Patents Represented by Attorney Incyte Corporation
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Patent number: 6881552Abstract: The invention provides human protease associated proteins (HPRAP) and polynucleotides which identify and encode HPRAP. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating or preventing disorders associated with expression of HPRAP.Type: GrantFiled: November 14, 2000Date of Patent: April 19, 2005Assignee: Incyte CorporationInventors: Jennifer L. Hillman, Y. Tom Tang, Preeti Lal, Neil C. Corley, Karl J. Guegler, Chandra Patterson
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Patent number: 6864057Abstract: Methods are provide for preparing cDNA corresponding to a mRNA. In the subject methods, a mRNA is first contacted with a mixture of primers under first strand cDNA synthesis conditions. The primer mixture contains primers that have at least 10 contiguous deoxythymidines, a double stranded restriction enzyme recognition sequence near one end and a non-polyA-complementary region near the other end, where the non-polyA-complementary region is -VV, -VTV, -VTTV, -VTTTV, and -VVVVV. The resultant cDNA is modified such that the polyT tail is substantially removed. The modified cDNA is then ligated into a vector. The subject methods find use in a variety of applications, and find particular use in the sequencing of DNA and in the synthesis of cDNA libraries.Type: GrantFiled: January 4, 2002Date of Patent: March 8, 2005Assignee: Incyte CorporationInventors: Glenn K. Fu, Steven Starnes, Laura L. Stuve
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Patent number: 6838245Abstract: The present invention provides a human lysophospholipase (NHLP) and polynucleotides which identify and encode NHLP. The invention also provides expression vectors, host cells, agonists, antibodies and antagonists. In addition, the invention provides methods for producing NHLP and for treating or preventing disorders associated with expression of NHLP.Type: GrantFiled: November 19, 2001Date of Patent: January 4, 2005Assignee: Incyte CorporationInventors: Jennifer L. Hillman, Purvi Shah, Lynn E. Murry
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Patent number: 6808895Abstract: The invention provides human oxidoreductase molecules (OXRE) and polynucleotides which identify and encode OXRE. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating, or preventing disorders associated with expression of OXRE.Type: GrantFiled: March 28, 2001Date of Patent: October 26, 2004Assignee: Incyte CorporationInventors: Preeti Lal, Karl J. Guegler, Gina A. Gorgone, Neil C. Corley, Mariah R. Baughn, Y. Tom Tang, Jennifer L. Hillman, Olga Bandman, Yalda Azimzai, Janice Au-Young, Henry Yue, Dyung Aina M. Lu, Junming Yang
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Patent number: 6783955Abstract: The invention provides a cDNA which encodes human presenilin variant. It also provides for the use of the cDNA and protein in the diagnosis, prognosis, treatment and evaluation of therapies for cancer or neurodegenerative or immune disorders. The invention further provides vectors and host cells for the production of the protein and transgenic model systems.Type: GrantFiled: June 29, 2001Date of Patent: August 31, 2004Assignee: Incyte CorporationInventors: Chandra Arvizu, Lynn E. Murry, Matthew R. Kaser
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Patent number: 6750027Abstract: The invention provides human ubiquitin-conjugating enzyme homologs (UCEH) and polynucleotides which identify and encode UCEH. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating or preventing disorders associated with expression of UCEH.Type: GrantFiled: August 14, 2001Date of Patent: June 15, 2004Assignee: Incyte CorporationInventors: Preeti Lal, Jennifer L. Hillman, Karl J. Guegler, Neil C. Corley, Yalda Azimzai
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Patent number: 6739448Abstract: A shuttle apparatus for transferring sample carriers comprising a shuttle table having a mating section, the mating section allowing a sample carrier to be transferred between the shuttle table and a mating support structure. The shuttle table can optionally further comprise a mating section having a void section.Type: GrantFiled: February 1, 2000Date of Patent: May 25, 2004Assignee: Incyte CorporationInventors: JoeBen Bevirt, Gabriel Noah Brinton
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Patent number: 6727066Abstract: The present invention relates to a composition comprising a plurality of cDNAs which are differentially expressed in treated human C3A liver cell cultures and which may be used entirely or in part to diagnose, to stage, to treat, or to monitor the progression or treatment of liver disorders such as hyperlipidemia.Type: GrantFiled: July 30, 2001Date of Patent: April 27, 2004Assignee: Incyte CorporationInventor: Matthew R. Kaser
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Patent number: 6713060Abstract: The invention provides a human Nek1-related protein kinase (NRPK) and polynucleotides which identify and encode NRPK. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating or preventing disorders associated with expression of NRPK.Type: GrantFiled: January 11, 2000Date of Patent: March 30, 2004Assignee: Incyte CorporationInventors: Olga Bandman, Neil C. Corley, Karl J. Guegler, Mariah Baughn
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Patent number: 6703239Abstract: Methods and compositions are provided for producing full-length cDNA libraries. In the subject methods, full length first strand cDNAs are isolated using a fusion protein of an eIF-4E domain and an eIF-4G domain separated by a flexible linker. Also provided is the novel fusion protein employed in the subject methods, as well as nucleic acids encoding, and host cells capable of expressing, the same. Finally, kits for use in practicing the subject methods are provided. The subject invention finds use in a variety of applications in which full-length cDNA libraries are employed.Type: GrantFiled: June 25, 2002Date of Patent: March 9, 2004Assignee: Incyte CorporationInventors: Karl Guegler, Ruoying Tan, Michael J. Rose
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Patent number: 6692920Abstract: The present invention provides nucleotide and amino acid sequences that identify and encode a novel expressed chemokine (ADEC) from inflamed adenoid tissue. The present invention also provides for antisense molecules to the nucleotide sequences which encode ADEC, expression vectors for the production of purified ADEC, antibodies capable of binding specifically to ADEC, hybridization probes or oligonucleotides for the detection of ADEC-encoding nucleotide sequences, genetically engineered host cells for the expression of ADEC, diagnostic tests for inflammation or disease based on ADEC-encoding nucleic acid molecules or antibodies capable of binding specifically to ADEC.Type: GrantFiled: June 5, 2000Date of Patent: February 17, 2004Assignee: Incyte CorporationInventors: Karl J. Guegler, Phillip R. Hawkins, Craig G. Wilde, Jeffrey J. Seilhamer
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Patent number: 6692923Abstract: The invention provides a cDNA which encodes tapasin-like protein. It also provides for the use of the cDNA, protein, and antibody in the diagnosis, prognosis, treatment and evaluation of therapies for cancer. The invention further provides vectors and host cells for the production of the protein and transgenic model systems.Type: GrantFiled: August 20, 2001Date of Patent: February 17, 2004Assignee: Incyte CorporationInventors: Preeti G. Lal, Matthew R. Kaser, Mariah R. Baughn
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Patent number: 6682888Abstract: The present invention relates to a composition comprising a plurality of cDNAs which are differentially expressed in disorders of the brain, particularly Alzheimer's disease and which may be used in their entirety or in part as to diagnose, to stage to treat or to monitor the treatment of a subject with a brain disorder.Type: GrantFiled: May 5, 2000Date of Patent: January 27, 2004Assignee: Incyte CorporationInventors: Jeanne F. Loring, Debora W. Tingley, Carla M. Edwards
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Patent number: 6677126Abstract: The invention provides a human translational regulator (TRANAC) and polynucleotides which identify and encode TRANAC. The invention also provides expression vectors, host cells, agonists, antibodies and antagonists. The invention also provides methods for treating disorders associated with expression of TRANAC.Type: GrantFiled: March 12, 2002Date of Patent: January 13, 2004Assignee: Incyte CorporationInventors: Jennifer L. Hillman, Phillip R. Hawkins
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Patent number: 6673549Abstract: The present invention relates to a combination comprising a plurality of cDNAs which are differentially expressed in human C3A liver cell cultures treated with steroids or synthetic steroid analogues and which may be used entirely or in part to detect metabolic and toxicological responses to treatment with steroids and steroid antagonists, to diagnose, to stage, to treat, or to monitor the treatment of a subject with an steroid responsive disorder.Type: GrantFiled: October 12, 2001Date of Patent: January 6, 2004Assignee: Incyte CorporationInventors: L. Michael Furness, Jenny L. Buchbinder
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Patent number: 6673545Abstract: The present invention relates to a composition comprising a plurality of cDNAs which are differentially expressed in prostate cancer and which may be used in their entirety or in part as to diagnose, to stage to treat or to monitor the treatment of a subject with prostate cancer.Type: GrantFiled: July 30, 2001Date of Patent: January 6, 2004Assignee: Incyte CorporationInventors: Mary Faris, Christopher M. Turner
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Patent number: 6660485Abstract: The invention provides a human goose-type lysozyme (GOLY) and polynucleotides which identify and encode GOLY. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating or preventing disorders associated with expression of GOLY.Type: GrantFiled: April 26, 2001Date of Patent: December 9, 2003Assignee: Incyte CorporationInventors: Preeti Lal, Karl J. Guegler, Neil C. Corley, Chandra Patterson
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Patent number: 6645499Abstract: The invention provides a human ena/VASP-like protein splice variant (EVL1) and polynucleotides which identify and encode EVL1. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for treating or preventing disorders associated with expression of EVL1.Type: GrantFiled: September 1, 1999Date of Patent: November 11, 2003Assignee: Incyte CorporationInventors: Preeti Lal, Karl J. Guegler, Neil C. Corley
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Patent number: 6632617Abstract: The invention provides a cDNA which encodes a TUAN. It also provides for the use of the cDNA, fragments, complements, and variants thereof and of the encoded protein, portions thereof and antibodies thereto for diagnosis and treatment of inflammatory and cell proliferative disorders, in particular, Crohn's disease and colon cancer. The invention additionally provides expression vectors and host cells for the production of the protein and a transgenic model system.Type: GrantFiled: May 14, 2001Date of Patent: October 14, 2003Assignee: Incyte CorporationInventors: Olga Bandman, Surya K. Goli, Purvi Shah, Neil C. Corley, David G. Streeter
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Patent number: 6627605Abstract: The invention provides human proteinase molecules, the polynucleotides which encode them, and methods for their use. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention further provides methods for diagnosing or treating disorders associated with expression of HPRM.Type: GrantFiled: March 8, 2001Date of Patent: September 30, 2003Assignee: Incyte CorporationInventors: Olga Bandman, Neil C. Corley, Karl J. Guegler, Mariah R. Baughn