Patents Represented by Attorney Jason C. Fedon

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  • PgsA
    Patent number: 6448037
    Abstract: The invention provides pgsA polypeptides and polynucleotides encoding pgsA polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing pgsA polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: February 20, 1998
    Date of Patent: September 10, 2002
    Assignee: SmithKline Beecham Corporation
    Inventors: David John Holmes, Chantal Myriam Petit, Christopher Michael Traini, Richard Lloyd Warren
  • BirA from staphylococcus aureus
    Patent number: 6448038
    Abstract: The invention provides birA polypeptides and polynucleotides encoding birA polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing birA polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: January 26, 1999
    Date of Patent: September 10, 2002
    Assignee: SmithKline Beecham Corporation
    Inventors: Jianzhong Huang, Howard Kallender, Damien McDevitt, Stephanie Van Horn, Daniel R Sylvester
  • ribB
    Patent number: 6448036
    Abstract: The invention provides ribB polypeptides and polynucleotides encoding ribB polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing ribB polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: November 25, 1997
    Date of Patent: September 10, 2002
    Assignees: SmithKline Beecham Corporation, SmithKline Beecham plc
    Inventors: Michael Terence Black, Martin Karl Russell Burnham, Jason Craig Fedon, John Edward Hodgson, David Justin Charles Knowles, Michael Arthur Lonetto, Richard Oakley Nicholas, Leslie Marie Palmer, Julie M Pratt, Raymond Winfield Reichard, Martin Rosenberg, Christopher Michael Traini, Judith M Ward, Richard Lloyd Warren
  • Ribonuclease III from Streptococcus pneumoniae
    Patent number: 6444208
    Abstract: The invention provides rnc polypeptides and DNA (RNA) encoding rnc polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing rnc polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: December 16, 1998
    Date of Patent: September 3, 2002
    Assignee: SmithKline Beecham Corporation
    Inventors: Michael Arthur Lonetto, Martin Rosenberg
  • RATC from Streptococcus pneumoniae
    Patent number: 6432703
    Abstract: The invention provides ratC polypeptides and polynucleotides encoding ratC polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing ratC polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: August 27, 1998
    Date of Patent: August 13, 2002
    Assignee: SmithKline Beecham Corporation
    Inventor: Howard Kallender
  • dnaB from Staphylococcus aureus
    Patent number: 6420161
    Abstract: The invention provides dnaB polypeptides and polynucleotides encoding dnaB polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing dnaB polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: April 5, 2000
    Date of Patent: July 16, 2002
    Assignee: SmithKline Beecham Corporation
    Inventors: David Lawrence Earnshaw, Earl William May, Damien McDevitt
  • Histidine kinase
    Patent number: 6410263
    Abstract: The invention provides histidine kinase polypeptides and polynucleotides encoding histidine kinase polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing histidine kinase polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: January 29, 1998
    Date of Patent: June 25, 2002
    Assignees: Smithkline Beecham Corporation, Smithkline Beecham p.l.c.
    Inventors: Nicola Gail Wallis, Lisa Kathleen Shilling, Richard Lloyd Warren
  • 509HK
    Patent number: 6406889
    Abstract: The invention provides 509HK polypeptides and polynucleotides encoding 509HK polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing 509HK polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: May 4, 2000
    Date of Patent: June 18, 2002
    Assignee: SmithKline Beecham Corporation
    Inventors: Weonhye Bae, Sanjoy Biswas, Martin K. R. Burnham, John P. Throup, Stephanie Van Horn, Richard L. Warren, Jr.
  • Method for modulating gene expression
    Patent number: 6387703
    Abstract: This invention relates to a method of screening for compounds that modulate gene expression, particularly those which lower gene expression.
    Type: Grant
    Filed: April 6, 2000
    Date of Patent: May 14, 2002
    Assignee: SmithKline Beecham Corporation
    Inventor: Catherine D Prescott
  • Methods for the characterization and selection of RNA target motifs that bind compounds of pharmaceutical use
    Patent number: 6355426
    Abstract: Methods are disclosed for identifying an RNA fragment that mimics the structure of a defined or undefined target RNA molecule to which a compound binds inside of a cell resulting in retardation of cell growth or cell death. Methods using these RNA fragments for identifying unknown compounds of pharmaceutical interest, and for identifying unknown RNA targets for use in treating disease are disclosed. These methods and compositions are used in screening for novel antibiotics, bacteriostatics, or modifications thereof or for identifying compounds useful to alter expression levels of proteins encoded by mRNA. The methods involve providing random DNA fragments from DNA which encodes RNA target molecules, cloning such fragments to create a plasmid library of same; transfecting cells which contain the native RNA target molecule with the plasmid library and exposing the cells to one or more of test compounds.
    Type: Grant
    Filed: April 30, 1999
    Date of Patent: March 12, 2002
    Assignee: Smithkline Beecham Corporation
    Inventor: Catherine Denise Prescott