Patents Represented by Attorney Human Genome Sciences, Inc.

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  • Gabaa receptor epsilon subunits
    Patent number: 7029870
    Abstract: The present invention relates to a novel GABAA receptor ? subunit (GABRE) and an alternative transcript thereof (ET2). More specifically, isolated nucleic acid molecules are provided encoding human GABRE and ET2 receptor subunits. ET2 and GABRE polypeptides are also provided, as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of ET2 and GABRE activities. Also provided are diagnostic methods for detecting aberrant GABRE and ET2 expression, as well as therapeutic methods for treating disorders involving ET2 and GABRE.
    Type: Grant
    Filed: February 26, 1998
    Date of Patent: April 18, 2006
    Assignee: Human Genome Sciences, Inc.
    Inventors: Michael C. Hanna, Ewen F. Kirkness
  • Connective tissue growth factor-2
    Patent number: 7026299
    Abstract: The present invention relates to a human CTGF-2 polypeptide and DNA (RNA) encoding such polypeptide. Also provided is a procedure for producing such polypeptide by recombinant techniques and antibodies and antagonist/inhibitors against such polypeptide. Also provided are methods of using the polypeptide therapeutically for stimulating angiogenesis enhancing the repair of connective and support tissue, promoting the attachment, fixation and stabilization of tissue implants and enhancing wound healing. Diagnostic assays for identifying mutations in nucleic acid sequence encoding a polypeptide of the present invention and for detecting altered levels of the polypeptide of the present invention are also disclosed.
    Type: Grant
    Filed: July 11, 2001
    Date of Patent: April 11, 2006
    Assignees: Human Genome Sciences, Inc., Transgene S.A.
    Inventors: Haodong Li, Mark D. Adams, Valérie Calenda, Virginie Fataccioli
  • 53 human secreted proteins
    Patent number: 7026447
    Abstract: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.
    Type: Grant
    Filed: October 30, 2001
    Date of Patent: April 11, 2006
    Assignee: Human Genome Sciences, Inc.
    Inventors: Craig A. Rosen, Steven M. Ruben, Charles Florence
  • Serum paraoxonase
    Patent number: 7026140
    Abstract: Human serum paraoxonase enzyme and DNA (RNA) encoding such serum paraoxonase enzymes are disclosed. Also provided is the procedure for producing such polypeptides by recombinant techniques. Uses of such polypeptides include their use as an antidote for organophosphate poisoning and to prevent neuronal cell death.
    Type: Grant
    Filed: September 2, 2004
    Date of Patent: April 11, 2006
    Assignee: Human Genome Sciences, Inc.
    Inventors: Peter L. Hudson, Wei Wu He, Steven M. Ruben
  • Dendritic enriched secreted lymphocyte activation molecule
    Patent number: 7012134
    Abstract: The present invention relates to a novel human protein called Dendritic Enriched Secreted Lymphocyte Activation Molecule, and isolated polynucleotides encoding this protein. Also provided are vectors, host cells, antibodies, and recombinant methods for producing this human protein. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to this novel human protein.
    Type: Grant
    Filed: February 5, 2002
    Date of Patent: March 14, 2006
    Assignee: Human Genome Sciences, Inc.
    Inventors: Steven M. Ruben, Paul E. Young
  • Breast cancer specific gene 1
    Patent number: 7008778
    Abstract: The present invention relates to a novel BCSG1 protein. In particular, isolated nucleic acid molecules are provided encoding the human BCSG1 protein. BCSG1 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. Also provided are diagnostic methods for detecting breast cancer.
    Type: Grant
    Filed: February 3, 1998
    Date of Patent: March 7, 2006
    Assignee: Human Genome Sciences, Inc.
    Inventors: Hongjun Ji, Craig A. Rosen
  • Antibodies to secreted protein HEMCM42
    Patent number: 7001992
    Abstract: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.
    Type: Grant
    Filed: February 5, 2002
    Date of Patent: February 21, 2006
    Assignee: Human Genome Sciences, Inc.
    Inventors: Steven M. Ruben, Craig A. Rosen, Gregory A. Endress
  • Chemokine ?-7 variants
    Patent number: 7001595
    Abstract: The present invention relates to deletion and substitution mutant polypeptides of human chemokine ?-7 (Ck?-7), as well as nucleic acid molecules encoding such polypeptides and processes for producing such polypeptides using recombinant techniques. In one aspect, the invention also relates to uses of the full-length and mature forms of Ck?-7, as well as deletion and substitution mutants, in medical treatment regimens. In particular, the Ck?-7 polypeptides described herein may be employed to treat a variety of conditions, including rheumatoid arthritis, inflammation, respiratory diseases, allergy, and IgE-mediated allergic reactions.
    Type: Grant
    Filed: October 1, 2002
    Date of Patent: February 21, 2006
    Assignees: Human Genome Sciences Inc., Beatson Institute for Cancer Research
    Inventors: Theodora W. Salcedo, Vikram P. Patel, Robert John Benjamin Nibbs, Gerard John Graham
  • Human osteoclast derived cathepsin
    Patent number: 6994978
    Abstract: Disclosed is a human osteoclast-derived cathepsin (Cathepsin O) polypeptide and DNA(RNA) encoding such cathepsin O polypeptides. Also provided is a procedure for producing such polypeptide by recombinant techniques. The present invention also discloses antibodies, antagonists and inhibitors of such polypeptide which may be used to prevent the action of such polypeptide and therefore may be used therapeutically to treat bone diseases such as osteoporosis and cancers, such as tumor metastases.
    Type: Grant
    Filed: December 4, 2003
    Date of Patent: February 7, 2006
    Assignees: Human Genome Sciences, Inc., SmithKline Beecham Corporation
    Inventors: Gregg A. Hastings, Mark D. Adams, Claire M. Fraser, Norman H. Lee, Ewen F. Kirkness, Judith A. Blake, Lisa M. Fitzgerald, Fred H. Drake, Maxine Gowan
  • Cytokine receptor common gamma chain like
    Patent number: 6982320
    Abstract: The present invention relates to a novel human protein called Cytokine Receptor Common Gamma Chain Like, and isolated polynucleotides encoding this protein. Also provided are vectors, host cells, antibodies, and recombinant methods for producing this human protein. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to this novel human protein.
    Type: Grant
    Filed: August 18, 1999
    Date of Patent: January 3, 2006
    Assignee: Human Genome Sciences, Inc.
    Inventors: Paul A. Moore, Craig A. Rosen, Steven M. Ruben
  • Chemokine ?-6
    Patent number: 6979443
    Abstract: The present invention relates to a novel CK?-6 protein which is a member of the alpha chemokine family. In particular, isolated nucleic acid molecules are provided encoding the human CK?-6 protein. CK?-6 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of CK?-6 activity. Also provided are diagnostic methods for detecting CNS and immune system-related disorders and therapeutic methods for treating CNS and immune system-related disorders.
    Type: Grant
    Filed: March 4, 2002
    Date of Patent: December 27, 2005
    Assignee: Human Genome Sciences, Inc.
    Inventors: Ying-Fei Wei, Steven M. Ruben, Craig A. Rosen
  • Soluble interleukin-1 receptor accessory molecule
    Patent number: 6974682
    Abstract: The present invention relates to a novel soluble IL-1 receptor accessory molecule (IL-1R AcM) protein which is a member of the Ig superfamily. In particular, isolated nucleic acid molecules are provided encoding the human IL-1R AcM protein IL-1R AcM polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. Screening methods are further provided for identifying agonist and antagonists of IL-1 signal transduction. The invention further relates to methods for treating physiologic and pathologic disease conditions with IL-1R AcM antagonists.
    Type: Grant
    Filed: August 26, 1997
    Date of Patent: December 13, 2005
    Assignee: Human Genome Sciences, Inc.
    Inventors: Daniel P. Bednarik, Henrik S. Olsen, Craig A. Rosen
  • Methods of using an agonistic antibody human tumor necrosis factor receptor (TR17)
    Patent number: 6969519
    Abstract: The present invention relates to a novel protein, TR17, which is a member of the tumor necrosis factor (TNF) receptor superfamily. In particular, isolated nucleic acid molecules are provided encoding the human TR17. TR17 polypeptides are also provided as anti TR17 antibodies and vectors, host cells and recombinant methods for producing the same. The invention further relates to methods of killing cells using the antibodies of the invention.
    Type: Grant
    Filed: September 25, 2001
    Date of Patent: November 29, 2005
    Assignee: Human Genome Sciences, Inc.
    Inventors: Steven M. Ruben, Kevin P. Baker
  • Nucleic acids encoding tumor necrosis factor receptor TR10
    Patent number: 6969599
    Abstract: The present invention relates to a novel protein, TR10, which is a member of the tumor necrosis factor (TNF) receptor superfamily and the TRAIL receptor subfamily. In particular, isolated nucleic acid molecules are provided encoding the human TR10 protein. TR10 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of TR10 activity.
    Type: Grant
    Filed: October 25, 2002
    Date of Patent: November 29, 2005
    Assignee: Human Genome Sciences, Inc.
    Inventors: Jian Ni, Craig A. Rosen
  • Human stanniocalcin-alpha
    Patent number: 6955885
    Abstract: A human stanniocalcin-alpha polypeptide and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for the regulation of electrolyte imbalances which can lead to renal, bone and heart diseases and osteoporosis and Paget's Disease. Antagonists against such polypeptides and their use in the regulation of electrolyte imbalances which can lead to hypocalcemia and osteoporosis are also disclosed. Use of the stanniocalcin-alpha sequence as a diagnostic to detect diseases or the susceptibility to diseases related to a mutated form of stanniocalcin-alpha sequences is also disclosed.
    Type: Grant
    Filed: April 18, 2003
    Date of Patent: October 18, 2005
    Assignee: Human Genome Sciences, Inc.
    Inventors: Henrik S. Olsen, Robert D. Fleischmann
  • Follistatin-3
    Patent number: 6953662
    Abstract: The present invention relates to a novel follistatin-3 protein which is a member of the family of inhibin-related proteins. In particular, isolated nucleic acid molecules are provided encoding the human follistatin-3 protein. Follistatin-3 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of follistatin-3 activity. Also provided are diagnostic methods for detecting reproductive system-related disorders and disorders of the regulation of cell growth and differentiation and therapeutic methods for treating reproductive system-related disorders and disorders of the regulation of cell growth and differentiation.
    Type: Grant
    Filed: February 26, 2003
    Date of Patent: October 11, 2005
    Assignee: Human Genome Sciences, Inc.
    Inventors: D. Roxanne Duan, Steven M. Ruben
  • Antibodies against human protein HUVDJ43
    Patent number: 6953667
    Abstract: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.
    Type: Grant
    Filed: January 25, 2002
    Date of Patent: October 11, 2005
    Assignee: Human Genome Sciences, Inc.
    Inventors: Paul A. Moore, Steven M. Ruben, Henrik S. Olsen, Yanggu Shi, Craig A. Rosen, Kimberly A. Florence, Daniel R. Soppet, David W. LaFleur, Gregory A. Endress, Reinhard Ebner, George Komatsoulis, Roxanne D. Duan
  • Human tumor necrosis factor receptors TR13 and TR14
    Patent number: 6951738
    Abstract: The present invention relates to two novel proteins, TR13 and TR14, which are members of the tumor necrosis factor (TNF) receptor superfamily. In particular, isolated nucleic acid molecules are provided encoding the human TR13 and TR14 proteins. TR13 and TR14 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of TR13 and TR14.
    Type: Grant
    Filed: January 16, 2002
    Date of Patent: October 4, 2005
    Assignee: Human Genome Sciences, Inc.
    Inventors: Jian Ni, Kevin P. Baker, Steven M. Ruben, Paul E. Young
  • Antibodies against secreted protein HTEBYII
    Patent number: 6951924
    Abstract: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.
    Type: Grant
    Filed: January 30, 2002
    Date of Patent: October 4, 2005
    Assignee: Human Genome Sciences, Inc.
    Inventors: Craig A. Rosen, Steven M. Ruben, ZhiZhen Zeng
  • Death domain containing receptors
    Patent number: 6951735
    Abstract: The present invention relates to novel Death Domain Containing Receptor (DR3 and DR3-V1) proteins which are members of the tumor necrosis factor (TNF) receptor family. In particular, isolated nucleic acid molecules are provided encoding the human DR3 and DR3-V1 proteins. DR3 and DR3-V1 polypeptides are also provided, as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of DR3 and DR3-V1 activity.
    Type: Grant
    Filed: May 19, 1999
    Date of Patent: October 4, 2005
    Assignees: Human Genome Sciences, Inc., The Regents of the University of Michigan
    Inventors: Guo-Liang Yu, Jian Ni, Vishva Dixit, Reiner L. Gentz, Patrick J. Dillon