Patents Represented by Attorney Jon S. Saxe

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  • Method of treating milk fever
    Patent number: 4599330
    Abstract: The present invention relates to a method of preventing milk fever which comprises administering to a preparturient female ruminant an effective amount of 24,24-difluoro-1.alpha.,25-dihydroxycholecalciferol.
    Type: Grant
    Filed: May 17, 1982
    Date of Patent: July 8, 1986
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Alfred Boris, John J. Partridge, Milan R. Uskokovic
  • Process for the preparation of aqueous solutions of potentiated sulfonamides
    Patent number: 4599416
    Abstract: Aqueous solutions of antibacterially active sulfonamides and sulfonamide potentiators, which are suitable for parenteral administration and which contain no organic solvent, are prepared by reacting a sulfonamide RH with an aldehyde R.sup.1 CHO to give a compound of the formula R.sup.1 CH(R).sub.2 and dissolving said compound in water together with the sulfonamide potentiator.
    Type: Grant
    Filed: September 3, 1982
    Date of Patent: July 8, 1986
    Assignee: Hoffmann-La Roche Inc.
    Inventor: Ivan Kompis
  • Unsaturated eicosanoic acids
    Patent number: 4599443
    Abstract: A compound of the formula ##STR1## where R.sub.1 is hydrogen, lower alkyl, alkaline earth metal or alkali metal; or magnesium halide salts thereof, useful as intermediates for unsaturated eicosanoic acids and derivatives thereof which inhibit the synthesis of SRS-A.
    Type: Grant
    Filed: October 31, 1984
    Date of Patent: July 8, 1986
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Ka-Kong Chan, George W. Holland, Perry Rosen
  • Leucine derivatives
    Patent number: 4598089
    Abstract: Novel compounds of the formula ##STR1## wherein A signifies the group ##STR2## or --(CH.sub.2).sub.5 --, which inhibit pancreas lipase and can be used for the control or prevention of obesity and hyperlipaemia, are disclosed. The inventive compounds can be produced by the cultivation of microorganism Streptomyces toxytricini, identified as NRRL 15443.
    Type: Grant
    Filed: June 18, 1984
    Date of Patent: July 1, 1986
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Paul Hadvary, Erich Hochuli, Ernst Kupfer, Hans Lengsfeld, Ernst K. Weibel
  • Intermediate phenolic compounds for the catalytic synthesis of chromans
    Patent number: 4598160
    Abstract: A catalytic synthesis of chromans in racemic or optically active forms, including intermediates thereto; the synthesis employs an asymmetric palladium (II) catalyzed oxidative cyclization of a 2-homoallylphenol and provides intermediates useful in making chromans, especially vitamin E in racemic or optically active forms.
    Type: Grant
    Filed: March 11, 1985
    Date of Patent: July 1, 1986
    Assignee: Hoffmann-La Roche Inc.
    Inventor: Larry K. Truesdale
  • Process for producing intermediate furanones from diol derivative and thionyl chloride
    Patent number: 4596879
    Abstract: A novel process for the manufacture of the furanone of the formula ##STR1## is described. In this process, a diol is firstly reacted with thionyl chloride, then the sulphite formed, optionally after oxidation to the corresponding sulphate, is treated with sodium cyanide and the resulting hydroxynitrile is hydrolyzed.The furanone of formula I can be used as a starting material for the manufacture of R-(-)-pantolactone.
    Type: Grant
    Filed: July 10, 1985
    Date of Patent: June 24, 1986
    Assignee: Hoffmann-La Roche Inc.
    Inventor: Christian Fizet
  • Pyridazine derivatives useful as components of liquid crystal mixtures
    Patent number: 4595521
    Abstract: Compounds of the formula ##STR1## wherein B is --C.tbd.C-- or --CH.sub.2 CH.sub.2 --, R.sup.1 is straight-chain C.sub.1 -C.sub.12 -alkyl and R.sup.2 is straight-chain C.sub.1 -C.sub.12 -alkyl or straight-chain C.sub.1 -C.sub.12 -alkoxy, their manufacture and use in liquid crystalline mixtures are described.
    Type: Grant
    Filed: November 14, 1983
    Date of Patent: June 17, 1986
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Martin Petrzilka, Georg Trickes
  • 4-(8-bromodibenz[b,f]oxepin-10-yl)-1,2,3,6-tetrahydro-1-methylpyridine and 4-(2-bromodibenzo[a,d]cyclophetatriene-11-yl)-1,2,3,6-tetrahydro-1-methy lpyridine for dermal inflammation
    Patent number: 4595689
    Abstract: A method of treating inflammation which comprises topically administering to the affected area a compound of the formula ##STR1## or a pharmaceutically acceptable addition salt thereof, is described.
    Type: Grant
    Filed: February 9, 1984
    Date of Patent: June 17, 1986
    Assignee: Hoffmann-LaRoche Inc.
    Inventors: Alfred Boris, Robert W. Guthrie, Richard W. Kierstead
  • Apparatus for sample transfer and analysis by centrifugation
    Patent number: 4595563
    Abstract: Apparatus for sample transfer and analysis by centrifugation, comprising a rotor having rotary joints at its periphery, to which cuvette carriers are connected so as to be able to perform a tipping movement through an angle of 90.degree., a locking device for locking the cuvette carriers in an inclined position, and cuvette assemblies for use in the cuvette carriers, the rotor preferably being in the form of a rotary beam at the two ends of which two cuvette carriers are disposed, and the cuvette carrier is in the form of a comb so that the teeth engage between the cuvette rows of the cuvette assembly. This apparatus enables samples to be transferred without mixing the cuvette contents.
    Type: Grant
    Filed: May 10, 1985
    Date of Patent: June 17, 1986
    Assignee: Kontron Holding A.G.
    Inventor: Philippe L. Degrave
  • Synthesis of 1.alpha.,25-dihydroxyergocalciferol
    Patent number: 4595776
    Abstract: The invention is directed to a process and intermediates for the preparation of 1.alpha.,25-dihydroxyergocalciferol as well as substantially pure and crystalline 1.alpha.,25-dihydroxyergocolciferol. The end-product 1.alpha.,25-dihydroxyergocalciferol is useful in the treatment of disease states which are characterized by insufficient amounts of 1.alpha., 25-dihydroxycholecalciferol.
    Type: Grant
    Filed: December 17, 1984
    Date of Patent: June 17, 1986
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Enrico G. Baggiolini, Andrew D. Batcho, Alfred Boris, Milan R. Uskokovic
  • Naphthalenyloxy substituted carboxylic acids
    Patent number: 4594442
    Abstract: Compounds of the formula ##STR1## wherein R is hydrogen or lower alkyl, X is hydrogen or halogen, and A is the group ##STR2## wherein R.sub.1 is hydrogen, acyl or lower alkyl, R.sub.2 is hydrogen or lower alkyl, m is an integer from 2 to 4, n is an integer from 1 to 3, and t is an integer from 1 to 5, provided that R.sub.1 is adjacent to --(CH.sub.2).sub.m --O(CH.sub.2).sub.m ].sub.n O--, and, when R.sub.2 is hydrogen, salts thereof with pharmaceutically acceptable bases, are described. The compounds of formula I are useful as agents for the treatment of allergic conditions.
    Type: Grant
    Filed: April 1, 1985
    Date of Patent: June 10, 1986
    Assignee: Hoffman-La Roche Inc.
    Inventor: Ronald A. LeMahieu
  • Animal feed compositions containing the antibiotic X-537A
    Patent number: 4594354
    Abstract: Compositions containing the antibiotic having the designation X-537A, useful for the treatment and prevention of coccidiosis in poultry feed compositions containing the antibiotic and methods of treating coccidiosis are disclosed.
    Type: Grant
    Filed: September 30, 1981
    Date of Patent: June 10, 1986
    Assignee: Hoffmann-La Roche Inc.
    Inventor: Julius Berger
  • Process for the synthesis of 1.alpha.,23(S),25-trihydroxycholecalciferol and 1.alpha.,23(R),25-trihydroxycholecalciferol
    Patent number: 4594432
    Abstract: The invention is directed to a process and intermediates for the preparation of 1.alpha.,23(S),25-trihydroxycholecalciferol and 1.alpha.,23(R),25-trihydroxycholecalciferol. The end-products, 1.alpha.,23(S),25-trihydroxycholecalciferol and 1.alpha.,23(R),25-trihydroxycholecalciferol, are useful for the treatment of disease states which are characterized by insufficient amounts of 1,25 dihydroxycholecalciferol.
    Type: Grant
    Filed: December 27, 1983
    Date of Patent: June 10, 1986
    Assignee: Hoffman-La Roche Inc.
    Inventors: Enrico G. Baggiolini, Milan R. Uskokovic, Peter M. Wovkulich
  • 25,26-dehydro-1.alpha.,24R-dihydroxycholecalciferol and 25,26-dehydro-1.alpha.,24S-dihydroxycholecalciferol and the epimeric mixture
    Patent number: 4594340
    Abstract: The syntheses of 25,26-dehydro-1.alpha.,24R-dihydroxycholecalciferol and 25,26-dehydro-1.alpha.,24S-dihydroxycholecalciferol and the epimeric mixture which are useful as differentiation inducing agent and anti-proliferation agents are described. 25,26-dehydro-1.alpha.,24R-dihydroxycholecalciferol, 25,26-dehydro-1.alpha.,24S-dihydroxycholecalciferol, and the epimeric mixture are useful in treating osteoporosis, tumors and leukemia.
    Type: Grant
    Filed: November 29, 1984
    Date of Patent: June 10, 1986
    Assignee: Hoffmann-La Roche Inc.
    Inventors: John J. Partridge, Shian-Jan Shiuey, Gary A. Truitt, Milan R. Uskokovic
  • Acyl derivatives
    Patent number: 4593093
    Abstract: There are presented compounds of the formula ##STR1## wherein R.sup.1 is one of the 3-substituents usable in cephalosporin chemistry, R.sup.2 is hydrogen, lower alkyl or COOR.sup.3 -lower alkyl, wherein R.sup.3 is hydrogen, a cation of a base or a readily hydrolyzable ester group, and X is sulphur, oxygen or one of the groups --SO-- and --SO.sub.2 --,and the readily hydrolyzable esters, readily hydrolyzable ethers and salts of these compounds and hydrates of the compounds of formula I or of their esters, ethers and salts, also presented are methods for the manufacture of these compounds as well as compounds used in their manufacture.
    Type: Grant
    Filed: April 16, 1984
    Date of Patent: June 3, 1986
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Roland Reiner, Urs Weiss
  • Anthracycline glycosides
    Patent number: 4591636
    Abstract: The invention relates to compounds of the formula ##STR1## wherein R is lower alkyl or a carboxy group or a group of the formula--(CH.sub.2).sub.n --OY ain which n stands for 1 or 2 and Y is hydrogen or alkyl and R.sup.Y and R.sup.z each are hydrogen or one of R.sup.Y and R.sup.z is hydrogen and the other is hydroxy,and pharmaceutically acceptable acid addition salts thereof.These compounds and salts possess antibiotic and antitumor activity and can be used as medicaments in the form of pharmaceutical preparations.
    Type: Grant
    Filed: December 17, 1984
    Date of Patent: May 27, 1986
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Michael J. Broadhurst, Cedric H. Hassall, Gareth J. Thomas
  • Thromboxane synthase inhibitors as antiobesity agents
    Patent number: 4591594
    Abstract: The present disclosure relates to the use of thromboxane synthase inhibitors as antiobesity agents and insulin lowering agents. Such compounds fall into a variety of classes among which are 1-substituted imidazoles, 4-substituted imidazoles, 3-substituted pyridines, 3-substituted indoles, 4-substituted pyrimidines, 5-substituted tetrazoles, pyrazolidines, quinazolines, and substituted xanthene carboxylic acids.
    Type: Grant
    Filed: December 12, 1984
    Date of Patent: May 27, 1986
    Assignee: Hoffmann-La Roche Inc.
    Inventors: James G. Hamilton, Ann C. Sullivan, Lawrence D. Tobias, Joseph Triscari
  • Antibiotic X-14934A and a method for its preparation
    Patent number: 4591559
    Abstract: The present invention relates to a novel polyether ionophore antibiotic of the formula ##STR1## and its pharmaceutically acceptable salts. The compound of formula I and its salts exhibit activity as an antibacterial agent and as an anticoccidial agent.
    Type: Grant
    Filed: January 22, 1985
    Date of Patent: May 27, 1986
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Chao-Min Liu, John Westley
  • 2,4-diamino-[4-piperidinyl]pyrimidines useful as antibacterial agents, antimalarial agents, antitumors agents
    Patent number: 4590270
    Abstract: The pyrimidine derivatives of formula I ##STR1## wherein R.sup.1 is naphthyl, substituted naphthyl or substituted phenyl; R.sup.2 is hydrogen or lower alkoxy; and A is an optionally present ethylene or 1,3-propylene, and wherein the diaminopyridine group has the exo-configuration when A is present,are described. These compounds are useful as antibacterial agents, antimalarial agents and antitumor agents, and can be used in combination with sulfonamides in the control of bacterial infections.
    Type: Grant
    Filed: April 9, 1984
    Date of Patent: May 20, 1986
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Ivan Kompis, Rita Locher, Hans Maag
  • Therapeutic compositions for reducing sebum secretion
    Patent number: 4588750
    Abstract: This invention is directed to methods for and compositions useful in reducing sebum secretion utilizing 1,2,3,4-tetrahydro-1,1,4,4-tetramethyl-6-[.alpha.-methylstyryl]naphthalene as an active ingredient.
    Type: Grant
    Filed: April 25, 1983
    Date of Patent: May 13, 1986
    Assignee: Hoffmann-La Roche Inc.
    Inventor: Alfred Boris