Patents Represented by Attorney Jill L. Woodburn
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Patent number: 6814844Abstract: The present invention relates to a biosensor. The biosensor includes a support substate, an electrically conductive coating positioned on the support substrate, the coating being formed to define electrodes and a code pattern, wherein there is sufficient contrast between the conductive coating and the substrate such that the code pattern is discernible, and a cover cooperating with the support substrate to define a channel. At least a portion of the electrodes are positioned in the channel.Type: GrantFiled: August 29, 2001Date of Patent: November 9, 2004Assignee: Roche Diagnostics CorporationInventors: Raghbir S. Bhullar, Henning Groll, John T. Austera, Douglas P. Walling, Timothy I. Ranney, James L. Pauley, Jr.
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Patent number: 6814843Abstract: A biosensor is provided that comprises a substrate, a reagent positioned on the substrate, and a cover including a top side and a generally flat bottom side. The bottom side is coupled to the substrate to define a sealed portion and an unsealed portion. The unsealed portion cooperates with the substrate to define a channel extending across the reagent.Type: GrantFiled: November 1, 2000Date of Patent: November 9, 2004Assignee: Roche Diagnostics CorporationInventors: Raghbir S. Bhullar, Douglas P. Walling, Brian S. Hill
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Patent number: 6767440Abstract: A biosensor is provided in accordance with the present invention. The biosensor includes an electrode support substrate, electrodes positioned on the electrode support substrate, a sensor support substrate coupled to the electrode support substrate, and electrically conductive tracks positioned on the sensor support substrate. Each track is in electrical communication with one of the electrodes.Type: GrantFiled: April 24, 2001Date of Patent: July 27, 2004Assignee: Roche Diagnostics CorporationInventors: Raghbir S. Bhullar, John T. Austera, Brian S. Hill, Christopher D. Wilsey
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Patent number: 6755949Abstract: A biosensor is provided in accordance with the present invention. The biosensor includes a substrate and a cover extending across at least a portion of the substrate. The cover includes a first surface facing the substrate and a second surface. At least a portion of the first surface is removed to define a capillary channel. The capillary channel has a surface energy ranging from about 60 mN/m to about 72 mN/m.Type: GrantFiled: October 9, 2001Date of Patent: June 29, 2004Assignee: Roche Diagnostics CorporationInventors: Raghbir S. Bhullar, Christopher D. Wilsey, John T. Austera
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Patent number: 6696024Abstract: The invention concerns a device for the capillary transport of a liquid between two opposite, essentially planar layers, in which the two layers are arranged parallel to one another at such a distance that there is a capillary-active gap between the two layers, wherein at least one of the two layers contains at least two discrete adjacent parts and capillary-active transport of the liquid is possible beyond the common boundary of the parts that lie in one layer.Type: GrantFiled: September 21, 2000Date of Patent: February 24, 2004Assignee: Roche Diagnostics GmbHInventors: Wilhelm Leichner, Wolfgang Schwobel, Volker Zimmer
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Patent number: 6679852Abstract: System for withdrawing body fluid from a body part in particular the finger pad, comprising a compression unit that can be deformed when the body part is pressed against it and increases the internal pressure in a region of the body part, and a withdrawal device. Deformation of the compression unit partially converts the primary pressing movement into a secondary movement which leads to an increase in the internal pressure in a region of the body part. The invention also comprises a system for stimulating the outflow of body fluid using a deformable compression unit.Type: GrantFiled: July 12, 2000Date of Patent: January 20, 2004Assignee: Roche Diagnostics CorporationInventors: Guenther Schmelzeisen-Redeker, Frank Deck, Richard Forster, Thomas Weiss
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Patent number: 6669910Abstract: System and process for isolating purified biological materials with a collecting unit which has collecting vessels that are accessible from above with a matrix unit in which matrix vessels are arranged in a holder as well as a closure unit which can be placed on the collecting unit to close the collecting vessel. In addition the invention also concerns a system having a collecting unit, a matrix unit, and a closure unit as well as a lysis unit and a waste unit. Moreover a new closure arrangement is disclosed which is suitable for closing vessels in which there is excess pressure.Type: GrantFiled: October 2, 2000Date of Patent: December 30, 2003Assignee: Roche Diagnostics GmbHInventors: Gerhard Bienhaus, Michael Fritz, Jurgen Schwab, Thomas Walter
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Patent number: 6662439Abstract: A method of making a patterned laminate includes ablating through a portion of a metallic layer with a laser, to form a pattern in the metallic layer, where the metallic layer is on and in contact with an insulating substrate. The patterned laminate may be patterned to form electrodes, and can be formed into an electrochemical sensor strip.Type: GrantFiled: October 4, 1999Date of Patent: December 16, 2003Assignee: Roche Diagnostics CorporationInventor: Raghbir Singh Bhullar
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Patent number: 6659966Abstract: A fluid sampling apparatus is provided that in accordance with the present invention. The apparatus includes a housing defining a chamber, a lancet positioned in the chamber and including an end formed to create a fluid collection incision, and a light source positioned in the chamber. The light source is formed to emit a light beam of a pre-determined wavelength and for a time sufficient to seal the incision.Type: GrantFiled: November 15, 2001Date of Patent: December 9, 2003Assignee: Roche Diagnostics CorporationInventor: Matthias Essenpreis
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Patent number: 6645359Abstract: A biosensor is provided that comprises a plate element with a pre-determined reaction zone and a recess positioned adjacent to the reaction zone. The biosensor also comprises a reagent that is positioned on the reaction zone. In preferred embodiments, the recess circumscribes at least a portion of the reaction zone.Type: GrantFiled: October 6, 2000Date of Patent: November 11, 2003Assignee: Roche Diagnostics CorporationInventors: Raghbir S. Bhullar, Christopher D. Wilsey, Brian S. Hill
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Patent number: 6630350Abstract: The invention concerns monoclonal antibodies against a complex of human ACT and a serine protease, preferably against a ACT-PSA, which have essentially no cross-reactivity with free, non-complexed human ACT and with free, non-complexed PSA, as well as diagnostic test methods for detecting serine protease-ACT complexes, in particular PSA-ACT, using these monoclonal antibodies.Type: GrantFiled: September 3, 1999Date of Patent: October 7, 2003Assignee: Roche Diagnostics GmbHInventors: Christa Hubner-Parajsz, Hartmut Schetters, Rosemarie Kientsch-Engel, Thomas Meier, Martin Kaufmann, Andreas Gallusser, Rolf Deeg
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Patent number: 6613570Abstract: An aqueous control liquid is provided that contains glucose at a known concentration and cyclodextrin. A method is also provided that binds a wetting agent from a region of a test element that comes into contact with a sample. The method includes contacting the region with a control liquid that has a substance selected from the group of cyclodextrin derivatives and dispersed materials having a specific surface of 100 m2/g to over 1000 m2/g. A method for controlling the function of a measuring system having test strips and a measuring instrument for the determination of glucose in liquid samples is provided that includes contacting the test strip with a control liquid containing glucose at a known concentration and at least one substance selected from the group consisting of cyclodextrins and cyclodextrin derivatives and detecting a signal caused by the glucose contained in the control liquid.Type: GrantFiled: June 29, 2001Date of Patent: September 2, 2003Assignee: Roche Diagnostics CorporationInventors: Wolfgang-Reinhold Knappe, Otto Gaa, Volker Zimmer, Joachim Hoenes, Bernd Hiller, Franz Wittmann, Beate Koschorreck
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Patent number: 6602268Abstract: Blood lancet system for blood withdrawal for diagnostic purposes with a housing, a lancet holder movable in the housing for holding an exchangeable lancet, and a lancet drive for driving the pricking movement of the lancet holder with the lancet contained herein. The housing has a cap at the front end in pricking direction which can be removed in order to remove a used lancet from the lancet holder. The lancet and the housing cap are coupled, during the attachment of the housing cap, by a coupling mechanism comprising coupling elements matched to each other and enabling the extraction of the lancet from the lancet holder simultaneously with removing the housing cap.Type: GrantFiled: June 19, 2001Date of Patent: August 5, 2003Assignee: Roche Diagnostics CorporationInventors: Hans-Jurgen Kuhr, Richard Forster
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Patent number: 6592815Abstract: The invention concerns an analytical test element for the determination of an analyte in a liquid containing a detection element and a channel capable of capillary liquid transport which has a sample application opening at one end of the channel capable of capillary liquid transport, wherein the channel capable of capillary liquid transport is continuously narrowed from the sample application opening in the direction of capillary transport at least up to the beginning of the detection element. In addition it also concerns the use of the said analytical test element for the determination of an analyte in a liquid as well as a method for determining an analyte in a liquid sample with the aid of the said analytical test element.Type: GrantFiled: May 19, 2000Date of Patent: July 15, 2003Assignee: Roche Diagnostics GmbHInventor: Volker Zimmer
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Patent number: 6589260Abstract: System for withdrawing body fluid from a body part in particular the finger pad, comprising a compression unit that is deformed when the body part is pressed against it and increases the internal pressure in a region of the body part, and a withdrawal device. Deformation of the compression unit partially converts the primary pressing movement into a secondary movement which leads to an increase in the internal pressure in a region of the body part. The invention also comprises a system for stimulating the outflow of body fluid using a deformable compression unit.Type: GrantFiled: July 12, 2000Date of Patent: July 8, 2003Assignee: Roche Diagnostics CorporationInventors: Guenther Schmelzeisen-Redeker, Thomas Weiss, Frank Deck, Klaus Peter Ebert
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Patent number: 6591126Abstract: The invention concerns a microdialysis system comprising a microdialysis probe (12) that can be inserted into organic tissue (10) and has a dialysis membrane (28) to separate a probe channel (18) filled with perfusion fluid from the tissue (10), a sensor cell (14) to determine the concentration of components and especially glucose in the perfusion fluid that is conveyed from the microdialysis probe (12) and a transport device (16) to convey the perfusion fluid through the probe channel (18) of the microdialysis probe (12) to the sensor cell (14).Type: GrantFiled: July 20, 2001Date of Patent: July 8, 2003Assignee: Roche Diagnostics CorporationInventors: Josef Roeper, Michael Schoemaker, Christian Hoerauf
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Patent number: 6584335Abstract: Analysis device for determining an analyte in vivo in the body of a patient, having a measuring probe with a hollow needle (18) which can pierce through the skin. Light is passed through the hollow needle (18) and into the body via an optical fiber (22) travelling in the hollow needle (18). The light transported in the optical fiber (22) is modified in the measuring probe (3), the modification being characteristic of the presence of the analyte. A measurement and evaluation unit (4) measures the change to extract information concerning the presence of the analyte in the body.Type: GrantFiled: May 8, 2000Date of Patent: June 24, 2003Assignee: Roche Diagnostics GmbHInventors: Hans-Peter Haar, Gerhard Werner, Dirk Boecker, Armin Lambrecht, Joachim Kastner
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Patent number: 6572566Abstract: The present invention concerns a system for determining the concentration of at least one analyte in a body fluid. The system has a first member and at least a second member of which at least one has a recess on its surface and the members are joined together in such a manner that the recess is closed by a surface of the other member to form a channel. The first and/or second member is composed at least partially of a membrane which is located either in the region of the recess or on the part of the other member that is opposite to the recess such that substances can be taken up from the surrounding fluid by means of the membrane. The system additionally has a sensor which can be used to determine the concentration of an analyte in the channel. Furthermore the system has at least one integrated reservoir which is connected to the channel.Type: GrantFiled: February 27, 2001Date of Patent: June 3, 2003Assignee: Roche Diagnostics CorporationInventor: Carlo Effenhauser
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Patent number: 6544212Abstract: A system is provided that enables glycemic control for a subject. The system includes an insulin delivery unit, a glucose sensor, and a control unit. The control unit includes a processor unit that receives glucose value readings from the glucose sensor, executes an algorithm that predicts a glucose value at a predetermined time in the future, compares that predicted glucose value to a pre-determined glucose value range, and determines a corrective amount of insulin to be administered when the predictive glucose value lies outside of the predetermined glucose value range. The control unit also includes a communication unit that transmits the corrective amount to the delivery unit.Type: GrantFiled: July 31, 2001Date of Patent: April 8, 2003Assignee: Roche Diagnostics CorporationInventors: Paul J. Galley, Ajay Thukral, Siva K. Chittajallu, Stefan Weinert
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Patent number: D487594Type: GrantFiled: October 30, 2000Date of Patent: March 16, 2004Assignee: Roche Diagnostics CorporationInventors: Hartmut Alscher, Joachim Kohl, Klaus-Dieter Sacherer