Patents Represented by Attorney, Agent or Law Firm James M. Hunter, Jr.
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Patent number: 6908113Abstract: A tamper-evident label suitable for placement onto a container and cap assembly. The label may be characterized as a planar sheet having a tear strip that divides upper and lower panels. The lower panel of the label attaches to the container, while the upper panel, defined by at least one tab, and preferably two tabs, is attached to the cap. To open the container and cap assembly, the tear strip is pulled across the label to separate the two panels of the label. Thereafter, the cap may be removed from the container to reveal the contents of the container.Type: GrantFiled: August 15, 2002Date of Patent: June 21, 2005Assignee: Laboratories Merck Sharp and Dohme-Chibret, SNCInventors: Alain Chaduc, Olivier Naudan
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Patent number: 6769555Abstract: An apparatus for the organizing, storage, display and removing clothing accessories and the like, wherein the apparatus may be, optionally, hanged in a clothing closet or placed on a stand for easy access thereto. The apparatus may be characterized as a multi-layer, laminated structure comprising outer, rigid layers on either side of an inner, pliable layer. Apertures in the outer layers cooperate with slits in the inner layer to form garment holding channels suitable for placing clothing accessories. Clothing accessories such as ties, scarves, belts, and the like may be placed on the apparatus.Type: GrantFiled: February 1, 2002Date of Patent: August 3, 2004Inventor: Yvonne M. Brady
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Patent number: 6736783Abstract: An apparatus and process for automatically, repetitively sampling blood from conscious animals. The apparatus can simultaneously extract blood from a number of conscious, catherized animals at programmable time intervals. The apparatus is characterized as a system of computer controlled valves and pumps connected by tubing filled with saline solution to a catherized animal. Blood samples are collected via a cannula from the animal and placed in a fraction collector for analyses.Type: GrantFiled: March 14, 2001Date of Patent: May 18, 2004Assignee: Merck & Co., Inc.Inventors: Kevin R. Blake, Kang Cheng, Glenn A. Clarke, Gary S. Kath, Gregory W. King, Tsuei-Ju Wu
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Patent number: 6699850Abstract: The present invention relates to oral compositions and methods for inhibiting bone resoprtion in a mammal while counteracting the occurrence of potentially adverse gastrointestinal effects. The compositions useful herein comprise the combination of a pharmaceutically effective amount of a nitrogen-containing bisphosphonate or a pharmaceutically-acceptable salt thereof and a pharmaceutically effective amount of an isoprenoid compound.Type: GrantFiled: December 21, 2001Date of Patent: March 2, 2004Assignee: Merck & Co., Inc.Inventors: Alfred A. Reszka, Edward S. Scolnick
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Patent number: 6638347Abstract: A carbon-based, adsorption powder containing an effective amount of cupric chloride suitable for removing mercury from a high temperature, high moisture gas stream, wherein the effective amount of cupric chloride ranges from about 1 to about 45 wt percent. Additional additives, such as potassium permanganate, calcium hydroxide, potassium iodide and sulfur, may be added to the powder to enhance the removal of mercury from the gas stream.Type: GrantFiled: July 10, 2001Date of Patent: October 28, 2003Assignee: Merck & Co., Inc.Inventors: Youssef El-Shoubary, Rudy Maes, Subash C. Seth
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Patent number: 6623755Abstract: The present invention relates to novel pharmaceutical tablets useful for administering pharmaceutical active ingredients, such as bisphosphonates. These tablets have improved surface properties which can aid esophageal transit, thereby reducing the potential for adverse gesture intestinal effects. The present invention also relates to processes for making said novel pharmaceutical tablets.Type: GrantFiled: March 15, 2002Date of Patent: September 23, 2003Assignee: Merck & Co., Inc.Inventors: Tzyy-Show H. Chen, Thomas G. Nyairo, Ashok V. Katdare
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Patent number: 6610822Abstract: There is disclosed a process for purifying a natural product using a two-phase, multi-solvent system followed by vacuum concentration and back extraction. The method allows for the removal of impurities by controlling the polarity balance of a two-phase system by manipulating the proportions of the four solvents and subsequently the relative distribution of the product versus the impurities.Type: GrantFiled: August 1, 2001Date of Patent: August 26, 2003Assignee: Merck & Co., Inc.Inventors: Martin A. Chandler, Kent E. Goklen, Steven S. Lee, David J. Roush
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Patent number: 6589318Abstract: An adsorption powder for removing mercury and other metals, dioxins, furans and other organic compounds from metal- and organic compound-comtaminated soil and method therefor. The adsorption powder may be characterized as containing from about 1 to 97% of carbon, from about 1 to 97% of calcium hydroxide, from about 1 to 97% of cupric chloride, and from about 1 to 60% of KI3 impregnated carbon.Type: GrantFiled: September 29, 1999Date of Patent: July 8, 2003Assignee: Merck & Co., Inc.Inventors: Youssef El-Shoubary, Rudy Maes, Subash C. Seth
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Patent number: 6586457Abstract: The present invention relates to methods for inhibiting bone resorption in a mammal comprising administering to a mammal in need thereof a therapeutically effective amount of an EP4 receptor subtype antagonist.Type: GrantFiled: March 26, 2001Date of Patent: July 1, 2003Assignees: Merck & Co., Inc., Merck Frosst Canada & Co.Inventors: Shun-Ichi Harada, Mohamed MacHwate, Gideon A. Rodan, Marc Labelle, Kathleen Metters, Robert N. Young
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Patent number: 6582497Abstract: There is disclosed an adsorption powder effective for capturing mercury from a high temperature, high moisture gas stream comprising: about 1-97% carbon; about 1-97% of alkaline material; about 1-97% cupric chloride impregnated carbon, and about 1-60% carbon impregnated with KI3. Additionally, a method of removing mercury from high temperature, high moisture gas streams, using the adsorption powder of the invention, is disclosed.Type: GrantFiled: June 9, 2000Date of Patent: June 24, 2003Assignee: Merck & Co., Inc.Inventors: Rudy J. Maes, Youssef El-Shoubary, Subash Seth
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Patent number: 6579894Abstract: Transfer ribonucleic acid (tRNA) synthetase inhibitors, salts, and pharmaceutically acceptable compositions thereof of the general formula: wherein Ar is aryl and heteroaryl; L is —C(O)N(Q)CH2—, or —CR10R11OCR12R13—; Q is hydrido, —(CH2)mCO2H and —(CH2)mCO2CH3, m is 1, 2, 3, and 4; R1, R2, R9, R10, R11, R12 and R13 are hydrido or lower alkyl; wherein Het is a heterocyclic moiety, the inhibitors are suitable for use as antimicrobial agents.Type: GrantFiled: June 17, 2002Date of Patent: June 17, 2003Assignees: Merck & Co., Inc., Cubist Pharmaceuticals, Inc.Inventors: Milton L. Hammond, Aaron H. Leeman, Milana Maletic, Gina M. Santorelli, Sherman T. Waddell, John Finn, Michael Morytko, Siya Ram, Dennis Keith
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Patent number: 6575181Abstract: A probe wash vessel characterized as having a cylindrical-shaped, outer test tube with at least two vertically aligned faucets, and an inner cannula positioned within the test tube, wherein the inner cannula is characterized by a top funnel opening attached to a stem, the stem characterized as having two arm extensions are attached to the two faucets, wherein washing fluid influent and effluent through the arm extensions washes a probe inserted through the top funnel into the stem.Type: GrantFiled: October 24, 2000Date of Patent: June 10, 2003Assignee: Merck & Co., Inc.Inventor: Gregory A. Wimmer
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Patent number: 6558642Abstract: A method and adsorption powder useful for the removal of mercury and other metals, as well as furans, dioxins and other organic compounds from high temperature and high moisture gaseous streams. The method utilizes an adsorption powder characterized as containing a carbon-based powder and an effective amount of cupric chloride suitable to remove metals and organic compounds. The powder may contain calcium hydroxide, sulfur, potassium permanganate, potassium iodide, and combinations thereof.Type: GrantFiled: March 29, 2001Date of Patent: May 6, 2003Assignee: Merck & Co., Inc.Inventors: Youssef El-Shoubary, Rudy Maes
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Patent number: 6545015Abstract: Compounds, pharmaceutically acceptable salts, and compositions thereof of the general formula: wherein Ar is aryl and heteroaryl; R1, R2, R3, and R4 are hydrido, alkyl, cyano, heteroaryl, hydroxy, amino, acylamino, halo, alkoxy, aryloxy, carboxyamido, alkenyl, cycloalkyl, heterocyclyl, acyl, acyloxy, carboalkoxy, carboxy, thio, sulfinyl, sulfonyl and sulfoxy, R5, R6, R7, and R8 are hydrido and lower alkyl; and Het is a nitrogen-containing heterocyclic ring.Type: GrantFiled: August 22, 2001Date of Patent: April 8, 2003Assignee: Merck & Co., Inc.Inventors: Milton L. Hammond, Aaron H. Leeman, Milana Maletic, Gina M. Santorelli, Sherman T. Waddell, John Finn, Michael Morytko, Jason Hill, Dennis Keith
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Patent number: 6544213Abstract: The present invention is directed to a dual compartment, mixing and dispensing device suitable for the containment of two separate pharmaceutical components that mixable, upon breaking of a seal that separates the compartments, to provide an instantly mixed dose of medication. The medication can be administered to a patient through an aperture located at one end of the device. The device is characterized as two compartments connected by a flexible, sealed orifice, wherein the two components are separated. Flexing of the device at the orifice breaks the seal and allows mixing of the components to prepare the dose. Thereafter, an end-portion of the device can be opened for oral administration of the dose.Type: GrantFiled: September 11, 2000Date of Patent: April 8, 2003Assignee: Merck & Co., Inc.Inventor: Arthur L. Lifshey
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Patent number: 6536609Abstract: A device suitable for dispensing a plurality of like articles therefrom, the device characterized as having a plurality of columns for storing and dispensing the articles, each column having a front opening for dispensing the articles and a bottom side for holding the articles, each column having resilient spring means for biasing the articles towards the front opening of the column, the improvement being a tilt ramp attached to the front opening, wherein the ramp is at a decreased angle.Type: GrantFiled: July 26, 2001Date of Patent: March 25, 2003Assignee: Merck & Co., Inc.Inventor: Thomas K. Lake
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Patent number: 6533842Abstract: There is disclosed an adsorption powder effective for capturing mercury from a high temperature, high moisture gas stream comprising: about 1-97% carbon; about 1-97% calcium hydroxide; about 1-97% cupric chloride impregnated carbon, and about 1-60% carbon impregnated with KI3. Additionally, a method of removing mercury from high temperature, high moisture gas streams is disclosed.Type: GrantFiled: February 24, 2000Date of Patent: March 18, 2003Assignee: Merck & Co., Inc.Inventors: Rudy J. Maes, Youssef El-Shoubary, Subash Seth
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Patent number: 6524371Abstract: A process for removing mercury and organic compounds from gaseous stream using an adsorption powder, characterized as containing a carbon-based powder and an effective amount of cupric chloride, the process characterized by the steps of: a) placing a solid phase mercury-containing contaminated soil into a rotary kiln/drum; b) heating the kiln/drum to form gaseous and solid components of the soil; c) transferring the gaseous component to an exhaust cleaning unit/afterburner, and transferring the soil component to a cooling unit; d) heating the gaseous component in the exhaust cleaning unit/afterburner; e) cooling the gaseous component; f) adding the adsorption powder to the gaseous component; g) transferring the powder-containing, gaseous component to a baghouse; and h) releasing the substantially mercury-free gaseous component to the atmosphere.Type: GrantFiled: July 10, 2001Date of Patent: February 25, 2003Assignee: Merck & Co., Inc.Inventors: Youssef El-Shoubary, Rudy Maes, Subash C. Seth
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Patent number: 6499584Abstract: There is disclosed an apparatus and method for evenly dispersing the contents of powder filled bulk bags, in order to create a flat, even, horizontal bulk bag surface for efficient attachment to the suction head of a vacuum lift.Type: GrantFiled: October 16, 2000Date of Patent: December 31, 2002Assignee: Merck & Co., Inc.Inventors: Wendy M. Keim, John E. DelGigante
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Patent number: D480958Type: GrantFiled: July 29, 2002Date of Patent: October 21, 2003Inventors: Sidney Mazel, James Marshall Mundt