Patents Represented by Attorney, Agent or Law Firm J. Timothy Meigs
  • Genes for the synthesis of antipathogenic substances
    Patent number: 5662898
    Abstract: The present invention is directed to the production of an antipathogenic substance (APS) in a host via recombinant expression of the polypeptides needed to biologically synthesize the APS. Genes encoding polypeptides necessary to produce particular antipathogenic substances are provided, along with methods for identifying and isolating genes needed to recombinantly biosynthesize any desired APS. The cloned genes may be transformed and expressed in a desired host organisms to produce the APS according to the invention for a variety of purposes, including protecting the host from a pathogen, developing the host as a biocontrol agent, and producing large, uniform amounts of the APS.
    Type: Grant
    Filed: June 1, 1995
    Date of Patent: September 2, 1997
    Assignee: Ciba-Geigy Corporation
    Inventors: James M. Ligon, Thomas Schupp, James Joseph Beck, Dwight Steven Hill, John Andrew Ryals, Thomas Deane Gaffney, Stephen Ting Lam, Philip E. Hammer, Scott Joseph Uknes
  • Chemically inducible promoter of a cucumber chitinase/lysozyme gene
    Patent number: 5654414
    Abstract: The present invention provides chemically regulatable DNA sequences capable of regulating transcription of an associated DNA sequence in plants or plant tissues, chimeric constructions containing such sequences, vectors containing such sequences and chimeric constructions, and transgenic plants and plant tissues containing these chimeric constructions. In one aspect, the chemically regulatable DNA sequences of the invention are derived from the 5' region of genes encoding pathogenisis-related (PR) proteins. The present invention also provides anti-pathogenic sequences derived from novel cDNAs coding for PR proteins which can be genetically engineered and transformed into plants to confer enhanced resistance to disease.
    Type: Grant
    Filed: May 19, 1995
    Date of Patent: August 5, 1997
    Assignee: Novartis Finance Corporation
    Inventors: John A. Ryals, James J. Beck, Leslie B. Friedrich
  • Chemically regulatable and anti-pathogenic DNA sequences and uses thereof
    Patent number: 5650505
    Abstract: The present invention provides chemically regulatable DNA sequences capable of regulating transcription of an associated DNA sequence in plants or plant tissues, chimeric constructions containing such sequences, vectors containing such sequences and chimeric constructions, and transgenic plants and plant tissues containing these chimeric constructions. In one aspect, the chemically regulatable DNA sequences of the invention are derived from the 5' region of genes encoding pathogenisis-related (PR) proteins. The present invention also provides anti-pathogenic sequences derived from novel cDNAs coding for PR proteins which can be genetically engineered and transformed into plants to confer enhanced resistance to disease.
    Type: Grant
    Filed: May 24, 1995
    Date of Patent: July 22, 1997
    Assignee: Novartis Corporation
    Inventors: John A. Ryals, Danny C. Alexander, James J. Beck, John H. Duesing, Robert M. Goodman, Leslie B. Friedrich, Christian Harms, Frederich Meins, Jr., Alice Montoya, deceased, Mary B. Moyer, Jean-Marc Neuhaus, George B. Payne, Christoph Sperisen, Jeffrey R. Stinson, Scott J. Uknes, Eric R. Ward, Shericca C. Williams
  • Genes for the synthesis of antipathogenic substance
    Patent number: 5643774
    Abstract: The present invention is directed to the production of an antipathogenic substance (APS) in a host via recombinant expression of the polypeptides needed to biologically synthesize the APS. Genes encoding polypeptides necessary to produce particular antipathogenic substances are provided, along with methods for identifying and isolating genes needed to recombinantly biosynthesize any desired APS. The cloned genes may be transformed and expressed in a desired host organisms to produce the APS according to the invention for a variety of purposes, including protecting the host from a pathogen, developing the host as a biocontrol agent, and producing large, uniform amounts of the APS.
    Type: Grant
    Filed: June 1, 1995
    Date of Patent: July 1, 1997
    Assignee: Ciba-Geigy Corporation
    Inventors: James M. Ligon, Thomas Schupp, James Joseph Beck, Dwight Steven Hill, John Andrew Ryals, Thomas Deane Gaffney, Stephen Ting Lam, Philip E. Hammer, Scott Joseph Uknes
  • Genes for the synthesis of antipathogenic substances
    Patent number: 5639949
    Abstract: The present invention is directed to the production of an antipathogenic substance (APS) in a host via recombinant expression of the polypeptides needed to biologically synthesize the APS. Genes encoding polypeptides necessary to produce particular antipathogenic substances are provided, along with methods for identifying and isolating genes needed to recombinantly biosynthesize any desired APS. The cloned genes may be transformed and expressed in a desired host organisms to produce the APS according to the invention for a variety of purposes, including protecting the host from a pathogen, developing the host as a biocontrol agent, and producing large, uniform amounts of the APS.
    Type: Grant
    Filed: June 8, 1994
    Date of Patent: June 17, 1997
    Assignee: Ciba-Geigy Corporation
    Inventors: James M. Ligon, Dwight Steven Hill, John Andrew Ryals, Stephen Ting Lam, Philip E. Hammer
  • Anti-pathogenically effective compositions comprising lytic peptides and hydrolytic enzymes
    Patent number: 5631007
    Abstract: Anti-pathogenically effective compositions are provided containing a combination of hydrolytic enzymes and lytic peptides as the active agent. Methods of controlling the growth of pathogens using the anti-pathogenically effective compositions are provided. Transgenic plants that contain genes that are able to express lytic peptides and hydrolytic enzymes are also provided.
    Type: Grant
    Filed: June 8, 1994
    Date of Patent: May 20, 1997
    Assignee: Ciba-Geigy Corporation
    Inventors: John A. Ryals, Philippe B. Gay, Patricia A. Ahl-Goy
  • Chemically regulatable and anti-pathogenic DNA sequences and uses thereof
    Patent number: 5614395
    Abstract: The present invention provides chemically regulatable DNA sequences capable of regulating transcription of an associated DNA sequence in plants or plant tissues, chimeric constructions containing such sequences, vectors containing such sequences and chimeric constructions, and transgenic plants and plant tissues containing these chimeric constructions. In one aspect, the chemically regulatable DNA sequences of the invention are derived from the 5' region of genes encoding pathogenisis-related (PR) proteins. The present invention also provides anti-pathogenic sequences derived from novel cDNAs coding for PR proteins which can be genetically engineered and transformed into plants to confer enhanced resistance to disease.
    Type: Grant
    Filed: January 13, 1994
    Date of Patent: March 25, 1997
    Assignee: Ciba-Geigy Corporation
    Inventors: John A. Ryals, Danny C. Alexander, James J. Beck, John H. Duesing, Robert M. Goodman, Leslie B. Friedrich, Christian Harms, Frederich Meins, Jr., Alice Montoya, deceased, Mary B. Moyer, Jean-Marc Neuhaus, George B. Payne, Christoph Sperisen, Jeffrey R. Stinson, Scott J. Uknes, Eric R. Ward, Shericca C. Williams