Abstract: Disclosed is an ophthalmic gel composition of unique rheological and lubricating properties comprising, inter alia, a carboxy vinyl polymer (carbomer) for use as a long lasting artificial tear. Also disclosed is a method of treatment comprising totally administering the composition when indicated for relief of dry eye syndrom, foreign body sensation, burning, hyperemia, corneal straining, and the like.

Abstract: Disclosed are substituted or unsubstituted planar tricyclic fluorene or nuclear analogs thereof, spiro-coupled to a five-membered ring containing a secondary amide, and the pharmaceutically acceptable salts thereof. These compounds are useful, inter alia in the treatment of diabetes. Also disclosed are processes for the preparation of such compounds; pharmaceutical compositions comprising such compounds; and methods of treatment comprising administering such compounds and compositions when indicated for, inter alia, long term, prophylactic treatment of the diabetes syndrome. A particularly preferred class of compounds comprise difluoro-dialkoxy substituted spiro-(9H-fluorene-9,4'-imidazolidine)-2,40 ,5-diones.

Abstract: A unit dose dispenser for dispensing a composition includes a compressible, air filled container in communication with an open end of a tube filled with the composition. The opposite end of the tube through which the composition is dispensed is sealed with a removable closure cap to maintain sterility of the composition prior to use. By removing the cap and applying external pressure to compress the container, air is forced to enter the tube and eject, by displacement, composition from the tube. To completely eject the predetermined dosage that completely fills the tube, the volume of air or other gaseous propellant within the compressible container is greater than the volume of the unit dose.

Abstract: Hypotonic contact lens care compositions containing a quaternary ammonium antimicrobial agent (e.g. Polyquad.RTM.) and an anionic complexing agent (e.g. citrate) are disclosed. The compositions are useful in the disinfection of hydrophilic contact lenses, particularly Group IV lenses, and in the preservation of products for treating such lenses. Methods for use of the compositions for disinfecting and preserving are also disclosed.

Abstract: Methods for preventing and treating oxidative insult to the eye by the administration of transition metal complexes are disclosed.

Abstract: Disclosed are esters and amides of (+) suprofen, substantially free of the corresponding enantiomorp, (-) suprofen, having enhanced delivery characteristics on topical administration to the eye; also disclosed are pharmaceutical compositions comprising such (+) suprofen derivatives and methods of using them when indicated to achieve an anti-inflammatory effect on topical delivery to the eye.

Abstract: A method of preparing aqueous pharmaceutical compositions containing a synergistic combination of trimethoprim and sodium sulfacetamide is described. The method results in a significant improvement in the aqueous solubility of trimethoprim due to a favorable interaction between the trimethoprim and sodium sulfacetamide which is dependent on a mildly acidic pH.

Abstract: Bicomposite, hydrogel intraocular lenses with one or more haptic portions having a lower water content than the corresponding optic portions, and methods for their manufacture are disclosed. The bicomposite lenses are manufactured by (i) preparing a bicomposite button of hydrogel material containing one or more polymers or copolymers; (ii) lathing the button to produce a dehydrated intraocular lens with an optic and at least one haptic; and (iii) hydrating the lens.

Abstract: Disclosed are ophthalmic pharmaceutical compositions comprising S(+)-flurbiprofen substantially free of R(+)-flurbiprofen and methods of topical administration to the eye when indicated for treatment of inflammation.

Abstract: Disclosed are esters and amides of suprofen having enhanced delivery characteristics on topical administration to the eye; also disclosed are pharmaceutical compositions comprising such suprofen derivatives and methods of using them when indicated to achieve an anti-inflammatory effect on topical delivery to the eye.

Abstract: New spirofluoreneisothiazolidinone dioxides and methods for their preparation are disclosed.

Abstract: Topical ophthalmic compositions containing microfine particles of one or more retinoids are described. The compositions are useful in the treatment of dry eye syndrome and related ophthalmic surface disorders and as ocular lubricants. A method of treating dry eye syndrome and related ophthalmic surface disorders and a method of providing topical ocular lubrication using these compositions are also described.

Abstract: An intraocular lens for replacing the natural lens of an eye including a pair of flexible loops connected to and projecting from the optic portion on one side of the first axis, adapted for supporting the IOL in the eye. The loops include outer end portions that terminate outwardly from the peripheral edge and on opposite sides of the second axis. A stabilizing member(s) is connected to and projects from the optic portion on the other side of the first axis from where the loops are connected, adapted for stabilizing the IOL in the eye. The flexible loops and stabilizing member(s) is shaped and dimensioned so that when the loops are moved toward the peripheral edge the outer end portions do not extend beyond the stabilizing member(s).

Abstract: Compounds which enhance the efficiency of the corneal endothelial fluid pump thereby promoting normal corneal function and deturgescence of swollen corneas, and methods for the compounds' synthesis are described. In addition, surgical irrigating solutions which include one or more of the compounds are discussed along with methods for their use.

Abstract: Pharmaceutical compositions useful in the treatment of ophthalmic inflammation and methods of treating ophthalmic inflammation with those compositions are disclosed. The compositions contain a combination of a glucocorticoid and tetrahydrocortexolone. The tetrahydrocortexolone serves to substantially prevent any significant increases in intraocular pressure which might otherwise by experienced by the patient as a side effect of the glucocorticoid component of the compositions. The therapeutic interaction of the two components therefore allows the potent antiinflammatory properties of the glucocorticoids to be utilized without fear of elevating intraocular pressure. A method of preventing increases in intraocular pressure attributable to systemic or topical corticosteroid therapy is also disclosed. That method involves the administration of a pharmaceutical composition containing tetrahydrocortexolone to a patient receiving such therapy.

Abstract: Methods for preventing and treating corneal haze resulting from exposure of the eye to laser irradiation are disclosed. The methods include administration of compositions of wound healing modulators to the eye. Compositions for use in preventing and treating the corneal haze are also disclosed.

Abstract: Contact lens cleaning compositions containing a combination of an enzyme and a carboxy vinyl polymer, and a method of cleaning contact lenses with such compositions are described. The compositions are capable of cleaning soiled contact lenses very rapidly and completely due to a favorable interaction between the enzyme component and an abrasive precipitate formed by the carboxy vinyl polymer component when a small amount of the compositions is rubbed on the lenses.

Abstract: Disclosed are nonstinging, sustained release ophthalmic formulations to control intraocular pressure in antiglaucoma therapy comprising a basic active, a cation exchange resin, and, inter alia, an acidic, mucomimetic polymer. Also disclosed are methods of treatment comprising administering such formulations topically to the eye when indicated for control and lowering of intraocular pressure.

Abstract: A means, method, and system for storing and caring for contact lenses, including cleaning, rinsing, storing, disinfecting, lubricating, etc., including a self-contained contact lens holder to support and contain one or more contact lenses. A fluid conduit is associated with the contact lens holder to provide a pathway for fluid to the chamber or chambers holding each contact lens. A fluid container holding a fluid used in contact lens care can be put in fluid communication with the fluid conduit and is operable to selectively introduce fluid into the fluid conduit and fill the contact lens holder with the fluid. The contact lens holder, fluid contact, and fluid container may all be incorporated in a unitary body, or fluid container and/or the fluid conduit can be selectively attachable to the contact lens holder so that different fluid containers can be interchangeable to the contact lens holder.

Abstract: A method for packaging intraocular lenses, contact lenses and other small, delicate devices which must be stored in a liquid is described. The method utilizes a container having a conically-shaped compartment to package small, delicate devices (e.G., intraocular lenses) in a manner such that the devices may be easily located in the compartment and removed from the container.