Patents Represented by Attorney James A. Nicholson

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  • Bicyclic benzenoid aminoalkylene ethers and thioethers, pharmaceutical compositions and use
    Patent number: 4745110
    Abstract: A class of bicyclic benzenoid aminoalkylene ether and thioether compounds exhibiting pharmacological activity, including anti-secretory and anti-ulcerogenic activity, pharmaceutical compositions comprising these compounds, and methods for the treatment of gastrointestinal hyperacidity and ulcerogenic disorders in mammals using said compositions.
    Type: Grant
    Filed: July 27, 1987
    Date of Patent: May 17, 1988
    Assignee: Rorer Pharmaceutical Corporation
    Inventors: Donald E. Kuhla, Henry F. Campbell, William L. Studt
  • Process for the preparation of a viscosity-stable antacid composition
    Patent number: 4744986
    Abstract: A process for the preparation of a viscosity-stable antacid composition containing an alginic acid salt comprising reacting an antacid material with said salt at elevated temperatures to form a reaction product and recovering said reaction product in stabilized form.
    Type: Grant
    Filed: March 7, 1986
    Date of Patent: May 17, 1988
    Assignee: Rorer Pharmaceutical Corporation
    Inventors: Joseph R. Luber, Kenneth M. Feld, Richard J. Harwood, Wayne M. Grim
  • Pyridone-pyridyl-imidazolyl and triazolyl compounds and their use as cardiotonic agents
    Patent number: 4743608
    Abstract: This invention relates to pyridone-pyridyl-imidazolyl and triazolyl compounds, including methods for increasing cardiac contractility, pharmaceutical compositions including the same and methods for the preparation thereof.
    Type: Grant
    Filed: July 15, 1986
    Date of Patent: May 10, 1988
    Assignee: Rorer Pharmaceutical Corporation
    Inventors: William C. Faith, Henry F. Campbell, Donald E. Kuhla
  • Benzocyclobutene aminoalkylene ethers and thioethers, pharmaceutical compositions and use
    Patent number: 4743600
    Abstract: A class of benzocyclobutene aminoalkylene ether and thioether compounds exhibiting pharmacological activity, including anti-secretory and anti-ulcerogenic activity, pharmaceutical compositions comprising these compounds, and methods for the treatment of gastrointestinal hyperacidity and ulcerogenic disorders in mammals using said compositions.
    Type: Grant
    Filed: July 28, 1986
    Date of Patent: May 10, 1988
    Assignee: Rorer Pharmaceutical Corporation
    Inventors: Donald E. Kuhla, Henry F. Campbell, William L. Studt
  • 3- and 5-amino thiatriazines, and their pharmaceutical uses
    Patent number: 4742055
    Abstract: A class of 3- and 5-amino thiatriazine compounds exhibiting pharmacological activity, including anti-ulcerogenic and gastrointestinal cytoprotective activity, pharmaceutical compositions comprising these compounds, and methods for the treatment of gastrointestinal hyperacidity and ulcerogenic disorders in mammals using said compositions.
    Type: Grant
    Filed: April 27, 1984
    Date of Patent: May 3, 1988
    Assignee: Rorer Pharmaceutical Corporation
    Inventors: William L. Studt, Donald E. Kuhla, Henry F. Campbell, Stuart A. Dodson
  • Method for the treatment of pruritus and composition for the use therein
    Patent number: 4734434
    Abstract: A method for the relief of pruritus comprising the administration of an effective antipruritic amount of a N-(trifluoromethylphenyl)anthranilic acid ester to an afflicted patient.
    Type: Grant
    Filed: March 11, 1986
    Date of Patent: March 29, 1988
    Assignee: Rorer Pharmaceutical Corporation
    Inventors: Robert L. Procaccini, Kim D. Lamon, Nicholas S. Hagen
  • 3- and 5-(bicyclic ether or bicyclic alkylene thioether) alkylene amino thiatriazines, and their pharmaceutical uses
    Patent number: 4727169
    Abstract: A class of 3- and 5-amino thiatriazine compounds exhibiting pharmacological activity, including gastrointestinal anti-ulcerogenic and cytoprotective activity, pharmaceutical compositions comprising these compounds, and methods for the treatment of gastrointestinal hyperacidity and ulcerogenic disorders in mammals using said compositions.
    Type: Grant
    Filed: February 4, 1987
    Date of Patent: February 23, 1988
    Assignee: Rorer Pharmaceutical Corporation
    Inventors: Donald E. Kuhla, Henry F. Campbell, William L. Studt, Stuart A. Dodson, Robert A. Galemmo, Jr., Pamela J. Durham
  • Benzodiazinone-pyridazinone and hydroxy-pyrazolyl compounds, cardiotonic compositions including the same, and their uses
    Patent number: 4725686
    Abstract: A method for increasing cardiotonic contractility in humans or other animals using a class of benzodiazinonepryidazinone and hydroxy-pyrazolyl compounds and pharmaceutical compositions including the same.
    Type: Grant
    Filed: November 22, 1985
    Date of Patent: February 16, 1988
    Assignee: William H. Rorer, Inc.
    Inventors: Donald E. Kuhla, Henry F. Campbell, William L. Studt, William C. Faith, Bruce F. Molino
  • Bicyclic benzo-oxy heterocyclic ethers and thioethers pharmaceutical compositions and use
    Patent number: 4722925
    Abstract: A class of bicyclic benzo-oxy heterocyclic ether and thioether compounds exhibiting pharmacological activity, including anti-secretory and anti-ulcerogenic activity, pharmaceutical compositions comprising these compounds, and methods for the treatment of gastro-intestinal hyperacidity and ulcerogenic disorders in mammals using said compositions.
    Type: Grant
    Filed: March 3, 1987
    Date of Patent: February 2, 1988
    Assignee: Rorer Pharmaceutical Corporation
    Inventors: Donald E. Kuhla, Henry F. Campbell, William L. Studt, Kent W. Neuenschwander
  • 6-(4-thiazole) compounds, cardiotonic compositions including the same, and their uses
    Patent number: 4721721
    Abstract: Cardiotonic fused aromatic bicyclic ring substituted thiazole compounds and their salts, methods for increasing cardiac contractility in humans and other mammals by the use of said compounds, pharmaceutical compositions including said compounds and methods for compound preparation.
    Type: Grant
    Filed: December 18, 1984
    Date of Patent: January 26, 1988
    Assignee: Rorer Pharmaceutical Corporation
    Inventors: Donald E. Kuhla, Henry F. Campbell, William L. Studt
  • Aryl substituted heterocycles for treating gastrointestinal motility dysfunction
    Patent number: 4714707
    Abstract: Aryl substituted diazaheterocyclic amines and their use in the treatment of gastrointestinal motility dysfunctions.
    Type: Grant
    Filed: January 13, 1984
    Date of Patent: December 22, 1987
    Assignee: Rorer Pharmaceutical Corporation
    Inventors: Donald E. Kuhla, William L. Studt, Henry F. Campbell, John Yelnosky
  • Heterocyclic amidino substituted ureas and their pharmaceutical uses
    Patent number: 4707478
    Abstract: This invention relates to methods for the prophylactic and curative treatment of gastrointestinal and cardiovascular disorders and parasitic infections in humans and animals, using a class of hetrocyclic amidino substituted urea and thiourea compounds, a novel class of heterocyclic amidino substituted urea and thiourea compounds and pharmaceutical compositions and animal feed additives including the same.
    Type: Grant
    Filed: September 16, 1982
    Date of Patent: November 17, 1987
    Assignee: Rorer Pharmaceutical Corporation
    Inventors: William L. Studt, Harry K. Zimmerman, Stuart A. Dodson
  • 3- And 5-(bicyclic ether or bicyclic alkylene thioether)alkylene amino thiatriazines, and their pharmaceutical uses
    Patent number: 4704388
    Abstract: A class of 3- and 5-amino thiatriazine compounds exhibiting pharmacological activity, including gastrointestinal anti-ulcerogenic and cytoprotective activity, pharmaceutical compositions comprising these compounds, and methods for the treatment of gastrointestinal hyperacidity and ulcerogenic disorders in mammals using said compositions.
    Type: Grant
    Filed: December 2, 1985
    Date of Patent: November 3, 1987
    Assignee: Rorer Pharmaceutical Corporation
    Inventors: Donald E. Kuhla, Henry F. Campbell, William L. Studt, Stuart A. Dodson
  • Substituted phenyl amidinoureas
    Patent number: 4704401
    Abstract: This invention relates to a method of lowering blood pressure in humans and mammals using 2,6-disubstituted phenyl amidinoureas in which the phenyl ring is additionally substituted by a hydroxy, alkoxy, aralkoxy, alkenyloxy, alkynyloxy, haloacyloxy, or acyloxy group and to novel 2,6-disubstituted phenyl amidinoureas which possess pharmaceutical properties, including blood pressure lowering activity.
    Type: Grant
    Filed: December 6, 1984
    Date of Patent: November 3, 1987
    Assignee: Rorer Pharmaceutical Corporation
    Inventors: William L. Studt, Richard L. Riley, George H. Douglas
  • Amidinoureas for treating irritable bowel syndrome
    Patent number: 4701457
    Abstract: Amidinoureas are disclosed as useful for the treatment of irritable bowel syndrome.
    Type: Grant
    Filed: January 13, 1984
    Date of Patent: October 20, 1987
    Assignee: Rorer Pharmaceutical Corporation
    Inventors: John Yelnosky, Ghulam N. Mir
  • Bicyclic benzenoid alkylene amino thieno[3,4-d]isothiazole ethers and thioethers, pharmaceutical compositions and use
    Patent number: 4699906
    Abstract: A class of bicyclic benzenoid aminoalkylene ether and thioether compounds exhibiting pharmacological activity, including anti-secretory and anti-ulcerogenic activity, pharmaceutical compositions comprising these compounds, and methods for the treatment of gastrointestinal hyperacidity and ulcerogenic disorders in mammals using said compositions.
    Type: Grant
    Filed: May 23, 1986
    Date of Patent: October 13, 1987
    Assignee: Rorer Pharmaceutical Corporation
    Inventors: Donald E. Kuhla, Henry F. Campbell, William L. Studt
  • Mandrel for opening a tube of flexible material
    Patent number: 4693059
    Abstract: A mandrel for opening a tube of flexible banding material wherein the tube is delivered in flat ribbon-like form with creased side edges is disclosed. The mandrel is in the form of a tetrahedron with two sets of surfaces which are in the form of isosceles triangles with each set of faces inclining towards one another to form a common base. A pair of relatively yieldable, sharp-edged wedging elements are disposed on each common base. Biasing means bias the wedging elements outwardly to limit positions at the ends of the common bases. Use of the mandrel to open a tube of flexible, heat-shrinkable banding material and creasing the material at points displaced 90.degree. from the initial creases is disclosed.
    Type: Grant
    Filed: February 28, 1986
    Date of Patent: September 15, 1987
    Assignee: Rorer Pharmaceutical Corporation
    Inventor: John B. O'Donnell
  • Erythromycin/benzoyl peroxide antiacne compositions
    Patent number: 4692329
    Abstract: Process and composition for the topical treatment of acne which comprises as ingredients a peroxide of an organic acid and an erythromycin compound selected from the group consisting of erythromycin and its stearate and glucoheptonate derivatives and in which said peroxide is from one-half to thirty times, the weight of said erythromycin compound, and a suitable pharmaceutically acceptable carrier.
    Type: Grant
    Filed: July 3, 1984
    Date of Patent: September 8, 1987
    Assignee: William H. Rorer, Inc.
    Inventors: Robert W. Klein, Mary E. Foxx
  • Bicyclic benzenoid aminoalkylene ethers and thioethers, pharmaceutical compositions and use
    Patent number: 4692445
    Abstract: A class of bicyclic benzenoid aminoalkylene ether and thioether compounds exhibiting pharmacological activity, including anti-secretory and anti-ulcerogenic activity, pharmaceutical compositions comprising these compounds, and methods for the treatment of gastrointestinal hyperacidity and ulcerogenic disorders in mammals using said compositions.
    Type: Grant
    Filed: November 12, 1986
    Date of Patent: September 8, 1987
    Assignee: Rorer Pharmaceutical Corporation
    Inventors: Donald E. Kuhla, Henry F. Campbell, William L. Studt
  • Heterocyclic guanidines for treating gastrointestinal motility dysfunction
    Patent number: 4689335
    Abstract: A method for treating gastrointestinal motility dysfunctions using phenylheterocyclic guanidines and novel heterocyclic guanidine compounds.
    Type: Grant
    Filed: January 13, 1984
    Date of Patent: August 25, 1987
    Assignee: William H. Rorer, Inc.
    Inventors: Donald E. Kuhla, William L. Studt, Henry F. Campbell, John Yelnosky