Patents Represented by Attorney John J. Maitner
  • Patent number: 6180781
    Abstract: The invention relates to the novel compound mometasone furoate monohydrate, process for its preparation and pharmaceutical compositions containing said compound.
    Type: Grant
    Filed: April 17, 1995
    Date of Patent: January 30, 2001
    Assignee: Schering Corporation
    Inventors: Pui-Ho Yuen, Charles Eckhart, Teresa Etlinger, Nancy Levine
  • Patent number: 6127353
    Abstract: The invention relates to the novel compound mometasone furoate monohydrate, process for its preparation and pharmaceutical compositions containing said compound.
    Type: Grant
    Filed: April 29, 1998
    Date of Patent: October 3, 2000
    Assignee: Schering Corporation
    Inventors: Pui-Ho Yuen, Charles Eckhart, Teresa Etlinger, Nancy Levine
  • Patent number: 5929236
    Abstract: Disclosed are compounds of the formula I wherein:Y represents --CO.sub.2 H, --CO.sub.2 R.sup.6, --C(O)NHR.sup.7, --SO.sub.2 H, --SO.sub.3 H, --SO.sub.3 R.sup.6, --SO.sub.2 NHR.sup.7, --C(O)--N(OH)--R.sup.8, or a group of the formula ##STR1## or a pharmaceutically acceptable addition salt or solvate thereof. Also disclosed are pharmaceutical compositions containing compounds of Formula I. Further disclosed is a method for treating or preventing respiratory depression, epileptic seizures or other central nervous system disorders, and for enhancing cognitive performance, by administering an effective amount of a compound of Formula I.
    Type: Grant
    Filed: September 22, 1995
    Date of Patent: July 27, 1999
    Assignee: Schering Corporation
    Inventors: Shen-Chun Kuo, David J. Blythin, William Kreutner
  • Patent number: 5908937
    Abstract: A process for preparing a compound of formula (I) ##STR1## wherein R is a methylthio, methylsulfoxy, methylsulfonyl or a nitro group; andX4 is --OH, fluorine or --O--SO.sub.2 R6 where R6 is methyl, trifluoromethyl, phenyl or p-methylphenyl which comprises contacting of a compound of formula (III) ##STR2## where R2 is C.sub.1-4 alkyl; and R and X4 have the above mentioned meanings, with a strong base selected from the group consisting of alkali earth metal alcoholates, alkaline earth metal alcoholates, and tertiary amines in an aprotic solvent, to obtain the compound of formula (I).
    Type: Grant
    Filed: June 3, 1993
    Date of Patent: June 1, 1999
    Inventors: Giancarlo Jommi, Dario Chiarino
  • Patent number: 5897858
    Abstract: Aqueous nasal spray compositions containing:0.001-2% by weight/volume of a medicament selected from the group consisting of chlorpheniramine maleate, oxymetazoline hydrochloride and mixtures thereof;0.50 to 15.00% by weight/volume of a water soluble polymer selected from the group consisting of polyvinylpyrrolidone having an average molecular weight of about 10,000 to 360,000 and mixtures thereof;2.5 to 10.00% by weight/volume of polyethylene glycol;1.00 to 10.00% by weight/volume of a moisturizing agent other than polyethylene glycol;0.01 to 0.05% by weight/volume of disodium edetate;0.001 to 0.3% by weight/volume of an antimicrobial preservative;0.20 to 5.00% by weight/volume of an aromatic alcohol;a sufficient amount of a pharmaceutically acceptable buffer to maintain the pH of the composition within the range of about 4.0 to 8.0; andQS water.
    Type: Grant
    Filed: November 4, 1997
    Date of Patent: April 27, 1999
    Assignee: Schering-Plough Healthcare Products, Inc.
    Inventors: Joseph A. Haslwanter, William F. Rencher
  • Patent number: 5866401
    Abstract: The invention discloses a vaccine and methods for the treatment of porcine reproductive and respiratory syndrome. The vaccine is derived from the viral agent NEB-l-P94, deposited at the American Type Culture Collection under accession number VR-2525.Further, the invention discloses a vaccine virus with phenotypic characteristics which can be distinguished from wild type PRRS virus.
    Type: Grant
    Filed: February 24, 1997
    Date of Patent: February 2, 1999
    Assignee: Schering Corporation
    Inventor: Richard A. Hesse
  • Patent number: 5854269
    Abstract: An aqueous nasal decongestant composition containing oxymatazoline is disclosed which does not contain mercurial preservatives.
    Type: Grant
    Filed: August 6, 1996
    Date of Patent: December 29, 1998
    Assignee: Schering-Plough Healthcare Products, Inc.
    Inventors: Joseph A. Haslwanter, William Rencher
  • Patent number: 5827506
    Abstract: Apparatus for simulating skin tanning comprises a receptacle containing a fluid comprising dihydroxyacetone, a receptacle containing a fluid comprising an amino acid, and dispensing means for simultaneously or sequentially providing desired amounts of dihydroxyacetone and amino acid.
    Type: Grant
    Filed: November 13, 1995
    Date of Patent: October 27, 1998
    Assignee: Schering-Plough HealthCare Products, Inc.
    Inventors: James E. McShane, Carl Kaplan, Thomas A. Meyer
  • Patent number: 5786480
    Abstract: Compounds of the formula ##STR1## wherein R.sub.1, R.sub.3, R.sub.4, R.sub.11, and c are as set forth herein are described. These compounds are useful as agents for the treatment of mammals infected with herpes group virus. Certain of these compounds are useful as antitumor agents.
    Type: Grant
    Filed: August 2, 1996
    Date of Patent: July 28, 1998
    Assignee: Schering Corporation
    Inventors: Adriano Afonso, Joseph M. Kelly, Samuel Chackalamannil
  • Patent number: 5780442
    Abstract: Orthosomycins have been isolated from the fermentation broth of the microorganism Micromonospora Carbonacea var Africana designated SCC 2146. These compounds are antibacterial agents. Compositions and methods for treating bacterial infections are also described.
    Type: Grant
    Filed: February 21, 1996
    Date of Patent: July 14, 1998
    Assignee: Schering Corporation
    Inventors: Ronald A. Mierzwa, Min Chu, John K. Jenkins, Mahesh G. Patel
  • Patent number: 5756075
    Abstract: Apparatus for simulating skin tanning comprises a receptacle containing a fluid comprising dihydroxyacetone, a receptacle containing a fluid comprising a primary amine, and dispensing means for simultaneously or sequentially providing desired amount of dihydroxyacetone and amine.
    Type: Grant
    Filed: September 13, 1996
    Date of Patent: May 26, 1998
    Assignee: Schering-Plough HealthCare Products, Inc.
    Inventor: Thomas A. Meyer
  • Patent number: 5750532
    Abstract: The disclosed invention is compounds represented by the formula ##STR1## and pharmacetically acceptable acid salts thereof, wherein each Z is independently tetiary butyl, phenyl, naphthyl or adamantyl; substituted phenyl, wherein the substituents are one or more of halogen, lower alkoxy, phenoxy, nitrile, nitro, phenylsulfonyl, loweralkyl-sulfonyl, oxazol-2-yl, lower alkanoyl, benzoyl, lower alkoxycarbonyl, lower alkyl, lower alkylthio, phenyl, phenylaminothiocarbonyl, or lower alkylaminothiocarbonyl, hydroxyiminoloweralkyl hydroxyloweralkyl or carbonyl; or 4 or 6 membered unsubstituted or substituted heterocyclic ring containing at least one nitrogen with the remaining member of the ring being at least one carbon, and optionally sulfur or oxygen,X and Y are each independently a bond, ##STR2## each Q is independently a divalent substituted or unsubstituted, straight or branched chain lower alkanediyl, lower alkanediyl-cycloalkanediyl-lower alkanediyl, lower alkenediyl, lower alkynediyl, phenylene, dihydrofura
    Type: Grant
    Filed: May 30, 1995
    Date of Patent: May 12, 1998
    Assignee: Schering Corporation
    Inventors: Viyyoor M. Girijavallabhan, Ashit K. Ganguly, Patrick A. Pinto, Richard W. Versace
  • Patent number: 5719156
    Abstract: The invention relates to compounds of the formulas ##STR1## wherein Z, R.sub.c, y, x, l.sub.1, l.sub.2, l.sub.3, u, R.sub.4,R.sub.c', n, R.sub.1, R.sub.2, and R.sub.3, are as described herein. These compounds are neurokinin antagonists. These compounds are useful in the treatment of chronic airway diseases such as asthma.
    Type: Grant
    Filed: May 2, 1995
    Date of Patent: February 17, 1998
    Assignee: Schering Corporation
    Inventors: Ho-Jane Shue, Neng-Yang Shih, John Piwinski, Xiao Chen, David J. Blythin
  • Patent number: 5693815
    Abstract: Compounds of formula ##STR1## wherein Ar, W, Z, Q, R.sub.1, U, and L are as set forth herein, are described. These compounds are active as agents against HIV and inhibit renin and therefore are also active against hypertension. Similar retroviruses against which the compounds of the invention are active include the retrovirus which causes feline AIDS, and the retrovirus which causes Rous' sarcoma which is a disease of chickens.
    Type: Grant
    Filed: July 14, 1995
    Date of Patent: December 2, 1997
    Assignee: Schering Corporation
    Inventors: Frank Bennett, Viyyoor M. Girijavallabhan, Naginbhai M. Patel
  • Patent number: 5687710
    Abstract: A powder dispenser includes a powder housing for holding a supply of powdered material to be dispensed, the powder housing including an inhalation conduit provided displaced relation to the powdered material supply; a metering plate including a metered dose hole for holding a metered amount of the powdered material, and positioned below the powdered material supply, the metering plate and the powder housing being relatively rotatable with respect to each other about a common central axis; a counter providing a visual count of the number of doses of the powdered material that have been dispensed or remain to be dispensed in response to the relative rotation, the counter including counter rings providing the visual count, the counter rings being rotatable about the common central axis and having indicia thereon which display the visual count, and an actuating mechanism rotatable about the central axis for incrementally rotating the counter rings in response to the relative rotation; a nozzle for breaking up agg
    Type: Grant
    Filed: June 1, 1995
    Date of Patent: November 18, 1997
    Assignee: Schering Corporation
    Inventors: Thomas J. Ambrosio, Alan J. Bilanin, Andrew E. Kaufman, David J. Kenyon, Srinivas Manthena, Tsong-Toh Yang
  • Patent number: 5686083
    Abstract: Topical compositions for the treatment of corns and calluses comprising a 4 carbon .alpha.-keto acid and a pharmaceutically acceptable carrier, are described.
    Type: Grant
    Filed: August 11, 1995
    Date of Patent: November 11, 1997
    Assignee: Schering-Plough HealthCare Products Inc.
    Inventor: Thomas W. Chamness
  • Patent number: 5663361
    Abstract: A process for preparing a compound of formula I ##STR1## wherein R and R" are as described herein. Compounds of formula I are useful as intermediates in the preparation of florfenicol.
    Type: Grant
    Filed: August 19, 1996
    Date of Patent: September 2, 1997
    Assignee: Schering Corporation
    Inventors: James C. Towson, Dhiru B. Vashi
  • Patent number: 5618793
    Abstract: Compounds of the formula ##STR1## wherein R.sub.3, R.sub.4, J, K, Z, and Het are as set forth herein are described.The compounds of formula I are useful as agents in the treatment of fungal infections.
    Type: Grant
    Filed: August 1, 1995
    Date of Patent: April 8, 1997
    Assignee: Schering Corporation
    Inventors: Alan B. Cooper, Anil K. Saksena, Raymond Lovey, Viyyoor Girijavallabhan, Ashit Ganguly
  • Patent number: D383535
    Type: Grant
    Filed: April 24, 1996
    Date of Patent: September 9, 1997
    Assignee: Schering Corporation
    Inventors: Jones W. Bryan, Jr., Robert T. Benz
  • Patent number: D387874
    Type: Grant
    Filed: March 20, 1996
    Date of Patent: December 16, 1997
    Assignee: Schering Corporation
    Inventor: Henry Vila