Patents Represented by Attorney James A. Nicholson

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  • Bicycle benzo-oxy heterocyclic ethers and thioethers, pharmaceutical compositions and use
    Patent number: 4668673
    Abstract: A class of bicyclic benzo-oxy heterocyclic ether and thioether compounds exhibiting pharmacological activity, including anti-secretory and anti-ulcerogenic activity, pharmaceutical compositions comprising these compounds, and methods for the treatment of gastrointestinal hyperacidity and ulcerogenic disorders in mammals using said compositions.
    Type: Grant
    Filed: July 2, 1986
    Date of Patent: May 26, 1987
    Assignee: William H. Rorer, Inc.
    Inventors: Donald E. Kuhla, Henry F. Campbell, William L. Studt, Kent W. Neuenschwander
  • Hydroxy and aminothiazolyl-benzodiazinone compounds, cardiotonic compositions including the same, and their uses
    Patent number: 4666913
    Abstract: A method for increasing cardiotonic contractility in humans or other animals using a class of hydroxy and aminothiazolyl-benzodiazinone compounds and pharmaceutical compositions including the same.
    Type: Grant
    Filed: November 22, 1985
    Date of Patent: May 19, 1987
    Assignee: William H. Rorer, Inc.
    Inventors: Donald E. Kubla, Henry F. Campbell, William L. Studt, Bruce F. Molino, Thomas J. Tucker
  • Bicyclic benzenoid aminoalkylene ethers and thioethers, pharmaceutical compositions and use
    Patent number: 4647559
    Abstract: A class of bicyclic benzenoid aminoalkylene ether and thioether compounds exhibiting pharmacological activity, including anti-secretory and anti-ulcerogenic activity, pharmaceutical compositions comprising these compounds, and methods for the treatment of gastrointestinal hyperacidity and ulcerogenic disorders in mammals using said compositions.
    Type: Grant
    Filed: May 23, 1986
    Date of Patent: March 3, 1987
    Assignee: William H. Rorer, Inc.
    Inventors: Donald E. Kuhla, Henry F. Campbell, William L. Studt
  • Benzocyclobutene aminoalkylene ethers and thioethers, pharmaceutical compositions and use
    Patent number: 4639442
    Abstract: A class of benzocyclobutene aminoalkylene ether and thioether compounds exhibiting pharmacological activity, including anti-secretory and anti-ulcerogenic activity, pharmaceutical compositions comprising these compounds, and methods for the treatment of gastrointestinal hyperacidity and ulcerogenic disorders in mammals using said compositions.
    Type: Grant
    Filed: November 1, 1985
    Date of Patent: January 27, 1987
    Assignee: William H. Rorer, Inc.
    Inventors: Donald E. Kuhla, Henry F. Campbell, William L. Studt
  • Bicyclic benzenoid aminoalkylene ethers and thioethers, pharmaceutical compositions and use
    Patent number: 4638001
    Abstract: A class of bicyclic benzenoid aminoalkylene ether and thioether compounds exhibiting pharmacological activity, including anti-secretory and anti-ulcerogenic activity, pharmaceutical compositions comprising these compounds, and methods for the treatment of gastrointestinal hyperacidity and ulcerogenic disorders in mammals using said compositions.
    Type: Grant
    Filed: April 27, 1984
    Date of Patent: January 20, 1987
    Assignee: William H. Rorer, Inc.
    Inventors: Donald E. Kuhla, Henry F. Campbell, William L. Studt
  • Articulated joint in aerosol medicament dispenser
    Patent number: 4637528
    Abstract: A sliding and pivoting joint, and a retractable medicament spray dispenser having such a joint. A sleeve is telescopically mounted on the dispenser housing by engaging a pair of pin-like projections on a pair of ears on the sleeve into slots which are in opposite side walls of the housing. An elongated stud protrudes perpendicularly from the inward end of each pin. When the sleeve has been telescopically extended relative to the housing, abutments in the housing interact with the protruding studs to prevent the sleeve from being pivoted to any positions beyond those which correspond to the storage and the operating configurations of the dispenser.
    Type: Grant
    Filed: January 19, 1984
    Date of Patent: January 20, 1987
    Assignee: William H. Rorer, Inc.
    Inventors: Clarence A. Wachinski, Thomas J. Bigger
  • Bicyclic nitrogen heterocyclic ethers and thioethers, and their pharmaceutical uses
    Patent number: 4632927
    Abstract: A class of bicyclic nitrogen heterocyclic ether and thioether compounds exhibiting pharmacological activity including cytoprotective, H.sub.2 -antagonist, anti-secretory and anti-ulcerogenic activity, pharmaceutical compositions comprising these compounds, and methods for the treatment of gastrointestinal hyperacidity and ulcerogenic disorders in mammals using said compositions are disclosed.
    Type: Grant
    Filed: March 20, 1984
    Date of Patent: December 30, 1986
    Assignee: William H. Rorer, Inc.
    Inventors: Henry F. Campbell, Donald E. Kuhla, William L. Studt, Stuart A. Dodson
  • Low viscosity aluminum hydroxy carbonate gel process
    Patent number: 4622167
    Abstract: Process and system for the preparation of a low viscosity Aluminum Hydroxy Carbonate Gel having viscosity-resistant properties and a predetermined alkali ion content, comprising reacting under constant pH conditions an aqueous carbonate solution and an aqueous aluminum salt solution to form a reaction product, equilibrating the reaction product at naturally occurring pH and washing the equilibrated reaction product to provide the predetermined alkali ion content and the gel product by same processes.
    Type: Grant
    Filed: December 27, 1984
    Date of Patent: November 11, 1986
    Assignee: Barcroft Company
    Inventors: Wilbur G. Heath, Robert B. Casey
  • Antisecretory bicyclic benzo-oxy heterocyclic ethers and thioethers
    Patent number: 4612309
    Abstract: A class of bicyclic benzo-oxy heterocyclic ether and thioether compounds exhibiting pharmacological activity, including anti-secretory and anti-ulcerogenic activity, pharmaceutical compositions comprising these compounds, and methods for the treatment of gastro-intestinal hyperacidity and ulcerogenic disorders in mammals using said compositions.
    Type: Grant
    Filed: October 23, 1984
    Date of Patent: September 16, 1986
    Assignee: William H. Rorer, Inc.
    Inventors: Donald E. Kuhla, Henry F. Campbell, William L. Studt, Kent W. Neuenschwander
  • Amidinoureas for treating irritable bowel syndrome
    Patent number: 4611011
    Abstract: 1-Phenyl-3N-alkyl amidinoureas are useful in the treatment of irritable bowel syndrome.
    Type: Grant
    Filed: January 13, 1984
    Date of Patent: September 9, 1986
    Assignee: William H. Rorer, Inc.
    Inventors: John Yelnosky, Ghulam N. Mir
  • Dry oil coated antacid process
    Patent number: 4605551
    Abstract: This invention relates to an improvement comprising coating agitated particles of substantially anhydrous antacid with a solvent-free mixture of electronegatively charged material in a non-toxic inert substantially water insoluble oil.
    Type: Grant
    Filed: November 30, 1984
    Date of Patent: August 12, 1986
    Assignee: William H. Rorer, Inc.
    Inventors: John D. Buehler, Hans J. Medal, Gregory A. Rhoa
  • 3- and 5-[bicyclic ether or bicyclic alkylene thioether]alkylene amino thiatriazines, and their pharmaceutical uses
    Patent number: 4595683
    Abstract: A class of 3- and 5-amino thiatriazine compounds exhibiting pharmacological activity, including gastrointestinal anti-ulcerogenic and cytoprotective activity, pharmaceutical compositions comprising these compounds, and methods for the treatment of gastrointestinal hyperacidity and ulcerogenic disorders in mammals using said compositions.
    Type: Grant
    Filed: October 23, 1984
    Date of Patent: June 17, 1986
    Assignee: William H. Rorer, Inc.
    Inventors: Donald E. Kuhla, Henry F. Campbell, William L. Studt, Stuart A. Dodson
  • 5-hetero aryl-substituted-2-pyridones useful as cardiotonic agents for treatment of congestive heart failure
    Patent number: 4593028
    Abstract: Cardiotonic 5-heteroaryl-substituted-2-pyridone compounds, pharamaceutical compositions, and a method for the treatment of congestive heart failure.
    Type: Grant
    Filed: April 19, 1984
    Date of Patent: June 3, 1986
    Assignee: William H. Rorer, Inc.
    Inventor: Henry F. Campbell
  • Bicyclic benzenoid aminoalkylene ethers and thioethers, pharmaceutical compositions and use
    Patent number: 4588719
    Abstract: A class of bicyclic benzenoid aminoalkylene ether and thioether compounds exhibiting pharmacological activity, including anti-secretory and anti-ulcerogenic activity, pharmaceutical compositions comprising these compounds, and methods for the treatment of gastrointestinal hyperacidity and ulcerogenic disorders in mammals using said compositions.
    Type: Grant
    Filed: October 24, 1984
    Date of Patent: May 13, 1986
    Assignee: William H. Rorer, Inc.
    Inventors: William L. Studt, Donald E. Kuhla, Henry F. Campbell
  • Heterocyclic amidinoureas
    Patent number: 4565826
    Abstract: This invention relates to a novel class of heterocyclic amidinourea and heterocyclic amidinothiourea compounds wherein the heterocyclic substitution is at the 1-N urea nitrogen atom. These compounds exhibit pharmaceutical activity and may be incorporated into pharmaceutical preparations for producing anti-ulcerogenic, antisecretory, antispasmodic, antimotility, cardiovascular, antidiarrheal or antiparasitic action.
    Type: Grant
    Filed: February 24, 1984
    Date of Patent: January 21, 1986
    Assignee: William H. Rorer, Inc.
    Inventors: William L. Studt, Harry K. Zimmerman, George H. Douglas
  • Amidinoureas substituted in both the urea and amidino nitrogen positions
    Patent number: 4564640
    Abstract: A method of inducing blood pressure reduction in humans and mammals by administering 2,6-disubstituted phenyl N-alkyl amidinoureas in which the phenyl ring is additionally substituted by a hydroxy, alkoxy, aralkoxy, alkenyloxy, alkynyloxy, acyloxy or halo acyloxy group and a novel class of amidinourea compounds having pharmaceutical uses, including blood pressure lowering activity.
    Type: Grant
    Filed: February 2, 1984
    Date of Patent: January 14, 1986
    Assignee: William H. Rorer, Inc.
    Inventors: William L. Studt, Richard L. Riley, George H. Douglas
  • Quinoline and quinazoline derivatives for treating gastrointestinal motility dysfunctions
    Patent number: 4563460
    Abstract: A method for treating gastrointestinal motility dysfunctions using 2-amino-quinoline and -quinazoline derivatives.
    Type: Grant
    Filed: January 13, 1984
    Date of Patent: January 7, 1986
    Assignee: William H. Rorer, Inc.
    Inventors: Donald E. Kuhla, William L. Studt, Henry F. Campbell, John Yelnosky
  • 1,2,4-Triazines for treating gastrointestinal motility dysfunction
    Patent number: 4563456
    Abstract: Method for treating gastrointestinal motility dysfunctions using 1,2,4-triazines.
    Type: Grant
    Filed: January 13, 1984
    Date of Patent: January 7, 1986
    Assignee: William H. Rorer, Inc.
    Inventors: Donald E. Kuhla, William L. Studt, Henry F. Campbell, John Yelnosky
  • Guanidine derivatives for treating gastrointestinal motility dysfunction
    Patent number: 4563475
    Abstract: A method for the treatment of a gastrointestinal motility dysfunction using a nitrogen containing heterocyclyl substituted acetylguanidine.
    Type: Grant
    Filed: January 13, 1984
    Date of Patent: January 7, 1986
    Assignee: William H. Rorer, Inc.
    Inventors: Donald E. Kuhla, William L. Studt, Henry F. Campbell, John Yelnosky
  • Triazinones for treating irritable bowel syndrome
    Patent number: 4562188
    Abstract: A method for the treatment of irritable bowel syndrome using a 1,3,5-triazin-2-one and a class of 6-amino and 6-mercaptyl-1,3,5-triazin-2-one compounds.
    Type: Grant
    Filed: January 13, 1984
    Date of Patent: December 31, 1985
    Assignee: William H. Rorer, Inc.
    Inventors: Donald E. Kuhla, William L. Studt, Henry F. Campbell, John Yelnosky