Abstract: The subject invention is related to a cell-mediated gene therapy treatment using a cell composition that includes bioadhesive material. The bioadhesive material allows targeted and localized delivery of therapeutic somatic cells to the site of interest.

Abstract: Disclosed relates to a method and an apparatus for measuring fluorescence polarization FP in a lab-on-a-chip and, more concretely, to a method and an apparatus that measure quantitatively interactions between biomolecules and fluorescently labeled biomaterials and enzyme activities using the measurement of fluorescence polarization FP. The method and the apparatus of the invention provide rapid assays with minute amounts of samples using an automated device compared to conventional methods. Accordingly, the method and the apparatus of the invention can be usefully applied to the measurement of interactions between biomolecules and to the protease assays using a protein substrate.

Abstract: The present application describes a purified covalently closed antisense molecule, which specifically inhibits expression of TGF-?.

Abstract: This application relates to monomers of the general formula (I) for the preparation of PNA (peptide nucleic acid) oglimers and provides method for the synthesis of both predefined sequence PNA oligomers and random sequence PNA oligomers: wherein E is nitrogen or C—R?; J is sulfur or oxygen; R?, R1, R2, R3, R4 is independently H, halogen, alkyl, nitro, nitrile, alkoxy, halogenated alkyl, halogenated alkoxy, phenyl or halogenated phenyl, R5 is H or protected or unprotected side chain of natural or unnatural ?-amino acid; and B is a natural or unnatural nucleobase, wherein when said nucleobase has an exocyclic amino function, said function is protected by protecting group which is labile to acids but stable to weak to medium bases in the presence of thiol.

Abstract: Disclosed is a method of preparing a catalyst for polymerization of aliphatic polycarbonates and a method of polymerizing an aliphatic polycarbonate. This method includes reacting a zinc precursor and organic dicarboxylic acid in a non-ionic surfactant-included solution.

Abstract: The present invention relates to a method for cell adhesion and wound healing with internal domains of ?ig-h3. Particularly, the present invention relates to the method of using recombinant proteins comprising one or more of 2nd or 4th internal domain of ?ig-h3 for cell adhesion and wound healing, wherein the 2nd or 4th internal domain of ?ig-h3 has aspartic acid and isoleucine essential for interaction with integrin which represent a high homology in base sequence of ?ig-h3 internal domains. The recombinant proteins comprising one or more 2nd or 4th internal domain of ?ig-h3 are effective for cell adhesion and wound healing by itself and can be used for developing cell culture medium and wound healing agent.

Abstract: The present invention relates to a multiple stress inducible promoter, more particularly to a multiple stress inducible peroxidase promoter derived by Ipomoea batatas, a expression vector for production of transgenic plants with enhanced tolerance to multiple stress containing the promoter, a transgenic plant cell and plants transduced by the expression vector, and a method for generating the transgenic plants. Promoter of present invention will be biotechnologically useful for development of industrial transgenic plants with enhanced toleransce to multiple stress and plant cell lines to produce useful proteins.

Abstract: This application relates to monomers of the general formula (I) for the preparation of PNA (peptide nucleic acid) oligomers and provides method for the synthesis of both predefined sequence PNA oligomers and random sequence PNA oligomers: wherein E is nitrogen or C—R?; J is sulfur or oxygen; R?, R1, R2, R3, R4 is independently H, halogen, alkyl, nitro, nitrite, alkoxy, halogenated alkyl, halogenated alkoxy, phenyl or halogenated phenyl, R5 is H or protected or unprotected side chain of natural or unnatural ?-amino acid; and B is a natural or unnatural nucleobase, wherein when said nucleobase has an exocyclic amino function, said function is protected by protecting group which is labile to acids but stable to weak to medium bases in the presence of thiol.

Abstract: This application relates to monomers of the general formula (I) for the preparation of PNA (peptide nucleic acid) oligomers and provides method for the synthesis of both predefined sequence PNA oligomers and random sequence PNA oligomers: wherein E is nitrogen or C—R?; J is sulfur or oxygen; R?, R1, R2, R3, R4 is independently H, halogen, alkyl, nitro, nitrile, alkoxy, halogenated alkyl, halogenated alkoxy, phenyl or halogenated phenyl, R5 is H or protected or unprotected side chain of natural or unnatural ?-amino acid; and B is a natural or unnatural nucleobase, wherein when said nucleobase has an exocyclic amino function, said function is protected by protecting group which is labile to acids but stable to weak to medium bases in the presence of thiol.

Abstract: An output circuit of a vacuum-tube amplifier is disclosed. An output circuit of a conventional vacuum-tube amplifier has shortcomings that a front end amplification unit uses a coupling condenser or a transformer to output an AC signal to an output node, a bias voltage of a cathode of a vacuum tube is varied in response to an input signal in an output buffer and, when the bias voltage is higher than a voltage set by a bias resistor, signal attenuation by the difference between the bias voltage and the set voltage is generated. To solve these shortcomings, the output circuit of the vacuum-tube amplifier includes a front end amplification unit for amplifying an input signal using a vacuum tube and an output amplification unit for power-amplifying the output signal of the front end amplification unit using a vacuum tube.

Abstract: Disclosed herein are a rotary atomizer and an air bearing protection system for the rotary atomizer. The structure of the system is simplified to reduce the manufacturing cost. An air bearing is used to enable high-speed rotation along with savings in the maintenance and repair cost. Compressed air can be temporarily supplied at emergency such as interruption of the compressed air. Thus the stability and durability of the entire system are improved, such as prevention of air bearing failure.

Abstract: Disclosed is a method of using a compound as an inhibitor for ?-secretase, wherein the compound is capable of binding to the site within the ?-secretase recognition and/or cleavage site on amyloid precursor protein to specifically inhibit the ?-secretase's activity to cleave amyloid precursor protein with maintaining its activities to other substrates. Further, the present invention relates to inhibitors of amyloid precursor protein (APP) processing which bind to the site within the ?-secretase or ?-secretase cleavage and/or recognition site on amyloid precursor protein.

Abstract: The subject invention is related to a cell-mediated gene therapy treatment for orthopedic disease using a member belonging to the transforming growth factor-? (TGF-?) superfamily. TGF-? gene therapy as a new treatment method for degenerative arthritis is demonstrated. After transfection of TGF-? cDNA expression vectors into fibroblasts (NIH 3T3-TGF-?1), the cells were injected into rabbit achilles tendon and knee joints with artificially-made cartilage defects. Intratendinous injections were performed to determine the optimal concentration for in vivo expression. Partially defected cartilage model was made to simulate degenerative arthritis of the knee joint. The partial cartilage defect treated with the cell-mediated gene therapy procedure was covered by newly formed hyaline cartilage which indicates that the cells survived and stimulated matrix formation in this area. Completely denuded cartilage areas were covered by fibrous collagen.

Abstract: The present invention relates to a fluorescent lamp including: a body (110) having fixtures (120 and 120a) mounted at both end portions thereof so as to detachably mount a fluorescent light bulb (105) thereon; and a connecting means (130) mounted at both end portions of the body (110) so as to continuously interconnect a plurality of bodies to one another, thereby electrically connecting the bodies (110) to one another, wherein the connecting means (130) having a sliding terminal part (131) slidably coupled to the fixture (120) mounted at one side of the body (110) in such a manner as to be selectively protruded by a given length outwardly from the fixture (120) at the end portion thereof during forward and backward movements thereof, and a fixed terminal part (135) formed at the fixture (120a) mounted at the other side of the body (110) in such a manner as to be connected to the sliding terminal part (131) by inserting the sliding terminal part (131) thereto.

Abstract: The present application describes a device for collecting biological samples comprising at least one collection protrusion comprising at least one tip; and at least one pad for contacting the tip.

Abstract: The present invention provides unsupported and supported cobalt oxide catalysts and preparation method thereof, and its application for hydrogen generation from a metal borohydride solution. More particularly, provided are an activation method of a newly prepared catalyst and a regeneration method of a deactivated cobalt oxide catalyst.

Abstract: The present application describes a fusion molecule that includes coiled coil domain, which renders the molecule soluble and provides potent activity.

Abstract: The present invention relates to novel Pcr family genes that confer tolerance to heavy metals to plants and microorganisms. More particularly, the present invention relates to novel Pcr family genes that confer tolerance to cadmium. The invention also relates to plant and microorganisms transformed with any of the Pcr genes thereby having improved resistance to and increased level of toxic materials, and methods of removing heavy metals from contaminated soil and water contaminated by growing the Pcr-transformed plants on the contaminated soils and water.