Abstract: Deuterated halo ethers useful as anesthetics and having lower toxicity than undeuterated analogues further including compositions, and methods of use.

Abstract: Deuterated analogues of methoxyflurane and a method of their use as an anesthetic.

Abstract: Novel 1,3,4-benzotriazepine-2-thiones and related tricyclic derivatives having central nervous system activity and a method of use for treating the symptoms of central nervous system depression and anxiety.

Abstract: Methods and pharmaceutical compositions using substituted phenyl hydrazo compounds for the treatment of depression and/or anxiety in a mammal.

Abstract: Novel antithrombotic 2-(aminoalkylthio)-N,N'-p-phenylenebissulfonamides, a method for inhibiting blood platelet aggregation, and pharmaceutical compositions.

Abstract: A method for preparing thiazolorifamycin derivatives from rifamycin S and a cysteine ester to produce an intermediate product which is cyclized to thiazolorifamycin and the novel products formed therefrom.

Abstract: Novel triazolo- or imidazo-benzotriazepines are prepared from 1,3,4-benzotriazepine-2-thiones which in turn are prepared from a 2-aminobenzophenone.

Abstract: New 2,4,6-trisubstituted-2,3-dihydro-benzofuran derivatives of the following general formula ##STR1## wherein R is selected from hydrogen or methyl; one of R.sub.1 and R.sub.2 represents hydroxy, (C.sub.1-4)alkoxy or (C.sub.2-4)alkanoyloxy, and the other one is selected from cyano, carboxy, carbo(C.sub.1-4)alkoxy, carbamoyl and a --NR.sub.3 R.sub.4 group, wherein R.sub.3 and R.sub.4 independently represent hydrogen (C.sub.1-4)alkyl, (C.sub.2-4)alkanoyl, carbo(C.sub.1-4)alkoxy, carbobenzyloxy, carbamoyl, mono- and di-(C.sub.1-4)alkylamino-(C.sub.1-4)alkyl, benzenesulfonyl, toluenesulfonyl, (C.sub.1-4)alkylsulfonyl or phenacylsulfonyl; and salts therewith of pharmaceutically acceptable acids. The compounds have antinflammatory, analgesic and antipyretic utility.

Abstract: A method for treating hyperglycemia in a mammal which comprises administering internally to said mammal a hyperglycemic amount of an arylamino benzoic acid or pharmaceutcially-acceptable salt thereof, wherein aryl represents phenyl, substituted phenyl, thienyl or substituted thienyl.

Abstract: A method for inhibiting blood platelet aggregation in a mammal by administering internally to the mammal an effective amount of a phenylthio(sulfinyl or sulfonyl)alkylamine compound or a pharmaceutically-acceptable salt thereof.

Abstract: Novel aminoalkyl purine and pyrazolopyrimidine compounds useful in the inhibition of blood platelet aggregation in animals.

Abstract: A method for inhibiting blood platelet aggregation in a mammal by administering internally to the mammal an effective amount of a phenylthio(sulfinyl or sulfonyl)alkylamine compound or a pharmaceutically-acceptable salt thereof.

Abstract: This invention relates to compositions of 4-(((1,3-benzodioxol-5-yl)methyl)amino)benzoic acid the corresponding pharmaceutically-acceptable salts and the esters thereof. The invention also relates to methods for reducing plasma lipid levels in mammals using the compounds and compositions.

Abstract: Deuterated methylene chloride is used to replace methylene chloride in a solvent system to reduce the overall toxicity of the composition.

Abstract: Novel 4-desoxy-thiazolo[5,4-c]rifamycin SV derivatives having antibacterial activity and a method of preparing same by the reaction of rifamycin S with a cysteine derivative followed by the oxidation of the resulting product.

Abstract: A two-step process for preparing quinazolinethiones by reacting a 2-aminobenzophenone with thiophosgene to give a 2-benzoylisothiocyanate and treating this compound with a predetermined primary amine. A series of substituted quinazolinethiones which display antidepressant and antianxiety properties also are disclosed.

Abstract: This invention concerns novel aminoalkylthiopyridazine compounds useful for inhibiting the aggregation of blood platelets in animals and a process for preparing the compounds from an isothiuronium salt generated in situ from an aminoalkyl halide and thiourea. The compounds also have fungicidal and nematocidal properties.

Abstract: Methods and pharmaceutical compositions using substituted phenyl hydrazo compounds for the treatment of depression and/or anxiety in a mammal.

Abstract: Dermatitis caused by exposure of the skin to a plant of the genus Rhus is treated and controlled by the topical application of an effective amount of a polyamine or polytertiaryamide.

Abstract: The subject compound is prepared by an activated manganese dioxide oxidation of N,15-didehydro-15-deoxo-3,15-epi(methano(imino)rifamycin SV. The new compound has antimicrobial utility.