Abstract: Disclosed are methods of using certain defined phenylene dioxamic acids in treating allergic ocular responses, such as, hayfever, conjunctivitis, atopic and keratoconjunctivitis, vernal conjunctivitis, giant capillary conjunctivitis and other diseases where mast cell degranulation are important in the etiology, by topical administration of said active to the affected eye; also disclosed are pharmaceutical compositions comprising said actives.

Abstract: The intraocular use of TGF-.beta..sub.3 in connection with glaucoma filtration surgery is described. A composition containing TGF-.beta..sub.3 is applied to the surgical site to suppress the production and/or alter the composition of extracellular matrix synthesized by fibroblasts at the surgical site, and thereby reduce the formation of scar tissue and consequent impairment of the outflow of aqueous humor through a fistula created during the surgery.

Abstract: Compounds having both calcium antagonist and antioxidant activity are disclosed. The compounds are useful in preventing or alleviating damage to tissues at the cellular level. Methods of treatment which employ these properties of the compounds and corresponding pharmaceutical compositions are also disclosed.

Abstract: Certain alkenyl diamines, the use of same for disinfecting and cleaning contact lenses and preserving ophthalmic products, and associated ophthalmic compositions are described.

Abstract: The use of TGF-.beta..sub.3 to reduce the formation of scar tissue as a result of trauma to the cornea of the eye is described. The invention is particularly directed to the use of TGF-.beta..sub.3 to reduce the formation of scar tissue in connection with ophthalmic surgical procedures involving the cornea, such as laser irradiation of the cornea. A composition containing TGF-.beta..sub.3 is applied to the site of the trauma to alter the production and composition of extracellular matrix synthesized by fibroblasts, and thereby reduce the formation of scar tissue and consequent impairment of vision.

Abstract: Methods for preventing and treating corneal haze resulting from exposure of the eye to laser irradiation are disclosed. The methods include administration of compositions of wound healing modulators to the eye. Compositions for use in preventing and treating the corneal haze are also disclosed.

Abstract: Methods for preventing and treating corneal haze resulting from exposure of the eye to laser irradiation are disclosed. The methods include administration of compositions of wound healing modulators to the eye. Compositions for use in preventing and treating the corneal haze are also disclosed.

Abstract: Certain amidoamines, the use of same for disinfecting and cleaning contact lenses and preserving ophthalmic products, and associated ophthalmic compositions are described.

Abstract: An improved process for cleaning and disinfecting contact lenses with a single solution is described. The process utilizes the cleaning effect of a cleaning agent in combination with the solvent action of water and physical agitation of the lens (i.e., by means of rubbing) to achieve a degree of cleaning which is comparable to or better than prior processes which utilize surfactant-cleaners. The cleaning agent is selected from polycarboxylates, polysulfonates and polyphosphates. The preferred cleaning agent is citrate. The process also offers greater convenience, relative to many prior systems for cleaning and disinfecting contact lenses, since the need to utilize additional products to clean the lenses is eliminated.

Abstract: Methods for treating the cornea following UV laser irradiation and resulting photoablation of corneal tissue are disclosed. The methods include administration of compositions of a non-steroidal antiinflammatory to the eye. Compositions for use in treating the cornea are also disclosed.

Abstract: An ultrasonic cutting tip assembly for an ultrasonic surgical cutting instrument having an ultrasonic transducer. The assembly includes a transition horn which is operatively couplable to the transducer, an elongated ultrasonic vibration-transmitting tube which is separable from the horn, and a threaded retaining nut. The threaded portion of the nut threadably engages the threaded portion of the transition horn to hold the proximal end of the tube and the horn together so that ultrasonic vibrations can thereby be efficiently transmitted from the transducer to the distal end of the tube, and then to the surgical site. The nut threaded portion can be formed either on the outside or the inside of the nut, and when on the outside in one embodiment, the nut and tube can be formed as an integral member to be threaded into the distal end of the horn. The elimination of all exposed tip nut surface angles greater than forty-five degrees increases the hydrodynamic performance of the assembly.

Abstract: Pharmaceutical compositions useful in the treatment of ophthalmic inflammation and methods of treating ophthalmic inflammation with those compositions are disclosed. The compositions contain a combination of a glucocorticoid and tetrahydrocortisol. The tetrahydrocortisol serves to substantially prevent any significant increases in intraocular pressure which might otherwise be experienced by the patient as a side effect of the glucocorticoid component of the compositions. The therapeutic interaction of the two components therefore allows the potent antiinflammatory properties of the glucocorticoids to be utilized without fear of elevating intraocular pressure. A method of preventing increases in intraocular pressure attributable to systemic or topical corticosteroid therapy is also disclosed. That method involves the administration of a pharmaceutical composition containing tetrahydrocortisol to a patient receiving such therapy.

Abstract: A contact lens cleaning solution containing an enzyme having proteolytic activity and a surfactant, and optionally also a chelating agent and urea, and a method of cleaning contact lenses utilizing this solution are described. The solution and method effectively remove deposits of proteinaceous material, mucins, lipids and calcium located either on or beneath the surface of the lens.

Abstract: Compounds having beta-2 adrenergic agonist activity and the use of these compounds in controlling intraocular pressure are disclosed. The compounds are believed to be useful in controlling intraocular pressure by increasing the outflow of aqueous humor. The compounds are considered to be less likely to cause cardiovascular side effects and various other side effects associated with stimulation of beta-1 receptors, relative to epinephrine.

Abstract: The multi-ported valve assembly includes a valve body having a plurality of individual ports disposed in a common plane and a common port having its axis disposed perpendicularly to the common plane of the individual ports. The valve assembly includes a selector means having a body portion designed to engage the valve body and provide selective communication between one of the individual ports and the common port. The selector means includes a handle to facilitate rotation thereof and selection of a desired fluid flow passageway as well as indicator means to indicate direction of fluid flow. Also provided are sealing means to prevent external leakage during use and suitable connecting or coupling means to provide connection especially in devices and apparatus used in ophthalmic surgical procedures.

Abstract: An intraocular lens designed for ease of insertion and for minimizing contact with intraocular tissues comprises a lens body having an optical axis, two optical surfaces and a periphery to which is fixed at least one filamentous haptic extending circumferentially and radially from the point of attachment along a curvilinear path in space to a maximum distance from the optical axis. The haptic has a proximal segment adjacent to the attachment point, a medial segment attached to and continuous with the proximal segment and a distal segment attached to and continuous with the medial segment. At least a part of the distal segment lies at the maximum distance from said optical axis and constitutes the tissue-contacting portion of the haptic. The tissue-contacting element is tangent to a second plane parallel to the first plane and displaced from it along the optical axis, and at least the medial segment of the haptic traverses a path concave toward the first plane and avoiding intersection with the second plane.

Abstract: A method for conducting ocular surgery using different viscoelastic agents is disclosed.

Abstract: Methods for preventing and treating corneal haze resulting from exposure of the eye to laser irradiation are disclosed. The methods include administration of compositions of wound healing modulators to the eye. Compositions for use in preventing and treating the corneal haze are also disclosed.

Abstract: A system and apparatus are disclosed for controlling amounts of fluid flow to and from a surgical site. The system includes a surgical handpiece having means including a passage for allowing fluid flow to and from a surgical site. A dispensing assembly is couplable to the handpiece for movement therewith and is selectively operable for automatically controlling continuously or discretely a controlled and metered amount of fluid flow to and from the surgical site.

Abstract: Sulfonamides and pharmaceutical compositions containing the compounds useful in controlling intraocular pressure are disclosed. Methods for controlling intraocular pressure through administration of the compositions are also disclosed.