Patents Represented by Attorney Jerome L. Jeffers

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  • Regioselective synthesis of mono-alkyl citric acid esters
    Patent number: 5049699
    Abstract: Disclosed are 1- and 2-mono esters of citric acid and methods for preparing them in the pure form. These novel compounds are useful as surfactants.
    Type: Grant
    Filed: January 22, 1990
    Date of Patent: September 17, 1991
    Assignee: Haarmanns' Reimer Corp
    Inventor: Michael P. Kotick
  • Method for the production of granular citric acid
    Patent number: 5045459
    Abstract: Disclosed is an improved method for preparing a particulate citric acid material. The method involves spray granulating citric acid from its partially purified fermentation broth to form granules which are freer flowing and less inclined to fracture than is citric acid prepared by crystallization techniques which properties render this material suitable for handling in bulk.
    Type: Grant
    Filed: October 5, 1990
    Date of Patent: September 3, 1991
    Assignee: Haarmann & Reimer Corp.
    Inventors: Helmut A. Mothes, Bhalchandra H. Patwardhan, Theo G. Schroeder, David J. Solow
  • Method of protecting hard surfaces
    Patent number: 5043191
    Abstract: Hard surfaces protection is accomplished by the application of a polyester formed by the copolymerization of polyethylene terephthalate and polyoxyethylene or polyoxypropylene terephthalate thereto.
    Type: Grant
    Filed: February 27, 1990
    Date of Patent: August 27, 1991
    Assignee: Miles Inc.
    Inventors: Michael T. Endres, Shanker B. Patel
  • Method for the preparation and recovery of alkali metal citrates
    Patent number: 5041645
    Abstract: Alkali metal citrates are prepared by the addition of an alkaline alkali metal base or salt to citric acid solutions and recovered in solid form by the addition of a C.sub.1 to C.sub.5 alcohol to the solution to cause precipitation.
    Type: Grant
    Filed: December 12, 1988
    Date of Patent: August 20, 1991
    Assignee: Haarmann & Reimer Corp.
    Inventors: Alexander Alon, Philip W. Staal
  • Acyl malate diesters
    Patent number: 5015418
    Abstract: Disclosed is a composition comprising a mixture of acylated diesters of dl-malic acid corresponding to the formula: ##STR1## where P is palmityl and S is stearyl.
    Type: Grant
    Filed: December 14, 1989
    Date of Patent: May 14, 1991
    Assignee: Haarmann & Reimer Corp.
    Inventors: Donald F. Hershberger, Richard A. Plunkett
  • Use of lanthionines for control of post-processing contamination in processed meat
    Patent number: 5015487
    Abstract: Disclosed is a method for inhibiting the contamination of processed meat products by pathogenic or spoilage microorganisms which method involves treating the surface of the meat product with a lanthionine bacteriocin.
    Type: Grant
    Filed: April 23, 1990
    Date of Patent: May 14, 1991
    Assignee: Haarmann & Reimer Corp.
    Inventors: Mark W. Collison, Terry F. Farver, Christine A. McDonald, Paula J. Herald, Daniel J. Monticello
  • Hard confections containing hydrogenated isomaltulose and medicinally active ingredient
    Patent number: 4971798
    Abstract: Disclosed is a hard confection containing Palatinit (hydrogenated isomaltulose) and a medicinally active ingredient. Such a formulation has been found to dissolve more slowly than similar formulations based on sugar rendering them suitable for dispensing the active ingredient over an extended period of time.
    Type: Grant
    Filed: November 30, 1989
    Date of Patent: November 20, 1990
    Assignee: Miles Inc.
    Inventors: Kenneth A. Coia, Michael J. Lynch
  • Method of high temperature laundering using sodium citrate and an anionic
    Patent number: 4965013
    Abstract: Disclosed is a fabric cleaning process which involves contacting the fabric with a cleaning solution comprising an anionic detergent and sodium citrate as detergent builder at a temperature above about 70.degree. C.
    Type: Grant
    Filed: May 1, 1989
    Date of Patent: October 23, 1990
    Assignee: Miles Inc.
    Inventor: Karen L. Pratt
  • Biotransformation of L-tyrosine and L-phenylalanine to 2,5-dihydroxyphenylacetic acid
    Patent number: 4956279
    Abstract: Disclosed is a method for the production of homogentisic acid which involves growing a fungus (typically a yeast of the species Yarrowia lipolytica) which has been mutated to provide a strain which is unable to grow on L-tyrosine and/or L-phenylalanine as the sole carbon source in a suitable growth medium containing L-tyrosine and/or L-phenylalanine together with a sub-optimal concentration of carbohydrate assimilable by the yeast. The yeast secretes recoverable quantities of homogentisic acid which can be rapidly and completely polymerized by raising the pH of the medium to above 10 thereby forming a melanin pigment.
    Type: Grant
    Filed: July 19, 1989
    Date of Patent: September 11, 1990
    Assignee: Miles Inc.
    Inventors: Ramunas Bigelis, Kathleen A. Black
  • Detergent formulations containing alkaline lipase derived from Pseudomonas plantarii
    Patent number: 4950417
    Abstract: Disclosed is a detergent formulation containing a nonionic and/or anionic detergent and the microbial lipase from a bacterium of the species Pseudomonas plantarii.
    Type: Grant
    Filed: May 1, 1989
    Date of Patent: August 21, 1990
    Assignee: Miles Inc.
    Inventors: Nancy L. Bycroft, Graham S. Byng
  • Process for producing glucose isomerase
    Patent number: 4920052
    Abstract: A glucose isomerase useful for the conversion of glucose to fructose can be prepared by growing under aerobic conditions a culture of a species of Microbacterium in a medium containing appropriate nutrients and then recovering the enzyme.
    Type: Grant
    Filed: February 5, 1988
    Date of Patent: April 24, 1990
    Assignee: Miles Inc.
    Inventor: Graham S. Byng
  • Biotransformation of L-tyrosine and L-phenylalanine to 2,5-dihydroxyphenylacetic acid followed by polymerization to melanin pigments
    Patent number: 4877728
    Abstract: Disclosed is a method for the production of homogentisic acid which involves growing a fungus (typically a yeast of the species Yarrowia lipolytica) which has been mutated to provide a strain which is unable to grow on L-tyrosine and/or L-phenylalanine as the sole carbon source in a suitable growth medium containing L-tyrosine and/or L-phenylalanine together with a sub-optimal concentration of carbohydrate assimilable by the yeast. The yeast secretes recoverable quantities of homogentisic acid which can be rapidly and completely polymerized by raising the pH of the medium to above 10 thereby forming a melanin pigment.
    Type: Grant
    Filed: March 28, 1988
    Date of Patent: October 31, 1989
    Assignee: Miles Inc.
    Inventors: Ramunas Bigelis, Kathleen A. Black
  • Stabilization of microbial rennet
    Patent number: 4853329
    Abstract: Microbial rennet from Rhizomucor pusillus which has been oxidized to increase its thermal lability has a normal pH of about 5.5 in aqueous solution. It has been discovered that the stability of such solutions can be increased by raising the pH to a level of from 6.0 to about 8.5.
    Type: Grant
    Filed: June 27, 1988
    Date of Patent: August 1, 1989
    Assignee: Miles Inc.
    Inventors: Herbert J. Havera, John D. Humphreys, Joan M. Jazdzewski
  • Method for the preparation of a hydrophobic enzyme-containing composition and the composition produced thereby
    Patent number: 4849357
    Abstract: A enzyme-containing solid composition is prepared by a process comprising removing the solvent from a mixture of a water-soluble enzyme, a water-insoluble metal salt of a fatty acid and an organic solvent.
    Type: Grant
    Filed: October 8, 1986
    Date of Patent: July 18, 1989
    Assignee: Miles Inc.
    Inventors: Koo-Heung Chung, Francis H. Verhoff
  • Use of stabilizing agents in culture media for growing acid producing bacteria
    Patent number: 4806479
    Abstract: Disclosed is a bulk starter medium for the propagation of a mother culture of an acid producing bacteria which medium contains a carbohydrate source, a nitrogen containing growth stimulant, a phage control agent and an essentially insoluble or temporarily insolubilized neutralizing agent to which has been added a foodgrade hydrocolloid stabilizing agent.
    Type: Grant
    Filed: May 13, 1985
    Date of Patent: February 21, 1989
    Assignee: Miles Inc.
    Inventors: Mary A. Kegel, Donald L. Wallace
  • Preparation of mycelial chitosan and glucan fractions from microbial biomass
    Patent number: 4806474
    Abstract: Chitin from microbial biomass is converted to chitosan and recovered as an essentially glucan-free product. The method involves contacting the biomass with a strong alkali solution at a temperature within the range of from 60.degree. to 90.degree. C. for a period of at least 10 hours to form an insoluble chitosan/glucan residue. The chitosan is then recovered by adding dilute acid to the residue to dissolve it without dissolving the glucan which can then be recovered separately.
    Type: Grant
    Filed: June 10, 1985
    Date of Patent: February 21, 1989
    Assignee: Miles Inc.
    Inventor: Donald F. Hershberger
  • Thermostable Rhizomucor rennet having increased milk clotting activity
    Patent number: 4766074
    Abstract: Disclosed is a method for increasing the milk clotting ability and reducing the thermal stability of microbial rennet from Rhizomucor pusillus. The method involves treating the rennet with a methionine oxidizing composition and the anhydride of a dicarboxylic organic acid.
    Type: Grant
    Filed: October 13, 1987
    Date of Patent: August 23, 1988
    Assignee: Miles Inc.
    Inventors: Herbert J. Havera, John D. Humphreys
  • Immobilization of enzymes
    Patent number: 4760024
    Abstract: An enzyme producing microorganism or an enzyme produced thereby is immobilized by contacting the microorganism or enzyme with polyethylenimine and adding chitosan and glutaraldehyde to form a reaction product. In a preferred embodiment, the reaction product is extruded onto the revolving plate of a spheronizing device to form spherical enzyme aggregates having enhanced physical and biocatalytic properties.
    Type: Grant
    Filed: January 17, 1986
    Date of Patent: July 26, 1988
    Assignee: Miles Inc.
    Inventor: Oreste J. Lantero, Jr.
  • Enzyme immobilization in a macroporous non-ionic resin
    Patent number: 4757008
    Abstract: Enzyme-containing microbial cells are contacted with a macro-porous non-ionic resin under reduced pressure below atmospheric to cause the cells to become incorporated into pores of the resin. The resin is then contacted with a multi-functional, amine reactive material to immobilize the cells within the pores. Prior to contacting with the resin, cells may be disrupted to produce a system containing cell fragments, intact cells and solubilized enzyme. A preferred enzyme is glucose isomerase.
    Type: Grant
    Filed: February 24, 1986
    Date of Patent: July 12, 1988
    Assignee: Miles Inc.
    Inventor: Lawrence F. Reverman
  • Purification of microbial rennet from Mucor miehei
    Patent number: 4743551
    Abstract: A method for the purification of a culture filtrate resulting from the fermentation of an organism of the species Mucor miehei involves the selective adsorption of the microbial rennet present in the culture filtrate by a blue dye affinity ligand with subsequent elution of the adsorbed microbial rennet to provide it in a purified form.
    Type: Grant
    Filed: November 5, 1984
    Date of Patent: May 10, 1988
    Assignee: Miles Inc.
    Inventor: Sethuraman Subramanian