Patents Represented by Attorney Joan Thierstein

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  • Purine derivatives
    Patent number: 4921859
    Abstract: Novel purine derivatives are described as agents for treating autoimmune diseases as well as a method of manufacture and pharmaceutical compositions as well as novel intermediates in the manufacture thereof.
    Type: Grant
    Filed: September 29, 1988
    Date of Patent: May 1, 1990
    Assignee: Warner-Lambert Company
    Inventors: Jagadish C. Sircar, Charles F. Schwender, Mark J. Suto
  • 7-deazaguanines as immunomodulators
    Patent number: 4921858
    Abstract: The present invention is various 7-deazaguanines having activity as immunomodulators. Also included are pharmaceutical compositions and methods of use thereof.
    Type: Grant
    Filed: March 13, 1989
    Date of Patent: May 1, 1990
    Assignee: Warner-Lambert Company
    Inventors: Thomas C. Malone, Jagadish C. Sircar
  • Enolamides, pharmaceutical compositions and methods of use thereof for treating inflammation
    Patent number: 4921871
    Abstract: The present invention relates to novel enolamide type compounds, pharmaceutical compositions, and methods of use thereof, useful in the treatment of diseases in which products of lipoxygenase enzyme activity or the action of leukotrienes contribute to the pathological condition.
    Type: Grant
    Filed: November 16, 1987
    Date of Patent: May 1, 1990
    Assignee: Warner-Lambert Company
    Inventors: Mary E. Carethers, Wiaczeslaw A. Cetenko, David T. Connor, Elizabeth A. Johnson, John S. Kiely, Charles F. Schwender, Jagadish C. Sircar, Roderick J. Sorenson, Paul C. Unangst, Robert F. Bruns
  • Glycerine derivatives
    Patent number: 4918219
    Abstract: Novel purine derivatives are described as agents for treating autoimmune diseases as well as a method of manufacture and pharmaceutical compositions as well as novel intermediates in the manufacture thereof.
    Type: Grant
    Filed: September 29, 1989
    Date of Patent: April 17, 1990
    Assignee: Warner-Lambert Company
    Inventors: Jagadish C. Sircar, Charles F. Schwender, Mark J. Suto
  • Various N-substituted 3-piperidine carboxylic acids or N-substituted 3-pyridinecarboxylic acids and derivatives thereof
    Patent number: 4910312
    Abstract: Selected analogs of nipecotic acid are the novel compounds of the present invention. The analogs are GABA uptake inhibitors for use to treat epilepsy and, thus, the invention is also pharmaceutical compositions and methods of use therefor.
    Type: Grant
    Filed: June 16, 1988
    Date of Patent: March 20, 1990
    Assignee: Warner-Lambert Company
    Inventor: Michael R. Pavia
  • Benzofurans and benzothiophenes having antiallergic activity and method of use thereof
    Patent number: 4910317
    Abstract: Novel benzothiophenes having antiallergic activity and both novel and other selected benzothiophenes having activity for treating acute respiratory distress syndrome. The benzothiophenes of the present invention are particularly 2-tetrazolylcarboxamides of the benzothiophenes.
    Type: Grant
    Filed: June 27, 1988
    Date of Patent: March 20, 1990
    Assignee: Warner-Lambert Company
    Inventors: David T. Connor, Michael D. Mullican, Roderick J. Sorenson, David O. Thueson
  • Process of preparing pyrazoles, isoxazoles and analogs thereof having activity as 5-lipoxygenase inhibitors
    Patent number: 4877881
    Abstract: The present invention is 3,5-substituted, isoxazoles, pyrazoles, isothiazoles, and analogs thereof having 5-lipoxygenase or cyclooxygenase inhibiting activity or as a sunscreen.
    Type: Grant
    Filed: September 21, 1988
    Date of Patent: October 31, 1989
    Assignee: Warner-Lambert Company
    Inventors: Thomas R Belliotti, David T. Connor, Daniel L. Flynn, Catherine R. Kostlan, Donald E. Nies
  • Novel enolamides, pharmaceutical compositions and methods of use thereof for activity as modulators of the arachidonic acid cascade
    Patent number: 4874758
    Abstract: The present invention relates to novel enolamide type compounds, pharmaceutical compositions, and method of use thereof, useful in the treatment of diseases in which products of lipoxygenase enzyme activity or the action of leukotrienes contribute to the pathological condition.
    Type: Grant
    Filed: March 4, 1988
    Date of Patent: October 17, 1989
    Assignee: Warner-Lambert Company
    Inventors: Mary E. Carethers, Wiaczeslaw A. Centenko, David T. Connor, Elizabeth A. Johnson, John S. Kiely, Charles F. Schwender, Jagadish C. Sircar, Roderick J. Sorenson, Paul C. Unangst, Robert F. Bruns
  • Process for preparing guanine derivatives
    Patent number: 4874862
    Abstract: Novel guanine derivatives are described as agents for treating autoimmune diseases as well as a method of manufacture and pharmaceutical compositions thereof.
    Type: Grant
    Filed: October 14, 1987
    Date of Patent: October 17, 1989
    Assignee: Warner-Lambert Company
    Inventors: Jagadish C. Sircar, Catherine R. Brungardt, Charles F. Schwender
  • Novel enolamides, pharmaceutical compositions and methods of use thereof for activity as modulators of the arachidonic acid cascade
    Patent number: 4868200
    Abstract: The present invention relates to novel enolamide type compounds, pharmaceutical compositions, and methods of use thereof, useful in the treatment of diseases in which products of lipoxygenase enzyme activity or the action of leukotrienes contribute to the pathological condition.
    Type: Grant
    Filed: March 9, 1988
    Date of Patent: September 19, 1989
    Assignee: Warner-Lambert Company
    Inventors: Mary E. Carethers, Wiaczeslaw A. Cetenko, David T. Connor, Elizabeth A. Johnson, John S. Kiely, Charles F. Schwender, Jagadish C. Sircar, Roderick J. Sorenson, Paul C. Unangst, Robert F. Bruns
  • Novel enolamides, pharmaceutical compositions and methods of use thereof for activity as modulators of the arachidonic acid cascade
    Patent number: 4868199
    Abstract: The present invention relates to novel enolamide type compounds, pharmaceutical compositions, and methods of use thereof, useful in the treatment of diseases in which products of lipoxygenase enzyme activity or the action of leukotrienes contribute to the pathological condition.
    Type: Grant
    Filed: March 9, 1988
    Date of Patent: September 19, 1989
    Assignee: Warner-Lambert Company
    Inventors: Mary E. Carethers, Wiaczeslaw A. Cetenko, David T. Connor, Elizabeth A. Johnson, John S. Kiely, Charles F. Schwender, Jagadish C. Sircar, Roderick J. Sorenson, Paul C. Unangst, Robert F. Bruns
  • Novel enolamides, pharmaceutical compositions and methods of use thereof for activity as modulators of the arachidonic acid cascade
    Patent number: 4868195
    Abstract: The present invention relates to novel enolamide type compounds, pharmaceutical compositions, and methods of use thereof, useful in the treatment of diseases in which products of lipoxygenase enzyme activity or the action of leukotrienes contribute to the pathological condition.
    Type: Grant
    Filed: March 7, 1988
    Date of Patent: September 19, 1989
    Assignee: Warner-Lambert Company
    Inventors: Mary E. Carethers, Wiaczeslaw A. Cetenko, David T. Connor, Elizabeth A. Johnson, John S. Kiely, Charles F. Schwender, Jagadish C. Sircar, Roderick J. Sorenson, Paul C. Unangst, Robert F. Bruns
  • Novel enolamides, pharmaceutical compositions and methods of use thereof for activity as modulators of the arachidonic acid cascade
    Patent number: 4868205
    Abstract: The present invention relates to novel enolamide type compounds, pharmaceutical compositions, and methods of use thereof, useful in the treatment of diseases in which products of lipoxygenase enzyme activity or the action of leukotrienes contribute to the pathological condition.
    Type: Grant
    Filed: March 11, 1988
    Date of Patent: September 19, 1989
    Assignee: Warner-Lambert Company
    Inventors: Mary E. Carethers, Wiaczeslaw A. Cetenko, David T. Connor, Elizabeth A. Johnson, John S. Kiely, Charles F. Schwender, Jagadish C. Sircar, Roderick J. Sorenson, Paul C. Unangst, Robert F. Bruns
  • Method of treating psychosis using N.sup.6 -substituted -5'-oxidized adenosine analogs
    Patent number: 4868160
    Abstract: Novel N.sup.6 -substituted-5'-oxidized adenosine analogs, and pharmaceutical compositions, methods of use or processes to make therefor. The novel adenosines have utility for the treatment of hypertension, coronary insufficiency, psychosis, pain, angina, and heart failure.
    Type: Grant
    Filed: December 31, 1987
    Date of Patent: September 19, 1989
    Assignee: Warner-Lambert Company
    Inventors: Harriet W. Hamilton, William C. Patt
  • 6-substituted-2(1H)-quinolinones and related compounds having use as cardiotonic, antihypertensive, and antithrombotic agents
    Patent number: 4840955
    Abstract: Novel 6-substituted-2(1H)-quinoline and related compounds having usefulness as cardiotonic, antihypertensive, and antithrombotic (platelet aggregation inhibition) agents.
    Type: Grant
    Filed: August 20, 1987
    Date of Patent: June 20, 1989
    Assignee: Warner-Lambert Company
    Inventor: Ila Sircar
  • Diastereoisomers of n.sup.6 -endo-bicyclo[2.2.1]heptyladenosine as antihypertensives with selective action
    Patent number: 4837207
    Abstract: (1R-endo) or (1S-endo)-N-bicyclo[2.2.1]heptyl adenosine and pharmaceutically acceptable acid addition salts having highly desirable antihypertensive properties and unexpected A.sub.1 and A.sub.2 receptor binding activity, processes for their manufacture and pharmaceutical compositions and methods for using said compounds and compositions.
    Type: Grant
    Filed: May 13, 1987
    Date of Patent: June 6, 1989
    Assignee: Warner-Lambert Company
    Inventor: Bharat K. Trivedi
  • Process for the preparation of n-1H-tetrazol-5-yl-2-pyrrole carboxamides
    Patent number: 4824958
    Abstract: The present invention is for compounds having the formula of N-1H-tetrazol-5-yl-2-thiophenecarboxamides, N-1H-tetrazol-5-yl-2-pyrrolecarboxamides, N-1H-tetrazol-5-yl-2-furancarboxamides or analogs of each of the carboxamides. The compounds are useful for the treatment of allergic or inflammatory conditions or diseases. Thus, pharmaceutical compositions and methods of use are also the invention. Processes of preparation for the compounds are also the invention.
    Type: Grant
    Filed: February 16, 1988
    Date of Patent: April 25, 1989
    Assignee: Warner-Lambert Company
    Inventors: Wiaczeslaw A. Cetenko, David T. Connor, Michael D. Mullican, Roderick J. Sorenson
  • 2-substituted-1,4-dihydropyridines
    Patent number: 4820842
    Abstract: The present invention provides a process for preparing a 5-cyano-2-substituted-1,4-dihydropyridine compound having cardiovascular activity.
    Type: Grant
    Filed: September 11, 1987
    Date of Patent: April 11, 1989
    Assignee: Warner-Lambert Company
    Inventors: Kevin R. Anderson, Ila Sircar
  • 4,5-dihydro-4,4-dialkyl-6-(substituted)phenyl-3(2H)-pyridazinones useful as cardiotonic agents
    Patent number: 4820697
    Abstract: Novel 4,5-dihydro-4,4-dialkyl-6-(substituted)phenyl-3(2H)-pyridazinones having unexpected activity for use as cardiotonic and antihypertensive agents.
    Type: Grant
    Filed: November 10, 1986
    Date of Patent: April 11, 1989
    Assignee: Warner-Lambert Company
    Inventors: Ila Sircar, James A. Bristol, Richard W. Skeean
  • Substituted diimidazo [1,5-a: 4',5'-d]pyridines having antihypertensive activity
    Patent number: 4816463
    Abstract: This invention relates to novel substituted derivatives of diimidazo[1,5-a:4',5'-d]pyridines and analogs thereof, which are useful for the treatment of hypertension, as well as, novel pharmaceutical compositions, methods of use, and as intermediates for preparing novel substituted derivatives of 4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine-6-carboxylic acid and analogs thereof having antihypertensive activity.
    Type: Grant
    Filed: April 7, 1987
    Date of Patent: March 28, 1989
    Assignee: Warner-Lambert Company
    Inventors: C. John Blankley, John C. Hodges, John S. Kiely, Sylvester R. Klutchko