Patents Represented by Attorney John M. Brown

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(-)-.alpha.-{2-[Bis(1-methylethyl)amino]ethyl}-.a lpha.-phenyl-2-pyridineacetamide and pharmacologically acceptable salts thereof

Patent number: 4255582

Abstract: Preparation of antiarrhythmic (-)-.alpha.-{2-[bis(1-methylethyl)amino]ethyl}-.alpha.-phenyl-2-pyridineac etamide and pharmacologically acceptable salts thereof characterized by advantageously diminished and/or favorably altered side-effects such as anticholinergic activity is disclosed.

Type: Grant

Filed: February 2, 1979

Date of Patent: March 10, 1981

Assignee: G. D. Searle & Co.

Inventor: Paul B. Sollman
25-Alkylcholest-5-ene-3.beta.,22-diols and esters thereof

Patent number: 4205004

Abstract: 25-Alkylcholest-5-ene-3.beta.,22-diols and esters thereof adapted to inhibit the activity of 3-hydroxy-3-methylglutaryl coenzyme A reductase are disclosed.

Type: Grant

Filed: July 28, 1978

Date of Patent: May 27, 1980

Assignee: D. G. Searle & Co.

Inventor: Robert J. Chorvat
N-[4-Azido-5-(2-ethoxyethyl)-6-phenyl-2-pyrimidinyl]acetamide and congeners

Patent number: 4205169

Abstract: Preparation and the diuretic utility of N-[4-azido-5-(2-ethoxyethyl)-6-phenyl-2-pyrimidinyl]acetamide and congeners are disclosed.

Type: Grant

Filed: April 9, 1979

Date of Patent: May 27, 1980

Assignee: G. D. Searle & Co.

Inventor: Hans A. Wagner
25-Alkyl-3.beta.-hydroxycholest-5-en-7-ones and esters thereof

Patent number: 4193930

Abstract: 25-Alkyl-3.beta.-hydroxycholest-5-en-7-ones and esters thereof adapted to lower serum cholesterol and inhibit the activity of 3-hydroxy-3-methylglutaryl coenzyme A reductase are disclosed.

Type: Grant

Filed: July 28, 1978

Date of Patent: March 18, 1980

Assignee: G. D. Searle & Co.

Inventor: Robert J. Chorvat
Phenyl 5Z,8Z,11Z,14Z-eicosatetraenoate and congeners

Patent number: 4181670

Abstract: Preparation and use of platelet aggregation inhibiting and antisecretory phenyl 5Z,8Z,11Z,14Z-eicosatetraenoate and congeners are disclosed.

Type: Grant

Filed: December 11, 1978

Date of Patent: January 1, 1980

Assignee: G. D. Searle & Co.

Inventor: Chi-Dean Liang
3 ,9-Dihydro-3,9-dioxo-2H-indeno(2,1-c)-pyridine-4-(carbonitriles/carboxami des)

Patent number: 4180666

Abstract: Preparation and use of anticonvulsant 3,9-dihydro-3,9-dioxo-2H-indeno[2,1-c]pyridine-4-(carbonitriles/carboxamid es) are disclosed.

Type: Grant

Filed: December 26, 1978

Date of Patent: December 25, 1979

Assignee: G. D. Searle & Co.

Inventor: Robert J. Chorvat
Alkyl 7-[tetrahydro-4-(3-hydroxy-1-octenyl)-2,6-dioxo-4H-cyclopenta-1,3-dioxol -5-yl]-5-heptenoates

Patent number: 4171312

Abstract: Preparation of alkyl 7-[tetrahydro-4-(3-hydroxy-1-octenyl)-2,6-dioxo-4H-cyclopenta-1,3-dioxol-5 -yl]-5-heptenoates adapted to counteract conception and suppress the activity of 3-methylglutaryl coenzyme A reductase is disclosed.

Type: Grant

Filed: May 8, 1978

Date of Patent: October 16, 1979

Assignee: G. D. Searle & Co.

Inventor: Karlene W. Salamon
Process for preparing steroidal 3-oxo-4,6-dienes such as 17-hydroxy-3-oxo-17.alpha.-pregna-4,6-diene-21-carboxylic acid.gamma.-lactone

Patent number: 4155906

Abstract: A process for preparing 17-hydroxy-3-oxo-17.alpha.-pregna-4,6-diene-21-carboxylic acid .gamma.-lactone by contacting 17-hydroxy-3-oxy-17.alpha.-pregna-3,5-diene-21-carboxylic acid .gamma.-lactone with an appropriate halogenating agent in the presence of an amine base, the corresponding hydrohalide salt thereof, and approximately 1-2 molar equivalents (relative to the lactonic starting material) of water, using a cold solvent as the contact medium, and heating the resultant mixture with a dehydrohalogenating agent, is disclosed.

Type: Grant

Filed: December 2, 1977

Date of Patent: May 22, 1979

Assignee: G. D. Searle & Co.

Inventors: Hugh L. Dryden, Jr., Gayle M. Webber
20/22/23/24-Oxa-7-oxocholesterols and esters thereof

Patent number: 4125544

Abstract: Preparation and the antimicrobial and antihypercholesterolemic utility of 20/22/23/24-oxa-7-oxocholesterols and esters thereof are disclosed.

Type: Grant

Filed: June 9, 1977

Date of Patent: November 14, 1978

Assignee: G. D. Searle

Inventor: John H. Dygos
21-(Acetyloxy)-3-oxo-24-norchola-4,20(22)-diene-23-nitrile and intermediates thereto

Patent number: 4110325

Abstract: Preparation of 21-(acetyloxy)-3-oxo-24-norchola-4,20(22)-diene-23-nitrile; its diuretic, antiulcerogenic, and antiviral utility; and intermediates whereby the preparation can be variously effected are disclosed.

Type: Grant

Filed: August 10, 1977

Date of Patent: August 29, 1978

Assignee: G. D. Searle & Co.

Inventors: George R. Lenz, John A. Schulz
3.beta.,17-Dihydroxy-5.alpha.,17.alpha.-pregn-20-ene-21-carboxylic acid .gamma.-lactone and esters thereof

Patent number: 4108851

Abstract: Preparation of 3.beta.,17-dihydroxy-5.alpha.,17.alpha.-pregn-20-ene-21-carboxylic acid .gamma.-lactone and esters thereof, the analgesic utility of the esters, and the utility of the diol both as an intermediate and by reason of its antiviral activity are disclosed.

Type: Grant

Filed: July 20, 1977

Date of Patent: August 22, 1978

Assignee: G. D. Searle & Co.

Inventors: Edward A. Brown, Frank B. Colton
11.beta.,18-EPOX Y-9.alpha.-HALO-17,18-DIHYDROXY-3-OXO-17.alpha.-PREGN-4-ENE-21-CARBOXYLIC ACID .gamma.-LACTONES AND CONGENERS

Patent number: 4104271

Abstract: Preparation and the diuretic utility of 11.beta.,18-epoxy-9.alpha.-halo-17,18-dihydroxy-3-oxo-17.alpha.-pregn-4-en e-21-carboxylic acid .gamma.-lactones and congeners are disclosed.

Type: Grant

Filed: June 13, 1977

Date of Patent: August 1, 1978

Assignee: G. D. Searle & Co.

Inventors: John S. Baran, Ivar Laos
7 .xi.-(Alkoxycarbonyl)-6.xi.-alkyl/halo-17-hydroxy-3-oxo-17.alpha.-pregn-4 -ene-21-carboxylic acid .gamma.-lactones and corresponding 21-carboxylic acids, their salts, and esters

Patent number: 4069219

Abstract: Various preparations and the diuretic activity of 7.xi.-(alkoxycarbonyl)-6.xi.-alkyl/halo-17-hydroxy-3-oxo-17.alpha.-pregn-4 -ene-21-carboxylic acid .gamma.-lactones and corresponding 21-carboxylic acids, their salts, and esters are disclosed.

Type: Grant

Filed: December 27, 1976

Date of Patent: January 17, 1978

Assignee: G. D. Searle & Co.

Inventor: Richard M. Weier
23-Hydroxy-3-oxo-24-norchola-4,17(20)-dien-21-oic acid .gamma.-lactone and intermediates thereto

Patent number: 4062843

Abstract: 23-Hydroxy-3-oxo-24-norchola-4,17(20)-dien-21-oic acid .gamma.-lactone, intermediates thereto, and antiviral utility thereof are disclosed.

Type: Grant

Filed: December 29, 1976

Date of Patent: December 13, 1977

Assignee: G. D. Searle & Co.

Inventor: Walter R. Benn
4-{[4-(Diphenylmethyl)-1-piperidinyl]methyl}benzenamines

Patent number: 4035372

Abstract: 4-{[4-(Diphenylmethyl)-1-piperidinyl]methyl}benzenamines useful by reason of their vasodilating activity are disclosed.

Type: Grant

Filed: August 13, 1976

Date of Patent: July 12, 1977

Assignee: G. D. Searle & Co.

Inventors: James R. Deason, Robert W. Hamilton, Harman S. Lowrie, Kurt J. Rorig
2-{3-[4-Azatricyclo(4.3.1.1.sup.3,8) undecan-4-yl]-1,1-diphenylpropyl}-5-methyl-1,3,4-oxadiazole and congeners

Patent number: 4025524

Abstract: Preparation and the valuable antispasmodic, antiarrhythmic, antidiarrheal, and antiviral properties of 2-{3-[4-azatricyclo(4.3.1.1.sup.3,8)undecan-4-yl]-1,1-diphenylpropyl}-5-me thyl-1,3,4-oxadiazole and congeners are disclosed.

Type: Grant

Filed: January 26, 1976

Date of Patent: May 24, 1977

Assignee: G. D. Searle & Co.

Inventors: Gilbert W. Adelstein, H. William Sause
(8.alpha.,13A.beta.)-8-CARBOCYCLIC/CARBOCYCLIC METHYL-5,8,13,13A-TETRAHYDRO-2,3,10,11-TETRAMETHOXY-6H-dibenzo[a,g]quino lizines and intermediates thereto

Patent number: 4013666

Abstract: Preparation of antiarrhythmic and antifungal (8.alpha.,13a.beta. )-8-carbocyclic/carbocyclic methyl-5,8,13,13a-tetrahydro-2,3,10,11-tetramethoxy-6H-dibenzo[a,g]quinoli zines is disclosed.

Type: Grant

Filed: March 15, 1976

Date of Patent: March 22, 1977

Assignee: G. D. Searle & Co.

Inventor: George R. Lenz
N,N-Disubstituted 2,3-diphenylallylamines

Patent number: 4013643

Abstract: The above-captioned compounds are produced from optionally substituted benzoin compounds by sequential reactions with trizincbismethylene dibromide, phosphorous trichloride and an appropriately substituted amine. The instant compounds are valuable as pharmacological agents as is evidenced by their anti-microbial, anti-arrhythmic, pepsin-inhibitory and anti-hypertensive activity.

Type: Grant

Filed: July 25, 1975

Date of Patent: March 22, 1977

Assignee: G. D. Searle & Co.

Inventor: Leonard N. Nysted
[8 .alpha.(E), 13a.beta.]-5,8,13,13a-tetrahydro-2,3,10,11-tetramethoxy-8-(2-phenylethen yl)-6H-dibenzo[a,g]quinolizines and intermediates thereto

Patent number: 4013644

Abstract: Preparation of antifungal [8.alpha.(E),13a.beta.]-5,8,13,13a-tetrahydro-2,3,10,11-tetramethoxy-8-(2- phenylethenyl)-6H-dibenzo[a,g]quinolizines is disclosed.

Type: Grant

Filed: March 15, 1976

Date of Patent: March 22, 1977

Assignee: G. D. Searle & Co.

Inventor: George R. Lenz
(E)-4-Hydroxy-11,15-dioxoprosta-8(12),13-dien-1-oic acid .gamma.-lactones

Patent number: 4010169

Abstract: Preparation and the antilipogenic utility of (E)-4-hydroxy-11,15-dioxoprosta-8(12),13-dien-1-oic acid .gamma.-lactones are disclosed.

Type: Grant

Filed: March 10, 1976

Date of Patent: March 1, 1977

Assignee: G. D. Searle & Co.

Inventors: Leland J. Chinn, Karlene W. Salamon

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