Patents Represented by Attorney John J. Maitner

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  • Sustained release tablet comprising loratadine, ibuprofen and pseudoephedrine
    Patent number: 5100675
    Abstract: Pharmaceutical compositions for use in the treatment of cough/cold symptoms comprising loratadine, ibuprofen and pseudoephedrine are disclosed.
    Type: Grant
    Filed: November 13, 1990
    Date of Patent: March 31, 1992
    Assignee: Schering Corporation
    Inventors: Wing-Kee P. Cho, Winston A. Vadino, Imtiaz A. Chaudry
  • Pharmaceutical composition of florfenicol
    Patent number: 5082863
    Abstract: An injectable pharmaceutical composition for veterinary use is disclosed comprising Florfenicol, N-methyl-2-pyrrolidone, polyethylene glycol and a viscosity reducing agent. The composition is chemically and physically stable, exhibits constant blood levels and does not product undesirable side effects.
    Type: Grant
    Filed: August 29, 1990
    Date of Patent: January 21, 1992
    Assignee: Schering Corporation
    Inventors: Henry M. Apelian, David Coffin-Beach, Abu S. Huq
  • Method for the preparation of .alpha..sup.1 [[(1,1-dimethylethyl)amino]methyl]-4-hydroxy-1,3-benzenedimethanol
    Patent number: 5011993
    Abstract: There is disclosed an improved process for preparing albuterol which comprises reacting a 5-(haloacetyl)-2-hydroxybenzaldehyde with 1,1-dimethylethanamine in an organic solvent and in an inert atmosphere to form 5-[[(1,1-dimethylethyl)amino]acetyl]- 2-hydroxybenzaldehyde and reducing the carbonyl functions to the corresponding hydroxy groups to form albuterol.
    Type: Grant
    Filed: April 20, 1990
    Date of Patent: April 30, 1991
    Assignee: Schering Corporation
    Inventors: Esther Babad, Nicholas Carruthers, Martin Steinman
  • Pharmaceutical composition comprising loratadine, ibuprofen and pseudoephedrine
    Patent number: 4990535
    Abstract: Pharmaceutical compositions for use in the treatment of cough/cold symptoms comprising loratadine, ibuprofen and pseudoephedrine are disclosed.
    Type: Grant
    Filed: May 3, 1989
    Date of Patent: February 5, 1991
    Assignee: Schering Corporation
    Inventors: Wing-Kee P. Cho, Winston A. Vadino, Imtiaz A. Chaudry
  • Parenteral compositions
    Patent number: 4988722
    Abstract: A process for preparing aqueous parenteral compositions of drugs which are weak bases and are only slightly soluble in water is disclosed. Aqueous parenteral compositions of the antifungal agent (.+-.) (2R*, 3R*)-2-(2,4-difluorophenyl)-3-methylsulfonyl-1-(1,2,4-triazol-1-yl)butan-2 -ol are also disclosed.
    Type: Grant
    Filed: October 3, 1989
    Date of Patent: January 29, 1991
    Assignee: Schering Corporation
    Inventor: Pui-Ho Yuen
  • Percutaneous penetration enhancer of oleic acid and 2-ethyl-1,3-hexanediol
    Patent number: 4983396
    Abstract: Pharmaceutical preparations comprised of a pharmaceutically active ingredient and a carrier which comprises a percutaneous penetration enhancer comprised of 2-ethyl-1, 3-hexanediol alone or in combination with oleic acid is disclosed. The 2-ethyl-1, 3-hexanediol may be present in an amount in the range of about 50% to 100% based on the weight of the carrier. The oleic acid may be used in combination with 2-ethyl-1, 3-hexanediol in an amount of about 1 to 40% based on the weight of the carrier to provide a synergistic effect with respect to percutaneous penetration enhancement. The compound 2-ethyl-1, 3-hexanediol as used alone and/or in combination with the oleic acid has been found to significantly enhance the delivery of a drug, to a patient, from a transdermal delivery system.
    Type: Grant
    Filed: September 26, 1989
    Date of Patent: January 8, 1991
    Assignee: Key Pharmaceuticals, Inc.
    Inventors: Nicholas Bodor, Thorsteinn Loftsson
  • Fruity flavored nasal decongestant composition
    Patent number: 4970240
    Abstract: An aqueous, flavored, topical, nasal decongestant composition containing an amount of oxymetazoline or a pharmaceutically acceptable salt thereof, e.g., oxymetazoline HCl sufficient to effect nasal decongestion and an amount of a fruity flavor e.g. cherry flavor, sufficient to mask the medicinal after-taste of the composition, together with an aqueous carrier.
    Type: Grant
    Filed: October 18, 1989
    Date of Patent: November 13, 1990
    Assignee: Schering Corporation
    Inventor: James R. Kielley
  • Non-cariogenic confections
    Patent number: 4963359
    Abstract: A non-cariogenic confectionery base free of cellulosics and graining compounds containing hydrogenated starch hydrolysates e.g. Lycasin 85%, more than 10 to about 50% by weight of at least one edible oil, fat, wax or mixtures thereof and an emulsifying amount of at least one emulsifier and a method of making same are disclosed. A non-cariogenic confectionery composition containing said confectionery base in homogeneous admixture with a semi-solid matrix containing various ingredients and optionally at least one medicament is also disclosed.
    Type: Grant
    Filed: January 30, 1989
    Date of Patent: October 16, 1990
    Assignee: Plough, Inc.
    Inventors: Joseph Haslwanter, Walter G. Chambliss
  • Extraction of human interleukin-4- from bacteria
    Patent number: 4958007
    Abstract: A method is provided for extracting human interleukin-4 (IL-4) from IL-4 expressing bacterial cells. The method comprises treating the bacterial cells with a deactivating agent, disrupting the cell membrane and recovering the IL-4.
    Type: Grant
    Filed: May 17, 1988
    Date of Patent: September 18, 1990
    Assignee: Schering-Plough Corp.
    Inventors: Yair Alroy, Paul Leibowitz
  • Intermediates in the preparation of alpha1(((1,1-dimethylethyl) amino) methyl)-4-hydroxy-1,3-benzenedimethanol
    Patent number: 4952729
    Abstract: There is disclosed an improved process for preparing albuterol which comprises reacting a 5-(haloacetyl)-2-hydroxybenzaldehyde with 1,1-dimethylethanamine in an organic solvent and in an inert atmosphere to form 5-[[(1,1-dimethylethyl)amino]acetyl]-2-hydroxybenzaldehyde and reducing the carbonyl functions to the corresponding hydroxy groups to form albuterol.
    Type: Grant
    Filed: November 3, 1989
    Date of Patent: August 28, 1990
    Assignee: Schering-Plough Corp.
    Inventors: Esther Babad, Nicholas Carruthers, Martin Steinman
  • Microbiological chiral reduction of carbonyl groups
    Patent number: 4948732
    Abstract: There is disclosed a novel microorganism Aspergillus niveus, ATCC 20922, and a process for chiral reduction of ketones using said microorganisms.
    Type: Grant
    Filed: September 26, 1989
    Date of Patent: August 14, 1990
    Assignee: Schering Corporation
    Inventor: William Charney
  • Sustained release labetalol tablets
    Patent number: 4940580
    Abstract: A sustained release dosage form of labetalol hydrochloride is disclosed comprising the active ingredient in a polymeric matrix of hydroxypropylmethylcellulose and polyvinylpyrrolidone and a pharmaceutically acceptable organic acid.
    Type: Grant
    Filed: February 2, 1989
    Date of Patent: July 10, 1990
    Assignee: Schering Corporation
    Inventors: Surendra Sangekar, Winston A. Vadino
  • Compositions and methods of decorating firm-rinded fruit
    Patent number: 4919954
    Abstract: A method of decorating the outside surface of a firm-rinded fruit of vines of the genus Cucurbita e.g. a pumpkin with a non-toxic, peelable film of predetermined design which comprises applying to the outer surface of said fruit at least one homogeneous film-forming composition containing a film-forming amount of a non-toxic polyvinyl alcohol polymer, a plasticizer, a volatile solvent ethanol and an amount of a colorant or a mixture of colorants sufficient to mask the color of said fruit, and allowing the solvent to evaporate thereby forming a non-toxic, peelable film of predetermined design on the surface of said fruit.
    Type: Grant
    Filed: December 20, 1988
    Date of Patent: April 24, 1990
    Assignee: Plough, Inc.
    Inventor: James E. McShane
  • Transdermal delivery of loratadine
    Patent number: 4910205
    Abstract: A pharmaceutical composition for the transdermal delivery of loratadine comprising isopropyl myristate and rosemary oil and the method of using such a composition for the treatment of allergic reactions are disclosed.
    Type: Grant
    Filed: May 2, 1988
    Date of Patent: March 20, 1990
    Assignee: Schering Corporation
    Inventors: Patricia W. Kogan, Joel A. Sequeira
  • Percutaneous penetration enhancer of oleic acid and 2-ethyl-1,3-hexanediol
    Patent number: 4885174
    Abstract: Pharmaceutical preparations comprised of a pharmaceutically active ingredient and a carrier which comprises a percutaneous penetration enhancer comprised of 2-ethyl-1, 3-hexanediol alone or in combination with oleic acid is disclosed. The 2-ethyl-1, 3-hexanediol may be present in an amount in the range of about 50% to 100% based on the weight of the carrier. The oleic acid may be used in combination with 2-ethyl-1, 3-hexanediol in an amount of about 1 to 40% based on the weight of the carrier to provide a synergistic effect with respect to percutaneous penetration enhancement. The compound 2-ethyl-1, 3-hexanediol as used alone and/or in combination with the oleic acid has been found to significantly enhance the delivery of a drug, to a patient, from a transdermal delivery system.
    Type: Grant
    Filed: May 25, 1988
    Date of Patent: December 5, 1989
    Assignee: Key Pharmaceuticals, Inc.
    Inventors: Nicholas Bodor, Thorsteinn Loftsson
  • Novel Aspergillus niveus microorganism used for the chiral reduction of carbonyl groups
    Patent number: 4879233
    Abstract: There is disclosed a novel microorganism Aspergillus niveus, ATCC 20922, and a process for chiral reduction of ketones using said mircoorganisms.
    Type: Grant
    Filed: February 10, 1989
    Date of Patent: November 7, 1989
    Assignee: Schering Corporation
    Inventor: William Charney
  • Pressurized fluorination of hydroxy alkyl groups
    Patent number: 4876352
    Abstract: There is disclosed a high yielding process for converting a hydroxy alkyl oxazolidine compound to the corresponding fluoro derivative by reacting the hydroxy compound with .alpha., .alpha.-difluoroalkylamine under pressure.
    Type: Grant
    Filed: September 14, 1988
    Date of Patent: October 24, 1989
    Assignee: Schering Corporation
    Inventors: Doris P. Schumacher, Jon E. Clark, Bruce L. Murphy
  • Nasal spray pump
    Patent number: D308100
    Type: Grant
    Filed: August 28, 1987
    Date of Patent: May 22, 1990
    Assignee: Schering Corporation
    Inventors: Keith A. Bishop, William S. Blake
  • Oral medicament dispenser for liquid or cream
    Patent number: D308101
    Type: Grant
    Filed: March 25, 1987
    Date of Patent: May 22, 1990
    Assignee: Plough, Inc.
    Inventor: Edward Tugwood
  • Bottle
    Patent number: D313751
    Type: Grant
    Filed: July 11, 1988
    Date of Patent: January 15, 1991
    Assignee: Plough, Inc.
    Inventor: Albert K. Taylor