Abstract: A method for the rapid quantitation of minute amounts of particulate insoluble substantially opaque colored light absorptive substances is disclosed. The method may be employed to quantitate such particulates which are formed as an end product of an assay productive thereof. The method is practiced by bringing into contact particles to be quantified and an optical component or matrix formed of substantially water insoluble reflective granules of material which is substantially nonabsorptive of light and has a light scattering coefficient of at least about eighty. The opacity of the particles to be quantitated, when in contact with the component granules, masks and prevents any substantial light flow through the contacted granule surface areas which, with the absorptivity of light by the contacting particles, is effective rapidly and dramatically to reduce the light transmittance capability of the optical component.

Abstract: A fluorescent backlit display embodying a rectangular supporting frame, a display panel on the front of the frame, a plurality of equally spaced elongated modular lamp units each having a base member including an elongated tube of triangular cross section which carries a cylindrical fluorescent lamp provided with light leveling masking, two exterior surfaces of each triangular tube are reflective and are joined at a vertex from which they diverge rearwardly to marginal portions located adjacent a rollable nonspecular diffusely reflective rear wall.

Abstract: An apparatus and method for removing unwanted substances from media such as water and soil. Various industrial waste water streams can be treated simply and effectively to remove therefrom such unwanted substances as petroleum hydrocarbons, heavy metals, phenolics, salt, ethylene glycol, and strontium, and sea water can be similarly treated to remove salt as well as petroleum hydrocarbons therefrom. Waste water or sea water is contacted with zeolite in the presence of a surfactant, and optionally hydrophobic cellulose, to effect removal of the unwanted substances therefrom; and soil contaminated with petroleum hydrocarbons, salt or agricultural chemicals can be rejuvenated by mixing the soil with zeolite and a surfactant followed by washing. The apparatus and method provides simultaneous removal of a wide variety of unwanted substances from a feed stream passed therethrough, in contrast to prior art procedures effective to remove only one such substance per treatment.

Abstract: A fluorescent backlit display or the like embodying a generally planar light transmissive display panel, a back wall having a generally planar diffusely reflective surface facing, spaced from and parallel with the display panel an array of spaced parallel cylindrical lamps between and parallel with the display panel and back wall, improved light leveling means including masking means on the side of each lamp facing the display panel, and a light spreader associated with each lamp at the diffusely reflective back wall surface and effective to reflect laterally outwardly onto the back wall surface light flux directed thereat from the side of said lamps facing said back wall, whereupon the thus reflected light flux is directed forwardly toward areas of said display panel in front of the respective lamps.

Abstract: A tabletop backlit display for use in tradeshows which can be readily assembled and disassembled on site, and when disassembled, can be accomodated in a single shipping carton of a size acceptable at normal rates by package delivery services. A major feature is an articulated lighting unit assembly which includes a pair of lighting units each carrying three equally spaced parallel fluorescent lamps, an intermediate reflector panel and a pair of auxiliary side reflector panels, the lighting assembly being foldable, without removing the lamps therefrom, from an in line operative configuration in which all of the fluorescent lamps are equally spaced, to a compact generally U-shaped alternative or shipping configuration. The assembly is removably mounted on a frame with supporting members, and a flexible, rollable light transmissive display panel is removably mounted on the front face of the frame.

Abstract: A light transmittance type analytical system for the rapid quantitation of minute amounts of an analyte in a fluid sample and an optical component and test device useful therein are; disclosed. The analytical system employs an assay in which the presence of the analyte in the assayed sample is productive of an insoluble substantially opaque, light absorptive colored end product. In the preferred use of the analytical system, the end product is formed in contact with a light and fluid permeable optical component in the form of a matrix of compacted substantially water insoluble granules of reflective material which has a light scattering coefficient of at least about 80 and is substantially nonabsorptive of light.

Abstract: A method of providing uniform illumination of a light transmissive image on the light transmissive display panel of a fluorescent backlit display or the like, which includes blocking of a portion of the light flux projecting from at least one elongated tubular lamp toward the display panel in a plane including the lamp axis and normal to said panel; and blocking decreasing amounts of light flux projected from said lamp toward the display panel at points thereon spaced at successively greater distances on each side of said plane. A variable opacity light leveling mask configured to produce the aforementioned uniform illumination is interposed between the lamp and the display panel.

Abstract: Method and means for accelerating the rate of hybridization of nucleic acid probes with complemental target sequences in probe assays of the filter binding or sandwich filter binding formats. The nucleic acid probes are electrophoretically concentrated at membrane means including at least a dialysis type membrane and to which the target sequences are bound. The rate of hybridization can be further enhanced by means for moving concentrated unannealed probe molecules successively in various directions along the surface of the membrane means to which the target sequences are bound. The invention further includes method and means for electrophoretically removing from the membrane means unannealed probe molecules which became adsorbed to the membrane means during hybridization.

Abstract: An apparatus and method useful for continuously dispensing from a bulk storage bin or silo at a precise weight per unit time nonfree-flowing particulate material. A feeder capable of discharging from the back storage bin or silo a precise volume per unit time of the particulate material is positioned to deposit the material onto the conveyor of a continuous weigh scale which, like the feeder, is driven by variable speed drive motor under the control of a control circuit responsive to changes in bulk density of the particulate material sensed by the weigh scale. There is an adjustable speed ratio driving connection between the feeder and conveyor for causing the conveyor to be driven at a predetermined constant speed with respect to the speed of the feeder, and the control circuit is effective to cause shut off of the apparatus in the event that the bulk density of the particulate material exceeds predetermined minimum or maximum limits.

Abstract: Apparatus and method for biological fluid analysis involving radiation measurement. The apparatus includes a pipetting dispenser having means for directing radiation from the piston thereof generally axially through the liquid in the pipette tube such that the pipetting dispenser serves not only as a means for measuring and mixing liquids, but also serves as a cuvette. The apparatus and method provide maximum radiation path length to accommodate liquids of different optical density. Still another feature of the apparatus and method is the provision of means for removing liquid from the outer surface of a pipette tube, which means are readily adapted to automated procedures. The apparatus in one embodiment is adapted for absorbance measurement of analyte samples, and in another embodiment is adapted for measurement of fluorescent radiation from analyte samples.

Abstract: Bubble detecting infusion apparatus for infusing a liquid from a source into a patient through the lumen of a light transmissive conduit member, which lumen has a flat wall surface portion contacted by the liquid in the lumen, the conduit member having an operative position within a yoke in which it is removable disposed, the yoke having a light source for directing a light beam through the conduit member wall toward the flat lumen wall surface portion thereof and having a light sensor positioned to receive light from the source reflected through the conduit member wall by the flat lumen wall surface portion, the angularity between the incident light beam and the normal to the flat lumen wall surface portion being such that when a gas bubble is in contact with the lumen flat wall surface portion, substantially all light from the source incident thereon is reflected by said surface portion toward the light sensor, and when a bubble-free liquid is in contact with the lumen flat wall surface portion, said surfac

Abstract: Apparatus and method for biological fluid analysis involving radiation measurement. The apparatus includes a pipetting dispenser having means for directing radiation from the piston thereof generally axially through the liquid in the pipette tube such that the pipetting dispenser serves not only as a means for measuring and mixing liquids, but also serves as a cuvette. The apparatus and method provide maximum radiation path length to accommodate liquids of different optical density. Still another feature of the apparatus and method is the provision of means for removing liquid from the outer surface of a pipette tube, which means are readily adapted to automated procedures. The apparatus in one embodiment is adapted for absorbance measurement of analyte samples, and in another embodiment is adapted for measurement of fluorescent radiation from analyte samples.

Abstract: Apparatus and method for converting heat to electrical energy by the use of one or more capacitors having temperature dependent capacitance. The capacitor is cycled between relatively high and relatively low temperatures by successive thermal contact with relatively high and relatively low temperature portions of a heat transfer medium having a temperature gradient therein. Upon heating of the capacitor, the capacitance thereof is reduced, so that a charge therein is caused to expand into associated external circuitry in which it is available to do electrical work. The capacitor is then cooled and recharged and the cycle is repeated. The electrical output of the capacitor results from the regenerative delivery of heat to and removal of heat from the capacitor by the heat transfer medium, and efficient conversion of heat to electric energy is thereby effected.

Abstract: Method and means useful in reflectance measurement is provided wherein radiation of one wavelength is separated from radiation of a different wavelength by the use of a composite of at least two components, one of which is absorptive of said one wavelength radiation and is highly transmissive of said other wavelength radiation, and the other of which is reflective of radiation of both of said wavelengths. The method and means are particularly adapted for use in fluorescent radiation measurement to prevent high intensity residual incident excitation radiation from interfering with measurement of the relatively low intensity fluorescent radiation.

Abstract: An improved stethoscope having means for measuring the frequency of a series of pulses, such as human heart pulses, is disclosed, in the use of which such pulses are detected simultaneously with detection of a series of timed detectable reference impulses produced by a reference impulse producer having means for adjusting the frequency of the reference impulses produced thereby and also having readout means indicating the frequency of the reference impulses, wherefore upon adjustment of the frequency of the reference impulses as necessary to match that of said pulses, the frequency of said pulses is indicated on the readout means.

Abstract: A method and apparatus for sensing the presence of bubbles in a liquid wherein radiation is directed through said liquid toward a radiation responsive sensor and the differential between the response of the sensor when a bubble is not present in the radiation path and the response thereof when a bubble is present in the radiation path is markedly increased by limitation of the radiation which can reach said sensor to wavelengths strongly absorbed by said liquid.

Abstract: An improved laser apparatus is provided wherein a laser and a pump source comprising an array of GaAs or GaAlAs light emitting laser diodes or of excimer fluorescors or lasers which emits a large cross section beam of generally collimated pumping radiation are coupled by flux concentrating means comprising a compound parabolic concentrator.

Abstract: An improved method is provided for producing monocellular layers of cell-containing biological fluid, such as blood, by spinning a sample slide bearing a sample to be analyzed. In the practice of the improved method, the slide is positioned with the sample-bearing surface thereof facing downwardly so that the force of gravity aids, rather than hinders, monocellular layer formation. Such layer formation is further facilitated by spinning of the slide in a holder provided with integral wall means shielding the sample from the buffeting effect of circumambient air to thereby avoid premature drying of the sample, minimize cell distortion and prevent aerosol formation.

Abstract: An improved method and apparatus are provided for producing monocellular layers of cell-containing biological fluid, such as blood, by spinning a sample slide bearing a sample to be analyzed. In the practice of the improved method and use of the improved apparatus, the slide is positioned with the sample-bearing surface thereof facing downwardly so that the force of gravity aids, rather than hinders, monocellular layer formation. Such layer formation is further facilitated by spinning of the slide in a holder provided with integral wall means shielding the sample from the buffeting effect of circumambient air to thereby avoid premature drying of the sample, minimize cell distortion and prevent aerosol formation.