Abstract: Use of a compound of general formula (I): ##STR1## wherein R.sup.1 represents hydrogen, halogen, trifluoromethyl, nitro, hydroxy, C.sub.1-6 alkyl, C.sub.1-6 alkoxy, arylC.sub.1-6 alkoxy, --CO.sub.2 R.sup.4, --(CH.sub.2).sub.n CN, --(CH.sub.2).sub.n CONR.sup.5 R.sup.6, --(CH.sub.2).sub.n SO.sub.2 NR.sup.5 R.sup.6, C.sub.1-6 alkanoylamino(CH.sub.2).sub.n, or C.sub.1-6 alkylsulphonylamino(CH.sub.2).sub.n ;R.sup.4 represents hydrogen, C.sub.1-6 alkyl or arylC.sub.1-6 alkyl;R.sup.5 and R.sup.6 each independently represent hydrogen or C.sub.1-6 alkyl, or R.sup.5 and R.sup.6 together with the nitrogen atom to which they are attached form a ring;n represents 0, 1 or 2; andR.sup.2 and R.sup.3 each independently represent hydrogen, C.sub.1-6 alkyl or benzyl or together with the nitrogen atom to which they are attached form a pyrrolidino, piperidino or hexahydroazepino ring;or a physiologically acceptable salt thereof, in the manufacture of a medicament for the treatment of a condition where a 5-HT.sub.

Abstract: A dispenser for dispensing together a first fluid material and a second fluid material comprising a first material chamber (1a) and a second material supply chamber (1b) for containing first and second fluid materials, and a headpiece (2) comprising a first pump chamber (24) having a first pump piston (27) and being connectable to a first discharge channel (30) and to the first material supply chamber (1a) and a second pump chamber (19) having a second pump piston (26) and being connectable to a second discharge channel (31) and to the second material supply chamber (1b), and having a coaxial arrangement.

Abstract: A toothbrush, having a handle (11) and a bristle bearing head (13), the head (13) being flexibly and resiliently linked to an extended portion (12) of the handle, the extended portion (12) either surrounding the head (13) or the head (44) partly surrounding the extended portion (42), the head (13, 44) being capable of rocking motion relative to the extended portion (12, 42).

Abstract: This invention relates to a polymer-based cleanser for superficial and deep cleansing of skin.

Abstract: NK.sub.3 receptor antagonists of formula (I): ##STR1## are useful in treating inter alia pulmonary disorders, CNS disorders and neurodegenerative disorders.

Abstract: Two-component pharmaceutical compositions for topical application to the human or animal body and intended for mixing together on or immediately prior to application, comprising two liquid phases having different lipophilicities and a drug dissolved in at least one of the liquid phases.

Abstract: This invention relates to libraries of non-peptide compounds each comprised of a core structure and methods for making such libraries. This invention also relates to novel silicon-based polymer resins and silane linkers, methods for their preparation and their use in the synthesis of libraries of compounds to be screened as pharmaceutical agents.

Abstract: A process is disclosed for preparing potassium clavulanate in the form of crystalline rosettes by addition of a solution of clavulanate ions to a solution of potassium ions in a non-solvent for potassium clavulanate.

Abstract: A container and closure combination wherein the closure comprises a skirt portion, the periphery of which has at least one rounded ramped portion adapted to cooperate with one or more corresponding rounded ramped portions on the container such that relative axial rotation of the container causes cooperation of the ramped portions and disengagement of the closure from the container.

Abstract: The invention relates to a novel douche nozzle suitable for vaginally administering a douche fluid.

Abstract: This invention relates to compounds of formula (I): ##STR1## wherein R.sup.1 represents C.sub.1-4 alkyl; andR.sup.2, R.sup.3, R.sup.4 and R.sup.5 each independently represent hydrogen, halogen, C.sub.1-4 alkyl, C.sub.1-4 alkoxy, C.sub.1-4 alkoxyC.sub.1-4 alkyl, C.sub.1-4 alkylsulphonyl, trifluoromethylsulphonyl; optionally substituted arylsulphonyl, optionally substituted heteroarylsulphonyl, optionally substituted aralkylsulphonyl, optionally substituted heteroaralkylsulphonyl, nitro, cyano, amino, mono- or di-alkylamino, trifluoromethyl, trifluoromethoxy, hydroxyl, hydroxyC.sub.1-4 alkyl, C.sub.1-4 alkylthio, C.sub.1-4 alkanoyl, C.sub.1-4 alkoxycarbonyl, aminosulphonyl, or mono- or diC.sub.1-4 alkylaminosulphonyl; orR.sup.1 and R.sup.2 together form a linking chain --(CH.sub.2).sub.m Op; (wherein m is 2 to 4 and p is zero or 1) which chain may be optionally substituted by one or two C.sub.1-4 alkyl groups;and Y represents a group of formula (.alpha.

Abstract: Potassium clavulanate exists in a novel crystalline habit, namely in the form of rosettes, having improved processing properties. The novel form may, for example, be obtained by crystallization or recrystallization using inverse precipitation, preferably at 8.degree.-15.degree. C.

Abstract: A dispenser is provided for the concurrent dispensing of two different fluid materials. The dispenser has a first and second supply chamber for containing the two separate fluids, and a headpiece having a first pump chamber and pump piston connected to the first supply chamber and a first discharge channel, and a second pump chamber and pump piston connected to the second supply chamber and a second discharge channel. The first and second supply chambers have a coaxial arrangement.

Abstract: A toothbrush having a handle and at one end having a bristle-bearing head which is in the form of one or more segments which are flexibly and/or resiliently linked to each other. Optionally, the head may also be flexibly and/or resiliently linked to the handle. The grooves between the linked segments of the head are wholly or partly filled with an elastomeric material. In one aspect, the bristle-bearing head of the toothbrush is attached to the handle by a frame which wholly or partly surrounds the head and is an integral extension of the handle.

Abstract: A method of treatment of Cryptococcus neoformans infection by administering to a patient in need thereof an effective amount of a benzimidazile compound.

Abstract: The present inventions relates to the use of certain benzimidazole compounds in the treatment of diseases caused by microsporidia organisms, in particular the treatment of diarrhea in patients infected with human immunodeficiency virus.

Abstract: This invention relates to an animal pour-on pesticidal formulation which comprises at least one pesticide selected from the group consisting of the synthetic pyrethroids, preferably cypermethrin, the organophosphates and the amidines, and at least one vegetable oil consisting of glycerides of carboxylic acids with carbon chain lengths of more than 14 carbon atoms e.g. sunflower oil, as carrier for the pesticide which carrier constitutes at least 70% m/v of the formulation. The formulation may optionally further include a synergist, preferably piperonylbutoxide and solvents such as diacetone alcohol and dibutylphthalate.