Patents Represented by Attorney Jon S. Saxe

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  • Bifunctional chelating agents
    Patent number: 4575556
    Abstract: Novel homocysteine thiolactone bifunctional chelating agents useful for chelating radionuclides to produce a radiodiagnostic agent for use in in vivo imaging and a method for producing this chelating agent.
    Type: Grant
    Filed: November 28, 1983
    Date of Patent: March 11, 1986
    Assignee: Medi-Physics, Inc.
    Inventors: Edmund F. Byrne, Glen L. Tolman
  • Homocysteine and homocysteinamide derivatives
    Patent number: 4571430
    Abstract: Novel homocysteine thiolactone bifunctional chelating agents useful for chelating radionuclides to produce a radiodiagnostic agent for use in vivo imaging and a method for producing this chelating agent.
    Type: Grant
    Filed: November 28, 1983
    Date of Patent: February 18, 1986
    Assignee: Medi-Physics, Inc.
    Inventors: Edmund F. Byrne, Glen L. Tolman
  • Process for the preparation of cholesterol derivatives and novel intermediates therefor
    Patent number: 4568491
    Abstract: The invention is concerned with a process for the preparation of 1 hydrogen or hydroxy cholesterol derivatives and intermediates therefor. The compounds of the present invention are useful as intermediates in the preparation of 24,25-dihydroxy and 1.alpha., 24,25-trihydroxycholecalciferol.
    Type: Grant
    Filed: February 27, 1984
    Date of Patent: February 4, 1986
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Andor Furst, Ludwig Labler, Werner Meier
  • 4-Methyl-2-oxo-cyclopentylidene acetic acid and esters thereof
    Patent number: 4568762
    Abstract: New optically active intermediates and processes for producing optically active prostaglandins which are useful for various therapeutic purposes such as antisecretory agents, cardiovascular agents, antiulcerogenic agents and as agents for inducing labor or terminating pregnancy in pregnant females.
    Type: Grant
    Filed: October 9, 1984
    Date of Patent: February 4, 1986
    Assignee: Hoffmann-La Roche Inc.
    Inventor: Percy Manchand
  • Liquid crystals
    Patent number: 4565425
    Abstract: Compounds of the formula ##STR1## wherein R.sup.1 is hydrogen or straight-chain alkyl; R.sup.2 is --CN, --R, --COR, --COOR or when R.sup.2 is positioned on an aromatic ring R.sup.2 also can be --OR, --OOCR or --F; R is alkyl; A is a group with 1 to 4 six-membered rings, these rings being linked directly with one another and with ring B in each case via a single covalent bond or being linked at one or two positions also via --COO--, --OOC-- or --CH.sub.2 CH.sub.
    Type: Grant
    Filed: March 5, 1984
    Date of Patent: January 21, 1986
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Martin Petrzilka, Martin Schadt
  • Ethers of antibiotic X-14868A
    Patent number: 4565862
    Abstract: There is presented compounds of the formula ##STR1## wherein R is C.sub.2 to C.sub.7 alkyl or lower alkyl hydroxy and their pharmaceutically acceptable salts.The compounds exhibit activity as antimalarial, anti-inflammatory, anticoccidial and animal growth promotant agents.Also disclosed is a process to produce said compounds.
    Type: Grant
    Filed: October 24, 1983
    Date of Patent: January 21, 1986
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Louise H. Foley, Lilian H. Sello, John Westley
  • Dicarbamates
    Patent number: 4565869
    Abstract: Novel pyrimidinedicarbamates of the formula ##STR1## wherein R is lower alkyl or (lower alkyloxy)-(lower alkyl) and X is a leaving group,can be manufactured by carbamoylating the corresponding free diamines. They are valuable intermediates and can be used, for example, for the manufacture of corresponding oxadiazolopyrimidines of the formula ##STR2## and pharmaceutically acceptable salts thereof. The latter have valuable long-lasting vasodilating and/or bloodpressure lowering properties and are accordingly suitable especially for the treatment of vascular-conditioned hypertensions or as vasodilators in the case of peripheral blood supply disorders.
    Type: Grant
    Filed: March 7, 1983
    Date of Patent: January 21, 1986
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Marquard Imfeld, Henri Ramuz, Peter Vogt, Jean-Claude Muller
  • Device for dispensing radioactive gas
    Patent number: 4565301
    Abstract: A device suitable for dispensing a radioactive gas from a sealed radioactive gas-containing vial having a pierceable septum wherein the dispenser contains two needles which pierce the septum, one of the needles conducting the radioactive gas from the vial into the dispenser and the other for the introduction of a displacement gas to the vial. The improvement being a means in the dispenser whereby the septum is automatically released from the needles without handling the vial so that the vial may be removed from the dispenser.
    Type: Grant
    Filed: June 10, 1982
    Date of Patent: January 21, 1986
    Assignee: Medi-Physics, Inc.
    Inventors: Robert E. Hubbard, Robert C. Wedemeyer
  • Retinoid carbohydrates
    Patent number: 4565863
    Abstract: The novel retinoids of the formula ##STR1## wherein R represents a residue of a sugar attached ester-wise or a residue of an amino-sugar attached amide-wise or of derivatives of such sugars and n is 1 or 2,can be used as medicaments, e.g. for the treatment of neoplasms, acne and psoriasis. These compounds are obtained by reacting a sugar or an aminosugar or a derivative thereof with a reactive derivative of 9-(4-methoxy-2,3,6-trimethylphenyl)-3,7-dimethyl-2,4,6,8-nonatetraenoic acid, optionally followed by the modification of reactive groups present in the reaction product.
    Type: Grant
    Filed: December 3, 1984
    Date of Patent: January 21, 1986
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Werner Bollag, Hans J. Mayer, Pierre-Charles Wyss
  • N.sup..alpha. -desacetylthymosin.alpha..sub.1 and process
    Patent number: 4560676
    Abstract: The preparation of N.sup..alpha. -desacetylthymosin.alpha..sub.1 and its use as a hormonally active agent participating in the regulation, differentiation and function of thymic dependent lymphocytes (T-cells) is described.
    Type: Grant
    Filed: April 13, 1981
    Date of Patent: December 24, 1985
    Assignee: The Rockefeller University
    Inventor: Robert B. Merrifield
  • 4-Piperidino-2-phenylquinolines
    Patent number: 4560692
    Abstract: Disclosed are compounds of the formula ##STR1## wherein: R.sup.1 and R.sub.2 may be either the same or different and each is hydrogen or lower alkyl;and wherein R.sup.3 and R.sup.4 may be either the same or different and each is hydrogen, halogen, or lower alkyl, with the proviso that R.sup.3 and R.sup.4 cannot both be hydrogen.These compounds are useful as anticonvulsant or anxiolytic agents.
    Type: Grant
    Filed: July 18, 1984
    Date of Patent: December 24, 1985
    Assignee: Hoffmann-La Roche Inc.
    Inventors: George F. Field, William J. Zally
  • Antibody/antigen determination method
    Patent number: 4560647
    Abstract: A method for the determination of antigens or antibodies in a fluid by incubation of particles, which have antigens on the surface, and antibodies, whereby either the antigens or the antibodies are of known specificity is described. This method comprises introducing the antigen/antibody complex into a container having a conical-shaped or keel-shaped bottom recess, whereby at least the recess of the container is coated with an immunoglobulin-building component which is directed against the antibodies. After centrifugation the amount of the sediment is determined, which indicates whether the antigen or antibody to be determined is present or not.
    Type: Grant
    Filed: January 30, 1984
    Date of Patent: December 24, 1985
    Assignee: Hoffmann-La Roche Inc.
    Inventor: John Stocker
  • Optical immersion oil
    Patent number: 4559147
    Abstract: There are described an immersion oil containing one or more compounds of the formula ##STR1## wherein R is hydrogen or methyl, and its use in optics, especially fluorescence microscopy.
    Type: Grant
    Filed: November 30, 1983
    Date of Patent: December 17, 1985
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Georges Hirth, Martin Petrzilka, Inge Pracht
  • Substituted isoquinolines
    Patent number: 4559403
    Abstract: Substituted isoquinolines of the formula ##STR1## wherein R is a lower alkoxy, n is the integer zero or 1, andA is ##STR2## wherein R.sub.1 is phenyl halophenyl, lower-alkylphenyl or lower-alkoxyphenyl, and pharmaceutically acceptable acid addition salts thereof, are described. The compounds of formula I are useful in the treatment of cerebral and cardiac ischemias.
    Type: Grant
    Filed: February 25, 1985
    Date of Patent: December 17, 1985
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Hans Bruderer, Richard W. Kierstead, John G. Mullin, Jr., Keiji Nakamura, Mitsuru Tateishi, Sidney Teitel, Jay P. O'Brien
  • Intermediate in the production of vitamin E
    Patent number: 4559407
    Abstract: There is described a novel process for the manufacture of hydroquinone derivatives of the formula ##STR1## wherein R represents an ether protecting group, and their conversion into d-.alpha.-tocopherol starting from compounds of the formula ##STR2## wherein R has the above significance.
    Type: Grant
    Filed: October 11, 1983
    Date of Patent: December 17, 1985
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Richard Barner, Josef Hubscher
  • 7-Fluoro-prostacyclin analogs
    Patent number: 4558142
    Abstract: The prostacyclins 7-fluoro-6,9-epoxy-16-substituted-15-hydroxyprost-[4 or 5,13]-dienoic acids and esters useful as anti-secretory agents, blood pressure lowering agents, anti-ulcerogenic agents, anti-hypertensive agents, bronchodilation agents and for combating gastro-hyperacidity and as anti-blood platelet aggregating agents.
    Type: Grant
    Filed: September 7, 1982
    Date of Patent: December 10, 1985
    Assignee: Hoffmann-La Roche Inc.
    Inventors: George W. Holland, Perry Rosen, Hans Maag
  • Cyclopenta[b]furan-2-ones
    Patent number: 4558140
    Abstract: New optically active intermediates and processes thereto are provided for use in synthesizing therapeutically active prostaglandins of the formula: ##STR1## wherein R.sup.1 is hydrogen or lower alkyl; from a compound of the formula: ##STR2## wherein R.sup.1 is as above and R.sup.2 is hydrogen or a carboxy blocking group convertible to an acid by hydrolysis.
    Type: Grant
    Filed: March 6, 1984
    Date of Patent: December 10, 1985
    Assignee: Hoffmann-La Roche Inc.
    Inventors: David L. Coffen, George W. Holland, Perry Rosen, Frederick Wong
  • Pyridine derivatives
    Patent number: 4556661
    Abstract: Novel pyridine and pyrazine derivatives of the formula ##STR1## wherein R.sup.4 is 3-pyridyl, 3-pyridyl-1-oxide, 2-pyrazinyl, 2-pyrazinyl-1-oxide, 2-pyrazinyl-4-oxide or 2-pyrazinyl-1,4-dioxide, and R, R.sup.1, R.sup.2 and R.sup.3 are as hereinafter set forth, processes for their preparation, fungicidal compositions containing said compounds, and methods for the use of such compounds or compositions for combatting fungi in agriculture and in horticulture are disclosed. Novel starting materials and fungicidal active substances of the formula ##STR2## wherein R.sup.4' is 3-pyridyl or 2-pyrazinyl, and R and R.sup.1" as hereinafter set forth, which are used for the preparation of the compounds of formula I, and their N-oxides, as well as fungicidal compositions containing these compounds as the active substance, are also described.
    Type: Grant
    Filed: August 27, 1982
    Date of Patent: December 3, 1985
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Franz Dorn, Francois Montavon, Milos Suchy
  • Certain aryloxy-benzoyl sulfoximines having herbicidal activity
    Patent number: 4556413
    Abstract: Benzoic acid compounds of the formula ##STR1## wherein A, R.sup.1, R.sup.2, R.sup.4, R.sup.5, R.sup.6, R.sup.7, n and X are as defined hereinafter, processes for their preparation, herbicidal compositions containing these compounds and methods for the use of the compounds and the herbicidal compositions are disclosed. Novel compounds which useful as starting materials for the preparation of the benzoic acid compounds of formula I are also disclosed.
    Type: Grant
    Filed: October 28, 1983
    Date of Patent: December 3, 1985
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Georg Frater, Milos Suchy, Jean Wenger, Paul Winternitz
  • Preparation of 13-cis retinoic acid
    Patent number: 4556518
    Abstract: A new process for producing 13-cis retinoic acid in high yields from the reaction product of a butenolide and a Wittig salt.
    Type: Grant
    Filed: July 16, 1984
    Date of Patent: December 3, 1985
    Assignee: Hoffmann-La Roche Inc.
    Inventor: Robert Lucci