Patents Represented by Attorney, Agent or Law Firm John W. Harbour
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Patent number: 7288540Abstract: Substituted phenylalkynes of formula (I) compositions containing them and their methods of use to treat histamine related disorders are described, wherein R1, R2, R3, R4, R5 and n are as defined.Type: GrantFiled: July 20, 2006Date of Patent: October 30, 2007Assignee: Ortho-McNeil Pharmaceutical, Inc.Inventors: Richard Apodaca, Xiaohu Deng, Jill A. Jablonowski, Neelakandha Mani, Chennagiri R. Pandit, Wei Xiao
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Patent number: 6573267Abstract: This invention is directed to aroyl aminoacyl pyrroles pharmaceutically useful as agents and modulators for the treatment of central nervous system disorders and a method for the treatment of central nervous system disorders including, but not limited to, use of the compounds of the present invention as anticonvulsant agents and modulators, antiepileptic agents and modulators, neuroprotective agents and modulators, muscle relaxant agents and modulators and as agents and modulators for the treatment of neuropathic pain.Type: GrantFiled: June 29, 2001Date of Patent: June 3, 2003Assignee: Ortho-McNeil Pharmaceutical, Inc.Inventors: John R. Carson, Philip M. Pitis
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Patent number: 6521655Abstract: This invention relates to a series of substituted imidazoles of Formula I pharmaceutical compositions containing them and intermediates used in their manufacture. The compounds of the invention inhibit the production of a number of inflammatory cytokines, and are useful in the treatment of diseases associated with overproduction of inflammatory cytokines.Type: GrantFiled: November 3, 2000Date of Patent: February 18, 2003Assignee: Ortho-McNeil Pharmaceutical, Inc.Inventors: Scott A. Beers, Elizabeth A. Malloy, Michael P. Wachter, Wei Wu
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Patent number: 6492387Abstract: This invention is directed to isoindolyl and isoquinolinyl aroyl pyrrole compounds pharmaceutically useful as agents or modulators for the treatment of central nervous system disorders and methods for the treatment of central nervous system disorders.Type: GrantFiled: December 11, 2001Date of Patent: December 10, 2002Assignee: Ortho-McNeil Pharamaceutical, Inc.Inventors: John R. Carson, Philip M. Pitis
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Patent number: 6426356Abstract: Certain imidazoethyl thiophenes/thiazoles and benzothiophenes of the formula: where Z is CH or N; and X is independently selected from the group consisting of hydrogen, C1-4alkyl, bromine, chlorine, iodide, trifluoromethyl, C4-1alkoxy and nitro; are &agr;2-adrenoceptor agonists/antagonists which are useful in the treatment of hypertension, glaucoma, sexual dysfunction, depression, attention deficit hyperactivity disorder, the need for anesthesia, cardiac arrythmia or the need for analgesia.Type: GrantFiled: November 16, 1999Date of Patent: July 30, 2002Assignee: Ortho-McNeil Pharmaceutical, Inc.Inventors: Ellen W. Baxter, Michele C. Jetter
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Patent number: 6067749Abstract: There is disclosed an improved poppy straw of a stably reproducing Papaver somniferum for the extraction of thebaine and/or oripavine, the threshed straw having thebaine and oripavine constituting about 50% by weight or greater of the alkaloid combination consisting of morphine, codeine, thebaine and oripavine.Type: GrantFiled: July 11, 1996Date of Patent: May 30, 2000Assignee: Tasmanian Alkaloids Pty. Ltd.Inventors: Anthony John Fist, Christopher James Byrne, Wayne Lyle Gerlach
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Patent number: 5641757Abstract: Shelf stable formulations of 2-CdA in water are disclosed which contain benzyl alcohol, m-cresol, a buffer and sodium chloride or a solubilizing agent such as propylene glycol or polyethylene glycol.Type: GrantFiled: December 22, 1994Date of Patent: June 24, 1997Assignee: Ortho Pharmaceutical CorporationInventors: Michael Bornstein, Rosemary Rozman, Kevin Francis Long, Hsiao Yung Guh
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Patent number: 5621113Abstract: The 4-[(thien-2-yl)methyl]-imidazoles of the formulae: ##STR1## wherein R is hydrogen or methyl,X is hydrogen, C.sub.1-4 alkyl, bromine or chlorine, andY is hydrogen, C.sub.1-4 alkyl, bromine or chlorine;with the proviso that X and Y are not both simultaneously hydrogen.have exceptional analgesic activity.Type: GrantFiled: March 28, 1996Date of Patent: April 15, 1997Assignee: Ortho Pharmaceutical CorporationInventors: Robert E. Boyd, Chris R. Rasmussen, Jeffrey B. Press
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Patent number: 5601092Abstract: A process for drawing, with plug assist, thin walled, closed-ended, tubular articles of thermoplastic elastomer is disclosed as well as a thermoplastic elastomer and apparatus therefor. According to the process, a plug, extensible into the mold cavity, is employed concurrently with a varying air pressure differential across the faces of the preform to bias the flow of the drawn article axially along the length of the tubular mold and away from the mold walls. At a point where the article is drawn substantially the length of the tubular mold, the mold is evacuated and the article finally formed against the mold walls. Such articles are usefully employed as condoms or finger cots.Type: GrantFiled: May 31, 1995Date of Patent: February 11, 1997Assignee: Ortho-McNeil, Inc.Inventors: Robert G. Miller, William C. Miller, Oskar T. Tankovitz
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Patent number: 5565456Abstract: Aroyl(piperidinyl and piperazinyl)acyl pyrroles of the following formula have anxiolytic activity: ##STR1## wherein, Y is selected from the group consisting of N, CH or COH;A.sup.1 is selected from the group consisting of ##STR2## n is an integer from 1 to 5; R1 is selected from the group consisting of H and C.sub.1-4 alkyl;R.sup.2 and R.sup.3 are selected from the group consisting of H and C.sub.1-4 alkyl;R.sup.4 is selected from the group consisting of halo, C.sub.1-4 alkyl, hydroxy, C.sub.1-4 alkoxy, nitro, amino, C.sub.1-4 acylamino, cyano, trihaloC.sub.1-4 alkyl, C.sub.1-4 alkylsulfonyl, C.sub.1-4 alkylsulfinyl and C.sub.1-4 acyl; andR.sup.5 is selected from the group consisting of halo, C.sub.1-4 alkyl, hydroxy, C.sub.1-4 alkoxy, nitro, amino, C.sub.1-4 acylamino, cyano, trihaloC.sub.1-4 alkyl, C.sub.1-4 alkylsulfonyl, C.sub.1-4 alkylsulfinyl and C.sub.1-4 acyl; and acid addition salts thereof.Type: GrantFiled: March 15, 1995Date of Patent: October 15, 1996Assignee: Ortho Pharmaceuctical CorporationInventors: Richard J. Carmosin, John R. Carson, Philip Pitis
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Patent number: 5543530Abstract: The 4-arylisoindoles of the following formula are effective analgesics: ##STR1## including the purified stereoisomers and pharmaceutically acceptable salts thereof,wherein ##STR2## R.sup.b is hydroxy or C.sub.1-5 alkylcarbonyloxy.Type: GrantFiled: December 23, 1993Date of Patent: August 6, 1996Assignee: Ortho Pharmaceutical CorporationInventors: Richard J. Carmosin, John R. Carson, Philip Pitis, Robert B. Raffa
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Patent number: 5458936Abstract: A condom of thermoplastic elastomer is drawn from a polyesterurethane.Type: GrantFiled: November 29, 1993Date of Patent: October 17, 1995Assignee: Ortho-McNiel, Inc.Inventors: Robert G. Miller, Oskar T. Tankovitz
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Patent number: 5457212Abstract: A process for the preparation of enantiomerically pure thienopyran derivatives of the formula ##STR1## is described. The thienopyran derivatives are relaxants of smooth muscle tone and as such are useful in vascular tissue for the treatment of hypertension disease, angina and other vascular disorders characterized by poor regional perfusion.Type: GrantFiled: September 30, 1994Date of Patent: October 10, 1995Assignee: Ortho Pharmaceutical CorporationInventors: Jeffery B. Press, Pauline J. Sanfilippo, Maud Urbanski
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Patent number: 5387602Abstract: 1,5-Diphenyl-3-(N-hydroxycarbamoyloxyalkyl)pyrazoles of the general formula: ##STR1## are disclosed to have anti-inflammatory activity in mammals.Type: GrantFiled: August 30, 1993Date of Patent: February 7, 1995Assignee: Ortho Pharmaceutical CorporationInventor: Michael Ferro
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Patent number: 5382666Abstract: Biphenylyl tetrazoles for treating hypertension in mammals of the formula: ##STR1## where X is CH.sub.2, O, S, N--R.sup.4, NH, NCHO, NCOCH.sub.3 or NCO.sub.2 R.sup.4 ;R.sup.1 and R.sup.2 are the same or different and are C.sub.1-6 alkyl; andR.sup.4 is C.sub.1-6 alkyl;including methods and intermediates for the production of the same.Type: GrantFiled: October 20, 1993Date of Patent: January 17, 1995Assignee: Ortho Pharmaceutical CorporationInventors: Jeffrey D. Hsi, William V. Murray
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Patent number: 5256658Abstract: Biphenylyl tetrazoles for treating hypertension in mammals of the formula: ##STR1## where X is CH.sub.2, O, S, N--R.sup.4, NH, NCHO, NCOCH.sub.3 or NCO.sub.2 R.sup.4 ;R.sup.1 and R.sup.2 are the same or different and are C.sub.1-6 alkyl; andR.sup.4 is C.sub.1-6 alkyl;including methods and intermediates for the production of the same.Type: GrantFiled: January 15, 1993Date of Patent: October 26, 1993Assignee: Ortho Pharmaceutical CorporationInventors: Jeffrey D. Hsi, William V. Murray
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Patent number: 5144028Abstract: Carbapenems of the formula ##STR1## are useful intermediates in the preparation of 2-(9-fluorenonyl)-carbapenem antibacterial agents.Type: GrantFiled: October 9, 1990Date of Patent: September 1, 1992Assignee: Merck & Co., Inc.Inventors: Mark L. Greenlee, Frank P. DiNinno, Lovji D. Cama, James V. Heck
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Patent number: 5140030Abstract: Disclosed are 2-aza-substituted 1-carbadethiapen-2-em-3-carboxylic acids. I, where the generic 2-aza group includes azido, acylamino, amino, alkylamino, dialkylamino, triazolyl, triazolinyl, aziridinyl, and their pharmaceutically acceptable salt, ester, anhydride and amide derivatives which are useful as antibiotics. Also disclosed are processes for the preparation of I from the known, appropriately substituted bicyclic keto ester II via the 2-azido central intermediate III: ##STR1## wherein R.sup.16 is H or CH.sub.3, preferably beta-methyl; R.sup.6, and R.sup.7 are independently hydrogen, linear, branched or cyclic C.sub.1 -C.sub.5 alkyl, which can be substituted with fluoro, hydroxy, protected hydroxy, sulfoxy, amino, protected amino, wherein R.sup.6 and R.sup.7 taken together can also be C.sub.2 -C.sub.4 alkylidene, similarly substituted; with the proviso that both R.sup.6 and R.sup.7 are not unsubstituted alkyl, R.sup.1 and R.sup.Type: GrantFiled: August 16, 1990Date of Patent: August 18, 1992Assignee: MerckInventors: Burton G. Christensen, Ronald W. Ratcliffe, John C. Chabala
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Patent number: 5138050Abstract: New antibacterial 6-amido-1-methylcarbapenems and process for their synthesis involving new azetidinone intermediates.Type: GrantFiled: March 7, 1991Date of Patent: August 11, 1992Assignee: Merck & Co., Inc.Inventors: Ravindra N. Guthikonda, Frank P. DiNinno, Thomas N. Salzmann
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Patent number: 5132422Abstract: Carbapenems of the formula ##STR1## are useful intermediates to antibacterial agents.Type: GrantFiled: October 9, 1990Date of Patent: July 21, 1992Assignee: Merck & Co., Inc.Inventors: Frank P. Dininno, Mark L. Greenlee