Patents Represented by Attorney, Agent or Law Firm James M. Hunter, Jr.
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Patent number: 6461345Abstract: There is disclosed a pinch valve for allowing access to a sterile reaction vessel using a cannula. The valve remains closed until a cannula is inserted. Upon removal of the cannula, the valve automatically closes maintaining the sterile or otherwise controlled conditions of the reaction vessel.Type: GrantFiled: November 9, 1999Date of Patent: October 8, 2002Assignee: Merck & Co., Inc.Inventor: Gary S. Kath
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Patent number: 6449827Abstract: An apparatus suitable for securely gripping and holding a microplate or other containers during robotic de-lidding operations. A microplate placed on the apparatus is held by a vacuum drawn through the base thereof, allowing the lid of the microplate to be removed without movement of the plate. Afterwards, the vacuum can be discontinued and the plate removed from the apparatus.Type: GrantFiled: October 10, 2000Date of Patent: September 17, 2002Assignee: Merck & Co., IncInventors: Glenn A. Clarke, Marc N. Feiglin, Gary S. Kath, Gregory W. King
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Patent number: 6417217Abstract: Transfer ribonucleic acid (tRNA) synthetase inhibitors, salts, and pharmaceutically acceptable compositions thereof of the general formula: wherein Ar is aryl and heteroaryl; L is —C(O)N(Q)CH2—, or —CR10R11OCR12R13—; Q is hydrido, —(CH2)mCO2H and —(CH2)mCO2CH3, m is 1, 2, 3, and 4; R1, R2, R9, R10, R11, R12 and R13 are hydrido or lower alkyl; wherein Het is a heterocyclic moiety, the inhibitors are suitable for use as antimicrobial agents.Type: GrantFiled: August 22, 2001Date of Patent: July 9, 2002Assignees: Merck & Co., Inc., Cubist Pharmaceuticals, Inc.Inventors: Milton L. Hammond, Aaron H. Leeman, Milana Maletic, Gina M. Santorelli, Sherman T. Waddell, John Finn, Michael Morytko, Siya Ram, Dennis Keith
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Patent number: 6348482Abstract: Compounds, pharmaceutically acceptable salts, and compositions thereof of the general formula: wherein Ar is aryl and heteroaryl; R1, R2, R3, and R4 are hydrido, alkyl, cyano, heteroaryl, hydroxy, amino, acylamino, halo, alkoxy, aryloxy, carboxyamido, alkenyl, cycloalkyl, heterocyclyl, acyl, acyloxy, carboalkoxy, carboxy, thio, sulfinyl, sulfonyl and sulfoxy, R5, R6, R7, and R8 are hydrido and lower alkyl; and Het is a nitrogen-containing heterocyclic ring.Type: GrantFiled: May 5, 2000Date of Patent: February 19, 2002Assignees: Merck & Co., Inc., Cubist Pharmaceuticals, Inc.Inventors: Milton L. Hammond, Aaron H. Leeman, Milana Maletic, Gina M. Santorelli, Sherman T. Waddell, John Finn, Michael Morytko, Jason Hill, Dennis Keith
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Patent number: 6333344Abstract: Transfer ribonucleic acid (tRNA) synthetase inhibitors, salts, and pharmaceutically acceptable compositions thereof of the general formula: wherein Ar is aryl and heteroaryl; L is —C(O)N(Q)CH2—, or —CR10R11OCR12R13—; Q is hydrido, —(CH2)mCO2H and —(CH2)mCO2CH3, m is 1, 2, 3, and 4; R1, R2, R9, R10, R11, R12 and R13 are hydrido or lower alkyl; wherein Het is a heterocyclic moiety, the inhibitors are suitable for use as antimicrobial agents.Type: GrantFiled: May 5, 2000Date of Patent: December 25, 2001Assignees: Merck & Co., Cubist Pharmaceuticals, Inc.Inventors: Milton L. Hammond, Aaron H. Leeman, Milana Maletic, Gina M. Santorelli, Sherman T. Waddell, John Finn, Michael Morytko, Siya Ram, Dennis Keith
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Patent number: 6293699Abstract: There is disclosed a method for continuously monitoring temperature at multiple locations within a controlled temperature unit (CTU) using RTDs that can be removed and reinserted. The key to the method is the collection of data using an RTD fixed in a phenolic thermowell, which in turn is inserted through a polytetrafluoroethylene-coated sleeve in the wall of the CTU. The temperature information is transmitted from a data module to an interfaced computer system where it may be presented to the operator in a graphical, tabular or text format or stored in memory. The temperature probes are easily removable so as to facilitate calibration without disruption of the contents of the CTU and can be consistently replaced in the same location within the CTU.Type: GrantFiled: October 26, 1999Date of Patent: September 25, 2001Assignee: Merck & Co., Inc.Inventors: Fred J. Bailey, Mark Pinder, Carl W. Holz
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Patent number: 6244023Abstract: This system comprises a compacted bag, in particular under vacuum, having an appendage into which a spacer device is inserted (2) which forms a pocket (140) separating two facing flexible partition sections from each other (120,121) of which one (121) is adapted to be applied when placed under vacuum against a set of heatable blades with closed outline linked to each other (51, 61) the interior blade (61) being carried by a mobile part (6) of which the end is able to penetrate into the cut pocket (140) with a view to the inflation of the bag with air brought by a channel (600′) through a sterilizing filter (8).Type: GrantFiled: November 8, 1999Date of Patent: June 12, 2001Assignee: Laboratoires Merck Sharp & Dohme-Chibret SNCInventor: Gilbert Lataix
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Patent number: 6220450Abstract: A device to separate rubber stoppers that have adhered together, typically as a result of sterilization. The device contains a hopper, a pair of rollers and a mechanism to turn the rollers. The rollers are hexagonal-shaped and each face has a scalloped concavity. The adhering stoppers are gravity-fed into the rollers from the hopper, where they are compressed and a shearing force is applied to separate the adherent stoppers. The separated stoppers are then collected for further processing.Type: GrantFiled: July 21, 1999Date of Patent: April 24, 2001Assignee: Merck & Co., Inc.Inventors: Kristian N. Weeder, Gordon D. Deacon
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Patent number: 6201158Abstract: The present invention relates to a process for making propargylic alcohols by zinc-mediated catalytic, asymmetric addition of acetylenes to aldehydes.Type: GrantFiled: May 27, 1999Date of Patent: March 13, 2001Assignee: Merck & Co., Inc.Inventors: Zhen Li, Ann Decamp, Veena Upadhyay
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Patent number: 6162911Abstract: Novel crystalline carbapenem intermediate compounds of formula I: ##STR1## wherein: R.sub.1 represents CH.sub.3 or H and an efficient process for synthesis thereof are described.Type: GrantFiled: August 13, 1998Date of Patent: December 19, 2000Assignee: Merck & Co., Inc.Inventors: Richard G. Ball, Nancy N. Tsou, James A. Mc Cauley, Chunhua Yang, Nobuyoshi Yasuda
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Patent number: 6143885Abstract: The instant invention relates to a compound of the formula: ##STR1## wherein R.sub.a and P are: (a) hydrogen,(b) methyl, or(c) a hydroxy protecting groupand an efficient process for its synthesis characterized by combining a ketoester with an acid and a catalyst at a temperature of from about 0.degree. to about 50.degree. C. and from about 0 to 500 psig to produce the above compound.Type: GrantFiled: July 28, 1998Date of Patent: November 7, 2000Assignee: Merck & Co., Inc.Inventors: Woo-Baeg Choi, Jaemoon Lee, Joseph E. Lynch, Paul J. Reider, Ralph P. Volante
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Patent number: 6140318Abstract: Compounds of formula I are disclosed. ##STR1## as well as pharmaceutically acceptable salts thereof. The naphthosultam is substituted with various substituent groups including at least one cationic group -A-Q-L-B.The carbapenems of the invention are effective against susceptible bacterial organisms, including methicillin resistant Staphylococcus aureus (MRSA), methicillin resistant Staphylococcus epidermidis (MRSE), and methicillin resistant coagulase negative Staphylococci (MRCNS).Type: GrantFiled: October 8, 1998Date of Patent: October 31, 2000Assignee: Merck & Co., Inc.Inventors: Lovji D. Cama, Robert R. Wilkening, Ronald W. Ratcliffe, Kenneth J. Wildonger, Wanying Sun
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Patent number: 6080854Abstract: A process of synthesizing a compound of formula I is described: ##STR1## wherein P and P' independently represent H or a protecting group, R.sub.1 represents H or C.sub.1-4 alkyl, and Hal represents a halogen characterized by reacting a compound of formula 2: ##STR2## with R.sub.2 OH, wherein R.sub.2 is C.sub.1-4 alkyl, C.sub.6-10 aryl or C.sub.5-10 heteroaryl in the presence of an acid catalyst or carbodiimide reagent to produce a compound of formula 3: ##STR3## and reacting a compound of formula 3 in the presence of a base and a haloalkylating agent to produce a compound of formula 1.Type: GrantFiled: July 27, 1998Date of Patent: June 27, 2000Assignee: Merck & Co., Inc.Inventors: John Y. Chung, Nobuyoshi Yasuda, Johnnie L. Leazer, Jr.
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Patent number: 6068031Abstract: A sterile transfer system between a bag and a enclosure suitable for use in the pharmaceutical industry, characterized on the one hand of a first part of a bag having a mouth in the form of a pocket, in which the bottom is constituted by a flexible partition separating the interior spaces of the pocket and the bag and capable of being heat-cut, on the other hand a lock chamber installed at the entrance to the sterile enclosure which includes a fixed part on which the pocket can be mounted, this part presenting a central opening receiving a mobile element constituting the door of the lock chamber, the fixed and mobile parts each being equipped with a heatable blade with closed outline overlapping and joined at their apex in airtight manner when the bag is in the closed state, vacuum outlets being provided for applying the flexible partition by means of suction against the heatable blades and effecting the cutting of it by fusion of the zones which come into contact with the blades.Type: GrantFiled: May 21, 1998Date of Patent: May 30, 2000Assignee: Laboratoires MSD- ChibretInventors: Gilbert Lataix, Charles Wicky
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Patent number: 6030996Abstract: The present invention addresses compounds which inhibit Mur D. The compounds are represented by structural formula 1: ##STR1## wherein: X represents OH, OC.sub.1-6 alkyl, O-aryl, O-Har, uridinyl, 5-iodouridinyl or O--Y.sup.+, wherein Y.sup.+ represents a charge balancing group; R.sup.1 and R.sup.2 independently represent H or C.sub.1-6 alkyl, or R.sup.1 and R.sup.2 taken together represent C.sub.1-6 alkylene unsubstituted or substituted with from 1-2 aryl or Har groups; W represents H, aryl, C.sub.1-6 alkyl or a charge balancing group; each M independently represents a member selected from the group consisting of: H, a charge balancing group and a protecting group.Salts and hydrates thereof are included.Also included are pharmaceutical compositions and methods of treatment.Type: GrantFiled: March 11, 1998Date of Patent: February 29, 2000Assignee: Merch & Co., Inc.Inventor: Laura D. Gegnas
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Patent number: 5994345Abstract: Carbapenems substituted with a naphthosultam at position 2 and linked through a CH.sub.2 group are disclosed. Pharmaceutical compositions and methods of treatment are also included. The naphthosultam is substituted with at least one cationic group --A--Q--L--B. ##STR1## A--Q--L--B represents a side chain wherein in part: A is a C.sub.1-6 alkylene group, straight or branched, and optionally interrupted or terminated by 1-2 of --O--, --S--, NR.sup.a --, --C(O)-- and CH.dbd.CH--Q is ##STR2## L represents a C.sub.1-8 alkylene group, straight or branched, and unsubstituted or substituted with 1-3 R.sup.c groups andB represents ##STR3## The carbapenems of the present invention are useful against gram positive microorganisms, especially methicillin resistant Staphylococci.Type: GrantFiled: October 8, 1998Date of Patent: November 30, 1999Assignee: Merck & Co., Inc.Inventors: Lovji D. Cama, Robert R. Wilkening, Ronald W. Ratcliffe, Kenneth J. Wildonger, Wanying Sun
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Patent number: 5994343Abstract: The present invention relates to carbapenem antibacterial agents in which the carbapenem nucleus is substituted at the 2-position with a naphthosultam linked through a --Z--CH.sub.2 group. The naphthosultam is further substituted with various substituent groups including cationic groups. The compounds are represented by formula I: ##STR1## Pharmaceutical compositions and methods of use are also included.Type: GrantFiled: September 10, 1998Date of Patent: November 30, 1999Assignee: Merck & Co., Inc.Inventors: Frank P. Dininno, Kevin D. Dykstra
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Patent number: 5973142Abstract: A process of synthesizing a compound of formula 1: ##STR1## wherein P and P' each independently represent H or a protecting group, R.sup.1 represents H or C.sub.1-4 alkyl, andHal represents a halogen selected from Cl, Br and I, comprising: reacting a compound of formula 2: ##STR2## wherein P, P' and R.sub.1 are as defined above with an N,O-di-C.sub.1-4 alkyl hydroxylamine in the presence of a carbodiimide to produce a compound of formula 3: ##STR3## reacting compound 3 with a compound of formula 4:MetCH.sub.2 SiR.sub.2 R.sub.3 R.sub.4 4wherein Met represents lithium or halomagnesium;R.sub.2, R.sub.3 and R.sub.4 are C.sub.1-4 alkyl or C.sub.1-4 alkoxy, and the halo portion of halomagnesium is Cl, Br or I, to produce a compound of formula 5: ##STR4## and reacting compound 5 with a halogenating agent to produce a compound of formula 1.Type: GrantFiled: January 9, 1998Date of Patent: October 26, 1999Inventors: Nobuyoshi Yasuda, Chunhua Yang
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Patent number: 5952323Abstract: A pharmaceutical composition is disclosed which contains a compound of formula I: ##STR1## or a pharmaceutically acceptable salt, prodrug or hydrate thereof, in the stabilized form and/or in combination with a carbon dioxide source.Type: GrantFiled: April 22, 1998Date of Patent: September 14, 1999Assignee: Merck & Co., Inc.Inventors: Jeffrey A. Zimmerman, John M. Williams, Paul A. Bergquist, Lisa M. DiMichele, David C. DuBost, Michael J. Kaufman, Daniel R. Sidler, William A. Hunke
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Patent number: 5886066Abstract: A low wear polymeric composition exhibiting improved surface wear resistance and coefficients of friction characterized as a melt blend of a thermoplastic polymer and a lubricating system containing PTFE, pentaerythritol tetrastearate and fine particle, stearate coated calcium carbonate, a hindered amine, N,N'-ethylene bis-stearamide, and calcium ricinoleate. The composition is suitable for the preparation of shaped articles for use in fricitional environments.Type: GrantFiled: July 17, 1997Date of Patent: March 23, 1999Assignee: Hoechst Celanese CorporationInventor: Alex Forschirm