Abstract: Systemic delivery of insulin to a mammalian host is accomplished by inhalation of a dry powder of insulin. It has been found that dry insulin powders are rapidly absorbed through the alveolar regions of the lungs.
Type:
Grant
Filed:
July 1, 2003
Date of Patent:
April 21, 2009
Assignee:
Novartis AG
Inventors:
John S. Patton, Linda S. Foster, Robert M. Platz
Abstract: The invention relates to a process for the manufacture of a compound of formula: (Formula I); or a salt, especially a pharmaceutically acceptable salt with a base, thereof or a lactone thereof wherein the element (a) represents —CH2—CH2— or —CH?CH— and R represents a cyclic radical.
Abstract: The present invention provides compounds of the formula wherein R is optionally substituted lower alkyl, cycloalkyl or aryl; R? is alkyl or aryl; n is zero or an integer of 1 or 2; or an enantiomer thereof; or an enantiomeric mixture thereof. The compounds of formula (I) are bridged C2-symmetric biphenyldiphosphine analogs and, thus, may be employed as ligands to generate chiral transition metal catalysts which may be applied in a variety of asymmetric reactions. The compounds of the present invention are easily accessible in high diastereomeric and optical purity according to the methods disclosed herein.
Abstract: The present invention provides methods for the efficient preparation of indole derivatives of the formula wherein X is methyl or benzyl; and R1, R2, R3 and R4 are independently hydrogen, halogen, cyano, nitro, hydroxy, optionally substituted alkyl, alkoxy, aralkoxy, carboxy, alkoxycarbonyl, aryl or heteroaryl; or R1 and R2 combined together with the carbon atoms to which they are attached form a fused 6-membered aromatic ring; by reacting indoles of the formula wherein R1, R2, R3 and R4 have meanings as defined for formula I, with dimethyl carbonate when X is methyl, or with dibenzyl carbonate when X is benzyl, in the presence of a catalytic amount of a base at an ambient temperature to afford compounds of formula I wherein X, R1, R2, R3 and R4 have meanings as defined herein above. In particular, the present invention provides methylation and benzylation of the indole nitrogen in nearly quantitative yields using 1,4-diazabicyclo[2.2.
Type:
Grant
Filed:
December 10, 2004
Date of Patent:
June 27, 2006
Assignee:
Novartis AG
Inventors:
Steven Dell, Mario E Lozanov, Wen-Chung Shieh
Abstract: A method of successfully controlling sea lice in commercial fish farming, in an efficient and environmentally friendly way, with the compounds named in claim 1, preferably by injection, and a method of automating this type of control, are described.
Abstract: A drinking vessel with adjustable handles for a juvenile is disclosed. The drinking vessel features two handles that can be adjusted apart from each other at varying fixed or articulated angles. Furthermore, the two handles can be adjusted without the intervention of a person disassembling the drinking vessel in order to reorient or readjust the handles. The adjustable handles allow the juvenile to manipulate and hold the drinking vessels with greater flexibility.
Abstract: The present invention provides methods for the efficient preparation of indole derivatives of the formula wherein X is methyl or benzyl; and R1, R2, R3 and R4 are independently hydrogen, halogen, cyano, nitro, hydroxy, optionally substituted alkyl, alkoxy, aralkoxy, carboxy, alkoxycarbonyl, aryl or heteroaryl; or R1 and R2 combined together with the carbon atoms to which they are attached form a fused 6-membered aromatic ring; by reacting indoles of the formula wherein R1, R2, R3 and R4 have meanings as defined for formula I, with dimethyl carbonate when X is methyl, or with dibenzyl carbonate when X is benzyl, in the presence of a catalytic amount of a base at an ambient temperature to afford compounds of formula I wherein X, R1, R2, R3 and R4 have meanings as defined herein above. In particular, the present invention provides methylation and benzylation of the indole nitrogen in nearly quantitative yields using 1,4-diazabicyclo[2.2.
Type:
Grant
Filed:
July 16, 2003
Date of Patent:
December 6, 2005
Assignee:
Novartis AG
Inventors:
Steven Dell, Mario Emilov Lozanov, Wen-Chung Shieh
Abstract: A drinking vessel with adjustable handles for a juvenile is disclosed. The drinking vessel features two handles that can be adjusted apart from each other at varying fixed or articulated angles. Furthermore, the two handles can be adjusted without the intervention of a person disassembling the drinking vessel in order to reorient or readjust the handles. The adjustable handles allow the juvenile to manipulate and hold the drinking vessels with greater flexibility.