Patents Represented by Attorney John M. Brown

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  • 2,2-Dimethyl-2-[(7,15 ,16,17-tetrahydro-17,17-dimethyl-6H-cyclopenta[a]phenanthren-3-yl)oxy]eth yl alkanedioates and intermediates thereto
    Patent number: 4008257
    Abstract: Preparation and the antihypercholesterolemic activity of 2,2-dimethyl-2-[(7,15,16,17-tetrahydro-17,17-dimethyl-6H-cyclopenta[a]phen anthren-3-yl)oxy]ethyl alkanedioates and intermediates thereto are disclosed.
    Type: Grant
    Filed: March 10, 1976
    Date of Patent: February 15, 1977
    Assignee: G. D. Searle & Co.
    Inventors: John H. Dygos, Karlene W. Salamon
  • 6-(Aminated methyl)-3.beta.-oxy-5.alpha.-(cholestane-stigmastane)-5,6-diols, salts thereof, and intermediates thereto
    Patent number: 4001220
    Abstract: Preparation and the analgesic, antiulcerogenic, hypolipemic, and antimicrobial activity of 6-(aminated methyl)-3.beta.-oxy-5.alpha.-(cholestane/stigmastane)-5,6-diols, salts thereof, and intermediates thereto are disclosed.
    Type: Grant
    Filed: January 27, 1976
    Date of Patent: January 4, 1977
    Assignee: G. D. Searle & Co.
    Inventor: Leonard N. Nysted
  • 5-Alkyl-10-(aminocarbonyl/aminomethyl/cyano)-10,11-dihy dro-5H-dibenz[b,f]azepine-10-alkanamines
    Patent number: 3985730
    Abstract: Preparation and the antiarrhythmic and antimicrobial properties of 5-alkyl-10-(aminocarbonyl/aminomethyl/cyano)-10,11-dihydro-5H-dibenz[b,f]a zepine-10-alkanamines and equivalent salts are disclosed.
    Type: Grant
    Filed: November 4, 1974
    Date of Patent: October 12, 1976
    Assignee: G. D. Searle & Co.
    Inventors: John W. Cusic, Charles R. Ellefson
  • (16.alpha.)-16,17-ALKYLIDENEBIS(OXY)-3-ARYLPREGNA-2,4-TRIEN-20-ONES
    Patent number: 3974143
    Abstract: Preparation of (16.alpha.)-16,17-alkylidenebis(oxy)-3-arylpregna-2,4,6-trien-20-ones and their progestational and glucocorticoid antiinflammatory utility are disclosed.
    Type: Grant
    Filed: September 19, 1975
    Date of Patent: August 10, 1976
    Assignee: G. D. Searle & Co.
    Inventor: Charles S. Markos
  • 5-(1,2,3,4-Tetrahydro-6-methoxy-2-naphthyl )-2-hydroxy-1-methylcyclopentaneethanols and esters
    Patent number: 3970686
    Abstract: Preparation and the antihypercholesterolemic activity of 5-(1,2,3,4-tetrahydro-6-methoxy-2-napthyl)-2-hydroxy-1-methylcyclopentanee thanols and esters thereof are disclosed.
    Type: Grant
    Filed: March 31, 1975
    Date of Patent: July 20, 1976
    Assignee: G. D. Searle & Co.
    Inventor: John H. Dygos
  • 1-Azidoalkylimidazoles
    Patent number: 3962274
    Abstract: Preparation and the antimicrobial and antihypertensive properties of 1-azidoalkylimidazoles and their salts are disclosed.
    Type: Grant
    Filed: August 11, 1975
    Date of Patent: June 8, 1976
    Assignee: G. D. Searle & Co.
    Inventor: Ernest F. Levon
  • 6-Aminomethylated 3-oxygenated cholest-5-enes
    Patent number: 3960904
    Abstract: Preparation of analgesic, antisecretory, anti-ulcerogenic, hypolipemic, and antimicrobial 6-aminomethylated 3-oxygenated cholest-5-enes is disclosed.
    Type: Grant
    Filed: June 6, 1975
    Date of Patent: June 1, 1976
    Assignee: G. D. Searle & Co.
    Inventor: Leonard N. Nysted
  • (5Z,13E,15S)-15-Hydroxy-11-oxoprosta-5,9.13-trien-1-oic acid and esters
    Patent number: 3954844
    Abstract: Preparation and the antispasmodic utility of (5Z,13E,15S)-15-hydroxy-11-oxoprosta-5,9,13-trien-1-oic acid and esters are disclosed.
    Type: Grant
    Filed: January 3, 1975
    Date of Patent: May 4, 1976
    Assignee: G. D. Searle & Co.
    Inventors: Frank B. Colton, Leland J. Chinn
  • 4',5'-Dihydrospiro[androst/estr-4-ene-17,2'(3'H)-furan]3,4'-dione and congeners, and intermediates thereto
    Patent number: 3939155
    Abstract: 4',5'-Dihydrospiro[androst/estr-4-ene-17,2'(3'H)-furan]-3,4'-dione and congeners; the antiviral, antiandro genic, diuretic, and/or antiestrogenic activity inherent therein; and means of preparing them via novel intermediates are disclosed.
    Type: Grant
    Filed: June 28, 1974
    Date of Patent: February 17, 1976
    Assignee: G. D. Searle & Co.
    Inventor: Edward A. Brown
  • 1-(10-Cyano/halo-5H-dibenzo[a,d]cyclohepte n-5-yl)-4-[(pyridylmethylene)amino]piperazines
    Patent number: 3937701
    Abstract: Preparation and the anticonvulsant utility of 1-(10-cyano/halo-5H-dibenzo[a,d]cyclohepten-5-yl)-4-[(pyridylmethylene)ami no]piperazines are disclosed.
    Type: Grant
    Filed: November 1, 1974
    Date of Patent: February 10, 1976
    Assignee: G. D. Searle & Co.
    Inventors: John W. Cusic, Charles R. Ellefson