Patents Represented by Attorney Jill H. Krafte

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  • Multiplying bovine embryos
    Patent number: 4994384
    Abstract: A method of multiplying bovine embryos by transfer of nuclei is described. The method includes enucleating a recipient oocyte, transferring the donor embryo nucleus to the enucleated recipient oocyte, and fusing the donor nucleus to the recipient oocyte by dielectrophoresis. The method is intended to allow the generation of multiplied genetically identical cattle.
    Type: Grant
    Filed: October 27, 1987
    Date of Patent: February 19, 1991
    Assignee: W. R. Grace & Co.-Conn.
    Inventors: Randall S. Prather, Frank Barnes, James Robl, Neal L. First, Vincent F. Simmon
  • Process for preparing isotropic microporous polysulfone membranes
    Patent number: 4970034
    Abstract: Isotropic microporous polysulfone membranes can be prepared by using a particular combination of casting solution and precipitation solution formulations, and casting conditions. Both hollow fiber and flat membranes can be prepared in this manner. The membranes are skinless and are characterized by uniform porosity throughout the membrane.
    Type: Grant
    Filed: September 23, 1988
    Date of Patent: November 13, 1990
    Assignee: W. R. Grace & Co.-Conn.
    Inventors: Ann L. Ly, Chaokang Chu, Thanh D. Nguyen
  • Use of chitosan to improve membrane filter performance
    Patent number: 4970001
    Abstract: Improvement in cross-flow membrane filtration. Chitosan is admixed with an aqueous dispersion of colloids or finely divided solids to flocculate the solids. The chitosan-flocculated liquid is then filtered on a membrane by cross-flow under pressure. A layer of chitosan-containing flocculant material deposits on the membrane and provides superior flux performance as compared to certain commerical flocculants.
    Type: Grant
    Filed: May 5, 1989
    Date of Patent: November 13, 1990
    Assignee: W. R. Grace & Co.-Conn.
    Inventor: John J. Sheehan
  • Molecular cloning and expression of a vibrio proteolyticus neutral protease gene
    Patent number: 4966846
    Abstract: Neutral protease genes from Vibrio proteolyticus or Bacillus can be cloned and expressed in gram-negative microorganisms, such as E. coli or Serratia. The functional neutral protease enzyme is expressed.
    Type: Grant
    Filed: November 19, 1987
    Date of Patent: October 30, 1990
    Assignee: W. R. Grace & Co.-Conn.
    Inventors: Alan H. Deutch, Victor A. David
  • Organic acid-treated amorphous silicas for refining glyceride oils
    Patent number: 4939115
    Abstract: Adsorbents comprising organic acid-treated amorphous silicas with effective average pore diameters of about 60 to about 5000 Angstroms are useful in processes for the removal of trace contaminants, specifically phospholipids and associated metal ions, from glyceride oils.
    Type: Grant
    Filed: March 13, 1987
    Date of Patent: July 3, 1990
    Assignee: W. R. Grace & Co.-Conn.
    Inventors: Perry M. Parker, William A. Welsh
  • Contact lenses based on biocompatible polyurethane and polyurea-urethane hydrated polymers
    Patent number: 4886866
    Abstract: Hydrophilic polymeric soft contact lenses which are characterized by their biocompatibility and resistance to nonspecific protein adsorption. At least 75%, preferably at least 80%, of the prepolymers from which the lenses are prepared are isocyanate-capped oxyethylene-based diols or polyols having molecular weight of about 7000-30,000. Essentially all of the hydroxyl groups of the diols or polyols are capped with polyisocyanate prior to formation of the hydrated polymer of which the contact lenses are made.
    Type: Grant
    Filed: February 16, 1989
    Date of Patent: December 12, 1989
    Assignee: W. R. Grace & Co.-Conn.
    Inventors: James A. Braatz, Clifton L. Kehr
  • Method for refining glyceride oils using partially dried amorphous silica hydrogels
    Patent number: 4880574
    Abstract: Adsorbents comprising partially dried amorphous silica hydrogels having a moisture content of at least about 25 wt % and an average pore diameter of about 60 Angstroms or less are useful in processes for the removal of trace contaminants, specifically phospholipids and associated metal ions, from glyceride oils. Treatment of the partially dried hydrogels with organic acid increases their adsorption capacity for these trace contaminants.
    Type: Grant
    Filed: November 24, 1986
    Date of Patent: November 14, 1989
    Assignee: W. R. Grace & Co.-Conn.
    Inventor: William A. Welsh
  • Adsorptive material for the removal of chlorophyll, color bodies and phospholipids from glyceride oils
    Patent number: 4877765
    Abstract: Acid-treated amorphous silica has superior properties for the removal of phospholipids and chlorophyll from glyceride oils. The acid-treated adsorbent comprises a high surface area amorphous silica on which is supported an acid having a pK.sub.a of about 3.5 or lower.
    Type: Grant
    Filed: May 15, 1987
    Date of Patent: October 31, 1989
    Assignee: W. R. Grace & Co.
    Inventors: James N. Pryor, James M. Bogdanor, William A. Welsh
  • Transamination process for producing amino acids
    Patent number: 4859591
    Abstract: A process is disclosed for catalyzing the transamination of an amino acid precursor to the corresponding L-amino acid by using aspartic acid as the amino donor and by adding certain multivalent metal ions, in the form of solid metal particles or pieces, to the system to catalyze the decomposition of oxalacetic acid, a by-product of the transamination.
    Type: Grant
    Filed: August 7, 1987
    Date of Patent: August 22, 1989
    Assignee: W. R. Grace & Co.-Conn.
    Inventors: James F. Walter, Martin B. Sherwin
  • Synthetic bovine parainfluenza viral proteins
    Patent number: 4847081
    Abstract: A method is disclosed for constructing a synthetic gene for the production of a viral protein or portion thereof. The method is useful for genes found on minus-strand RNA viral genomes, such as those of rhabdoviruses or paramyxoviruses. The protein or a portion thereof prepared by expression of the synthetic gene in a suitable host may be used for vaccine or diagnostic purposes.
    Type: Grant
    Filed: March 30, 1987
    Date of Patent: July 11, 1989
    Assignee: W. R. Grace & Co.-Conn.
    Inventor: John M. Rice
  • N-formylation of amino carboxylates with alkyl formates
    Patent number: 4801742
    Abstract: Formylating the amino nitrogen of an alkali metal salt of an amino carboxylic acid, by reacting the salt with an alkyl formate in an alkanol solvent. In one embodiment, the alkyl formate is added to the reaction as such; in another embodiment, the alkyl formate is formed in situ by reaction of carbon monoxide with the alkanol solvent in the presence of the alkali metal salt of the amino carboxylic acid. The process provides a new class of compounds, the alkali metal salts of N-formyl-aspartic acids.
    Type: Grant
    Filed: July 17, 1987
    Date of Patent: January 31, 1989
    Assignee: W. R. Grace & Co.-Conn.
    Inventors: Jennifer M. Quirk, Charles G. Carter, Robert J. Kupper
  • Immobilization support for biologicals
    Patent number: 4794090
    Abstract: A diagnostic assay support matrix is prepared by coating a support matrix with a polymer resistant to nonspecific protein binding and immobilizing the desired biologically active agent on the polymer surface.
    Type: Grant
    Filed: September 26, 1986
    Date of Patent: December 27, 1988
    Assignee: W. R. Grace & Co.-Conn.
    Inventors: Marc E. Parham, Julie L. Rudolph
  • N-formylation of amino carboxylic compounds with formamide
    Patent number: 4789757
    Abstract: The amine nitrogen of an amino carboxylic acid is formylated by reacting the amino carboxylic acid with formamide.
    Type: Grant
    Filed: July 17, 1987
    Date of Patent: December 6, 1988
    Assignee: W. R. Grace & Co.-Conn.
    Inventor: Charles G. Carter
  • Non-adsorptive, semipermeable filtration membrane
    Patent number: 4787976
    Abstract: Disclosed is a protein non-adsorptive semipermeable filtration membrane and a process for producing the same. Said membrane, which comprises an interpenetrating polymer network, is prepared from a casting solution comprising a prepolymer polymerizable upon contact with a coagulating liquid, a polymer that will not react readily with the prepolymer and that is substantially insoluble in said coagulating liquid, and solvent.
    Type: Grant
    Filed: April 29, 1985
    Date of Patent: November 29, 1988
    Assignee: W. R. Grace & Co.
    Inventors: Marc E. Parham, Karen E. Milligan
  • Process for the removal of chlorophyll, color bodies and phospholipids from glyceride oils using acid-treated silica adsorbents
    Patent number: 4781864
    Abstract: Phospholipids and/or chlorophyll and other color bodies are removed from glyderide oil by contacting the oil with an acid-treated amorphous silica adsorbent comprising a high surface area amorphous silica on which is supported an acid having a pK.sub.a of about 3.5 or lower.
    Type: Grant
    Filed: May 15, 1987
    Date of Patent: November 1, 1988
    Assignee: W. R. Grace & Co.-Conn.
    Inventors: James N. Pryor, James M. Bogdanor, William A. Welsh
  • Sealant compositions
    Patent number: 4780521
    Abstract: A polyurethane sealant, particularly suitable for forming the seal around a double glazing unit, is formed by reacting an isocyanate component with a reactive component that is an isoprene polymer having terminal functional groups.
    Type: Grant
    Filed: December 18, 1987
    Date of Patent: October 25, 1988
    Assignee: Teroson GmbH
    Inventors: Edward W. Duck, Ingolf Scheffler
  • Synthetic genes for bovine parainfluenza virus
    Patent number: 4743553
    Abstract: A method is disclosed for constructing a synthetic gene for the production of a viral protein or portion thereof. The method is useful for genes found on minus-strand RNA viral genomes, such as those of rhabdoviruses or paramyxoviruses. The protein or a portion thereof prepared by expression of the synthetic gene in a suitable host may be used for vaccine or diagnostic purposes.
    Type: Grant
    Filed: July 18, 1984
    Date of Patent: May 10, 1988
    Assignee: W. R. Grace & Co.
    Inventor: John M. Rice
  • Process for spray drying amino acid compositions
    Patent number: 4734401
    Abstract: A process is disclosed whereby a depyrogenated solution comprising one or more amino acids is converted to a dried, amorphous product by spray drying. The solution optionally may contain one or more additional components, such as salts, buffers, lipids, vitamins, trace elements and electrolytes. Products may be prepared according to this method which are suitable for enteral or parenteral nutritive therapeutic use.
    Type: Grant
    Filed: March 17, 1986
    Date of Patent: March 29, 1988
    Assignee: W. R. Grace & Co.
    Inventor: John J. Blouin
  • Method for refining glyceride oils using acid-treated amorphous silica
    Patent number: 4734226
    Abstract: Adsorbents comprising organic acid-treated amorphous silicas with effective average pore diameters of about 60 to about 5000 Angstroms are useful in processes for the removal of trace contaminants, specifically phospholipids and associated metal ions, from glyceride oils.
    Type: Grant
    Filed: January 28, 1986
    Date of Patent: March 29, 1988
    Assignee: W. R. Grace & Co.
    Inventors: Perry M. Parker, William A. Welsh
  • Sealant compositions and sealed double glazing units
    Patent number: 4716070
    Abstract: A polyurethane sealant, particularly suitable for forming the seal around a double glazing unit, is formed by reacting an isocyanate component with a reactive component that is an isoprene polymer having terminal functional groups.
    Type: Grant
    Filed: March 28, 1986
    Date of Patent: December 29, 1987
    Assignee: Teroson G.m.b.H.
    Inventors: Edward W. Duck, Ingolf Scheffler