Abstract: Glucosamine compositions comprising the compounds glucosamine sulfate metal chloride, wherein the metal, i.e., the cation is potassium, sodium, magnesium, lithium, calcium, zinc or manganese. The compounds have purity levels of at least about 97%, with water present in a maximum amount of about 10 wt. %, based on the weight of the composition. The compounds are prepared by contacting glucosamine hydrochloride with a hydroxide of the metal in the presence of water to form a first aqueous solution of the free glucosamine base and a chloride of the metal, acidifying the first aqueous solution with sulfuric acid to form a second aqueous solution of glucosamine sulfate and the chloride of the metal, and thereafter freeze-drying the second aqueous solution at a temperature and at a reduced pressure for such period of time that at least about 90 wt. % of the water is removed and decomposition of the compound glucosamine sulfate metal chloride is limited to a maximum of about 3%.
Type:
Grant
Filed:
November 8, 2000
Date of Patent:
October 29, 2002
Assignee:
Jame Fine Chemicals, Inc.
Inventors:
James R. Schleck, Christopher M. Burger, Vilas M. Chopdekar
Abstract: The invention pertains to a process for preparing carbetapentane tannate. The process involves the steps of heating carbetapentane to a temperature of about 80 to about 120° C. and slowly adding tannic acid to the carbetapentane while agitating the reaction mixture. Preferably, no water or any other solvent or diluent is utilized in the process.
Type:
Grant
Filed:
December 14, 2001
Date of Patent:
September 24, 2002
Assignee:
Jame Fine Chemicals, Inc.
Inventors:
Vilas M. Chopdekar, James R. Schleck, Hemant S. Desai
Abstract: An aqueous, curable coating composition comprising a mixture of:
(a) at least one water soluble alkali metal silicate; and
(b) an effective amount of a water-soluble crosslinking agent comprising an alkali metal aluminophosphate, or an alkali metal aluminoborophosphate, or an ammonia aluminophosphate, or an ammonia aluminoborophosphate, or an alkali metal ammonia aluminophosphate, an alkali metal ammonia aluminoborophosphate, or a mixture of two or more of the foregoing phosphates.
Preferably, the coating composition will not contain any visually discernable precipitate. The coating composition may be applied to a substrate such as a glass, a ceramic, concrete or a metal and thereafter cured by air drying or by heating to a temperature of up to about 240° C. (or higher, if desired).
Abstract: An edible composition for use as an anti-inflammatory agent for alleviation of arthritis and gout in mammals. The edible composition is a mixture of at least three, preferably at least seven, herbs selected from the group consisting of Tanacetum parthenium, Zingibar officinale, Curcuma longa, Coriandrum sativum, Centella asiatica, Oenothera biennis, Valeriana officinalis, Tabebuia impetiginosa, Thymus vulgaris and Sambucus nigra. A preferred composition will contain at least Tanacetum parthenium, Zingibar officinale and Curcuma longa. The composition preferably contains the herbs in approximately equal amounts.
Type:
Grant
Filed:
July 1, 1999
Date of Patent:
August 14, 2001
Assignee:
Chromak Research, Inc.
Inventors:
Onkar S. Tomer, Peter Glomski, Kripanath Borah
Abstract: Methods and formulations for making extended release bupropion hydrochloride tablets using direct compression, and tablets formed thereby, are provided which combine bupropion hydrochloride, binders such as polyethylene oxide or hydroxypropyl cellulose, a filler such as lactose, glidants and lubricants under low shear conditions to form hard, chip-resistant tablets which exhibit improved cohesiveness and are easily and reproducibly formed without adhering to the compression punches and dies.
Abstract: Edible herbal compositions for use as agents for the control of hypertension, hypercholesterolemia and hyperlipidemia in mammals. The edible composition is a mixture of at least three, preferably at least six, herbs selected from the group consisting of Terminalia arjuna, Cynara scolymus, Zingibar officinale, Allium sativum, Crataegus oxycantha, Curcuma longa, Boerhaavia diffusa and Trigonella foenumgraecum. The composition preferably contains the herbs in approximately equal amounts.
Type:
Grant
Filed:
June 24, 1999
Date of Patent:
December 19, 2000
Assignee:
Chromak Research, Inc.
Inventors:
Onkar S. Tomer, Peter Glomski, Kripanath Borah
Abstract: The instant invention is directed to a method of making a library of compounds using a segmentable support material comprised of a particulate resin affixed to a porous laminar material.
Type:
Grant
Filed:
May 16, 1997
Date of Patent:
November 28, 2000
Assignee:
Cambridge Combinatorial Limited
Inventors:
Ryszard Jurek Kobylecki, John Mark Francis Gardner
Abstract: Glucosamine compositions comprising the compounds glucosamine sulfate metal chloride, wherein the metal, i.e. the cation, is lithium, sodium, magnesium, zinc or manganese. The compounds have purity levels of at least about 97%, with water present in a maximum amount of about 10 wt. %, based on the weight of the composition. The compounds are prepared by contacting glucosamine hydrochloride with the metal sulfate in the presence of water to form an aqueous solution of glucosamine sulfate metal chloride and thereafter freeze-drying the solution at a temperature and at a reduced pressure for such period of time that at least about 90 wt. % of the water is removed and decomposition of the compound glucosamine sulfate metal chloride is limited to a maximum of about 3%.
Type:
Grant
Filed:
November 13, 1998
Date of Patent:
May 11, 1999
Assignee:
Jame Fine Chemicals, Inc.
Inventors:
James R. Schleck, Christopher M. Burger, Vilas M. Chopdekar
Abstract: An edible composition comprising a mixture of at least two herbs selected from the group consisting of Syzygium cumini, Gymnema sylvestre, Momordica charantia and Solanum melongena. Preferably, the composition comprises a mixture of Syzygium cumini and Momordica charantia. A mixture of Syzygium cumini, Gymnema sylvestre and Momordica charantia is particularly preferred. The herbal mixtures are useful as dietary supplements and are especially useful for lowering the glucose level of the blood in mammals, particularly humans suffering from diabetes mellitus.
Type:
Grant
Filed:
March 6, 1998
Date of Patent:
May 4, 1999
Assignee:
Cromak Research, Inc.
Inventors:
Onkar S. Tomer, Peter Glomski, Kripanath Borah
Abstract: A composition comprising the compound glucosamine sulfate potassium chloride having a purity level of at least about 97% and water present in a maximum amount of about 10 wt. %, based on the weight of the composition. The compound is prepared by contacting glucosamine hydrochloride with potassium sulfate in the presence of water to form an aqueous solution of glucosamine sulfate potassium chloride and thereafter freeze-drying the solution at a temperature and at a reduced pressure for such period of time that at least about 90 wt. % of the water is removed and decomposition of the compound glucosamine sulfate potassium chloride is limited to a maximum of about 3%.
Type:
Grant
Filed:
May 22, 1998
Date of Patent:
December 1, 1998
Assignee:
Jame Fine Chemicals, Inc.
Inventors:
James R. Schleck, Christopher M. Burger, Vilas M. Chopdekar
Abstract: A water-based offset lithographic printing ink comprising 10-70 wt. % macromolecular binders comprising macromolecular binders soluble in water regardless of the pH; macromolecular rosin salt binders soluble in water at a pH ranging from 7.5 to 10; and macromolecular binders comprised of aqueous emulsions; pigment; and a hydroxyethylethylene urea re-wetting agent.
Type:
Grant
Filed:
March 13, 1996
Date of Patent:
March 10, 1998
Assignee:
Sun Chemical Corporation
Inventors:
Ramasamy Krishnan, Marilyn C. Yamat, Hugo Babij
Abstract: The invention relates to a heatset intaglio printing ink especially suited for the intaglio printing of security documents such as currency, postage stamps, stock certificates, bank notes and the like. The ink comprises: a) an epoxy resin ester reacted with an unsaturated monobasic acid and a reactive monomer, b) a glycol and/or glycol ether, c) a pigment, d) a drier and e) a compound obtained by reacting an amine/epoxy adduct with a phenolic resin or polyhydric phenol compound.
Type:
Grant
Filed:
June 13, 1995
Date of Patent:
March 3, 1998
Assignee:
Sun Chemical Corporation
Inventors:
Solomon J. Nachfolger, Hugo Babij, Joseph Malanga, Ralph H. Reiter, Walter J. Glesias
Abstract: A chemiluminescent composition comprising an oxalate component comprising polystyrene or homopoly-.alpha.-methylstyrene containing an oxalate ester; an activator component comprising a solution of a peroxide compound and a catalyst in a first solvent; and a fluorescer contained in the oxalate component, activator component, or in both the oxalate component and the activator component. The first solvent is preferably a propylene glycol dialkyl ether. The chemiluminescent composition, when activated, permits light to be produced of controllable duration.
Type:
Grant
Filed:
November 22, 1996
Date of Patent:
January 6, 1998
Assignee:
Jame Fine Chemicals, Inc.
Inventors:
Vilas M. Chopdekar, James R. Schleck, Cheng Guo, Amanda J. Hall
Abstract: Novel aminosaccharide biguanides are prepared by either reacting a aminosaccharide with a mono- or multi-functional cyanoguanidine or by reacting a monocyano-guanidine of an aminosaccharide with a mono- or multi-functional primary and/or secondary amine. The amines may be straight or branched chain alkyl, aryl, alkaryl, aralkyl, acylic, alicyclic, heterocyclic or polycyclic in nature. The aminosaccharide biguanides have a variety of uses such as for anti-microbial compositions, chelating compositions, cosmetic compositions, surface tension reductants, flocculants for flocculating negatively charged suspended particles, and the like.
Abstract: A camera speed lithographic plate precursor composition is used for the preparation of waterless, imaged printing plates. The plates comprise a solid substrate with a first layer of a photopolymerizable, oleophilic coating; a second layer of silicone rubber; a third protective film layer; and a top or fourth layer comprising a silver halide emulsion containing polymeric binders or keying agents.
Type:
Grant
Filed:
December 1, 1995
Date of Patent:
March 11, 1997
Assignee:
Sun Chemical Corporation
Inventors:
Robert W. Hallman, Suck-Ju Hong, Ken-ichi Shimazu
Abstract: Phenylephrine tannate compositions are disclosed wherein the phenylephrine tannate has a minimum purity level of at least 95%. The composition also contains a minor amount of water, but no significant quantities of organic compounds or solvents other than water are present. The phenylephrine tannate will have a density of at least 0.6 g/cc.
Type:
Grant
Filed:
June 28, 1996
Date of Patent:
February 4, 1997
Assignee:
Jame Fine Chemicals, Inc.
Inventors:
Vilas M. Chopdekar, James R. Schleck, Vernon A. Brown, Cheng Guo
Abstract: A chemiluminescent composition comprising an oxalate component comprising an oxalate ester and a solvent, an activator component comprising a peroxide compound and a catalyst and a fluorescer contained in the oxalate component and/or the activator component. The solvent contained in the oxalate component comprises a propylene glycol dihydrocarbyl ether containing one to three propylene moieties and each hydrocarbyl moiety contains up to 8 carbon atoms and is independently selected from the group consisting of straight chain alkyl, branched chain alkyl, cycloalkyl, aryl, alkaryl and aralkyl groups.
Type:
Grant
Filed:
April 30, 1996
Date of Patent:
January 28, 1997
Assignee:
Jame Fine Chemicals, Inc.
Inventors:
Vilas M. Chopdekar, James R. Schleck, Cheng Guo, Amanda J. Hall
Abstract: The invention comprises a process for forming a high contrast photographic image including the steps of imagaewise exposing a silver halide photographic element containing a hydrazine compound which functions as a nucleating agent, wherein the element is free of incorporated amine boosters. The exposed element is developed with a chemically stable aqueous alkaline developing solution that is free of dihydroxybenzene developing agents and has a pH between 9.5 and 11. The developing solution comprises an ascorbic acid developing agent; an auxiliary developing agent; and a combination of an alkali metal carbonate and an alkali metal borate comprising between 0.125 and 0.5 molar concentration of the carbonate and between 0.04 and 0.35 molar concentration of the borate.
Abstract: A process for improving the color value of a pigment and for imparting stability to a water-based printing ink containing such pigment which comprises adding a polyester or polyether to the strike tank during the pigment conditioning step; the preferred polyether is methyl hydroxypropyl cellulose and the preferred polyester is benzoic acid-modified trimellitic anhydride polyester.
Type:
Grant
Filed:
December 16, 1994
Date of Patent:
November 19, 1996
Assignee:
Sun Chemical Corporation
Inventors:
Ramasamy Krishnan, Marilyn C. Yamat, Manuel Z. Gregorio, Russell J. Schwartz
Abstract: The invention relates to a water-based oxidizing printing ink especially suited for flexographic printing. The ink comprises an epoxy ester resin, an inorganic and/or organic pigment, a drier, a cyclodextrin and water. Preferably, the ink also includes a drier activator such as 2,2'-bipyridyl and a wax.
Type:
Grant
Filed:
July 18, 1995
Date of Patent:
October 22, 1996
Assignee:
Sun Chemical Corporation
Inventors:
Anthony R. Cappuccio, Athanasios P. Rizopoulos