Abstract: Novel para-[thienyl and furyl(alkyl or alkenyl)amino]-benzoic acids, esters, pharmaceutically acceptable salts and pharmaceutical compositions thereof and a method of lowering serum-lipid levels in mammals therewith.
Type:
Grant
Filed:
October 5, 1979
Date of Patent:
January 20, 1981
Assignee:
American Cyanamid Company
Inventors:
Jay D. Albright, Thomas G. Miner, Robert G. Shepherd
Abstract: A process for resolving DL-Mandelic acid which comprises reacting at moderately elevated temperatures in a two-phase liquid mixture of water and a suitable water-immiscible organic solvent about equimolecular amounts of DL-Mandelic acid and an optically active 2-benzylamino-1-butanol, represented by formula (I), ##STR1## to form a crude mandelate salt, represented by formula (II), ##STR2## wherein X is chloro, bromo, fluoro, or nitro; said crude mandelate salt is recovered and purified by contact with a suitable solvent to obtain an optically pure mandelate salt, represented by formula (II); the optically active mandelate salt is hydrolyzed with aqueous sodium or potassium hydroxide in a two-phase liquid mixture to obtain an organic phase containing an optically active compound of formula (I) and an alkalized aqueous phase containing the sodium or potassium salt of an optically active mandelic acid. The latter is acidified and an optically active mandelic acid is recovered therefrom.
Abstract: This invention relates to a surgical needle comprising a point and dual cutting blades. The point is defined by a symmetrical angle of width and an angle of slope. The needle point geometry and the dual cutting blades provide a flap incision and a reduction in the tissue penetration properties.
Type:
Grant
Filed:
February 16, 1979
Date of Patent:
December 9, 1980
Assignee:
American Cyanamid Company
Inventors:
Thomas A. Ritter, Leonard J. Laskowski, Donald S. Kaplan
Abstract: A magazine tape is described comprising a flat flexible belt and a plurality of units attached to the belt. Each unit contains a hemostatic clip. Each unit consists of, in succession, a parallel aligned pair of: leading tabs; side retaining tabs and apex retaining tabs; and feeding and positioning tabs.The retaining tabs contain a groove adjacent the sides of the belt to accomodate the sides of a hemostatic clip. The apex retaining tabs have a contour about equal to the clip apex contour.The feeding and positioning tabs have flanged upper portions parallel with the longitudinal direction of the belt and extending away from the apex retaining tabs. The flanged portions decrease in thickness away from the feeding and positioning tabs.
Abstract: 5,5'-[5-Nitro-1,3-phenylenebis(carbonylimino)]disalicyclic acid and 5,5'-[5-amino and nitro-1,3-phenylenebis(carbonylimino)]bis[3-sulfosalicylic acid]dialkali metal salts useful as complement inhibitors.