Patents Represented by Attorney, Agent or Law Firm Joseph A. Fuchs
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Patent number: 6083587Abstract: The present invention provides a multiple layer structure for fabricating medical products. The layer structure has a core layer of an ethylene vinyl alcohol copolymer having an ethylene content of about 25-45 mole percent, a solution contact layer of a polyolefin positioned on a first side of the core layer, an outer layer positioned on a second side of the core layer opposite the solution contact layer, the outer layer being selected from the group consisting of polyamides, polyesters and polyolefins; two tie layers--one of each adhered to the first and second sides of the core layer and positioned between the solution contact layer and the core layer and between the outer layer and the core layer, and wherein the structure is produced in a cast coextrusion process.Type: GrantFiled: September 22, 1997Date of Patent: July 4, 2000Assignee: Baxter International Inc.Inventors: Sidney T. Smith, Larry Rosenbaum, Steven Giovanetto, Bradley Buchanan, Y. Samuel Ding, Suchuan C. Fan, Gregg Nebgen
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Patent number: 6083584Abstract: A container (10) suitable for medical uses comprising a first planar member (18), a second planar member (22), a first seam (24) and a second seam (26). The first planar member (18) is of a multi-layered polymeric material and further comprises a first substrate (38) and a first layer (46). The first layer (46) is disposed on a portion of the first substrate (38) to separately define a first overlap area (58) and an adjacent first peripheral flange (62). The second planar member (22) is of a multi-layered polymeric material. The first seam (24) attaches a portion of the first overlap area (58) to the second planar member (22). The second seam (26) is spaced from the first seam (24) and attaches a portion of the first peripheral flange (62) to the second planar member (22).Type: GrantFiled: January 30, 1998Date of Patent: July 4, 2000Assignee: Baxter International Inc.Inventors: Sidney T. Smith, Steven H. Giovanetto
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Patent number: 6071270Abstract: The present invention provides a connector device for establishing fluid communication between a first container and a second container. The device has a first sleeve member having a first and a second end, the first sleeve member having at the first end a first attaching member adapted to attach to the first container. The device further has a second sleeve member having a first end and a second end, the second sleeve member being associated with the first sleeve member and movable with respect thereto from an inactivated position to an activated position, the second sleeve member having at the second end a second attaching member adapted to attach the second sleeve member to the second container. First and second piercing members project from one of the first and second sleeve members for providing a fluid flow path from the first container to the second container, and the first and second piercing members are independently hermetically sealed.Type: GrantFiled: December 4, 1997Date of Patent: June 6, 2000Assignee: Baxter International Inc.Inventors: Thomas A. Fowles, Thomas J. Progar, Robert J. Weinberg, Craig A. Fuller
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Patent number: 6063068Abstract: The present invention provides a connector device for establishing fluid communication between a first container and a second container. The device has a first sleeve member having a first and a second end, the first sleeve member having at the first end a first attaching member adapted to attach to the first container. The device further has a second sleeve member having a first end and a second end, the second sleeve member being associated with the first sleeve member and movable with respect thereto from an inactivated position to an activated position, the second sleeve member having at the second end a second attaching member adapted to attach the second sleeve member to the second container. First and second piercing members project from one of the first and second sleeve members for providing a fluid flow path from the first container to the second container, and the first and second piercing members are independently hermetically sealed.Type: GrantFiled: September 15, 1998Date of Patent: May 16, 2000Assignee: Baxter International Inc.Inventors: Thomas A. Fowles, Robert J. Weinberg, Thomas J. Progar
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Patent number: 6036676Abstract: The present invention provides a polymeric blend suitable for adhesive bonding to polar polymeric materials comprising an ultra-low density polyethylene in an amount by weight within the range of 99.999%-90.0%; and an additive selected from the group consisting of polyoxyethylene(5)oleylamine, bis(2-hydroxyethyl)soyaamine, bis(2-hydroxyethyl)oleylamine, and polyoxyethylene(5)octadecylamine, the additive in an amount by weight within the range of 0.001%-10%.Type: GrantFiled: February 4, 1998Date of Patent: March 14, 2000Assignee: Baxter International Inc.Inventors: Chuan Qin, Patrick T. Ryan, Donna L. Rostron, Birendra K. Lal, Yuanpang S. Ding, Susan R. Mizener, Lecon Woo, Michael T. K. Ling, John O'Connor
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Patent number: 6028170Abstract: A tyrosine-substituted hirudin analog has antithrombogenic activity. Further simultaneous reaction at native tyrosine residues is prevented by mutation at those sites to encode nonreactive amino acids. Several novel strategies for coupling the hirudin analog to solid surfaces while simultaneously conserving antithrombogenic activity are disclosed.Type: GrantFiled: May 18, 1998Date of Patent: February 22, 2000Assignee: Baxter International Inc.Inventors: Cecilia S. L. Ku, Richard Johnson, Julian Breillatt
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Patent number: 6024220Abstract: A container is disclosed comprising a first sidewall having a first layer and a second layer. The second layer overlaps a portion of the first layer to define an overlap area. A sealing flange extends from the first layer outward of the overlap area. A second sidewall is connected to the first sidewall along the sealing flange to define an inner chamber therebetween. The second sidewall and the sealing flange define a first layered structure having a first number of layers along the sealing flange. The overlap area and the second sidewall define a second layered structure having a second number of layers. The second number of layers is greater than the first number of layers. The container is sealed by positioning peripheral edges of the first and second sidewalls into registration so that the overlap area is substantially centrally disposed over the second sidewall and applying sealing energy to the first number of layers to define a peripheral seam.Type: GrantFiled: December 24, 1997Date of Patent: February 15, 2000Assignee: Baxter International Inc.Inventors: Sidney T. Smith, Bradley Buchanan, Steven Giovanetto, Larry Rosenbaum
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Patent number: 6022339Abstract: A connector device is disclosed for establishing fluid communication between a diluent container having sidewalls and a drug vial. The connector has a piercing member having a first end and a second end and a central fluid pathway. The piercing member is mounted to the liquid container and has fluid accessing portions hermetically sealed from an outside environment. A vial receiving chamber is associated with the piercing member and is dimensioned to connect to the vial. The vial may be selectively attached to the device without piercing the closure of the vial and without breaching the hermetic seal of the fluid accessing portions of the piercing member. Means are provided for connecting the vial receiving chamber to the liquid container.Type: GrantFiled: September 15, 1998Date of Patent: February 8, 2000Assignee: Baxter International Inc.Inventors: Thomas A. Fowles, Robert J. Weinberg, Thomas J. Progar
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Patent number: 6019750Abstract: The present invention provides a septum for sealing an end of a medical connector. The connector has an end to attach to a closure of a container, the closure of the container having a target site, the connector further having a piercing member therein for piercing the target site of the closure. The septum comprises a disk having opposing first and second surfaces, a sheath extending axially from the first surface of the disk, and an annular ridge extending from the second surface of the disk, the annular ridge having a flared distal end, the distal end being dimensioned to form a fluid tight seal with the target area of the closure.Type: GrantFiled: December 4, 1997Date of Patent: February 1, 2000Assignee: Baxter International Inc.Inventors: Thomas A. Fowles, Thomas J. Progar, Robert J. Weinberg, Craig A. Fuller
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Patent number: 5998019Abstract: A multiple layer structure comprising a skin layer composed of a polypropylene copolymer with styrene ethylene-butene styrene block copolymer within a range of 0-20% by weight skin layer, and, a radio frequency ("RF") susceptible layer adhered to the skin layer. The RF layer has a first component of a propylene based polymer, a second component of a nonpropylene polyolefin, a third component of a radio frequency susceptible polymer, and a fourth component of a polymeric compatibilizing agent.Type: GrantFiled: November 16, 1993Date of Patent: December 7, 1999Assignee: Baxter International Inc.Inventors: Larry A. Rosenbaum, William Anderson, Lecon Woo, Dean Laurin, Angeles Lillian Buan, Michael T.K. Ling, Yuan Pang Samuel Ding, Denise S. Hayward, Joseph P. Hoppesch, Gregg Nebgen, Stanley Westphal
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Patent number: 5993949Abstract: A multiple layer structure comprising a skin layer, a barrier layer, a radio frequency susceptible layer having a first polyolefin in an amount within a range of 30-60% by weight, a second polyolefin in an amount within the range of 25-50% by weight, a radio frequency susceptible polymer in an amount within the range of 3-40% by weight, a styrene and hydrocarbon block copolymer in an amount within the range of 5-40% by weight of the sealant layer.Type: GrantFiled: November 21, 1997Date of Patent: November 30, 1999Assignee: Baxter International Inc.Inventors: Larry Rosenbaum, Steven Giovanetto, Sidney T. Smith, David V. Bacehowski, Gregg Nebgen, Varsha Kalyankar
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Patent number: 5989237Abstract: The present invention provides a connector device for establishing fluid communication between a first container and a second container. The device has a first sleeve member having a first end and a second end and a sidewall defining a chamber, the first sleeve member having at the first end a first attaching member adapted to attach to the first container. The device further has a second sleeve member having a first end and a second end, the second sleeve member being associated with the first sleeve member and is movable axially with respect thereto from an inactivated position to an activated position. A second attaching member is positioned on the second end of the second sleeve and adapted to attach the second sleeve member to the second container. A piercing member positioned in the chamber and projecting from one of the first and second sleeve members is provided for establishing a fluid flow path from the first container to the second container. The piercing member is hermetically sealed.Type: GrantFiled: December 4, 1997Date of Patent: November 23, 1999Assignee: Baxter International Inc.Inventors: Thomas A. Fowles, Thomas J. Progar, Robert J. Weinberg, Craig A. Fuller
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Patent number: 5954702Abstract: The present invention provides a housing for use in the administration of medical fluids comprising a body having an opening at a distal end to a chamber, the chamber is connected to an interior flow channel, and a plurality of ribs are positioned in the chamber and are circumferentially spaced, the ribs are positioned inward of the body opening.Type: GrantFiled: May 3, 1996Date of Patent: September 21, 1999Assignee: Baxter International Inc.Inventors: Birendra K. Lal, Donna L. Rostron, JoAnn DeMarco
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Patent number: 5935847Abstract: A multi-layer, flexible, gas-permeable film (10) suitable for forming a cell culture container (20), the film (10) comprising a first layer (12) composed of a polystyrene having a thickness within the range of 0.0001 inches to about 0.0010 inches and, a second layer (14) adhered to the first layer (12) composed of a polymer material having a thickness within the range of 0.004 inches to about 0.025 inches.Type: GrantFiled: May 4, 1998Date of Patent: August 10, 1999Assignee: Baxter International Inc.Inventors: Sidney T. Smith, David V. Bacehowski, William Kolanko, Larry Rosenbaum, Stephen L. Smith, James G. Bender, Lecon Woo, Michael T. K. Ling
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Patent number: 5932307Abstract: A polymeric tubing having an initial diameter and suitable for connecting to rigid housings including a sidewall defining a fluid pathway and having a longitudinal axis, the sidewall of a polymeric material in an amount by weight within the range of 99.999%-90.0%, and an additive in an amount by weight within the range of 0.001%-10%, and wherein the tubing has been oriented along its longitudinal axis to decrease its diameter to define a oriented diameter.Type: GrantFiled: May 3, 1996Date of Patent: August 3, 1999Assignee: Baxter International Inc.Inventors: Patrick T. Ryan, Chuan Qin, Donna L. Rostron, Birendra K. Lal, Yuanpang S. Ding, Susan R. Mizener, Lecon Woo, Michael T. K. Ling, Martin F. Miller
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Patent number: 5854347Abstract: Multiple component polymer compositions for fabrication into articles. In particular, polymeric compositions comprising a heat resistant polymer; a radio frequency ("RF") susceptible polymer; a compatibilizing polymer; the composition having physical properties within the range a<40,000 psi; b>=70%; c<30%; d>1.0; e<0.1%; f<0.1%; g>=0.05; h<=60%; i=0; wherein: a is the mechanical modulus of the composition measured according to ASTM D-882; b is the percent recovery in length of the composition after an initial 20% deformation; c is the optical haze of the composition being 9 mils in thickness according to ASTM D-1003; d is the loss tangent of the composition at 1 Hz measured at melt processing temperatures; e is the elemental halogen content by weight of the composition; f is the low molecular weight water soluble fraction of the composition; g is the dielectric loss between 1 and 60 MHz and over temperatures of 25.degree. to 250.degree. C.Type: GrantFiled: June 5, 1995Date of Patent: December 29, 1998Assignee: Baxter International Inc.Inventors: Dean Laurin, Angeles Lillian Buan, Lecon Woo, Michael T. K. Ling, Yuan Pang Samuel Ding, William Anderson, Larry A. Rosenbaum, Denise S. Hayward, Joseph P. Hoppesch, Gregg Nebgen, Stanley Westphal
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Patent number: 5849843Abstract: Multiple component polymer compositions for fabrication into articles. In particular, polymeric compositions comprising a heat resistant polymer; a radio frequency ("RF") susceptible polymer; a compatibilizing polymer; the composition having physical properties within the range a<40,000 psi; b>=70%; c<30%; d>1.0; e<0.1%; f<0.1%; g>=0.05; h<=60%; i=0; wherein: a is the mechanical modulus of the composition measured according to ASTM D-882; b is the percent recovery in length of the composition after an initial 20% deformation; c is the optical haze of the composition being 9 mils in thickness according to ASTM D-1003; d is the loss tangent of the composition at 1 Hz measured at melt processing temperatures; e is the elemental halogen content by weight of the composition; f is the low molecular weight water soluble fraction of the composition; g is the dielectric loss between 1 and 60 MHz and over temperatures of 25.degree. to 250.degree. C.Type: GrantFiled: November 16, 1993Date of Patent: December 15, 1998Assignee: Baxter International Inc.Inventors: Dean Laurin, Angeles Lillian Buan, Lecon Woo, Michael T. K. Ling, Yuan Pang Samuel Ding, William Anderson, Larry A. Rosenbaum, Denise S. Hayward, Joseph P. Hoppesch, Gregg Nebgen, Stanley Westphal
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Patent number: 5840146Abstract: The coating of a RF active material on a non-RF active substrate material of typical thickness for packaging purposes, can generate sufficient thermal energy to effect strong bonding of the substrate materials. The RF active material may be-deposited on less than the entire inner surface area of the substrate material, preferably, at or near the portion of the substrate surface which represents the heat seal interface. In this manner of application, additional coating or printing of other substances on the substrate surface can be achieved without hampering the heat sealing process. Flexible medical containers capable of containing a product which is maintained and removed under sterile conditions, can be constructed on commercial production machines from these coated non-RF active substrate materials.Type: GrantFiled: June 6, 1995Date of Patent: November 24, 1998Assignee: Baxter International Inc.Inventors: Lecon Woo, Ying Lo, Michael T. K. Ling, Dean Laurin, Byron Gleason, Lillian A. Buan, William D. Johnston
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Patent number: 5837808Abstract: A tyrosine-substituted hirudin analog has antithrombogenic activity. Further simultaneous reaction at native tyrosine residues is prevented by mutation at those sites to encode nonreactive amino acids. Several novel strategies for coupling the hirudin analog to solid surfaces while simultaneously conserving antithrombogenic activity are disclosed.Type: GrantFiled: June 19, 1995Date of Patent: November 17, 1998Assignee: Baxter International Inc.Inventors: Cecilia S. L. Ku, Richard Johnson, Julian P. Breillatt, Jr.
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Patent number: 5741452Abstract: The present invention provides a method for fabricating flexible medical tubings including the steps of providing a polymeric material, forming a tubing from the polymeric material, the tubing having a longitudinal axis and an initial diameter, and orienting the tubing along the longitudinal axis of the tubing to reduce the diameter of the tubing to define an oriented diameter.Type: GrantFiled: May 3, 1996Date of Patent: April 21, 1998Assignee: Baxter International Inc.Inventors: Patrick T. Ryan, Chuan Qin, Donna L. Rostron, Birendra K. Lal, Yuanpang S. Ding, Susan R. Mizener, Lecon Woo, Michael T. K. Ling, Martin F. Miller