Patents Represented by Attorney John H. Runnels
  • Patent number: 8350064
    Abstract: Xanthene compounds are disclosed having fluorescence at multiple wavelengths. Also disclosed are methods for their synthesis and use. Some of the compounds fluoresce at three wavelengths, emitting white light. Uses include the imaging of biological tissues, illumination, and display technologies. Many of the compounds have large Stokes shifts, and are resistant to photobleaching. The fluorescence may be readily distinguished from that of endogenous fluorophores, and from that of most existing, commercially-available fluorescent probes. The compounds are well suited for use in “multiplexing” techniques. They exhibit clear isosbestic and isoemissive points, and have broad absorption and emission ranges.
    Type: Grant
    Filed: July 19, 2007
    Date of Patent: January 8, 2013
    Assignee: Board of Supervisors of Louisiana State University And Agricultural and Mechanical College
    Inventors: Robert M. Strongin, Isiah M. Warner, Youjun Yang, Mark Lowry, Sayo O. Fakayode, Jorge O. Escobedo Cordova, Xiangyang Xu
  • Patent number: 8323183
    Abstract: A forward-looking, optical coherence tomography, endoscopic probe is disclosed capable of high resolution with a small diameter. Light is focused and scanned during three passes through a lens. A light source supplies light to the proximal side of the lens. The light makes a first pass through the lens, and is reflected from a fixed mirror on the distal side. The reflected light makes a second pass from the distal side to the proximal side, and exits the lens at the proximal side, and is reflected by a scanning mirror. The light makes a third pass through the lens from the proximal side to the distal side to a sample to be imaged. The light is focused during each of the three passes through the lens. Light reflected from the sample passes back through and is focused by the same system.
    Type: Grant
    Filed: October 9, 2007
    Date of Patent: December 4, 2012
    Assignee: Board of Supervisors of Louisiana State University And Agricultural and Mechanical College
    Inventors: Martin Feldman, Dooyoung Hah
  • Patent number: 8233154
    Abstract: An apparatus and method are disclosed for imaging a diffraction grating with a very high depth of focus, using a highly accurate code plate position measurement system. Positions may be measured to an accuracy of 1 nm or even smaller. The system may be used in fields such as manufacturing integrated circuits, and low- and very-low-frequency geophones, and other low- and very-low-frequency acoustic detectors.
    Type: Grant
    Filed: December 20, 2006
    Date of Patent: July 31, 2012
    Assignee: Board of Supervisors of Louisiana State University And Agricultural and Mechanical College
    Inventors: Martin Feldman, Li Jiang
  • Patent number: 8217173
    Abstract: Chelating monomers and fluoride-releasing compositions are disclosed that may be incorporated into dental composite restorative materials, dental bonding agents or other dental materials, to produce materials with high fluoride release rates, and high fluoride recharge capability. Such dental restorative materials may help reduce the level of dental caries in patients, particularly the level of caries occurring on the margins of the restorative materials.
    Type: Grant
    Filed: February 12, 2008
    Date of Patent: July 10, 2012
    Assignee: Board of Supervisors of Louisiana State University and Agricultural and Mechanical College
    Inventors: Xiaoming Xu, Shailaja Jayaramachandran, Liang Chen
  • Patent number: 8217037
    Abstract: Thiazole and thiophene compounds are disclosed having utility in treating inflammatory conditions, immunoinflammatory conditions, autoimmune diseases, and cancers. Methods for the synthesis of these compounds are also disclosed.
    Type: Grant
    Filed: April 5, 2007
    Date of Patent: July 10, 2012
    Assignees: Board of Supervisors of Louisiana State University and Agricultural and Mechanical College, B.V. Patel Pharmaceutical Education & Research Development (PERD)
    Inventors: Anthony Giordano, Kamala K. Vasu, Hardik M. Thakar, Rajan S. Giri, Swapnil G. Yerande, Gajanan S. Inamdar, Vasudevan Sudarsanam
  • Patent number: 8215392
    Abstract: A rapid and inexpensive process for increasing the amount of hydrocarbons (e.g., oil) produced and the rate of production from subterranean hydrocarbon-bearing reservoirs by displacing oil downwards within the oil reservoir and into an oil recovery apparatus is disclosed. The process is referred to as “gas-assisted gravity drainage” and comprises the steps of placing one or more horizontal producer wells near the bottom of a payzone (i.e., rock in which oil and gas are found in exploitable quantities) of a subterranean hydrocarbon-bearing reservoir and injecting a fluid displacer (e.g., CO2) through one or more vertical wells or horizontal wells. Pre-existing vertical wells may be used to inject the fluid displacer into the reservoir. As the fluid displacer is injected into the top portion of the reservoir, it forms a gas zone, which displaces oil and water downward towards the horizontal producer well(s).
    Type: Grant
    Filed: April 7, 2006
    Date of Patent: July 10, 2012
    Assignee: Board of Supervisors of Louisiana State University And Agricultural and Mechanical College
    Inventor: Dandina N. Rao
  • Patent number: 8167986
    Abstract: An airborne particulate sampling device is disclosed. The device includes a conduit whose interior allows the flow of air through the device. The conduit, or at least its surface, is a conductor. The device also includes an electrode with a sharp tip or edge on or near the output side of the conduit. An electrically conducting particle collector outside the conduit is positioned so that a surface is perpendicular or approximately perpendicular to the axis of the funnel. A fan or other blower forces air through the funnel. A power supply imparts an electrostatic potential difference between the electrode, on the one hand, and the holder and particle collector, on the other hand. The electrostatic potential difference produces a corona field in the air in the vicinity of the electrode's sharp tip. The corona field imparts a charge to airborne particles.
    Type: Grant
    Filed: July 21, 2009
    Date of Patent: May 1, 2012
    Assignee: Board of Supervisors of Louisiana State University and Agricultural and Mechanical College
    Inventors: Raymond W. Schneider, Erik Durr
  • Patent number: 8071760
    Abstract: Boron-containing porphyrin compounds are disclosed that may be used for boron neutron capture therapy of tumors, radiotherapy of tumors, and photodynamic therapy of tumors.
    Type: Grant
    Filed: October 25, 2006
    Date of Patent: December 6, 2011
    Assignee: Board of Supervisors of Louisiana State University and Agricultural and Mechanical College
    Inventors: Maria da Graça Henriques Vicente, Erhong Hao
  • Patent number: 8035400
    Abstract: The enhanced detection of defects and features in bulk dielectric materials is disclosed. Microwave radiation partly reflected at interfaces where the dielectric constant changes (e.g., where there are defects or structures). A sinusoidal or quasi-sinusoidal wave results. Localization or imaging of features is enhanced by exploiting the variation in distance resolution in a sinusoidal or quasi-sinusoidal standing wave. At characteristic distances, the wave has a high slope, and the amplitude of the wave varies strongly with small changes in distance. By inspecting at these characteristic distances, the resolution is enhanced. By systematically varying the position of the transducer or specimen, detailed images may be formed of the internal structure of the specimen across a range of depths. Defects and structures may be detected at smaller sizes than has previously been possible. The resolution of the imaging may be substantially smaller than the wavelength of the interrogating radiation.
    Type: Grant
    Filed: July 21, 2010
    Date of Patent: October 11, 2011
    Inventor: Jack R. Little, Jr.
  • Patent number: 7888039
    Abstract: Provided is a novel method for detecting Transmissible Spongiform encephalopathies (TSE). The method comprises: selecting a body fluid sample from a subject to determine whether the subject has transmissible spongiform encephalopathy; and detecting antibodies that immune react with Spiroplasma proteins in the sample. The method detects antibodies in the individual sera samples that react with recombinant Spiroplasma-specific Hsp60 by standard ELISA methodology. This method provides for rapid detection of TSE by determination of presence of antibodies in test samples showing associated Spiroplasma infection that has become consistent with presence of TSE. The method provides a mechanism to detect presence of TSE without invasive techniques currently needed to make diagnosis using brain tissues for prion detection. This method provides means of detection of TSE in the live patient without need for using necropsy tissues.
    Type: Grant
    Filed: May 23, 2005
    Date of Patent: February 15, 2011
    Assignees: Board of Supervisors of Louisiana State University and Agricultural and Mechanical College, The Administrators of the Tulane Educational Fund
    Inventor: Frank O. Bastian
  • Patent number: 7786360
    Abstract: A novel rice cultivar, designated ‘CL131,’ is disclosed. The invention relates to the seeds of rice cultivar ‘CL131,’ to the plants of rice ‘CL131,’ and to methods for producing a rice plant produced by crossing the cultivar ‘CL131’ with itself or another rice variety, and to single gene conversions of such plants. The invention further relates to hybrid rice seeds and plants produced by crossing the cultivar ‘CL131’ with another rice cultivar. The invention further relates to other derivatives of the cultivar ‘CL131.
    Type: Grant
    Filed: March 30, 2006
    Date of Patent: August 31, 2010
    Assignee: Board of Supervisors of Louisiana State University and Agricultural and Mechanical College
    Inventor: Steven D. Linscombe
  • Patent number: 7777499
    Abstract: The enhanced detection of defects in the bulk dielectric material (Specimen) having radiation partly reflected at interfaces where the dielectric constant changes (e.g., where there are defects or structures). A sinusoidal or quasisinusoidal wave (Microwave Source) results. Localization or imaging of features is enhanced by exploiting the variation in distance resolution (Standoff+/?) in a sinusoidal or quasi-sinusoidal standing wave. At characteristic distances, the wave has a high slope and the amplitude of the wave varies strongly with small changes in distance (Standoff+/?). By inspecting at these characteristic distances (Standoff+/?), the resolution is enhanced. By systematically varying the position of the transducer or specimen, detailed images may be formed of the internal structure of the specimen across a range of depths. Defects and structures may be detected at smaller sizes than has previously been possible.
    Type: Grant
    Filed: August 1, 2005
    Date of Patent: August 17, 2010
    Inventor: Jack R. Little, Jr.
  • Patent number: 7754947
    Abstract: Rice plants are disclosed with multiple sources of resistance to herbicides that normally inhibit a plant's acetohydroxyacid synthase (AHAS) enzyme. Besides controlling red rice, many AHAS-inhibiting herbicides also effectively control other weeds that are common in rice fields. Several of these herbicides have residual activity, so that one treatment can control both existing weeds and weeds that sprout later. With effective residual activity against red rice and other weeds, rice producers now have a weed control system superior to those that are currently available commercially.
    Type: Grant
    Filed: March 18, 2008
    Date of Patent: July 13, 2010
    Assignee: Board of Supervisors of Louisiana State University And Agricultural and Mechanical College
    Inventor: Timothy P. Croughan
  • Patent number: 7687248
    Abstract: A method has been discovered to produce a resistant starch product that retains the same cooking quality as found in untreated rice starch or flour, but has a higher percentage of starch resistant to ?-amylase digestion. This method uses a debranching enzyme, e.g., pullulanase, to digest the starch, but does not require pre-treating the starch source prior to enzymatic treatment. This method produced resistant starch from low amylose starches, rice starch (24%) and rice flour (20%). Surprisingly the resistant starch product formed by this method retained the pasting characteristics of the untreated flour or starch, and was heat stable. This method may also be used to produce resistant starch from other botanical sources, e.g., corn, wheat, potato, oat, barley, tapioca, sago, and arrowroot. Resistant starch produced by this method has a variety of uses in food products.
    Type: Grant
    Filed: April 3, 2007
    Date of Patent: March 30, 2010
    Assignee: Board of Supervisors of Louisiana State University And Agricultural and Mechanical College
    Inventors: Joan M. King, Siow Ying Tan
  • Patent number: 7671242
    Abstract: An efficient method is disclosed for extracting lutein from corn, sweet potato, and other plant products, and for extracting aflatoxin-free lutein from aflatoxin-contaminated plant grains and other plant products safely without any toxic by-products. The lutein is extracted using acetone, and either chilled or saponified to separate from the lipids. If contaminated with aflatoxin, the extracted aflatoxin-contaminated lutein is treated with lipoxidase. This method may be used in producing aflatoxin-free lutein from other contaminated grains or plant oils, or other plant products, including corn, cotton, soybean, rice, barley, wheat, maize, millet, and peanut.
    Type: Grant
    Filed: December 21, 2005
    Date of Patent: March 2, 2010
    Assignee: Board of Supervisors of Louisiana State University and Agricultural and Mechanical College
    Inventors: Jack N. Losso, Evdokia Menelaou, Joan M. King
  • Patent number: 7569547
    Abstract: Small, polybasic peptides are disclosed that are effective as furin inhibitors, e.g. hexa- to nona-peptides having L-Arg or L-Lys in most positions. Removing the peptide terminating groups can improve inhibition of furin. High inhibition was seen in a series of non-amidated and non-acetylated polyarginines. The most potent inhibitor identified to date, nona-L-arginine, had a Ki against furin of 40 nM. Non-acetylated, poly-D-arginine-derived molecules are preferred furin inhibitors for therapeutic uses, such as inhibiting certain bacterial infections, viral infections, and cancers. Due to their relatively small size, these peptides should be non-immunogenic. These peptides are efficiently transported across cell membranes.
    Type: Grant
    Filed: April 21, 2006
    Date of Patent: August 4, 2009
    Assignees: Board of Supervisors of Louisiana State University and Agricultural and Mechanical College, Torrey Pines Institute for Molecular Studies
    Inventors: Iris Lindberg, Angus Cameron, Richard A. Houghten, Jon Richard Appel
  • Patent number: 7549427
    Abstract: A novel nanocatalyst is disclosed containing titanium oxide, iron oxide, and calcium oxide. The catalyst comprises a layer of iron oxide in the gamma form supported on a titanium oxide core. Addition of calcium cations helps to stabilize the iron oxide in the gamma form. The iron oxide layer is on the order of a few nanometers thick on the surface of the titanium oxide core, in an “egg-in-shell” structure. The nanocatalyst is highly active in promoting the oxidation of compounds such as hydroquinone, catechol, other hydrocarbons, chlorinated phenols, and carbon monoxide, even at moderately elevated temperatures. The catalyst remains active in a pyrolytic environment for extended periods of time, and possesses high redox cycling potential. The efficiency of the catalyst is not strongly affected by coking in a combustion environment.
    Type: Grant
    Filed: July 13, 2005
    Date of Patent: June 23, 2009
    Assignee: Board of Supervisors of Louisiana State University and Agricultural and Mechanical College
    Inventors: Harold B. Dellinger, Slawomir M. Lomnicki
  • Patent number: 7495153
    Abstract: Rice plants are disclosed with multiple sources of resistance to herbicides that normally inhibit a plant's acetohydroxyacid synthase (AHAS) enzyme. Besides controlling red rice, many AHAS-inhibiting herbicides also effectively control other weeds that are common in rice fields. Several of these herbicides have residual activity, so that one treatment can control both existing weeds and weeds that sprout later. With effective residual activity against red rice and other weeds, rice producers now have a weed control system superior to those that are currently available commercially.
    Type: Grant
    Filed: March 17, 2006
    Date of Patent: February 24, 2009
    Assignee: Board of Supervisors of Louisiana State University and Agricultural and Mechanical College
    Inventor: Timothy P. Croughan
  • Patent number: PP19710
    Abstract: A new variety of sweetpotato identified as ‘Evangeline’ is disclosed having disease resistance to both southern root-knot nematode and soil rot, a deep orange flesh, a high sucrose content, and high yield characteristics.
    Type: Grant
    Filed: April 25, 2007
    Date of Patent: February 10, 2009
    Assignee: Board of Supervisors of Louisiana State University And Agricultural and Mechanical College
    Inventors: Don R. LaBonte, Arthur Q. Villordon, Christopher A. Clark
  • Patent number: PP19955
    Abstract: A new variety of sweetpotato identified as ‘Murasaki-29’ is disclosed having disease resistance to southern root-knot nematode and soil rot, a white flesh, and purple skin.
    Type: Grant
    Filed: October 18, 2007
    Date of Patent: April 28, 2009
    Assignee: Board of Supervisors of Louisiana State University and Agricultural and Mechanical College
    Inventors: Don R. LaBonte, Arthur Q. Villordon, Christopher A. Clark