Abstract: A microchannel reactor is disclosed that provides superior performance for three-phase (gas/liquid/solid-catalyst) reactions. The reactor may be used, for example, in industrial-scale catalysis, e.g., in large-scale chemical production, and also in catalyst screening. Each microchannel in the reactor has a separate micro-outlet to supply gas to the channel. Each microchannel is open on both ends, so that liquid may freely flow through the channels in both directions. Oscillatory forcing is applied to the liquid outside the microreactor. The combined effect of the separate gas inlets for each microchannel, the open nature of the microchannels on both ends, and oscillatory forcing results in highly efficient transport of both gas and liquid through all of the microchannels, promotes efficient mixing, and enhances catalysis.

Abstract: An accurate and inexpensive integral micro-optical system for coupling and aligning optical fibers with other optical components, such as other optical fibers, diffusers, beam shapers, beam splitters, mirrors, or lenses is disclosed. The micro-optical coupler disclosed comprises one or more fiberport collimators and one or more microlens arrays, optically aligned during fabrication so that an optical fiber, or other source of light, was coupled to another optical fiber, or other light receiver, by simple inserting the optical source in one side of the micro-coupler and inserting the optical receiver in the other side of the micro-coupler. Often the fabrication process for this system can be done in a single lithography procedure. Since the optical axis of each component was aligned during the fabrication step, no subsequent alignment was required.

Abstract: Nucleotide sequences are disclosed that may be used to impart herbicide resistance to green plants. The sources of novel herbicide resistance were originally isolated in mutant rice plants. The sequences impart pre-emergence resistance, post-emergence resistance, or both pre-emergence resistance and post-emergence resistance to multiple herbicides. To date, resistance has been demonstrated against at least the following herbicides: imazethapyr, imazapic, imazapyr, imazamox, sulfometuron methyl, imazaquin, chlorimuron ethyl, metsulfuron methyl, rimsulfuron, thifensulfuron methyl, pyrithiobac sodium, tribenuron methyl, and nicosulfuron. Green plants transformed with these sequences are resistant to these herbicides and to derivatives of these herbicides, and to at least some of the other herbicides that normally inhibit acetohydroxyacid synthase (AHAS), particularly imidazolinone and sulfonylurea herbicides.

Abstract: A one-step procedure for sentinel lymph node identification and biopsy using a single compound, a radiolabeled, low molecular weight dye (e.g., 125I-labeled methylene blue). This radiolabled dye is mixed with an unlabeled, similar molecular weight dye (e.g., isosulfan or methylene blue). The mixture is injected at the time of surgery, and rapidly migrates to reach the lymph nodes in less than 20 min, more preferably in less than 15 min and most preferably in less than 10 min. Using rabbits, rapid transit of 125I-methylene blue to regional lymph nodes with limited systemic biodistribution has been confirmed. By admixing small amounts of radiolabeled dye with a large amount of unlabeled dye, the sentinel lymph node identification was similar to that for the prior two-step dual mapping process, but with enhanced SLN localization because of the lower energy gamma emission of 125I as compared with 99mTc.

Abstract: An environmentally-friendly method is disclosed for transforming preserved wood, for example creosote-treated or CCA-treated wood with supercritical water. The product of treating weathered creosote-treated wood is a mixture that is similar to fresh creosote. The novel system is akin to a closed-loop system for recovering and rejuvenating creosote. In another aspect of the invention, acidic supercritical water is used to extract copper, chromium, and arsenic from CCA-treated wood, or more generally, to extract metals from an organic matrix.

Abstract: Several derivatives of naphthalene, including 1?-acetonaphthone, 2?-acetpnaphthone, 1-methoxynaphthalene, and 2-methoxynaphthalene, were discovered to be effective toxicants and repellents of termites, and resulted in significant reduction in termite feeding activity. For example, 2?-acetonaphthone was found to be an effective repellent and feeding deterrent of termites. Termites exposed to concentrations as low as 8 mg/kg sand exhibited a significant reduction in tunneling and feeding activity. Moreover, some of the dead termites had symptoms indicative of a failure to molt. At concentrations ?20 ?g/cm2, 2?-acetonaphthone was a strong repellent. Interestingly, at 160-fold lower concentration (0.125 ?g/cm2), 2?-acetonaphthone stimulated termite feeding activity. As a sand barrier, 2?-acetonaphthone significantly inhibited tunneling and feeding activity in concentrations from 8.33 to 35.0 mg/kg. Molting problems were also identified in termites exposed to 2?-acetonaphthone.

Abstract: Novel peptides are disclosed that may be used as inhibitors of amyloidogenesis, as suppressors of amyloid toxicity, and as therapeutic agents for amyloid-associated diseases such as Alzheimer's disease, Parkinson's Disease, Creutzfeldt-Jakob Disease, Huntington's Disease, and Type II Diabetes. These new ?-strand mimics (?-sheet “blockers”), containing C?,?-disubstituted amino acids, specifically interact with and block the development of the ?-sheet structure of the developing fibrils of amyloid diseases, such as Alzheimer's disease amyloid ?-peptide (A?). We have discovered that oligomerization of ?-sheet structures, including those implicated in amyloid-associated diseases, may be inhibited or even reversed by the presence of extended peptide structures that have only one edge available for hydrogen bonding. Without a second edge that is also available for hydrogen bonding, the extension of a developing ?-sheet is blocked by binding to the novel peptides.

Abstract: A device and method of providing thermal compensation for integrated circuits, e.g., complementary metal-oxide semiconductor integrated circuits (“IC”) is described. The device is an IC (e.g., digital, analog, and mixed-signal circuits) with a digital voltage control system (“VCS”) having a temperature-adaptive digital DC-to-DC power converter. In one embodiment, the DC-to-DC converter includes a power stage, which converts a voltage of an input power source to a variable supply voltage, a delay-line-based temperature sensing circuit that continuously monitors temperature changes, and adjusts the frequency and process speed of the IC to compensate for any performance degradation caused by thermal effects by adjusting the voltage supplied to the IC to increase or decrease the frequency and process speed of the IC in proportion to any abnormal temperature changes in the IC.

Abstract: Rice plants are disclosed with multiple sources of resistance to herbicides that normally inhibit a plant's acetohydroxyacid synthase (AHAS) enzyme. Besides controlling red rice, many AHAS-inhibiting herbicides also effectively control other weeds that are common in rice fields. Several of these herbicides have residual activity, so that one treatment can control both existing weeds and weeds that sprout later. With effective residual activity against red rice and other weeds, rice producers now have a weed control system superior to those that are currently available commercially.

Abstract: A surgical instrument and method are disclosed for enhancing the overall performance of arterial occludes, by allowing the repetitive obstruction of blood flow to a targeted organ or tissue (e.g., heart muscle, brain, kidney, gastrointestinal tissue, leg muscles, arm muscles, other skeletal muscles, or tumors), while reducing the potential for side effects such as gangrene or infarction and for post-implantation movement of the occlude during ischemia. The micro-pneumatic snare allows the repeated occlusion (i.e., the iterated obstruction or closure of a passageway or vessel) of targeted vessels to deprive a selected organ or tissue of blood and oxygen profusion, while the patient may, in general, remain conscious. The micro-pneumatic snare also allows for the stimulation of functional response adjustments in targeted tissues and organs, such as angiogenesis and collateral vessel growth in response to repetitive per fusion obstruction.

Abstract: An apparatus and method of conditioning humidity and temperature in the process airstream of a desiccant dehumidifier used to dry moisture-laden spaces and structures by replacing moisture-laden air with dehumidified air to increase the rate of water evaporation within the affected areas. A heat-modulating dehumidifier comprises a dehumidification assembly having a desiccant rotor assembly, a post-process pre-reactivation heat exchanger assembly, a reactivation air bypass damper, a reactivation heater, and a control system. The apparatus regulates the temperature level of the dehumidified air exiting the apparatus by extracting heat from the dehumidified air prior to its ejection into an affected area, using a bypass damper that controls the amount of heat transfer from the dehumidified air to a second airstream entering the apparatus.

Abstract: A system is disclosed for implementing WDM optical networks, without blocking, and without the need for wavelength converters. The method is based on a hypercube topology for connecting the nodes, and a novel algorithm for constructing a routing tree such that blocking cannot occur even under the stringent requirement of all-to-all broadcasting. The algorithm uses shortest paths and a small number of wavelengths to satisfy the all-to-all connectivity requirement. The number of wavelengths used may, in fact, be the minimum number needed to satisfy the all-to-all connectivity requirement, using shortest paths.

Abstract: A method is disclosed for reliably stabilizing eukaryotic cells that express the P2X7 receptor channel, particularly mammalian and other vertebrate cells, including human cells, for example mammalian macrophages, or hematopoietic stem cells, in order to introduce otherwise membrane-impermeable compounds that are helpful for stabilizing the cells during drying, chilling, freezing, freeze-drying, or cryopreservation. The cells are exposed to extracellular ATP in concentration sufficient to open pores in the plasma membrane. One or more otherwise membrane-impermeable compounds that aid the survivorship of cells are then introduced, for example, trehalose, and after a brief time the pores are closed—for example, by adding divalent cations, or by diluting the extracellular solution. Once the trehalose or other stabilizing compound has been introduced, the cells may be stably preserved. By taking advantage of an endogenous mammalian receptor and ATP, no antigenic compounds need be introduced.

Abstract: Polymeric surfactants (molecular micelles) are disclosed for use in open tubular capillary electrochromatography or in high performance liquid chromatography. For example, fused silica capillaries are coated with thin films of charged polymers in a polyelectrolyte multilayer (PEM). A PEM coating may be formed in situ by alternate rinses with positive and negative polyelectrolytes. At least the innermost of the negatively charged polymer layers is a molecular micelle. Prototype embodiments have successfully separated seven benzodiazepines from one another. The run-to-run, day-to-day, week-to-week and capillary-to-capillary reproducibilities were very good, with relative standard deviation values less than 0.01. The PEM-coated capillary was very robust over at least 200 runs. Stability against high and low pH values was also observed. Using chiral polymerized micelles, chiral separations may be achieved, as was demonstrated with a separation of the enantiomers of 1,1?-binaphthyl-2,2?-dihydrogenphosphate.

Abstract: A device and method for enhancing the surgical replacement of defective natural eye lenses with an intraocular lens. The device is an intraocular lens injector that prevents an intraocular lens from uncontrollably rotating or flipping as it is advanced towards a mammalian recipient's eye, while providing an ideal lens exit orientation to help reduce the occurrence of trauma. The lens injector comprises an insertion tube having a loading port and an ejection port, a plunger, a loading carriage, and a lens carrier. In one embodiment, the insertion tube allows for the controlled insertion of a lens by rolling one side of the lens onto itself as the lens is guided through the ejection port using a guide displaced in the insertion tube from a position near the loading port to the end of the ejection port. In an alternative embodiment, controlled insertion is achieved by rolling both sides of the lens at varying degrees so that one side eventually encircles the other side.

Abstract: Porphyrins containing one or more neutral or negatively-charged, closo- or nido-carborane substituents are useful as chelators. The carbon-carbon bonds linking the boron-containing groups to the porphyrin ring make the compounds highly resistant to hydrolysis. These compounds have potential for use in selective binding to specific ligands. These compounds are highly stable, soluble in water and organic solvents, and have low toxicity.

Abstract: “Minimalist” antimicrobial peptides are disclosed based on 50 to 80% ?,?-dialkylated amino acids. The peptides are short, cationic, amphipathic, and possess a high helix propensity. Polar ?,?-dialkylated amino acids are also disclosed. These peptides are easy and inexpensive to synthesize via solid-phase techniques. The peptides exhibit in vitro anti-bacterial properties at concentrations that are not lethal to normal mammalian cells. The peptides exhibit in vivo bioactivity against intracellular pathogens.

Abstract: A novel rice cultivar, designated ‘Trenasse,’ is disclosed. The invention relates to the seeds of rice cultivar ‘Trenasse,’ to the plants of rice ‘Trenasse,’ and to methods for producing a rice plant produced by crossing the cultivar ‘Trenasse’ with itself or another rice variety, and to single gene conversions of such plants. The invention further relates to hybrid rice seeds and plants produced by crossing the cultivar ‘Trenasse’ with another rice cultivar.

Abstract: A new variety of sugarcane, identified as ‘L99-226’, is disclosed having superior sugarcane rust disease resistance, and high sugar/sucrose content and cane yield characteristics.

Abstract: A new variety of sugarcane, identified as ‘L99-233’, is disclosed having superior sugarcane rust disease resistance, excellent ratooning ability, and high sugar/sucrose content and cane yield characteristics.

Abstract: A finned tube heat exchanger having an improved flat louver fin configuration for increased heat transfer efficiency and low air pressure drop. The fins comprise generally planar sheet metal plates having a pattern of spaced apertures for receiving a group of heat exchanger tubes perpendicularly to the fin plate. Groups of louvers are formed as elongate strips extending generally in an area between adjacent tubes. The strips are selectively offset, i.e. raised or lowered from the nominal plane of the fin, so as to establish a louver pattern having flat louvers in a number of different planes each parallel to the direction of flow of air across the fin. Stiffness is provided for the fin plate by providing a slope and offset of the leading and trailing edges of the fin plate such that they are displaced in a direction parallel to the axes of the tube.