Patents Represented by Attorney Jason C. Fedon

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  • Ornithine carbamoyltransferase
    Patent number: 6706508
    Abstract: The invention provides ornithine carbamoyltransferase polypeptides and DNA (RNA) encoding ornithine carbamoyltransferase polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing ornithine carbamoyltransferase polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: November 2, 1999
    Date of Patent: March 16, 2004
    Assignee: SmithKline Beecham Corporation
    Inventors: James Raymond Brown, Magdalena Zalacain
  • FabH
    Patent number: 6682919
    Abstract: The invention provides FabH polypeptides and polynucleotides encoding FabH polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing FabH polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: November 14, 1997
    Date of Patent: January 27, 2004
    Assignee: SmithKline Beecham Corporation
    Inventors: Christine Debouck, Daniel Robert Gentry, Deborah Dee Jaworski, John Timothy Londsdale, Jeffrey L Mooney, David John Payne, Stewart Campbell Pearson, Lisa Kathleen Schilling, Glenn Scott Van Aller, Min Wang, Yi Yi Zhong
  • NRDE
    Patent number: 6660520
    Abstract: The invention provides nrdE polypeptides and polynucleotides encoding nrdE polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing nrdE polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: June 5, 1998
    Date of Patent: December 9, 2003
    Assignee: SmithKline Beecham Corporation
    Inventors: Michael Terence Black, Deborah Dee Jaworski, Anna Lisa Kosmatka, Lisa Kathleen Shilling, Min Wang, Edwina Imogen Wilding
  • Rnase P polypeptides, polynucleotides, and methods using their mechanisms of action
    Patent number: 6649744
    Abstract: This invention relates to a novel bacterial ribonucleoprotein complex and the component parts thereof. More specifically, this invention relates to RNase P RNA isolated from Staphylococcus aureus and the use of RNase P RNA in screens for the identification of antimicrobial compounds and to the use of such compounds in therapy.
    Type: Grant
    Filed: November 5, 2001
    Date of Patent: November 18, 2003
    Assignees: SmithKline Beecham Corporation, SmithKline Beecham P.L.C.
    Inventors: Michael J. Gress, Lisa A Hegg, Hu Li, Joseph J. Park
  • Defl
    Patent number: 6586578
    Abstract: The invention provides Defl polypeptides and DNA (RNA) encoding Defl polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing Defl polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: August 15, 1997
    Date of Patent: July 1, 2003
    Assignee: SmithKline Beecham Corporation
    Inventors: Michael Arthur Lonetto, Richard Lloyd Warren, Daniel Robert Sylvester
  • FtsH from Staphylococcus aureus
    Patent number: 6573066
    Abstract: The invention provides ftsH polypeptides, polynucleotides encoding ftsH polypeptides and related polynucleotides and methods for producing such polypeptides by recombinant techniques. Also provided are diagnostic methods for detecting Staphylococcus aureus.
    Type: Grant
    Filed: March 12, 1997
    Date of Patent: June 3, 2003
    Assignees: SmithKline Beecham Corporation, SmithKline Beecham plc
    Inventors: John Edward Hodgson, Owen Jenkins, Gillian Sarginson
  • AmpS from Streptococus pneumoniae
    Patent number: 6558919
    Abstract: The invention provides ampS polypeptides and DNA (RNA) encoding ampS polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing ampS polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: December 4, 1998
    Date of Patent: May 6, 2003
    Assignee: SmithKline Beecham Corporation
    Inventors: Magdalena Zalacain, James Raymond Brown
  • NrdF from Staphylococcus aureus
    Patent number: 6555338
    Abstract: The invention provides nrdF polynucleotides encoding nrdF polypeptides from Staphylococcus aureus and methods for producing such polypeptides by recombinant techniques. The invention also provides polynucleotides having high identity to the nrdF polynucleotides. Also provided are preferred methods for utilizing these polynucleotides and polypeptides as diagnostic reagents and in diagnostic assays to screen for microbial infections in organisms and materials.
    Type: Grant
    Filed: March 17, 1998
    Date of Patent: April 29, 2003
    Assignee: SmithKline Beecham Corporation
    Inventors: Michael Terence Black, Christopher Michael Traini
  • Histidine kinase
    Patent number: 6548281
    Abstract: The invention provides Histidine Kinase polypeptides and polynucleotides encoding Histidine Kinase polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing Histidine Kinase polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: August 18, 2000
    Date of Patent: April 15, 2003
    Assignee: SmithKline Beecham Corporation
    Inventors: Karen M O'Dwyer, Deborah D Jaworski, Jeffrey L Mooney, Lisa K Shilling, John Peter Throup, Nicola Gail Wallis, Yi Yi Zhong, Min Wang
  • lacR from Streptococcus pneumoniae
    Patent number: 6548273
    Abstract: The invention provides lacR polypeptides and polynucleotides encoding lacR polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing lacR polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: July 17, 2000
    Date of Patent: April 15, 2003
    Assignee: SmithKline Beecham Corporation
    Inventors: Pan Fong Chan, David J. Holmes, Michael A. Lonetto, Christopher M. Traini, Magdalena Zalacain
  • UPS (undecaprenyl diphosphate synthase
    Patent number: 6537774
    Abstract: The invention provides ups (undecaprenyl diphosphate synthase) polypeptides and polynucleotides encoding ups (undecaprenyl diphosphate synthase) polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing ups (undecaprenyl diphosphate synthase) polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: October 14, 1998
    Date of Patent: March 25, 2003
    Assignee: SmithKline Beecham Corporation
    Inventors: Jianzhong Huang, Xinhe Jiang, Damien McDevitt
  • Polynucleotide encoding spo0J1 of Staphylococcus aureus
    Patent number: 6524813
    Abstract: The invention provides spo0J1 polypeptides and polynucleotides encoding spo0J1 polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing spo0J1 polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: March 18, 1998
    Date of Patent: February 25, 2003
    Assignees: SmithKline Beecham Corporation, SmithKline Beecham plc
    Inventors: Martin Karl Russel Burnham, Andrew Fosberry, John Hodgson, Deborah Jaworski, Elizabeth Lawlor, Martin Rosenberg, Lisa Kathleen Shilling, Min Wang, Judith Ward
  • Compounds
    Patent number: 6498234
    Abstract: The invention provides histidine kinase polypeptides and DNA (RNA) encoding histidine kinase polypetides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing histidine kinase polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: March 14, 2000
    Date of Patent: December 24, 2002
    Assignees: SmithKline Beecham Corporation, SmithKline Beecham plc
    Inventor: Nicola Gail Wallis
  • Hepatitis B vaccine
    Patent number: 6488934
    Abstract: A novel vaccine formulation is provided, comprising a hepatitis B component, particularly hepatitis B surface antigen, in combination with aluminum phosphate and 3 de-O-acylated monophosphoryl lipid A.
    Type: Grant
    Filed: December 6, 2000
    Date of Patent: December 3, 2002
    Assignee: SmithKline Beecham Biologicals S.A.
    Inventors: Pierre Hauser, Nathalie Marie-Josephe Claude Garcon, Pierre Desmons
  • FabZ from Staphylococcus aureus
    Patent number: 6489139
    Abstract: The invention provides fabZ polypeptides and polynucleotides encoding fabZ polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing fabZ polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: June 24, 1999
    Date of Patent: December 3, 2002
    Assignee: SmithKline Beecham Corporation
    Inventors: Howard Kallender, John T. Lonsdale, Stephanie Van Horn, Patrick V. Warren
  • Compounds
    Patent number: 6465621
    Abstract: The invention provides ERA polypeptides and DNA (RNA) encoding ERA polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing ERA polypeptide for the protection against infection, particularly bacterial infections.
    Type: Grant
    Filed: August 3, 2000
    Date of Patent: October 15, 2002
    Assignees: SmithKline Beecham Corporation, SmithKline Beecham plc
    Inventors: Michael Terence Black, John Edward Hodgson, David Justin Charles Knowles, Raymond Winfield Reichard, Richard O Nicholas, Martin Karl Russel Burnham, Julie M Pratt, Martin Rosenberg, Judith M Ward
  • Fibronectin binding proteins
    Patent number: 6461614
    Abstract: The invention provides Fibronectin Binding Protein polypeptides and DNA (RNA) encoding Fibronectin Binding Protein polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing Fibronectin Binding Protein polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: January 21, 2000
    Date of Patent: October 8, 2002
    Assignees: SmithKline Beecham Corporation, SmithKline Beecham PLC
    Inventors: John Edward Hodgson, Martin Karl Russel Burnham
  • Phosphatidylglycerophosphate synthase from Staphylococcus aureus
    Patent number: 6458572
    Abstract: The invention provides Phosphatidylglycerophosphate Synthase polypeptides from Staphylococcus aureus (“pgsA polypeptides”). Also provided are methods for utilizing pgsA polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: August 3, 2000
    Date of Patent: October 1, 2002
    Assignee: SmithKline Beecham Corporation
    Inventors: David John Holmes, Chanal Myriam Petit, Christopher Michael Traini, Richard Lloyd Warren
  • EF-Tu
    Patent number: 6451556
    Abstract: The invention provides EF-Tu polypeptides and polynucleotides encoding EF-Tu polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing EF-Tu polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: December 21, 1998
    Date of Patent: September 17, 2002
    Assignee: SmithKline Beecham Corporation
    Inventors: Howard Kallender, Stephanie Van Horn
  • Member of ATP dependent protease family, clpL
    Patent number: 6447773
    Abstract: The invention provides clpL polypeptides and DNA (RNA) encoding clpL polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: October 13, 1999
    Date of Patent: September 10, 2002
    Assignees: SmithKline Beecham Corporation, SmithKline Beecham plc
    Inventors: Michael Terence Black, John Edward Hodgson, David Justin Charles Knowles, Raymond Winfield Reichard, Richard Oakley Nicholas, Martin Karl Russel Burnham, Julie M Pratt, Martin Rosenberg, Judith M Ward, Andrew Fosberry, Elizabeth J Lawlor