Patents Represented by Attorney Janice E. Williams
  • Patent number: 6414142
    Abstract: A new crystalline form of potassium clavulanate is disclosed. Also disclosed are a process for producing the new crystalline form of potassium clavulanate, pharmaceutical compositions containing it and methods of treating bacterial infections.
    Type: Grant
    Filed: December 8, 1997
    Date of Patent: July 2, 2002
    Assignee: SmithKline Beecham Corporation
    Inventors: Paul Gerard Butterly, Gilroy John Keohane, Esin Fatma Kosal
  • Patent number: 6247604
    Abstract: A container having a closure comprising a closure wall having a puncturable region in communication with the interior of the vessel, and having on an inwardly facing region of the closure wall a desiccant material separated from the interior of the vessel by a semi-permeable membrane which permits transmission of water vapor therethrough but is substantially impermeable to liquid water.
    Type: Grant
    Filed: January 20, 1999
    Date of Patent: June 19, 2001
    Assignee: SmithKline Beecham p.l.c.
    Inventors: Charles Bernard Taskis, Paul John Whatmore
  • Patent number: 6218380
    Abstract: A new antibacterially active agent has been isolated from Streptomyces clavuligerus. This new compound which is designated clavulanic acid has the formula (I): In addition to being a broad spectrum antibiotic of medium potency, clavulanic acid and its salts and esters have the ability to enhance the effectiveness of &bgr; lactam antibiotics against many &bgr;-lactamase producing bacteria.
    Type: Grant
    Filed: August 15, 1991
    Date of Patent: April 17, 2001
    Assignee: SmithKline Beecham p.l.c.
    Inventors: Martin Cole, Thomas Trevor Howarth, Christopher Reading
  • Patent number: 6161260
    Abstract: A pharmaceutical tablet, with a break line aligned along a long dimension of the tablet, such that a twisting action, in which parts of the tablets on opposite sides if the break line are subjected to a rotational twisting force in respectively opposite senses, causes the tablet to break into two or more parts. The tablet is of the type which may be broken into two or more parts in order to ease swallowing or to allow administration of a partial dose.
    Type: Grant
    Filed: May 26, 1999
    Date of Patent: December 19, 2000
    Inventor: Harry Flewitt
  • Patent number: 6162774
    Abstract: A skin wash composition intended for topical application to water-wetted skin comprising an .alpha.-hydroxy acid active ingredient formulated in a mild and non-irritant detergent base consisting of a mixture of a non-ionic alkylpolyglucoside surfactant and an amphoteric surfactant.
    Type: Grant
    Filed: November 25, 1998
    Date of Patent: December 19, 2000
    Assignee: SmtihKline Beecham p.l.c.
    Inventors: Lynda Rosemary Charlton, Juliet Teresa McGillycuddy, Sharon Owen
  • Patent number: 6143281
    Abstract: The problem of formulating a dentifrice which is compatible with a bis-biguanide anti-bacterial agent, for instance chlorhexidine or alexidine, is solved by using a nonionic thickening agent; a nonionic surfactant; and an abrasive which is either a sparingly soluble salt, for instance calcium carbonate, (used in combination with an agent to suppress anion formation), or an essentially insoluble compound, for instance, a silica of low anion content, or a mixture thereof. Preferably, the composition has a flavor which is mainly aniseed, balanced by mints. Preferably during the preparation of a silica containing dentifrice, chlorhexidine and saccharin are added together at an early stage, prior to the addition of silica, to avoid the formation of lumps. Such dentifrices are useful in the prophylaxis and/or treatment of periodontal disease and caries.
    Type: Grant
    Filed: May 26, 1999
    Date of Patent: November 7, 2000
    Assignee: SmithKline Beecham p.l.c.
    Inventors: Stephan Edward Alexander, Geoffrey Royston Doel, Peter John Edwards
  • Patent number: 6136345
    Abstract: This invention concerns a tablet formulation which comprises a core containing a pharmaceutically active material, coated with a release retarding coating, and surrounded by a casing layer which includes a second pharmaceutically active material.
    Type: Grant
    Filed: November 25, 1996
    Date of Patent: October 24, 2000
    Assignee: SmithKline Beecham p.l.c.
    Inventors: Francis Walter Grimmett, Nigel Philip McCreath Davidson
  • Patent number: 6117417
    Abstract: Mouthwash compositions are described comprising cetylpyridinium chloride and amidobetaine amphoteric surfactants of formula (I): RC(O)NH(CH.sub.2).sub.a N.sup.+ (R.sup.1)(R.sup.2)(CH.sub.2).sub.b CO.sub.2.sup.-, wherein R is C.sub.10-20 alkyl; R.sup.1 and R.sup.2 are independently C.sub.1-4 alkyl; a is an integer from 1 to 4; and b is an integer from 1 to 4.
    Type: Grant
    Filed: November 25, 1998
    Date of Patent: September 12, 2000
    Assignee: SmithKline Beecham p.l.c.
    Inventors: Mark Andrew Wicks, Peter Scott McConville, Paula Walsh
  • Patent number: 6101659
    Abstract: A toothbrush, in the neck region of which there is an integral thinned part laterally surrounded by a mass of elastomeric material bonded to the plastics material, the mass being of a shape which bulges laterally beyond the line of the surface of the longitudinally adjacent parts of the neck or the head to which it is connected. The thinned part and the bulging mass provide a toothbrush of improved flexibility.
    Type: Grant
    Filed: June 10, 1999
    Date of Patent: August 15, 2000
    Assignee: SmithKline Beecham GmbH
    Inventor: Hans Halm
  • Patent number: 6077535
    Abstract: This invention relates to a pharmaceutical composition for use as a direct compression tableting agent containing carbonyl iron and a process for making the same.
    Type: Grant
    Filed: June 17, 1998
    Date of Patent: June 20, 2000
    Assignee: SmithKline Beecham Corporation
    Inventor: Antonio Tiongson
  • Patent number: 6071712
    Abstract: An enzymatic process for hydrolyzing the 7-position acyl ester of certain cephalosporin compounds to the corresponding alcohol is disclosed.
    Type: Grant
    Filed: September 18, 1997
    Date of Patent: June 6, 2000
    Assignee: SmithKline Beecham Corporation
    Inventors: Vedanthadesikan Renganathan, Martin Brenner
  • Patent number: 6066282
    Abstract: This invention relates to a process for making a toothbrush comprising making a toothbrush head having at its basal end a first engagement part, then making a toothbrush grip handle from a plastics material by a handle molding process, during the handle molding process forming a second engagement part at the head end of the handle in engagement with the first engagement part, such that the engagement between the first and second engagement parts retains the head and grip handle together, and toothbrushes made by this process.
    Type: Grant
    Filed: May 27, 1998
    Date of Patent: May 23, 2000
    Assignee: SmithKline Beecham Consumer Healthcare GmbH
    Inventor: Hans Kramer
  • Patent number: 6051703
    Abstract: A new antibacterially active agent has been isolated from Streptomyces clavuligerus. This new compound which is designated clavulanic acid has the formula (I): ##STR1## In addition to being a broad spectrum antibiotic of medium potency, clavulanic acid and its salts and esters have the ability to enhance the effectiveness of .beta.-lactam antibiotics against many .beta.-lactamase producing bacteria.
    Type: Grant
    Filed: April 6, 1995
    Date of Patent: April 18, 2000
    Assignee: SmithKline Beecham p.l.c.
    Inventors: Martin Cole, Thomas Trevor Howarth, Christopher Reading
  • Patent number: 6048977
    Abstract: A new antibacterially active agent has been isolated from Streptomyces clavuligerus. This new compound which is designated clavulanic acid has the formula (I): ##STR1## In addition to being a broad spectrum antibiotic of medium potency, clavulanic acid and its salts and esters have the ability to enhance the effectiveness of .beta.-lactam antibiotics against many .beta.-lactamase producing bacteria.
    Type: Grant
    Filed: April 6, 1995
    Date of Patent: April 11, 2000
    Assignee: SmithKline Beecham p.l.c.
    Inventors: Martin Cole, Thomas T Howarth, Christopher Reading
  • Patent number: 6047862
    Abstract: A pump dispenser suitable for striped toothpaste, comprising a pump head [1] and a replaceable reservoir [2] for the toothpaste, in which the toothpaste is packed in radially disposed segments, and the reservoir is locked against rotation relative to the pump head.
    Type: Grant
    Filed: January 28, 1998
    Date of Patent: April 11, 2000
    Assignee: SmithKline Beecham p.l.c.
    Inventor: David Eifion Davies
  • Patent number: 6046210
    Abstract: This invention relates to compounds of formula (I): ##STR1## which are useful as modulators of D.sub.3 receptors, in particular in the treatment of psychoses.
    Type: Grant
    Filed: November 3, 1998
    Date of Patent: April 4, 2000
    Assignee: SmithKline Beecham p.l.c.
    Inventors: Geoffrey Stemp, Amanda Johns
  • Patent number: 6037000
    Abstract: The present invention is to a process for producing a matrix particle of a colored lake or dye which matrix reduces the leeching or bleeding of the colored lake or dye into the surrounding medium. The present inventive process is particularly useful in toothpaste formulations.
    Type: Grant
    Filed: May 14, 1998
    Date of Patent: March 14, 2000
    Assignee: SmithKline Beecham Corporation
    Inventors: Howard Chang, Indrajit N. Desai, Arthur Vinen
  • Patent number: 6031093
    Abstract: A new antibacterially active agent has been isolated from Streptomyces clavuligerus. This new compound which is designated clavulanic acid has the formula (I): ##STR1## In addition to being a broad spectrum antibiotic of medium potency, clavulanic acid and its salts and esters have the ability to enhance the effectiveness of .beta.-lactam antibiotics against many .beta.-lactamase producing bacteria.
    Type: Grant
    Filed: April 6, 1995
    Date of Patent: February 29, 2000
    Assignee: SmithKline Beecham p.l.c.
    Inventors: Martin Cole, Thomas T Howarth, Christopher Reading
  • Patent number: D433570
    Type: Grant
    Filed: October 27, 1999
    Date of Patent: November 14, 2000
    Assignee: SmithKline Beecham GmbH & Co. KG
    Inventor: Harry Landauer
  • Patent number: D434907
    Type: Grant
    Filed: October 27, 1999
    Date of Patent: December 12, 2000
    Assignee: SmithKline Beecham GmbH & Co. KG
    Inventor: Harry Landauer