Abstract: The present invention provides a method of inhibiting gastric acid secretion in mammals by administering a 5-HT1A agonist compound or a pharmaceutically acceptable salt thereof.
Abstract: The invention relates to 1,2,3,4,5,6-hexahydrobenzo[f]quinolin-3-ones, pharmaceutical formulations containing those compounds, and their use as steroid 5.alpha.-reductase inhibitors.
Abstract: This invention relates to N-[2-amino-4-substituted-[[(pyrrolo or pyrido) [2,3-d]pyrimidinyl]-alkyl]benzoyl]-L-glutamic acid compounds, intermediates for their synthesis, pharmaceutical formulations containing those compounds, and their use as antineoplastic agents.
Abstract: A pharmaceutical compound of the formula ##STR1## in which A is selected from --NHCOR.sup.1, --NHCOOR.sup.1, --NHCONHR.sup.1, --NHCSNHR.sup.1, --CONHR.sup.1, where R.sup.1 is optionally halo-substituted C.sub.1-10 alkyl, C.sub.2-10 alkenyl, C.sub.3-7 cycloalkyl-C.sub.1-4 alkyl or phenyl-C.sub.1-4 alkyl B is optionally substituted phenyl, and --X--Y-- is --CH=CH-- or --CH.sub.2 --CH.sub.2 --; and salts thereof. The compounds are leukotriene antagonists.
Abstract: This invention provides benzene derivatives which are leukotriene antagonists, formulations of those derivatives, intermediates for preparing the derivatives, and a method of using those derivatives for the treatment of conditions characterized by an excessive release of leukotrienes.
Abstract: The present invention provides a method of inhibiting gastric acid secretion in mammals by administering a 5-HT1A agonist compound or a pharmaceutically acceptable salt thereof.
Abstract: A pharmaceutical compound of the formula ##STR1## in which R.sup.1 is halo-C.sub.1-10 alkyl, C.sub.1-10 alkylthio, halo-C.sub.1-10 alkylthio or optionally substituted phenylthio, R.sup.2 is hydrogen or C.sub.1-4 alkyl, R.sup.3 and R.sup.4 are each hydrogen or C.sub.1-4 alkyl, and X is oxygen or sulphur; and salts thereof.
Abstract: Excitatory amino acid receptor antagonists and methods for the use thereof are disclosed. The antagonists include compounds having the preferred formula: ##STR1## in which: each of A.sub.1, A.sub.2 and A.sub.3 is independently either C or N, except that at least one of A.sub.1, A.sub.2 and A.sub.3 is N; one of A.sub.4 and A.sub.5 is C and the other is N; each R.sub.1 and R.sub.2 is independently hydrogen, halogen, CN, NO.sub.2, alkyl, aromatic, azido or CF.sub.3 ; and R.sub.3 is hydrogen, alkyl, aromatic or CF.sub.3. Also included are the tautomers thereof, and the pharmaceutically acceptable salts of (III) and (IV) and the tautomers thereof. These compounds are useful as EAA antagonists for blocking one or more EAA receptors, as neurological disorders associated with EAA receptors.
Type:
Grant
Filed:
June 5, 1991
Date of Patent:
October 6, 1992
Assignee:
Eli Lilly and Company
Inventors:
Loretta A. McQuaid, Charles H. Mitch, Paul L. Ornstein, Darryle D. Schoepp, Edward C. R. Smith
Abstract: Substituted propanamines having anticoagulant or antifungal activity are disclosed. Also disclosed are methods of use involving the substituted propanamines as well as pharmaceutical compositions containing them.
Type:
Grant
Filed:
February 22, 1989
Date of Patent:
August 4, 1992
Assignee:
Eli Lilly and Company
Inventors:
Jack B. Campbell, Gerald F. Smith, William W. Turner
Abstract: This invention relates to N-hydroxy-N-[3-(2-substituted phenyl)prop-2-enyl]ureas and thioureas, formulations containing those compounds, and methods of using such compounds as 5-lipoxygenase inhibiting agents.
Type:
Grant
Filed:
April 23, 1991
Date of Patent:
July 14, 1992
Assignee:
Eli Lilly and Company
Inventors:
Gary A. Hite, Edward D. Mihelich, David W. Snyder, Tulio Suarez
Abstract: The present invention provides a method of inhibiting gastric acid secretion in mammals by administering a 5-HT1A agonist compound or a pharmaceutically acceptable salt thereof.
Abstract: A method of inhibiting bone demineralization comprising administration of an effective amount of a compound having the formula ##STR1## where X is CH or N;Y is O or S;R.sup.1 is 2-propenyl, C.sub.1 -C.sub.3 alkyl, benzyl or substituted benzyl where the substitutents are one or two of the same or different and are selected from methyl, ethyl, methoxy, ethoxy, hydroxy, chloro, bromo, or fluoro;R.sup.2 is C.sub.2 -C.sub.3 alkyl, allyl or cyclopropylmethyl;R.sup.3 and R.sup.4 are both hydrogen or combine to form a carbon-carbon bond; and pharmaceutically acceptable acid addition salts thereof to a mammal requiring bone demineralization inhibition.
Abstract: This invention relates to 2-(substituted)-N-hydroxy-N-alkylcinnamamides of the formula: ##STR1## where R.sup.1 is C.sub.1 -C.sub.4 alkyl;n is 0 or 1;R.sup.2 is trifuloromethyl, C.sub.1 -C.sub.10 alkyl, phen(C.sub.1 -C.sub.4)alkylene or ##STR2## where m is 0, 1 or 2 and R.sup.3 is C.sub.1 -C.sub.4 alkyl; X is C.sub.1 -C.sub.6 alkyl, phenyl, phen(C.sub.1 -C.sub.4)alkylene where the phenyl ring is unsubstituted or monosubstituted with --S(O).sub.m --R.sup.3 and m and R.sup.3 are as defined above, or ##STR3## where m is 0, 1 or 2 and R.sup.4 is C.sub.2 -C.sub.12 alkenyl, C.sub.2 -C.sub.12 alkynyl, or unsubstituted or monosubstituted C.sub.1 -C.sub.20 alkyl where the substituent is CF.sub.3, C.sub.3 -C.sub.8 cycloalkyl, or phenyl,or a pharmaceutically acceptable salt thereof; formulations containing those compounds and methods of using such compounds as 5-lipoxygenase inhibiting agents.
Type:
Grant
Filed:
March 28, 1990
Date of Patent:
July 2, 1991
Assignee:
Eli Lilly and Company
Inventors:
Gary A. Hite, Edward D. Mihelich, Tulio Suarez
Abstract: 7-Substituted bicyclic pyrazolidinone compounds as antimicrobials and the corresponding intermediates, are discussed or provided. The use of the antimicrobial compounds in pharmaceutical compositions and in methods for treating bacterial infections is set forth.
Type:
Grant
Filed:
April 3, 1990
Date of Patent:
April 30, 1991
Assignee:
Eli Lilly and Company
Inventors:
Charles J. Barnett, Richard E. Holmes, Louis N. Jungheim, Sandra K. Sigmund, Robert J. Ternansky
Abstract: Disclosed is a process for the preparation of primarily closed cell rigid foams, useful for strengthening mechanical construction parts or for use as insulation material, containing urethane groups, or urethane and isocyanurate groups where the polyol component is a higher molecular weight polyester polyol, containing in bonded form units having one or more of the structures: ##STR1## or a mixture of said polyester polyol and known polyester polyols and/or polyether polyols.
Abstract: Slightly crosslinked, water-soluble polymaleic acid which is obtainable by polymerization of maleic anhydride with from 0.1 to 10% by weight of a crosslinking agent in an aromatic hydrocarbon at from 60.degree. to 200.degree. C. in the presence of from 1 to 20% by weight, based on maleic anhydride, of a peroxyester, and hydrolysis of the polymer to give slightly crosslinked polymaleic acid having a Fikentscher K value of from 8 to 20 (measured at 20.degree. C. in 5% strength aqueous solution at pH 7 as the Na salt), a process for the preparation of slightly crosslinked polymaleic acid, and its use as a water treatment agent for reducing boiler scale and hard water deposits in water-conveying systems.
Type:
Grant
Filed:
October 27, 1988
Date of Patent:
December 12, 1989
Assignee:
BASF Aktiengesellschaft
Inventors:
Walter Denzinger, Heinrich Hartmann, Ulrich Gockel, Felix Richter, Hans-Jurgen Raubenheimer, Ekhard Winkler
Abstract: This invention relates to novel N-aryl-3-aryl-4,5-dihydro-1H-pyrazole-1-carboxamide compounds which are useful as pesticides, compositions containing those compounds, methods of controlling pests and processes for preparing these compounds.
Abstract: The instant invention relates to an apparatus for treating wastewater containing bentazon by decomposing the bentazon therein and thus eliminating or substantially reducing the bentazon content. This apparatus includes means for adjusting the pH of the wastewater to a value of less than 7 and heating it to a temperature of at least about 60.degree. C.
Abstract: A process for the preparation of polymaleic acid by polymerizing maleic anhydride in an aromatic hydrocarbon at from 60.degree. to 200.degree. C., using from 1 to 20% by weight, based on maleic anhydride, of peroxyesters derived from saturated or ethylenically unsaturated carboxylic acids, as the polymerization initiators and hydrolyzing the polymer, the polymaleic acid thus obtained and the use of the polymaleic acid as an agent for reducing scale formation and hard water deposits in systems through which water flows.
Type:
Grant
Filed:
September 3, 1987
Date of Patent:
April 4, 1989
Assignee:
BASF Aktiengesellschaft
Inventors:
Walter Denzinger, Heinrich Hartmann, Ulrich Goeckel, Felix Richter, Ekhard Winkler, Hans-Juergen Raubenheimer