Abstract: The present invention relates to a method of protecting cells against damage caused at least in part by apoptosis, comprising administering to subjects a therapeutic dose of leumorphin having cytoprotective activity, and a pharmaceutical composition comprising an effective amount of leumorphin having a cytoprotective activity.

Abstract: The present invention relates to a neuronal regeneration material screening method using ex vivo models, more precisely a neuronal regeneration material screening method using an organotypic spinal cord slice culture. The neuronal regeneration material screening method using spinal cord slices of living bodies of the present invention can be effectively applied for the development of a novel therapeutics for neurodegenerative diseases, such as spinal cord injury.

Abstract: For a method for inspecting in vivo migration of fat soluble vitamins and/or fat soluble food factors in the ingestion of a drug or a health supplement, it is necessary to use saliva as a specimen, to contact a saliva collecting tool with a certain amount of saliva to absorb for collection, and to select a solvent for efficiently extracting a measurement target component from the saliva collecting tool. Accordingly, there are provided a method for inspecting in vivo migration of fat soluble vitamins and/or fat soluble food factors in the ingestion of a drug or a health supplement, by using saliva as a specimen to determine; the property of a saliva collecting tool; and a method for extracting from the saliva collecting tool.

Abstract: The present disclosure is directed to protective materials and methods for producing protective materials. The protective materials include a plurality of foam elements having a molded surface and a cut surface. The molded surfaces of the foam elements are attached to a fabric sheet such that the cut surfaces each define planes that are spaced from the fabric sheet when the fabric sheet is substantially planar. The protective materials are produced by using a mold to form the plurality of foam elements on one side of a foam sheet, attaching a fabric sheet to the top of the foam elements, and cutting the foam elements from the foam sheet.

Abstract: The present invention relates to the IL-12p40 subunit mutant gene which can produce IL-12 (interleukin 12) of human and mouse origin with high activity, the expression vector including above mutant gene and the use of them to DNA vaccine adjuvant. Particularly, it relates to IL-12p40 mutant gene which inhibits the secretion of IL-12p40 but normally secretes active IL- 12p70 by making mutation at Asn-222 (human) or Asn- 220 (mouse) amino acid of IL-12p40, which acts as a competitive inhibitor of active form of IL-12, IL-12p70. Therefore, the IL-12p40 mutant gene of the present invention can be useful for DNA vaccination and gene therapy against various diseases, for example, AIDS, hepatitis C or hepatitis B, cancer, influenza, tuberculosis and malaria, which essentially require cellular immune responses for their therapy.

Abstract: Disclosed is a diagnostic marker specific for lung cancer. Also, the present invention relates to a composition and a kit, comprising an agent measuring the presence of the marker, and a method of diagnosing lung cancer using the composition or kit.

Abstract: Disclosed is a system for detecting a protease inside a cell. In one embodiment, the system includes a chimeric protein that comprises as covalently linked components: 1) at least one optionally masked signal protein; 2) at least one protease-specific cleavage site; and 3) at least one detectable amino acid sequence. The invention has a wide spectrum of applications including use in the detection of novel protease inhibitors inside cells and tissue.

Abstract: Disclosed is a centrifugal impact wrench using an electric driving motor, which is rotated by electricity supplied from an electric power source, as a power source.

Abstract: The subject of the present invention is to provide a useful antibody for measuring ADAMTS13 activity, in particular, a monoclonal antibody and a method for measuring ADAMTS13 activity. Further, another subject of the present invention also is to provide a monoclonal antibody which has specific reactivity to an antigenic determinant site produced by reacting ADAMTS13 with VWF that is a substrate or a partial peptide of VWF that is a potential substrate, but has no specific reactivity to the complete VWF molecule, and a use of the antibody of interest. Those subjects were achieved by succeeding in obtaining a monoclonal antibody (anti-N-10 monoclonal antibody) which has specific reactivity to a cleavage site that is cleavable by ADAMTS13 in the partial peptide of VWF, and further by finding a method for measuring ADAMTS13 activity using the monoclonal antibody of interest.

Abstract: The present application discloses an apparatus for gasification of solid, liquid and gaseous organic feed materials having a fuel value into synthesis gas. The apparatus comprises: a gasification reactor vessel having a tapered interior with a minimum of four zones for introducing reaction gas mixtures, a central perforated diffuser pipe, a solid and liquid material inlet at the upper end of the uppermost zone, a solid and gas discharge outlet at the lower end of the bottom zone, wherein the reactor vessel defining a sequence of reaction zones from the material inlet to the material outlet including drying, pyrolysis, combustion and gasification zones, and confining downwardly moving the column of the feed materials within the zones, gas feed inlet pipes for introducing reaction gas into the zones, a synthesis gas discharge pipe below the zones, and a heat exchanger below the zones.

Abstract: Disclosed herein is a bottom thread supply device for sewing machines. The bottom thread supply device of the present invention includes a light source (500) and a light receiving sensor (110). When the light source (500) radiates light onto a bobbin (300), around which a bottom thread is wound, if there is no remaining thread, the light receiving sensor (110), which is disposed in a central portion of a rotary hook (100), detects the light, thus generating a signal to let a user know that there is no remaining thread. As such, when there is no remaining thread, the present invention automatically lets the user know this thanks to the operation of the light receiving sensor, thus preventing unproductive or defective sewing, thereby increasing productivity and preventing economic loss.

Abstract: The present invention relates to a VEGF polypeptide that binds to A?. The present invention also relates to a compound that sequesters A?. And conversely, the invention relates to a compound that sequesters VEGF. Thus, the present invention also relates to a method of screening for a compound that inhibits the binding of VEGF to A?, and thus relates to prevention and treatment of Alzheimer's Disease.

Abstract: Disclosed herein is a pharmaceutical composition for the prophylaxis and treatment of restenosis, comprising a peroxiredoxin 2 (Prx II) protein as an active ingredient. Optionally, the composition may contain other active ingredients suppressive of restenosis at the carotid artery, the coronary artery, the peripheral artery, and the renal artery. Also, a composition and a method are provided for screening therapeutics for restenosis. This screening composition comprises a peroxiredoxin 2 gene or protein. Together with the method, the composition is useful for searching and developing therapeutics for restenosis.

Abstract: The present application discloses a method of manipulating a biological sample of cells, which includes multi-lineage stem cells, progenitor cells, other marrow stromal cells: allowing the sample of cells to settle in a container; transferring supernatant from the container to another container; and isolating cells from the supernatant, which has comparatively lower density in the sample.

Abstract: The present invention relates to recombinant acetylcholine receptor polypeptides recognized by CD4 T cells of a myasthenia gravis patient and compositions for the treatment of myasthenia gravis containing the same as an effective ingredient, more precisely, recombinant acetylcholine receptor polypeptides deficient in B cell epitope, recombinant acetylcholine polypeptides in which two or more T cell epitopes are fused, a composition for the treatment of myasthenia gravis containing the above recombinant polypeptides as an effective ingredient and a treatment method for myasthenia gravis using the composition. The composition containing one or more recombinant polypeptides above can be effectively used as a myasthenia gravis specific therapeutic agent or immunomodulator without side effects.

Abstract: The present invention relates to IgE-dependent histamine releasing factor (HRF) and HRF-binding peptides, more precisely, deletion forms of HRF which are able to be formed as dimers containing amino acid sequence represented by SEQ ID NO:3, genes encoding thereof and novel HRF-binding peptides having an activity of inhibiting HRF. The deletion forms of HRF which are able to be formed as dimers of the present invention induces intracellular secretion of histamine and IL-8, making an excellent candidate for a drug for inhibiting allergic reaction triggered by HRF and a kit for detecting HRF in serum of an allergy patient. In addition, novel HFR-binding peptides of the present invention bind to HRF to inhibit the actions of HFR, so they can be effectively used for the prevention and the treatment of allergic diseases of animals including asthma and rhinitis or malaria.

Abstract: The present invention discloses a solid bio-material for the detection of a bio-electromagnetic signal, which senses an information signal generated from living organisms and changes thereof by using fish scale, feathers of fowl and carapaces of tortoises among epidermal tissues of animals having the function of detecting, memorizing and transferring a weak information signal (bio-signal) of an electromagnetic field generated from bio-tissues, and a method for producing the same. The method for producing a solid bio-material for the detection of a bio-electromagnetic signal by using epidermal tissues of living organisms comprises the steps of: immersing the carcass of an animal with a developed epidermis such as fish, fowl, tortoises, etc.

Abstract: The present invention relates to a manhole (10) with a locking device, and more particular to a manhole with a locking device, which comprises a manhole frame (20) having a plurality of insertion slots (24) inwardly protruded from an inner circumferential surface thereof, each insertion slot (24) having a latching protrusion (26) formed in such a manner that a top surface of the insertion slots (24) is partially opened; a bearing member (30) having a female screw portion formed on the center thereof and a plurality of fastening pieces (36) radially formed outwardly from the outer circumferential edge thereof, so that the bearing member (30) is detachably fastened to the manhole frame (20); and a manhole cover (40) having a through-hole (41) centrally formed therein so that an upper portion of the vertical screw rod (42) is rotatably inserted into the through-hole (41), the vertical screw rod (42) having a male screw portion (45) formed on the lower portion thereof so as to be threadably fastened to the female

Abstract: The application disclose a method of preventing immune cells from binding to other cells, which includes contacting the immune cells and the other cells with a composition comprising Bst2 antagonist.

Abstract: The present invention relates to detoxified and immunologically active proteins (“mutant LTs”) having mutated amino acid sequences of heat-labile enterotoxin of E. coli, DNA sequences encoding the mutant LTs, recombinant expression vectors comprising the DNAs, recombinant microorganisms transformed with the recombinant expression vectors, process for preparing the mutant LTs and pharmaceutical application of the said protein as immunogenic antigens for vaccination and as adjuvants for anti-body production. In contrast to wild-type LT, the mutant LTs did not induce any toxic activities. The mutant LTs elicited high and comparable levels of anti-LT antibodies when delivered either intragastrically or intranasally, inducing systemic and local responses in serum and fecal extracts. Thus, they might be useful for the development of a novel diarrheal vaccine in humans and animals.