Patents Represented by Attorney James W. Ambrosius

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  • Substituted N-(2-hydroxyethyl)morpholino carboxamides
    Patent number: 4107436
    Abstract: Novel N-(2-hydroxyethyl)cycloalkylaminocarboxamides are described. The compounds are pharmacodynamically active and serve as intermediates for the preparation of corresponding 2-amino-2-oxazolines which are active pharmacodynamically.
    Type: Grant
    Filed: May 27, 1977
    Date of Patent: August 15, 1978
    Assignee: The Dow Chemical Company
    Inventors: Shyam Sunder, Norton P. Peet
  • Hypolipidemic cycloalkylaminobenzoic acids
    Patent number: 4105791
    Abstract: The present invention relates to novel monocyclic and polycyclic p-cycloalkylaminobenzoic acids, the corresponding pharmaceutically-acceptable salts and the esters thereof. This invention also relates to methods for reducing plasma lipid levels, especially cholesterol and triglyceride levels, using the compounds of the present invention.
    Type: Grant
    Filed: March 22, 1976
    Date of Patent: August 8, 1978
    Assignee: The Dow Chemical Company
    Inventors: Eugene R. Wagner, Donald P. Matthews
  • Amino substituted arylthio-alkanoic acids having hypolipidemic activity
    Patent number: 4103029
    Abstract: This invention relates to novel compounds and compositions of amino substituted arylthio-alkanoic acid, the corresponding pharmaceutically-acceptable salts and the esters thereof. The invention also relates to methods for reducing plasma lipid levels in animals using the compounds of the present invention.
    Type: Grant
    Filed: August 10, 1977
    Date of Patent: July 25, 1978
    Assignee: The Dow Chemical Company
    Inventors: Eugene R. Wagner, Bobbie J. Allen
  • Amino substituted arylthio-alkanoic acids having hypolipidemic activity
    Patent number: 4103027
    Abstract: This invention relates to novel compounds and compositions of amino substituted arylthio-alkanoic acid, the corresponding pharmaceutically-acceptable salts and the esters thereof. The invention also relates to methods for reducing plasma lipid levels in animals using the compounds of the present invention.
    Type: Grant
    Filed: August 12, 1977
    Date of Patent: July 25, 1978
    Assignee: The Dow Chemical Company
    Inventors: Eugene R. Wagner, Bobbie J. Allen
  • Antibiotic substance from Actinoplanes sarveparensis CBS 305.76 (antibiotic L 13365)
    Patent number: 4100273
    Abstract: A new antibiotic prepared from aerobic cultivation of Actinoplanes sarveparensis and a method for producing the same from a culture medium.
    Type: Grant
    Filed: May 31, 1977
    Date of Patent: July 11, 1978
    Assignee: The Dow Chemical Company
    Inventors: Hermes Pagani, Francesco Parenti, Carolina Coronelli, Giorgio Tamoni
  • Antithrombotic 2-(aminoalkylthio)-N,N'-p-phenylenebissulfonamides
    Patent number: 4098889
    Abstract: Novel antithrombotic 2-(aminoalkylthio)-N,N'-p-phenylenebissulfonamides, a method for inhibiting blood platelet aggregation, and pharmaceutical compositions.
    Type: Grant
    Filed: September 1, 1977
    Date of Patent: July 4, 1978
    Assignee: The Dow Chemical Company
    Inventor: Joseph E. Dunbar
  • 1,3,4-Benzotriazepine-2-thiones
    Patent number: 4094871
    Abstract: Novel 1,3,4-benzotriazepine-2-thiones and related tricyclic derivatives having central nervous system activity and a method of use for treating the symptoms of central nervous system depression and anxiety.
    Type: Grant
    Filed: February 16, 1977
    Date of Patent: June 13, 1978
    Assignee: The Dow Chemical Company
    Inventors: Donald L. Trepanier, Thomas C. Britton
  • 4-Hydroxy-3,4-dihydro-2(1H)-quinazolinethiones
    Patent number: 4093805
    Abstract: A two-step process for preparing quinazolinethiones by reacting a 2-aminobenzophenone with thiophosgene to give a 2-benzoylisothiocyanate and treating this compound with a predetermined primary amine. A series of substituted quinazolinethiones which display antidepressant and antianxiety properties also are disclosed.
    Type: Grant
    Filed: February 17, 1977
    Date of Patent: June 6, 1978
    Assignee: The Dow Chemical Company
    Inventors: Thomas C. Britton, Donald L. Trepanier
  • Morpholinoalkylthiopyridazine compounds
    Patent number: 4087605
    Abstract: This invention concerns novel aminoalkylthiopyridazine compounds useful for inhibiting the aggregation of blood platelets in animals and a process for preparing the compounds from an isothiuronium salt generated in situ from an aminoalkyl halide and thiourea. The compounds also have fungicidal and nematocidal properties.
    Type: Grant
    Filed: July 22, 1977
    Date of Patent: May 2, 1978
    Assignee: The Dow Chemical Company
    Inventors: Joseph E. Dunbar, Louis E. Begin
  • Decarboxylation of endogenous serum glutamate in transaminase assays
    Patent number: 4086142
    Abstract: A spectrophotometric method for carrying out transaminase determinations of biological fluids wherein endogenous glutamate in a biological fluid is decarboxylated prior to transaminase determinations with bacterial glutamic acid decarboxylase.
    Type: Grant
    Filed: December 6, 1976
    Date of Patent: April 25, 1978
    Assignee: The Dow Chemical Company
    Inventors: Charles Y. Huang, William S. Stavropoulos
  • Antidepressant phenylazoimidazoles
    Patent number: 4079130
    Abstract: A method for treating Central Nervous System depression and anxiety in a mammal by administering internally to the mammal an effective psychoactive amount of a phenylazoimidazole compound.
    Type: Grant
    Filed: May 6, 1977
    Date of Patent: March 14, 1978
    Assignee: The Dow Chemical Company
    Inventors: Abdulmuniem H. Abdallah, Philip J. Shea
  • Novel hypolipidemic 2-(3,5-di-tert-butyl-4-hydroxyphenyl)thio carboxamides
    Patent number: 4078084
    Abstract: Novel 2-((3,5-di-tert-butyl-4-hydroxyphenyl)thio)carboxamides and compositions containing the compounds are disclosed. A method for reducing blood serum lipids using the compounds and compositions of the invention is also disclosed.
    Type: Grant
    Filed: March 4, 1977
    Date of Patent: March 7, 1978
    Assignee: The Dow Chemical Company
    Inventors: Eugene R. Wagner, Larry G. Mueller
  • Hypolipidemic 2-(3,5-di-tert-butyl-4-hydroxyphenyl)thio carboxamides
    Patent number: 4076841
    Abstract: Novel 2-((3,5-di-tert-butyl-4-hydroxyphenyl)-thio)carboxamides and compositions containing the compounds are disclosed. A method for reducing blood serum lipids using the compounds and compositions of the invention is also disclosed.
    Type: Grant
    Filed: March 4, 1977
    Date of Patent: February 28, 1978
    Assignee: The Dow Chemical Company
    Inventors: Eugene R. Wagner, Larry G. Mueller
  • Antithrombotic 1,3,4-thiadiazole
    Patent number: 4074049
    Abstract: A series of 1,3,4-thiadiazoles substituted in the 2,5-position with amino, dialkylaminoalkylthio, or heterocyclicalkylthio are useful as antithrombotic agents.
    Type: Grant
    Filed: November 19, 1976
    Date of Patent: February 14, 1978
    Assignee: The Dow Chemical Company
    Inventors: Louis E. Begin, Joseph E. Dunbar
  • Process for producing 3-substituted 1,2,4-triazines
    Patent number: 4071684
    Abstract: A process for producing 3-substituted 1,2,4-triazines comprising reacting a nitrile with a 2-aminoethylhydrazine in the presence of a catalytic amount of a transition metal salt or elemental sulfur.
    Type: Grant
    Filed: January 21, 1977
    Date of Patent: January 31, 1978
    Assignee: The Dow Chemical Company
    Inventors: Albert J. Schuster, Jr., John Martin
  • Compositions and methods for anesthetizing an animal using deuterated analogues of halothane and chloroform
    Patent number: 4069346
    Abstract: Deuterated analogues of halothane and chloroform are used to anesthetize an animal.
    Type: Grant
    Filed: February 14, 1977
    Date of Patent: January 17, 1978
    Assignee: The Dow Chemical Company
    Inventor: Leslie P. McCarty
  • 2-Cycloalkyl-amino-2-oxazolines
    Patent number: 4064348
    Abstract: Novel 2-cycloalkylamino-2-oxazolines and their salts are described which are biologically active. Member compounds exhibit useful activity as CNS-depressants, CNS-stimulants, platelet aggregation inhibitors, fungicides, and herbicides.
    Type: Grant
    Filed: November 10, 1976
    Date of Patent: December 20, 1977
    Assignee: The Dow Chemical Company
    Inventors: Norton P. Peet, Shyam Sunder
  • Amino substituted arylthio-alkanoic acids having hypolipidemic activity
    Patent number: 4062975
    Abstract: This invention relates to novel compounds and compositions of amino substituted arylthio-alkanoic acid, the corresponding pharmaceutically-acceptable salts and the esters thereof. The invention also relates to methods for reducing plasma lipid levels in animals using the compounds of the present invention.
    Type: Grant
    Filed: March 29, 1976
    Date of Patent: December 13, 1977
    Assignee: The Dow Chemical Company
    Inventors: Eugene R. Wagner, Bobbie J. Allen
  • Aminoalkylthiopyridazine compounds
    Patent number: 4058520
    Abstract: This invention concerns novel aminoalkylthiopyridazine compounds useful for inhibiting the aggregation of blood platelets in animals and a process for preparing the compounds from an isothiuronium salt generated in situ from an aminoalkyl halide and thiourea. The compounds also have fungicidal and nematocidal properties.
    Type: Grant
    Filed: May 7, 1976
    Date of Patent: November 15, 1977
    Assignee: The Dow Chemical Company
    Inventors: Joseph E. Dunbar, Louis E. Begin
  • Lipase composition for glycerol ester determination
    Patent number: 4056442
    Abstract: A synergistic composition of microbial lipases from Rhizopus arrhizirs and Candida cylindracea is used for the hydrolysis of glycerol esters such as triglycerides in the determination of glycerol esters present in an aqueous medium such as body fluid.
    Type: Grant
    Filed: June 1, 1976
    Date of Patent: November 1, 1977
    Assignee: The Dow Chemical Company
    Inventors: Charles Y. Huang, Alejo V. Roy