Patents Represented by Attorney Jon S. Saxe
  • Patent number: 4808713
    Abstract: Novel compounds of the formula ##STR1## wherein B represents a methylene, ethylene or vinylene group, R.sup.1 represents a hydrogen atom or an alkyl, aralkyl, amino-alkyl, mono-alkylamino-alkyl, dialkylamino-alkyl, acylamino-alkyl, phthalimido-alkyl, alkoxycarbonylamino-alkyl, aryloxycarbonylamino-alkyl, aralkoxycarbonylamino-alkyl, alkylaminocarbonylamino-alkyl, arylaminocarbonylamino-alkyl, aralkylaminocarbonylamino-alkyl, alkylsulphonylamino-alkyl or arylsulphonylamino-alkyl group, R.sup.2 represents a carboxyl, alkoxycarbonyl or aralkoxycarbonyl group or a group of the formula ##STR2## , R.sup.3 represents a carboxyl, alkoxycarbonyl or aralkoxycarbonyl group, R.sup.4 and R.sup.5 each represent a hydrogen atom or R.sup.4 and R.sup.5 together represent an oxo group, R.sup.6 and R.sup.7 each represent a hydrogen atom or an alkyl or aralkyl group or R.sup.6 and R.sup.
    Type: Grant
    Filed: June 10, 1988
    Date of Patent: February 28, 1989
    Assignee: Hoffman-La Roche Inc.
    Inventors: Michael R. Attwood, Cedric H. Hassall, Robert W. Lambert, Geoffrey Lawton, Sally Redshaw
  • Patent number: 4808736
    Abstract: In this process of the invention a compound of the formula ##STR1## wherein R is a leaving group, is reacted with a compound of the formula ##STR2## wherein R.sup.1 is an ether protecting group, and, if desired a thus-obtained compound of the formula ##STR3## is converted in a known manner into d-.alpha.-tocopherol.
    Type: Grant
    Filed: August 10, 1987
    Date of Patent: February 28, 1989
    Assignee: Hoffmann-LaRoche Inc.
    Inventors: Richard Barner, Josef Hubscher
  • Patent number: 4808630
    Abstract: This invention is directed towards methods for treating patients having a psychotic illness such as schizophrenia and/or inhibiting the occurrence of movement disorders in patients receiving or having received a neuroleptic medication by administering to the patients a pharmaceutically effective amount of a retinoid, such as retinoic acid, and particularly isotretinoin.
    Type: Grant
    Filed: February 16, 1988
    Date of Patent: February 28, 1989
    Assignee: United States of America
    Inventor: Gregory M. Straw
  • Patent number: 4808580
    Abstract: Compounds of the formula: ##STR1## wherein R.sub.1 is phenyl substituted with 1 to 3 substituents selected from the group consisting of lower alkoxy and halogen; R.sub.2 is hydroxy, lower alkoxy, lower alkanoyloxy, lower cycloalkylcarbonyloxy; ##STR2## or ##STR3## R.sub.3 and R.sub.4 are independently lower alkyl, phenyl lower alkyl or together form a piperidine or pyrrolidine ring; n is 2 to 4; m is 1 to 2; or pharmaceutically acceptable acid addition salts thereof are described. The compounds of formula I have activity as calcium channel blockers and accordingly, are useful as agents for lowering blood pressure, and as agents for treating ischemia.
    Type: Grant
    Filed: December 17, 1987
    Date of Patent: February 28, 1989
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Erno Mohacsi, Jay P. O'Brien
  • Patent number: 4808727
    Abstract: The pharmaceutically acceptable salts corresponding to the imidazolium hydrogen carbonates of the formula ##STR1## wherein the symbol Q is arylene or heteroarylene, the group --NR.sup.1 R.sup.2 is a basic amino group, R.sup.3 is hydrogen, lower alkyl, lower hydroxyalkyl, lower alkoxyalkyl, lower haloalkyl, lower alkylthio, lower alkoxy or the group --(A).sub.n --Ra, R.sup.4 is a saturated or partially unsaturated lower hydrocarbon group, a basic amino group or the group --N.dbd.CRc--Rb, --CHRcRd, --NH--CHRcRd, --NH--CO--Re or --CHRc--CO--Re, R.sup.5 is hydrogen, lower alkyl, lower hydroxyalkyl, lower alkoxyalkyl, lower haloalkyl, aryl or a fused benzene ring, R.sup.
    Type: Grant
    Filed: September 29, 1987
    Date of Patent: February 28, 1989
    Assignee: Hoffmann-LaRoche Inc.
    Inventor: Helmut Link
  • Patent number: 4808631
    Abstract: Use of compounds of the formula ##STR1## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4 and R.sup.5, independently are hydrogen, alkyl, or C.sub.3-7 -cycloalkyl or two adjacent residues R.sup.1 to R.sup.5 taken together with adjacent carbons of the phenyl ring form a 5- to 7-membered ring optionally substituted by one or more lower alkyl groups; X is --NR.sup.7 --CO-- or --CO-NR.sup.7 --; R.sup.6 is hydroxy, lower-alkoxy or --NR.sup.8 R.sup.9 ; and R.sup.7, R.sup.8 and R.sup.9, independently, are hydrogen or lower-alkyl, and where R.sup.6 is hydroxy, their pharmaceutically usable salts, for the treatment of inflammatory and rheumatic diseases.
    Type: Grant
    Filed: October 14, 1987
    Date of Patent: February 28, 1989
    Assignee: Hoffmann-La Roche Inc.
    Inventor: Michael Klaus
  • Patent number: 4808734
    Abstract: 16-Cycloalkyl-7-fluoro prostacyclins having a 16 lower alkyl or fluoro substituent useful as blood platelet anti-aggregating agent, vasodilators, cyto protective lowering agents, anti-ulcerogenic agent and for treating peripheral vascular diseases such as schleroderma.
    Type: Grant
    Filed: December 1, 1986
    Date of Patent: February 28, 1989
    Assignee: Hoffmann-La Roche Inc.
    Inventors: George W. Holland, Perry Rosen, Hans Maag, Ferdinand Lee
  • Patent number: 4806661
    Abstract: Novel 2-halochromans and their coupling to various nucleophiles to produce Vitamin E and as well as novel intermediates for Vitamin E.
    Type: Grant
    Filed: January 21, 1988
    Date of Patent: February 21, 1989
    Assignee: Hoffmann-La Roche Inc.
    Inventor: Noal Cohen
  • Patent number: 4806541
    Abstract: Tetracyclic compounds of the formula ##STR1## wherein R.sup.1, R.sup.2, X, Y, Z and n are as herein described, and salts thereof, are described. The compounds of formula III have antibacterial activity, and are therefore useful as antibacterial agents.
    Type: Grant
    Filed: September 22, 1986
    Date of Patent: February 21, 1989
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Synese Jolidon, Rita Locher, Ivan Kompis, Ekkehard Weiss, Pierre-Charles Wyss
  • Patent number: 4805821
    Abstract: An ampule opener is provided for automatically opening ampules. The ampule opener is especially suitable for use in a robotic sterility test system and is provided with a pneumatic actuator means releasably connected to an ampule opener arm. The head of an ampule is positioned with its neck on a knife edge so that when the ampule opener arm is rotated by the actuator means, the arm applies a pressure on the head of the ampule and the ampule head drops away.
    Type: Grant
    Filed: August 14, 1987
    Date of Patent: February 21, 1989
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Ludwik Kowalczyk, Gilbert C. Kaetzel
  • Patent number: 4804502
    Abstract: Compounds of the formula ##STR1## wherein R.sub.1 is hydrogen or hydroxy and R.sub.2 is hydrogen or fluorine are described. The compounds of formula I are useful as agents in the treatment of disease states characterized by metabolic calcium deficiencies. Examplary of such disease states are osteoporosis and renal osteodystrophy.
    Type: Grant
    Filed: January 20, 1988
    Date of Patent: February 14, 1989
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Enrico G. Baggiolini, John J. Partridge, Shian-Jan Shiuey, Gary A. Truitt, Milan R. Uskokovic
  • Patent number: 4801584
    Abstract: The invention is concerned with tricyclic compounds of the formula ##STR1## wherein R.sup.1 is a hydrogen atom or a carboxy-protecting radical; R.sup.2 is a hydrogen atom or a lower alkyl radical which may be substituted with a halogen atom; R.sup.3 and R.sup.4 independently are a hydrogen atom or a lower alkyl radical which may be substituted with a hydroxy radical or a substituted or unsubstituted amino radical; X is a halogen atom; and R.sup.5 and R.sup.6 are independently a hydrogen atom or a lower alkyl radical which may be substituted with a hydroxy radical, a lower alkoxy radical or a substituted or unsubstituted amino radical; or R.sup.5 and R.sup.6, taken together with the adjacent nitrogen atom, may form a 5 to 7 membered heterocyclic ring which may be substituted with one or more substituents at the carbon atom(s), and the heterocyclic ring may further contain --NR.sup.7 --, --O--, --S--, --SO--, --SO.sub.2 -- or --NR.sup.7 --CO--, and also R.sup.
    Type: Grant
    Filed: September 8, 1987
    Date of Patent: January 31, 1989
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Kazuteru Yokose, Nobuo Shimma, Miyako Kamata, Masahiro Aoki, Tatsuo Ohtsuka
  • Patent number: 4801724
    Abstract: A process for producing alpha-tocopherol and intermediates in this process.
    Type: Grant
    Filed: June 5, 1987
    Date of Patent: January 31, 1989
    Assignee: Hoffmann-La Roche Inc.
    Inventor: Noal Cohen
  • Patent number: 4801685
    Abstract: This invention relates to the microbial production, via recombinant DNA technology, of new human leukocyte interferons, Le IF-K and Le IF-L for use in the treatment of viral and neoplastic diseases, and to the means and end products of such production.
    Type: Grant
    Filed: June 1, 1987
    Date of Patent: January 31, 1989
    Assignees: Hoffmann-La Roche Inc., Genentech, Inc.
    Inventors: David V. Goeddel, Sidney Pestka
  • Patent number: 4801704
    Abstract: There are presented compounds of the formula ##STR1## wherein R.sub.2, R.sub.3, R.sub.4 and m are as described herein.
    Type: Grant
    Filed: May 16, 1988
    Date of Patent: January 31, 1989
    Assignee: Hoffman-La Roche Inc.
    Inventors: Dennis D. Keith, Chung-Chen Wei, Manfred Weigele
  • Patent number: 4800168
    Abstract: A method for measuring chloride ion concentration in a sample of body fluid, e.g., serum or plasma is described in which a sample blank is made in the same cuvette after the test measurement has been made.
    Type: Grant
    Filed: October 17, 1985
    Date of Patent: January 24, 1989
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Richard Kaufman, Alex Wesolowski
  • Patent number: 4800206
    Abstract: Pyridine-ethanolamines of the formula ##STR1## wherein n, X, Y, R.sup.1, R.sup.2 and R.sup.3 have the significances given in the description, their corresponding enantiomers, diastereomers, and racemates as well as the pysiologically compatible salts thereof are describe. The compounds of formula I have catabolic activity and can be used for the treatment of obesity and of diabetes mellitus or of conditions which are associated with an increased protein breakdown, or as feed additives for fattening animals. The compounds of formula I can be prepared by alkylating the primary or secondary amines corresponding to the secondary or tertiary amines of formula I.
    Type: Grant
    Filed: June 3, 1987
    Date of Patent: January 24, 1989
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Leo Alig, Marcel Muller
  • Patent number: 4792616
    Abstract: Novel diaryl ethers of the formula ##STR1## wherein A is CR.sup.3 or N and R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, n and R.sup.6 are as defined hereinafter, processes for their preparation, herbicidal compositions which contain these compounds as the active ingredient as well as the use of these compounds or compositions for the control of weeds is disclosed.
    Type: Grant
    Filed: April 17, 1986
    Date of Patent: December 20, 1988
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Paul Winternitz, Ren/e/ Zurfl/u/ h
  • Patent number: 4792557
    Abstract: 2,4-Diamino-5-benzylpyrimidines of the formula ##STR1## wherein R.sup.1, R.sup.2, A, Z and n are as hereinafter set forth, are described. The 2,4-diamino-5-benzylpyrimidines of the invention have useful antibacterial activity. More particularly, they inhibit bacterial dihydrofolate reductase and potentiate the antibacterial activity of sulfonamides.
    Type: Grant
    Filed: January 14, 1987
    Date of Patent: December 20, 1988
    Assignee: Hoffman-La Roche Inc.
    Inventors: Ivan Kompis, G/e/ rald Rey-Bellet, Guido Zanetti
  • Patent number: 4789453
    Abstract: A combined sensor for sensing partial O.sub.2 pressure and partial CO.sub.2 pressure and comprising measuring electrodes, a reference electrode, a diaphragm covering the electrodes and an electrolyte layer between the electrodes and the diaphragm wherein the reference electrode has disposed around it a screening of gold which is at the same potential as the reference electrode and the electrolyte contains a defined concentration of a soluble silver compound or of a silver complex.
    Type: Grant
    Filed: January 25, 1988
    Date of Patent: December 6, 1988
    Assignee: Kontron Holding A.G.
    Inventors: Patrick Eberhard, Wolfgang Mindt, Jean-Pierre Palma