Abstract: Tetrasubstituted urea and thiourea compounds useful as antiatherosclerotic agents, compositions thereof and processes for their preparation.

Abstract: This disclosure describes 4-heteroaryl-1-piperazinethiocarboxamides useful in the treatment of atherosclerosis in mammals.

Abstract: This invention relates to a novel process for the production of antibiotic X-14868A using the novel microorganism Antinomadura yumaense sp. nov.

Abstract: An inclusion compound of p-hexadecylamino benzoic acid sodium salt in .beta.-cyclodextrin which provides enhanced bioavailability of this antiatherosclerotic agent.

Abstract: Methods of treating atherosclerosis with di(aralkyl) ureas and di(aralkyl)thioureas, compositions thereof and processes for their preparation.

Abstract: Method of treating atherosclerosis with dialkylureas and dialkylthioureas, compositions thereof and processes for their preparation.

Abstract: An improved process for the preparation and purification of N-{p-([2,4-diamino-6-pteridinyl)-methyl]methylamino)benzoyl} glutamic acid, also known as methotrexate, using the alkali metal, calcium and zinc salts of N-methyl-p-aminobenzoylglutamate, tetraaminopyrimidine sulfate, 1,1,3-tribromoacetone and the alkali metal and zinc salts of methotrexate.

Abstract: Novel para-[aryl(alkyl or alkenyl)amino]benzoic acids, esters, pharmaceutically acceptable salts and pharmaceutical compositions thereof and a method of lowering serum lipid levels in mammals therewith.

Abstract: This disclosure describes novel 4-(monoalkylamino)phenyl alkane, alkene and alkyne carbinols, aldehydes, carboxylic acids and derivatives useful as hypolipidemic and antiatherosclerotic agents.

Abstract: A composition of matter in pharmaceutical dosage form comprising an amorphous coprecipitate of water-soluble polyhydroxylic organic compounds and 4-(monoalkylamino)-benzoic acid and derivatives for the treatment of atherosclerosis and hyperlipidemia.

Abstract: This disclosure describes novel aldehydes and ketones containing a 4-(monoalkylamino)phenyl moiety, derivatives and salts thereof, useful as hypolipidemic and antiatherosclerotic agents.

Abstract: Novel 4-monoalkylamino-benzaldehydes, 4-mono-alkylamino-alkanophenones, and 4-monoalkylamino-benzophenones, and derivatives and salts thereof, are disclosed which are useful as anti-atherosclerotic agents.

Abstract: This disclosure describes esters of 4-(monoalkylamino)benzoic acids with hydroxyalkanoic acids and derivatives, phenols, or 3-pyridinols useful as hypolipidemic and antiatherosclerotic agents.

Abstract: This disclosure describes pharmaceutical compositions having hypolipidemic and/or hypoglycemic activity which contain a substituted naphthyloxyalkylaminobenzoic acid or salt or ester thereof.

Abstract: A process for preparing a solution of DL-mandelic acid is disclosed. The process consists essentially of heating a solution consisting essentially of an optically active 2-amino-1-butanol mandelate and an alkalizing agent, with or without an alcohol solvent; neutralizing the resulting solution with a mineral acid or a mineral acid salt to precipitate an alkali or alkaline earth metal salt; separating the metal salt; and recovering the solution of DL-mandelic acid.

Abstract: An improved process is disclosed for resolving DL-mandelic acid using optically active 2-amino-1-butanol. The known process comprises: (a) reacting DL-mandelic acid with optically active 2-amino-1-butanol in an alcohol or alcohol mixture to form an optically active mandelate salt; (b) cooling and recovering the salt; (c) mixing the salt with water and distilling off any residual alcohol; (d) acidifying the mixture with a mineral acid; and (e) cooling and recovering the optically active mandelic acid.The improvement comprises: recycling the mother liquor of step (b) into step (a); heating the mother liquor with an alkalizing agent to obtain a racemic solution; neutralizing the racemic solution to precipitate an alkali or alkaline earth metal salt; separating the metal salt; recycling the mother liquor from the separating step into step (a); and recycling the mother liquor from step (e) into step (c).

Abstract: This disclosure describes esters of 4-(monoalkylamino)benzoic acids with hydroxyalkanoic acids and derivatives, phenols, or 3-pyridinols useful as hypolipidemic and antiatherosclerotic agents.

Abstract: A process for preparing 2,4,5,6-tetraaminopyrimidine sulfate is disclosed. The process comprises: (1) reacting about one molecular proportion of 5-nitroso-2,4,6-triaminopyrimidine (NTAP) in water with about 2.0 to 2.5 molecular proportions of zinc dust and about 4.0 to 4.7 molecular proportions of a suitable acid, to provide a reaction mixture having a pH below 7; (2) reacting the reaction mixture at a temperature of about 20.degree. to 65.degree. C. to form the acid salt of 2,4,5,6-tetraaminopyrimidine; (3) adjusting the pH to about 2.0 to 2.5 by adding the suitable acid to form a solution of the acid salt; (4) separating the insoluble materials from step (3) to obtain a wet cake and a mother liquor; (5) adding sulfuric acid to the mother liquor to adjust the pH to about 0.2 to 0.5 while maintaining the temperature at about 20.degree. to 60.degree. C.; (6) cooling the reaction mixture of step (5) to about 0.degree. to 10.degree. C.

Abstract: The surgical instrument comprises a single housing having a barrel and handle. The barrel contains jaws to maintain a hemostatic clip, and a jaw wedge. When actuated by the jaw wedge, the jaws operate in a "scissors action" to compress the hemostatic clip onto the vessel.The barrel portion also contains a feed bar and magazine tape. The magazine tape contains a plurality of hemostatic clips. On retraction, the jaw wedge coordinates with the feed bar and magazine tape to deliver a new clip to the jaws.The jaw wedge is actuated by a trigger pivotally mounted to the handle.