Patents Represented by Attorney Human Genome Sciences, Inc.

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  • Interleukin-1? converting enzyme like apoptotic protease-6
    Patent number: 6890721
    Abstract: Human ICE LAP-6 polypeptides and DNA (RNA) encoding such ICE LAP-6 and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilize such ICE LAP-6 for the treatment of a susceptibility to viral infection, tumorogenesis and to diseases and defects in the control embryogenesis and tissue homeostasis, and the nucleic acid sequences described above may be employed in an assay for ascertaining such susceptibility.
    Type: Grant
    Filed: September 24, 2001
    Date of Patent: May 10, 2005
    Assignees: Human Genome Sciences, Inc., SmithKline Beecham Corporation, The Regents of the University of Michigan
    Inventors: Vishva M. Dixit, Wei-Wu He, Kristine K. Kikly, Steven M. Ruben
  • Streptococcus pneumoniae SP036 polynucleotides
    Patent number: 6887663
    Abstract: The present invention relates to novel vaccines for the prevention or attenuation of infection by Streptococcus pneumoniae. The invention further relates to isolated nucleic acid molecules encoding antigenic polypeptides of Streptococcus pneumoniae. Antigenic polypeptides are also provided, as are vectors, host cells and recombinant methods for producing the same. The invention additionally relates to diagnostic methods for detecting Streptococcus nucleic acids, polypeptides and antibodies in a biological sample.
    Type: Grant
    Filed: January 22, 2001
    Date of Patent: May 3, 2005
    Assignee: Human Genome Sciences, Inc.
    Inventors: Gil H. Choi, Charles A. Kunsch, Steven C. Barash, Patrick J. Dillion, Brian Dougherty, Michael R. Fannon, Craig A. Rosen
  • Antibodies to growth factor HTTER36
    Patent number: 6884594
    Abstract: The present invention discloses Growth Factor HTTER36 polypeptides and polynucleotides encoding such polypeptides. Also disclosed are antibodies and fragments thereof that specifically bind to such polypeptides. Also provided is a procedure for producing such polypeptides by recombinant techniques and therapeutic uses of the polypeptides which include stimulating cellular growth and differentiation, bone formation and wound healing. Also disclosed are antagonists against such polypeptide and their use as a therapeutic to treat neoplasia and to prevent the formation of extracellular matrix molecules in the liver and lung. Also disclosed are diagnostic assays for detecting altered levels of the polypeptide of the present invention and mutations in the nucleic acid sequences which encode the polypeptides of the invention.
    Type: Grant
    Filed: April 8, 2002
    Date of Patent: April 26, 2005
    Assignee: Human Genome Sciences, Inc.
    Inventors: Daniel R. Soppet, Haodong Li
  • Methods of treatment of immune system related disorders using Neutrokine-alpha
    Patent number: 6881401
    Abstract: The present invention relates to a novel Neutrokine-alpha, and a splice variant thereof designated Neutrokine-alphaSV, polynucleotides and polypeptides which are members of the TNF family. In particular, isolated nucleic acid molecules are provided encoding the human Neutrokine-alpha and/or Neutrokine-alphaSV polypeptides, including soluble forms of the extracellular domain. Neutrokine-alpha and/or Neutrokine-alphaSV polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of Neutrokine-alpha and/or Neutrokine-alphaSV activity. Also provided are diagnostic methods for detecting immune system-related disorders and therapeutic methods for treating immune system-related disorders.
    Type: Grant
    Filed: June 8, 2000
    Date of Patent: April 19, 2005
    Assignee: Human Genome Sciences, Inc.
    Inventors: Guo-Liang Yu, Reinhard Ebner, Jian Ni, Craig A. Rosen
  • Human protein HFXJW48
    Patent number: 6881823
    Abstract: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.
    Type: Grant
    Filed: May 15, 2002
    Date of Patent: April 19, 2005
    Assignee: Human Genome Sciences, Inc.
    Inventors: Steven M. Ruben, Craig A. Rosen, Charles Florence
  • Protein HMAAD57
    Patent number: 6878687
    Abstract: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.
    Type: Grant
    Filed: July 20, 2000
    Date of Patent: April 12, 2005
    Assignee: Human Genome Sciences, Inc.
    Inventors: Steven M. Ruben, Craig A. Rosen, George Komatsoulis, Yanggu Shi
  • Human secreted protein HTEEB42
    Patent number: 6878806
    Abstract: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.
    Type: Grant
    Filed: May 11, 2001
    Date of Patent: April 12, 2005
    Assignee: Human Genome Sciences, Inc.
    Inventors: Steven M. Ruben, Craig A. Rosen, Zhizhen Zeng
  • Metalloproteinases
    Patent number: 6878812
    Abstract: The present invention relates to novel metalloproteinase-like proteins. In particular, isolated nucleic acid molecules are provided encoding the human TACE-like and matrilysin-like proteins. TACE-like and matrilysin-like polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of TACE-like and matrilysin-like activity. Also provided are diagnostic methods for detecting cancer and therapeutic methods for cancer and other disorders characterized by an over or under production of these metalloproteinases.
    Type: Grant
    Filed: September 13, 2001
    Date of Patent: April 12, 2005
    Assignee: Human Genome Science, Inc.
    Inventors: Jian Ni, Steve Ruben, Laurie Brewer, Reiner Gentz, Craig Rosen
  • Hyaluronan-binding proteins and encoding genes
    Patent number: 6872546
    Abstract: The present invention relates to full-length WF-HABP, WF-HABP, OE-HABP, and BM-HABP, novel members of the hyaluronan receptor family. The invention provides isolated nucleic acid molecules encoding human to full-length WF-HABP, WF-HABP, OE-HABP, and BM-HABP receptors. Full-length WF-HABP, WF-HABP, OE-HABP, and BM-HABP polypeptides are also provided, as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of full-length WF-HABP, WF-HABP, OE-HABP, and BM-HABP receptor activity. Also provided are diagnostic methods for detecting disease states related to the aberrant expression of full-length WF-HABP, WF-HABP, OE-HABP, and BM-HABP receptors.
    Type: Grant
    Filed: December 20, 1999
    Date of Patent: March 29, 2005
    Assignees: Human Genome Sciences, Inc., The American Red Cross
    Inventors: Gregg A. Hastings, Gene Liau, Elena Tsifrina
  • Scaffolded fusion polypeptides and compositions and methods for making the same
    Patent number: 6872548
    Abstract: The present invention provides soluble forms of integral membrane proteins, or domains or portions thereof, that retain the biological activity of the integral membrane protein, domain or portion from which they are designed or derived and that can readily be expressed in high yield.
    Type: Grant
    Filed: January 29, 2002
    Date of Patent: March 29, 2005
    Assignee: Human Genome Sciences, Inc.
    Inventors: Timothy A. Coleman, Brian C. Mansfield
  • Keratinocyte growth factor-2 formulations
    Patent number: 6869927
    Abstract: The invention is directed to liquid and lyophilized forms of Keratinocyte Growth Factor-2 (KGF-2) and derivatives thereof. This invention further relates to the formulation of KGF-2 for therapeutic use, for example, to promote or accelerate wound healing.
    Type: Grant
    Filed: June 2, 2000
    Date of Patent: March 22, 2005
    Assignee: Human Genome Sciences, Inc.
    Inventors: Reiner L. Gentz, Arvind Chopra, Parveen Kaushal, Thomas Spitznagel, Edward Unsworth, Fazal Khan
  • Antibodies to human chemotactic protein
    Patent number: 6867006
    Abstract: A human chemotactic polypeptide, DNA (RNA) encoding it, and a procedure for producing such a polypeptide by recombinant techniques are disclosed. Also disclosed are methods of using the polypeptide for a number of purposes, including: stem cell mobilization, myeloprotection, neuronal protection, treating tumors, wound healing, treating parasitic infection, and regulating hematopoiesis. Also disclosed are polypeptide antagonists and diagnostic assays for identifying mutations in nucleic acid sequence encoding a polypeptide of the present invention and for detecting altered levels of the polypeptide of the present invention for detecting diseases are also disclosed.
    Type: Grant
    Filed: May 10, 2002
    Date of Patent: March 15, 2005
    Assignee: Human Genome Sciences, Inc.
    Inventors: Haodong Li, Steven M. Ruben, Granger Sutton, III
  • Endothelial-monocyte activating polypeptide III
    Patent number: 6864226
    Abstract: A human EMAP III polypeptide and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for preventing and/or treating neoplasia. Diagnostic assays for identifying mutations in nucleic acid sequence encoding a polypeptide of the present invention and for detecting altered levels of the polypeptide of the present invention for detecting diseases, for example, cancer, are also disclosed.
    Type: Grant
    Filed: November 18, 1997
    Date of Patent: March 8, 2005
    Assignee: Human Genome Sciences, Inc.
    Inventors: Timothy A. Coleman, Craig A. Rosen
  • Human endometrial specific steroid-binding factor I, II and III
    Patent number: 6861226
    Abstract: The invention relates to hESF I, II and III polypeptides, polynucleotides encoding the polypeptides, methods for producing the polypeptides, in particular by expressing the polynucleotides, and agonists and antagonists of the polypeptides. The invention further relates to methods for utilizing such polynucleotides, polypeptides, agonists and antagonists for applications, which relate, in part, to research, diagnostic and clinical arts.
    Type: Grant
    Filed: November 6, 2001
    Date of Patent: March 1, 2005
    Assignee: Human Genome Sciences, Inc.
    Inventors: Jian Ni, Guo-Liang Yu, Reiner L. Gentz
  • Antibodies to cytokine receptor common gamma chain like
    Patent number: 6861227
    Abstract: The present invention relates to a novel human gene encoding a polypeptide which is a member of the Cytokine Receptor family. More specifically, the present invention relates to a polynucleotide encoding a novel human polypeptide named Cytokine Receptor Common Gamma Chain Like, or “CRCGCL.” This invention also relates to CRCGCL polypeptides, as well as vectors, host cells, antibodies directed to CRCGCL polypeptides, and the recombinant methods for producing the same. Also provided are diagnostic methods for detecting disorders related to the immune system, and therapeutic methods for treating diagnosing, detecting, and/or preventing such disorders. The invention further relates to screening methods for identifying agonists and antagonists of CRCGCL activity.
    Type: Grant
    Filed: February 20, 2002
    Date of Patent: March 1, 2005
    Assignee: Human Genome Sciences, Inc.
    Inventors: Steven M. Ruben, Craig A. Rosen, Paul A. Moore
  • Human glycosylation enzymes
    Patent number: 6858415
    Abstract: The present invention relates to novel human glycosylation enzyme polypeptides and isolated nucleic acids containing the coding regions of the genes encoding such polypeptides. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human glycosylation enzyme polypeptides. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human glycosylation enzyme polypeptides.
    Type: Grant
    Filed: January 20, 2004
    Date of Patent: February 22, 2005
    Assignees: Human Genome Sciences, Inc., Johns Hopkins University
    Inventors: Timothy A. Coleman, Michael J. Betenbaugh
  • Extracellular/epidermal growth factor-like protein
    Patent number: 6852506
    Abstract: The present invention discloses an extracellular/epidermal growth factor polypeptides and polynucleotides encoding such polypeptides. Also provided is a procedure for producing such polypeptides by recombinant techniques and therapeutic uses of the polypeptides which include induction of DNA synthesis, stimulating wound healing, treating neurological disorders, treating ocular disorders, treating kidney and liver disorders and stimulating embryogenesis and angiogenesis. Also disclosed are antagonists against such polypeptide and their use as a therapeutic to treat neoplasia. Also disclosed are diagnostic assays for detecting altered levels of the polypeptide of the present invention and mutations in the nucleic acid sequences which encode the polypeptides of the present invention.
    Type: Grant
    Filed: April 11, 1997
    Date of Patent: February 8, 2005
    Assignee: Human Genome Sciences, Inc.
    Inventors: Henrik S. Olsen, Haodong Li
  • Antibody to an IL-17 receptor like protein
    Patent number: 6849719
    Abstract: The present invention relates to a novel IL17RLP protein which is a member of the interleukin (IL)-17 receptor family. In particular, isolated nucleic acid molecules are provided encoding the human IL17RLP protein. IL17RLP polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of IL17RLP activity. Also provided are diagnostic methods for detecting immune system-related disorders and therapeutic methods for treating, diagnosing, detecting, and/or preventing immune system-related disorders.
    Type: Grant
    Filed: March 2, 2001
    Date of Patent: February 1, 2005
    Assignee: Human Genome Sciences, Inc.
    Inventors: Yanggu Shi, Steven M. Ruben
  • Human hypoxanthine-(guanine) phosphoribosyl transferase-2
    Patent number: 6849436
    Abstract: A human HPRT-2 polypeptide and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for the treatment of nephrolithiasis, anemia, precocious gout, kidney stones, Lesch-Nyhan syndrome, renal failure and uricaciduria. Antagonists against such polypeptides and their use as a therapeutic to treat disorders associated with excessive purine synthesis are also disclosed. Diagnostic assays for identifying mutations in nucleic acid sequences encoding a polypeptide of the present invention and for detecting altered levels of the polypeptide of the present invention are also disclosed.
    Type: Grant
    Filed: July 12, 2001
    Date of Patent: February 1, 2005
    Assignee: Human Genome Sciences, Inc.
    Inventors: Daniel P. Bednarik, Craig A. Rosen, Mark D. Adams
  • PGRP-L polynucleotides, polypeptides, and antibodies
    Patent number: 6849413
    Abstract: The present invention relates to novel human and murine proteins called PGRP-L, and isolated polynucleotides encoding these proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing this human protein. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to this novel human protein.
    Type: Grant
    Filed: February 11, 2002
    Date of Patent: February 1, 2005
    Assignee: Human Genome Sciences, Inc.
    Inventors: Paul E. Young, Steven M. Ruben