Patents Represented by Attorney, Agent or Law Firm Incyte Genomics
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Patent number: 6500642Abstract: The invention provides a mammalian cDNA which encodes a mammalian MAPOP-3. It also provides for the use of the cDNA, fragments, complements, and variants thereof and of the encoded protein, portions thereof and antibodies thereto for diagnosis and treatment of breast adenocarcinoma. The invention additionally provides expression vectors and host cells for the production of the protein and a transgenic model system.Type: GrantFiled: June 22, 2000Date of Patent: December 31, 2002Assignee: Incyte Genomics, Inc.Inventors: Henry Yue, Chandra Patterson, Neil C. Corley, Karl J. Guegler
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Patent number: 6500938Abstract: The present invention relates to a composition comprising a plurality of polynucleotide probes. The composition can be used as array elements in a microarray. The present invention also relates to a method for selecting polynucleotide probes of the composition.Type: GrantFiled: January 30, 1998Date of Patent: December 31, 2002Assignee: Incyte Genomics, Inc.Inventors: Janice Au-Young, Jeffrey J. Seilhamer
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Patent number: 6492505Abstract: The present invention relates to a composition comprising a plurality of polynucleotide sequences. The composition can be used as probes or array elements.Type: GrantFiled: January 31, 2000Date of Patent: December 10, 2002Assignee: Incyte Genomics, Inc.Inventors: Roopa Reddy, Karl J. Guegler, Janice Au-Young
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Patent number: 6492507Abstract: The present invention provides a human eosinophil-derived basic protein (EBPH) and polynucleotides which identify and encode EBPH. The invention also provides genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding EBPH and a method for producing EBPH. The invention also provides for use of EBPH and agonists, antibodies or antagonists specifically binding EBPH, in the prevention and treatment of diseases associated with expression of EBPH. Additionally, the invention provides for the use of antisense molecules to polynucleotides encoding EBPH for the treatment of diseases associated with the expression of EBPH. The invention also provides diagnostic assays which utilize the polynucleotide, or fragments or the complement thereof, and antibodies specifically binding EBPH.Type: GrantFiled: October 23, 1996Date of Patent: December 10, 2002Assignee: Incyte Genomics, Inc.Inventor: Ingrid E. Akerblom
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Patent number: 6492499Abstract: The present invention provides a novel human C-type lectin (human PAP-2) and polynucleotides which identify and encode human PAP-2. The invention also provides expression vectors, host cells, agonists, antibodies or antagonists. The invention also provides methods for treating or preventing diseases associated with expression of human PAP-2.Type: GrantFiled: January 7, 1999Date of Patent: December 10, 2002Assignee: Incyte Genomics, Inc.Inventors: Jennifer L. Hillman, Surya K. Goli
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Patent number: 6489444Abstract: The invention provides a human lysyl hydroxylase-like protein (HLHLP) and polynucleotides which identify and encode HLHLP. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for treating or preventing disorders associated with expression of HLHLP.Type: GrantFiled: June 13, 2000Date of Patent: December 3, 2002Assignee: Incyte Genomics, Inc.Inventors: Olga Bandman, Purvi Shah, Preeti Lal, Neil C. Corley
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Patent number: 6485910Abstract: The invention provides a mammalian cDNA which encodes a mammalian Ras association domain containing protein. It also provides for the use of the cDNA, fragments, complements, and variants thereof and of the encoded protein, portions thereof and antibodies thereto for diagnosis and treatment of cell proliferative and inflammatory disorders, particularly thymus hyperplasia, allergies, asthma, and hypereosinophilia. The invention additionally provides expression vectors and host cells for the production of the protein and a transgenic model system.Type: GrantFiled: July 11, 2000Date of Patent: November 26, 2002Assignee: Incyte Genomics, Inc.Inventors: Michael G. Walker, Tod M. Klinger, Randi E. Krasnow
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Patent number: 6486300Abstract: The present invention provides polynucleotides which identify and encode a novel human nm23-like protein (H-nm23). The invention provides for genetically engineered expression vectors and host cells comprising the nucleic acid sequence encoding H-nm23 and for a method for producing the protein. The invention also provides for the use of substantially purified H-nm23 for the for the treatment of diseases associated with the expression of H-nm23. The invention also describes diagnostic assays which utilize diagnostic compositions comprising the polynucleotides which hybridize with naturally occurring sequences encoding H-nm23 and antibodies which specifically bind to the protein.Type: GrantFiled: December 13, 1999Date of Patent: November 26, 2002Assignee: Incyte Genomics, Inc.Inventors: Olga Bandman, Phillip R. Hawkins
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Patent number: 6485933Abstract: The present invention provides B cell receptor associated proteins (BCRP) and polynucleotides which identify and encode BCRP. The invention also provides expression vectors, host cells, agonists, antibodies, and antagonists. The invention also provides methods for treating disorders associated with expression of BCRP.Type: GrantFiled: May 7, 1997Date of Patent: November 26, 2002Assignee: Incyte Genomics, Inc.Inventors: Olga Bandman, Jennifer L. Hillman, Surya K. Goli, Sherry A. Capitant
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Patent number: 6479630Abstract: The present invention provides nucleotide and amino acid sequences that identify and encode a novel purinergic PU2 receptor (PNR) expressed in human placenta. The present invention also provides for antisense molecules to the nucleotide sequences which encode PNR, expression vectors for the production of purified PNR, antibodies capable of binding specifically to PNR, hybridization probes or oligonucleotides for the detection of PNR-encoding nucleotide sequences, genetically engineered host cells for the expression of PNR, and diagnostic tests based on PNR-encoding nucleic acid molecules or antibodies produced against the polypeptide PNR.Type: GrantFiled: June 22, 1998Date of Patent: November 12, 2002Assignee: Incyte GenomicsInventors: Roger Coleman, Janice Au-Young, Susan G. Stuart, Karl J. Guegler
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Patent number: 6475752Abstract: The invention provide a mammalian nucleic acid molecule and fragments thereof. It also provides for the use of the mammalian nucleic acid molecule for the characterization, diagnosis, evaluation, treatment, or prevention of conditions, diseases and disorders associated with its expression and for the production of a model system. The invention additionally provides expression vectors and host cells for the production of the protein encoded by the mammalian nucleic acid molecule. The invention further provides a mammalian protein or portions thereof. The invention still further provides for the use of the nucleic acid molecule and protein in assays to detect or purify ligands.Type: GrantFiled: July 30, 1999Date of Patent: November 5, 2002Assignee: Incyte Genomics, Inc.Inventors: Preeti Lal, Y. Tom Tang, Mariah R. Baughn, Matthew R. Kaser
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Patent number: 6475485Abstract: The present invention provides two novel human cathepsin proteins (HCPs) and polynucleotides encoding HCPs. The invention provides for genetically engineered expression vectors and host cells comprising the nucleic acid sequence encoding HCPs. The invention also provides for the production and use of antibodies to HCPs in pharmaceutical compositions for the treatment of disease processes that include cancers, inflammation, metastasis and peptide and proenzyme processing. In addition, the invention provides for the production and use of inhibitors of HSPs in pharmaceutical compositions for the treatment of diseases. The invention also describes diagnostic assays which utilize the polynucleotide to hybridize with the transcripts encoding HCPs. The invention also provides for the use of antisense molecules in pharmaceutical compositions as a therapeutics in cancers, inflammation, metastasis and peptide and proenzyme processing.Type: GrantFiled: August 31, 1999Date of Patent: November 5, 2002Assignee: Incyte Genomics, Inc.Inventors: Olga Bandman, Roger Coleman
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Patent number: 6476212Abstract: The present invention provides purified, corn ear-derived polynucleotides (cdps) which encode corn ear-derived polypeptides (CDPs). The invention also provides for the use of cdps or their complements, oligonucleotides, or fragments in methods for determining altered gene expression, to recover regulatory elements, and to follow inheritance of desirable characteristics through hybrid breeding programs. The invention further provides for vectors and host cells containing cdps for the expression of CDPs. The invention additionally provides for (i) use of isolated and purified CDPs to induce antibodies and to screen libraries of compounds and (ii) use of anti-CDP antibodies in diagnostic assays.Type: GrantFiled: May 14, 1999Date of Patent: November 5, 2002Assignee: Incyte Genomics, Inc.Inventors: Raghunath V. Lalgudi, Laura Y. Ito, Bradley K. Sherman
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Patent number: 6472195Abstract: The present invention provides a human tumor suppressor (HKALL) and polynucleotides which identify and encode HKALL. The invention also provides expression vectors and host cells, agonists, antibodies, or antagonists. The invention provides methods for treating diseases associated with expression of HKALL.Type: GrantFiled: January 16, 2001Date of Patent: October 29, 2002Assignee: Incyte Genomics, Inc.Inventors: Jennifer L. Hillman, Preeti Lal
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Patent number: 6472508Abstract: The present invention provides a novel human tumor suppressor (NHTS) and polynucleotides which identify and encode NHTS. The invention also provides genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding NHTS and a method for producing NHTS. The invention also provides for agonists, antibodies, or antagonists specifically binding NHTS, and their use, in the prevention and treatment of diseases associated with expression of NHTS. Additionally, the invention provides for the use of antisense molecules to polynucleotides encoding NHTS for the treatment of diseases associated with the expression of NHTS. The invention also provides diagnostic assays which utilize the polynucleotide, or fragments or the complement thereof, and antibodies specifically binding NHTS.Type: GrantFiled: December 18, 1998Date of Patent: October 29, 2002Assignee: Incyte Genomics, Inc.Inventors: Sam La Brie, Surya K. Goli
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Patent number: 6471959Abstract: The invention provides three human transferases (HUTRAN) and polynucleotides which identify and encode HUTRAN. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating or preventing disorders associated with expression of HUTRAN.Type: GrantFiled: January 21, 2000Date of Patent: October 29, 2002Assignee: Incyte Genomics, Inc.Inventors: Preeti Lal, Olga Bandman, Jennifer L. Hillman, Karl J. Guegler, Gina A. Gorgone, Neil C. Corley, Chandra Patterson
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Patent number: 6465200Abstract: The invention provides a mammalian nucleic acid sequence and fragments thereof. It also provides for the use of these nucleic acid sequences in a model system for the characterization, diagnosis, evaluation, treatment, or prevention of conditions, diseases and disorders associated with expression of the mammalian nucleic acid sequence. The invention additionally provides expression vectors and host cells for the production of the protein encoded by the mammalian nucleic acid sequence.Type: GrantFiled: April 17, 2001Date of Patent: October 15, 2002Assignee: Incyte Genomics, Inc.Inventors: Matthew R. Kaser, Mariah R. Baughn
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Patent number: 6465619Abstract: The invention provides a human transducin beta-1 subunit (TBS) and polynucleotides which identify and encode TBS. The invention also provides expression vectors, host cells, agonists, antibodies, and antagonists. The invention also provides methods for treating or preventing diseases associated with expression of TBS.Type: GrantFiled: January 21, 2000Date of Patent: October 15, 2002Assignee: Incyte Genomics, Inc.Inventors: Olga Bandman, Preeti Lal, Neil C. Corley, Purvi Shah
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Patent number: 6458575Abstract: The invention provides a human cyclophilin-type peptidyl-prolyl cis/trans isomerase (CPCI) and polynucleotides which identify and encode CPCI. The invention also provides expression vectors, host cells, antibodies, agonists, and antagnists. The invention also provides methods for diagnosing, treating or preventing disorders associated with expression of CPCI.Type: GrantFiled: November 15, 1999Date of Patent: October 1, 2002Assignee: Incyte Genomics, Inc.Inventors: Jennifer L. Hillman, Neil C. Corley, Karl J. Guegler, Chandra Patterson
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Patent number: 6458561Abstract: The invention provides a nucleic acid molecule which encodes the human NIM1 kinase. It also provides for the use of the nucleic acid molecule, fragments, variants and complements thereof and of the protein, portions thereof and antibodies thereto for characterization, diagnosis, evaluation, treatment, or prevention of disorders associated with expression. The invention additionally provides expression vectors and host cells for the production of the protein and a transgenic organism or model system.Type: GrantFiled: March 13, 2000Date of Patent: October 1, 2002Assignee: Incyte Genomics, Inc.Inventors: Olga Bandman, Angela Molteni, Paola Magnaghi, Roberta Bosotti, Emanuela Scacheri, Antonella Isacchi, David M. Hodgson