Patents Represented by Attorney Joan Thierstein

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  • Novel N.sup.6 -substituted-5'-oxidized adenosine analogs
    Patent number: 4738954
    Abstract: Novel N.sup.6 -substituted-5'-oxidized adenosine analogs, and pharmaceutical compositions, methods of use or processes to make therefore. The novel adenosines have utility for the treatment of hypertension, coronary insufficiency, psychosis, pain, angina, and heart failure.
    Type: Grant
    Filed: November 6, 1985
    Date of Patent: April 19, 1988
    Assignee: Warner-Lambert Company
    Inventors: Harriet W. Hamilton, William C. Patt
  • 2-(2-aryl-2-oxoalkylidene) analogs of-3,5-pyridinedicarboxylic acid dialkyl esters useful for treatment of cardiovascular disorders
    Patent number: 4732898
    Abstract: The present invention are 2-(2-aryl-2-oxo-alkylidene) analogs of 1,2,3,4-tetrahydropyridine-3,5-pyridinecarboxylic acids and particularly esters thereof having valuable calcium antagonist and positive inotropic activity useful in the treatment of cardiovascular disorders, pharmaceutical compositions and methods of use therefor.
    Type: Grant
    Filed: March 3, 1987
    Date of Patent: March 22, 1988
    Assignee: Warner-Lambert Company
    Inventors: Edward W. Badger, Michael D. Taylor
  • Process for the preparation of 2-substituted-1,4-dihydropyridines
    Patent number: 4723014
    Abstract: The present invention provides a process for preparing a 2-substituted-1,4-dihydropyridine by providing a regiospecific bromine containing intermediate which is then reacted with a nucleophile to provide a wide range of substituents at the 2-position of 1,4-dihydropyridines. Also the present invention is novel 3-substituted-1,4-dihydropyridines having cardiovascular activity.
    Type: Grant
    Filed: November 19, 1986
    Date of Patent: February 2, 1988
    Assignee: Warner-Lambert Company
    Inventors: Kevin R. Anderson, Ila Sircar
  • Benzoic acid and benzoic acid ester derivatives to treat inflammation
    Patent number: 4719234
    Abstract: Novel benzoic acid or benzoic acid ester derivatives, pharmaceutical compositions and methods of use thereof are the present invention. Utility is for the treatment of arthritis, asthma, Raynaud's disease, inflammatory bowel disorders, trigeminal or herpetic neuralgia, inflammatory eye disorders, psoriasis, dental pain, and headaches, particularly vascular headache, such as a migraine, cluster, mixed vascular syndromes, as well as nonvascular, tension headaches.
    Type: Grant
    Filed: November 10, 1986
    Date of Patent: January 12, 1988
    Assignee: Warner-Lambert Company
    Inventors: Michael F. Rafferty, Graham Johnson
  • Benzoic acid and benzoic acid ester derivatives to treat headaches
    Patent number: 4719232
    Abstract: Novel benzoic acid or benzoic acid ester derivatives, pharmaceutical compositions and methods of use thereof are the present invention. Utility is for the treatment of arthritis, asthma, Raynaud's disease, inflammatory bowel disorders, trigeminal or herpetic neuralgia, inflammatory eye disorders, psoriasis, dental pain, and headaches, particularly vascular headache, such as migraine, cluster, mixed vascular syndromes, as well as nonvascular, tension headaches.
    Type: Grant
    Filed: November 10, 1986
    Date of Patent: January 12, 1988
    Assignee: Warner-Lambert Company
    Inventors: Michael F. Rafferty, Graham Johnson
  • Benzoic acid and benzoic acid ester derivatives to treat pain
    Patent number: 4719233
    Abstract: Novel benzoic acid or benzoic acid ester derivatives, pharmaceutical compositions and methods of use thereof are the present invention. Utility is for the treatment of arthritis, asthma, Raynaud's disease, inflammatory bowel disorders, trigeminal or herpetic neuralgia, inflammatory eye disorders, psoriasis, dental pain, and headaches, particularly vascular headache, such as migraine, cluster, mixed vascular syndromes, as well as nonvascular, tension headaches.
    Type: Grant
    Filed: November 10, 1986
    Date of Patent: January 12, 1988
    Assignee: Warner-Lambert Company
    Inventors: Michael F. Rafferty, Graham Johnson
  • Benzothiophenes and benzofurans and antiallergic use thereof
    Patent number: 4703053
    Abstract: Novel benzothiophene and benzofuran derivatives having antiallergic activity are described as well as a method of manufacture, pharmaceutical compositions, and methods of use therefor. The disclosure describes the use of derivatives for prevention of the release of mediators including histamine and leukotrienes from basophils and mast cells, and prevent respiratory burst in neutrophils providing activity useful in cardiovascular disorders as well as in antiinflammatory, psoriasis, and antimigraine treatment.
    Type: Grant
    Filed: October 28, 1985
    Date of Patent: October 27, 1987
    Assignee: Warner-Lambert Company
    Inventors: David T. Connor, Wiaczeslaw A. Cetenko, Paul C. Unangst, Elizabeth A. Johnson
  • Aminoalkoxybenzopyranones as antipsychotic and anxiolytic agents
    Patent number: 4701456
    Abstract: Aminoalkyoxybenzopyranones of the formula ##STR1## wherein R.sub.1 is of the formula ##STR2## are described as well as methods of preparation, pharmaceutical compositions and methods for treating anxiety and psychoses such as schizophrenia therewith.
    Type: Grant
    Filed: June 18, 1985
    Date of Patent: October 20, 1987
    Assignee: Warner-Lambert Company
    Inventors: Horace A. Dewald, Lawrence D. Wise, Thomas G. Heffner
  • Processes for the preparation of spectinomycin analogs, novel products and intermediates therein
    Patent number: 4698436
    Abstract: The present invention relates to novel methods of preparing a wide variety of spectinomycin analogs and biologically acceptable salts thereof. Further, the invention relates both to novel intermediates and novel products therein. The novel products are spectinomycin analogs which can be used for the same biological purposes as spectinomycin. The processes of the invention provide for novel intermediates that are versatile and highly reactive exocyclic enones.
    Type: Grant
    Filed: March 12, 1984
    Date of Patent: October 6, 1987
    Assignee: The Upjohn Company
    Inventors: David R. White, Clarence J. Maring
  • Method for using diltiazem for treating stroke
    Patent number: 4696924
    Abstract: The present invention is a method of use for the treatment of stroke with one of diltiazem, verapamil, or nifedipine.
    Type: Grant
    Filed: August 6, 1986
    Date of Patent: September 29, 1987
    Assignee: Warner-Lambert Company
    Inventor: Frank W. Marcoux
  • Method for using nifedipine for treating stroke
    Patent number: 4696934
    Abstract: The present invention is a method of use for the treatment of stroke with one of diltiazem, verapamil, or nifedipine.
    Type: Grant
    Filed: August 6, 1986
    Date of Patent: September 29, 1987
    Assignee: Warner-Lambert Company
    Inventor: Frank W. Marcoux
  • Method of treating heart failure and medicaments therefor
    Patent number: 4693996
    Abstract: The present invention relates to a combination of selected cardiotonic agents with selected adenosine receptor agonist antihypertensive agents resulting in a synergistic increase in myocardial contractility and cardiac output thereby rendering such combinations useful in treating heart failure.
    Type: Grant
    Filed: December 23, 1985
    Date of Patent: September 15, 1987
    Assignee: Warner-Lambert Company
    Inventor: Robert P. Steffen
  • Benzoic acid and benzoic acid ester derivatives having anti-inflammatory and analgesic activity
    Patent number: 4689182
    Abstract: Novel benzoic acid or benzoic acid ester derivatives, pharmaceutical compositions and methods of use thereof are the present invention. Utility is for the treatment of arthritis, asthma, Raynaud's disease, inflammatory bowel disorders, trigeminal or herpetic neuralgia, inflammatory eye disorders, psoriasis, dental pain, and headaches, particularly vascular headache, such as migraine, cluster, mixed vascular syndromes, as well as nonvascular, tension headaches.
    Type: Grant
    Filed: December 20, 1985
    Date of Patent: August 25, 1987
    Assignee: Warner-Lambert Company
    Inventors: Michael F. Rafferty, Graham Johnson
  • N.sub.6 -Benzopyrano-and benzothiopyrano adenosines and methods of use
    Patent number: 4683223
    Abstract: N.sup.6 -Benzopyrano- and benzothiopyranoadenosines and pharmaceutically acceptable acid addition salts having highly desirable central nervous system antiinflammatory and antihypertensive properties, processes for their manufacture and pharmaceutical compositions and methods for using said compounds and compositions are described.
    Type: Grant
    Filed: September 9, 1985
    Date of Patent: July 28, 1987
    Assignee: Warner-Lambert Company
    Inventor: Bharat K. Trivedi
  • 2-alkylidene derivatives of 1,2,3,4-tetrahydropyridine-2,5-pyridine carboxylic acid dialkyl esters useful for treatment of cardiovascular disorders
    Patent number: 4678796
    Abstract: Novel 2-(2-alkoxy-2-oxoethylidene)-1,2,3,4-tetrahydro-6-methyl-4-[2-(substituted )phenyl]-3,5-pyridinedicarboxylic acid dialkyl ester derivatives having novel inotropic and hypotensive activity, processes for their manufacture, pharmaceutical compositions, and methods for using said compounds and compositions are described.
    Type: Grant
    Filed: September 3, 1986
    Date of Patent: July 7, 1987
    Assignee: Warner-Lambert Company
    Inventors: Michael D. Taylor, Edward W. Badger
  • 4H-1-benzopyran-4-ones and their sulfur containing analogs
    Patent number: 4678787
    Abstract: Novel 4H-1-benzopyran-4-ones and their sulfur containing analogs are disclosed which are efficacious for the treatment of psychosis including schizophrenia.
    Type: Grant
    Filed: November 22, 1985
    Date of Patent: July 7, 1987
    Assignee: Warner-Lambert Company
    Inventors: Juan C. Jaen, Lawrence D. Wise
  • Acidic tetrazolyl substituted indole compounds and their use as antiallergy agents
    Patent number: 4675332
    Abstract: Novel acidic indole compounds having use as antiallergic agents, methods of synthesis, compositions, and uses are claimed.
    Type: Grant
    Filed: October 21, 1985
    Date of Patent: June 23, 1987
    Assignee: Warner-Lambert Company
    Inventors: David T. Connor, Paul C. Unangst, S. Russell Stabler
  • 5-Substituted pyrazolo[4,3-d]pyrimidine-7-ones and methods of use
    Patent number: 4666908
    Abstract: The present invention relates to novel 5-substituted pyrazolo[4,3-d]pyrimidine-7-one compounds, and compositions, methods of use and processes to make therefor. The novel compounds are useful in the treatment of cardiovascular disorders, such as heart failure or cardiac insufficiency. The novel compounds bind adenosine receptors and selectively inhibit phosphodiesterase.
    Type: Grant
    Filed: April 5, 1985
    Date of Patent: May 19, 1987
    Assignee: Warner-Lambert Company
    Inventor: Harriet W. Hamilton
  • Method for treating rejection of organ or skin grafts with 6-aryl pyrimidine compounds
    Patent number: 4665077
    Abstract: A method for treating rejection of organ or skin grafts in humans and animals by administering 2-amino-6-aryl-5-substituted pyrimidines.
    Type: Grant
    Filed: July 12, 1984
    Date of Patent: May 12, 1987
    Assignee: The Upjohn Company
    Inventors: Dale A. Stringfellow, Patricia E. Fast
  • N.sup.6 -tricyclic adenosines for treating hypertension
    Patent number: 4663313
    Abstract: N.sup.6 -Tricyclic adenosines and pharmaceutically acceptable acid addition salts having highly desirable central nervous system and cardiovascular properties, processes for their manufacture and pharmaceutical composition and methods for using said compounds and compositions are described.
    Type: Grant
    Filed: February 3, 1986
    Date of Patent: May 5, 1987
    Assignee: Warner-Lambert Company
    Inventors: James A. Bristol, Walter Moos, Bharat K. Trivedi