X?, X?, n and m are as defined in the description, Cy represents a grouping of formula (II) or (III): G2 represents an alkylene chain as defined in the description, and A represents a NRCOR?, NRCSR?, CONRR?, CSNRR?, NRCONR?R? or NRCSNR?R? group.
    Type: Grant
    Filed: July 16, 2001
    Date of Patent: January 9, 2007
    Assignee: Les Laboratoires Servier
    Inventors: Carole Descamps-Francois, Said Yous, Daniel Lesieur, Gérald Guillaumet, Marie-Claude Viaud, Hervé Da Costa, Caroline Bennejean, Philippe Delagrange, Pierre Renard
  • Method for synthesissing (2s, 3as, 7as)-perhydroindole-2-carboxylic acid and the esters thereof and the use thereof for perindopril synthesis
    Patent number: 7157484
    Abstract: Process for the synthesis of compounds of formula (I): wherein R represents hydrogen or a protecting group. Application in the synthesis of perindopril and pharmaceutically acceptable salts thereof.
    Type: Grant
    Filed: February 27, 2004
    Date of Patent: January 2, 2007
    Assignee: Les Laboratoires Servier
    Inventors: Thierry Dubuffet, Pascal Langlois
  • Method for synthesizing derivatives of (2S,3AS,7AS)-1-[(S)-alanyl]-octahydro,-1H-indole-2-carboxylic acid and the use thereof for perindopril synthesis
    Patent number: 7157485
    Abstract: Process for the synthesis of compounds of formula (I): wherein R1 represents hydrogen, alkyl or benzyl and R2 represents a protecting group for the amine function. Application in the synthesis of perindopril and pharmaceutically acceptable salts thereof.
    Type: Grant
    Filed: February 27, 2004
    Date of Patent: January 2, 2007
    Assignee: Les Laboratoires Servier
    Inventors: Thierry Dubuffet, Pascal Langlois
  • [3,4-a:3,4-c]carbazole compounds
    Patent number: 7151108
    Abstract: A compound selected from those of formula (I): wherein: W1 represents, together with carbon to which it is bonded, phenyl, pyridyl, Z represents a group of formula U—V as defined in the description, Q1 represents oxygen, NR2 as defined in the description, Q2 represents oxygen, NR?2 as defined in the description, X1, X2, X?1 and X?2 each represents hydrogen, hydroxy, alkoxy, mercapto or alkylthio, Y1, Y2, Y?1 and Y?2 each represents hydrogen, or X1 and Y1, X2 and Y2, X?1 and Y?1, X?2 and Y?2 with carbon carrying them, together form carbonyl or thiocarbonyl, R1 is as defined in the description, its isomers, and addition salts thereof with a pharmaceutically acceptable acid or base, and medicinal products containing the same which are useful in the treatment of cancer.
    Type: Grant
    Filed: September 26, 2003
    Date of Patent: December 19, 2006
    Assignee: Les Laboratories Servier
    Inventors: Michelle Prudhomme, Bernadette Hugon, Fabrice Anizon, John Hickman, Alain Pierre, Roy Golsteyn, Pierre Renard, Bruno Pfeiffer
  • Benzo[b ]pyrano[3,2- h ]acridin-7-one cinnamate compounds
    Patent number: 7144891
    Abstract: A compound selected from those of formula (I): wherein: X and Y represent a group selected from hydrogen, halogen, alkoxy, nitro, cyano, alkyl, alkenyl, polyhaloalkyl and —NRaRb wherein Ra and Rb are as defined in the description, Z represents oxygen or NRc wherein Rc is as defined in the description, Ar represents aryl or heteroaryl, R1 represents hydrogen or alkyl, R2 represents a group selected from hydrogen, alkyl, —ORa and —NRaRb wherein Ra and Rb are as defined in the description, R3 and R4 represent hydrogen or alkyl, R5 represents hydrogen, ORc, NRcRd, W1—C(W2)—U—V, W1—C(W2)—W3-T1 or Z-CO—CH?CHAr wherein Rc, Rd, W1, W2, W3, U, V, T, Z and Ar are as defined in the description, its isomers, and addition salts thereof with a pharmaceutically acceptable acid or base, and medicinal products containing the same which are useful in the treatment of cancer.
    Type: Grant
    Filed: December 21, 2005
    Date of Patent: December 5, 2006
    Assignees: Les Laboratoires Servier, Centre National de la Recherche Scientifique, University Rene Descartes Paris V
    Inventors: Michel Koch, François Tillequin, Sylvie Michel, John Hickman, Alain Pierre, Stéphane Leonce, Bruno Pfeiffer, Laurence Kraus-Berthier
  • Method for preparing a polypeptide soluble in an aqueous solvent in the absence of detergent
    Patent number: 7125696
    Abstract: A invention concerns a novel method for preparing a polypeptide soluble in an aqueous solvent in the absence of detergent, and polypeptides obtainable by said method. The invention also concerns the use of said polypeptides, in particular for preparing medicines or vaccines, for fighting against bacterial and viral infections or cancers.
    Type: Grant
    Filed: January 4, 2001
    Date of Patent: October 24, 2006
    Assignee: Pierre Fabre Medicament
    Inventors: Thierry Baussant, Pascale Jeannin, Yves Delneste, François Lawny, Jean-Yves Bonnefoy
  • Substituted cyclic compounds
    Patent number: 7126012
    Abstract: The invention concerns compounds of formula (I): R-A-R? wherein: A is as defined in the description; R represents a group (V), (VI), (VII) or (VIII), where E, Q, R1, R2, R3, v and R4 are as defined in the description; R? represents a —(CH2)t-R5 group wherein t and R5 are as defined in the description
    Type: Grant
    Filed: September 23, 2004
    Date of Patent: October 24, 2006
    Assignee: Les Laboratoires Servier
    Inventors: Daniel Lesieur, Frederique Klupsch, Gerald Guillaumet, Marie-Claude Viaud, Michel Langlois, Caroline Bennejean, Pierre Renaud, Philippe Delagrange
  • Substituted cyclic compounds
    Patent number: 7115752
    Abstract: The invention concerns compounds of formula (I): R—A—R? wherein: A is as defined in the description; R represents a group (V), (VI), (VII) or (VIII), where E, Q, R1, R2, R3, v and R4 are as defined in the description; R? represents a —(CH2)t-R5 group wherein t and R5 are as defined in the description.
    Type: Grant
    Filed: September 23, 2004
    Date of Patent: October 3, 2006
    Assignee: Les Laboratoires Servier
    Inventors: Daniel Lesieur, Frederique Klupsch, Gerald Guillaumet, Marie-Claude Viaud, Michel Langlois, Caroline Bennejean, Pierre Renaud, Philippe Delagrange
  • Benzoxathiepine derivatives and their use as medicines
    Patent number: 7109234
    Abstract: The invention concerns 3-arylthio-propyl-amino-3,4-dihydro-2H-1,5-aryloxathiepin derivatives of general formula (I), wherein: R1 and R2, identical or different, represent a hydrogen atom, a fluorine atom or a chlorine atom, a hydroxy group, an alkyl, cyclopropyl, alkoxy, cyclopropoxy radical or when they occupy adjacent positions, form with the carbon atoms bearing them a carbon-containing cycle or an oxygen-containing heterocycle with five non-aromatic rings; R3 represents an alkyl radical, a hydroxy group or a methoxy radical; R4 represents a hydrogen atom or a methyl radical; and R5 and R6, identical or different represent a hydrogen atom, an alkyl, alkoxy, alkylthio, alkylamino radical, or the groups OR4 and R5 form with the carbons which bear them a non-aromatic heterocycle with five or six rings containing at least an oxygen atom; and their pharmaceutically acceptable additions salts
    Type: Grant
    Filed: March 20, 2002
    Date of Patent: September 19, 2006
    Assignee: Pierre Fabre Medicament
    Inventors: Bernard Vacher, Florence Castan-Cuisat, Gareth John, Bruno Legrand
  • Process for the industrial synthesis of the methyl diester of 5-amino-3-carboxymethyl-4-cyano-2-thiophenecarboxylic acid, and application to the synthesis of bivalent salts of ranelic acid and their hydrates
    Patent number: 7105683
    Abstract: The process for the industrial the synthesis of the compound of formula (I): Application to the the synthesis of bivalent salts of ranelic acid and more especially strontium ranelate and its hydrates.
    Type: Grant
    Filed: September 24, 2003
    Date of Patent: September 12, 2006
    Assignee: Les Laboratoires Servier
    Inventors: Lucile Vaysse-Ludot, Jean-Pierre Lecouve, Pascal Langlois
  • Imidazopyridine derivatives, preparation method and pharmaceutical compositions containing same
    Patent number: 7098220
    Abstract: Compounds of formula (I): wherein: R1 represents hydrogen, halogen, alkyl, polyhaloalkyl, cyano, nitro, hydroxycarbonyl, alkoxycarbonyl, aminocarbonyl, alkylaminocarbonyl or dialkylaminocarbonyl, R2 represents hydrogen, alkyl, an optionally substituted aryl, optionally substituted heteroaryl, or R20—C(X)— wherein: R20 represents alkyl, alkoxy, amino, alkylamino, dialkylamino, optionally substituted aryl or optionally substituted heteroaryl, X represents oxygen, sulphur, or NR21 wherein R21 represents hydrogen or alkyl, R3 represents hydrogen atom or alkyl, n represents integer from 1 to 6 inclusive, the representation its enantiomers, diastereoisomers and also addition salts thereof with a pharmaceutically acceptable acid or base, and medicinal products containing the same which are useful as AMPK activators.
    Type: Grant
    Filed: November 4, 2003
    Date of Patent: August 29, 2006
    Assignee: Les Laboratoires Servier
    Inventors: Sylvain Rault, Jean-Charles Lancelot, Marina Kopp, Daniel-Henri Caignard, Bruno Pfeiffer, Jean-Guy Bizot-Espiard, Pierre Renard
  • Modified vaccinia virus ankara for the vaccination of neonates
    Patent number: 7097842
    Abstract: The invention concerns the use of a virus for the preparation of a medicament for the vaccination, treatment, or protection, of a neonatal or prenatal animal, including a human, wherein the virus is capable of infecting the cells of the neonatal or prenatal animal, including a human, but not capable of being replicated to infectious progeny virus in the neonatal or prenatal animal, including a human. The virus is preferably a Modified Vaccinia Virus Ankara. In particular, the invention concerns the vaccination of neonates against infections with viruses belonging the same virus group as the virus used for vaccination. Moreover, the invention concerns the vaccination of neonates against antigens selected from foreign antigens and tumor antigens, wherein the tumor antigen and/or the foreign antigen are different from the antigens associated with the virus.
    Type: Grant
    Filed: April 18, 2003
    Date of Patent: August 29, 2006
    Assignee: Bavarian Nordic A/S
    Inventors: Mark Suter, Sabine Vollstedt, Paul Chaplin
  • Process for the industrial synthesis of tetraesters of 5-[bis(carboxymethyl)amino]-3-carboxymethyl-4-cyano-2-thiophenecarboxylic acid, and application to the synthesis of bivalent salts of ranelic acid and their hydrates
    Patent number: 7091364
    Abstract: The process for the industrial synthesis of compounds of formula (I): wherein R and R?, which are the same or different, each represent linear or branched (C1–C6)alkyl. Application to the synthesis of bivalent salts of ranelic acid and more especially strontium ranelate and its hydrates.
    Type: Grant
    Filed: September 24, 2003
    Date of Patent: August 15, 2006
    Assignee: Les Laboratoires Servier
    Inventors: Lucile Vaysse-Ludot, Jean-Pierre Lecouve, Pascal Langlois
  • Dispenser of objects
    Patent number: 7073685
    Abstract: The invention concerns a dispenser of objects comprising a body forming a reservoir (2) for storing objects to be dispensed (8), an outlet passage (22) for said objects, arranged at one end of the body (2), and returned translation means (12) capable of performing a reciprocating movement relatively to the body (2) so as to release a predetermined number of objects (8) at each out and in stroke of the translation movement. The invention is characterized in that said returned translation movement are arranged in the form of a flexible membrane with shape memory (12) perforated with a calibrated opening (17), exerting both a spring force enabling said reciprocating movement and, by co-operation with thrust means (18), to control the dispensing of said objects.
    Type: Grant
    Filed: December 30, 1999
    Date of Patent: July 11, 2006
    Assignee: Laboratoires Dolisos
    Inventors: Jean-Pierre Giraud, Roger Nobilet
  • Use of the (1S,2R) enantiomer of milnacipran for the preparation of a drug
    Patent number: 7074833
    Abstract: A method for treating or preventing a disorder or a condition by double inhibition of serotonin (5-HT) and noradrenaline (NA) reuptake in a subject in need thereof, while limiting the risks of cardiovascular disturbances and/or organ and/or tissue toxicity, comprising the step of administering to said subject a mixture of enantiomers of milnacipran enriched in the (1S,2R) enantiomer of milnacipran and/or of at least one of its metabolites, as well as their pharmaceutically-acceptable salts.
    Type: Grant
    Filed: March 22, 2004
    Date of Patent: July 11, 2006
    Assignee: Pierre Fabre Medicament
    Inventors: Jean Deregnaucourt, Richard Grosse
  • Process for the synthesis of 1,3-dihydro-2H-3-benzazepin-2-one compounds, and to the application thereof in the synthesis of ivabradine and addition salts thereof with a pharmaceutically acceptable acid
    Patent number: 7074920
    Abstract: Process for the synthesis of compounds of formula (I): wherein R1 and R2, which may be the same or different, each represent a linear or branched (C1–C8)alkoxy group or form, together with the carbon atom carrying them, a 1,3-dioxane, 1,3-dioxolane or 1,3-dioxepane ring. Application in the synthesis of ivabradine, addition salts thereof with a pharmaceutically acceptable acid, and hydrates thereof.
    Type: Grant
    Filed: February 14, 2005
    Date of Patent: July 11, 2006
    Assignee: Les Laboratories Servier
    Inventors: Jean-Michel Lerestif, Jean-Pierre Lecouve, Daniel Brigot
  • Heterocyclic oxime compounds
    Patent number: 7071221
    Abstract: Compounds of formula (I): wherein: X represents oxygen or sulphur or a group CH2 or R1, R2, R3, R4, R5 and R6 are as defined in the description, A represents an alkylene chain as defined in the description, B represents alkyl or alkenyl substituted by a group ?or R9, or B represents a group ?or R9, D represents a benzene, pyridine, pyrazine, pyrimidine or pyridazine nucleus.
    Type: Grant
    Filed: July 29, 2004
    Date of Patent: July 4, 2006
    Assignee: Les Laboratoires Servier
    Inventors: Véronique Leclerc, Sylvie Pailloux, Pascal Carato, Carine Introvigne, Nicolas Lebegue, Pascal Berthelot, Catherine Dacquet, Jean Albert Boutin, Daniel Henri Caignard, Pierre Renard
  • Process for the synthesis of 1,3,4,5-tetrahydro-2H-3-benzazepin-2-one compounds, and application in the synthesis of ivabradine and addition salts thereof with a pharmaceutically acceptable acid
    Patent number: 7064200
    Abstract: Process for the synthesis of compounds of formula (I): wherein R1 and R2, which may be the same or different, each represent a linear or branched (C1–C8)alkoxy group or form, together with the carbon atom carrying them, a 1,3-dioxane, 1,3-dioxolane or 1,3-dioxepane ring. Application in the synthesis of ivabradine, addition salts thereof with a pharmaceutically acceptable acid, and hydrates thereof.
    Type: Grant
    Filed: February 17, 2005
    Date of Patent: June 20, 2006
    Assignee: Les Laboratoires Servier
    Inventors: Jean-Michel Lerestif, Jean-Pierre Lecouve, Jean-Claude Souvie, Daniel Brigot